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    • 5. 发明授权
    • Tissue chromophore measurement system
    • 组织发色团测量系统
    • US5879294A
    • 1999-03-09
    • US672625
    • 1996-06-28
    • David L. AndersonGalen D. HoukMark S. LewandowskiDean E. MyersJoseph P. Ortner
    • David L. AndersonGalen D. HoukMark S. LewandowskiDean E. MyersJoseph P. Ortner
    • G01N21/27A61B5/00A61B5/145A61B5/1455A61B5/1495A61B10/00G01J3/433G01N21/31
    • G01J3/433A61B5/14551G01N21/314A61B2562/0242A61B5/14553A61B5/1495A61B5/7264
    • A measurement system and method for measuring a relative concentration of a first form of a chromophore having a first form and a second form. The method comprises irradiating a tissue sample with light at a plurality of wavelengths within a wavelength range within which the first and second forms of the chromophore provide an overlapping spectral response. A detector is provided that detects spectral data emitted from the tissue. Furthermore, the method comprises determining a first and a second 2d derivative spectrum value, at first and second wavelengths, respectively, within said wavelength range at which the first 2d derivative spectrum value varies with the relative concentration of the first form of the chromophore. A scaled, 2d derivative spectrum value is derived from the first and second 2d derivative spectrum values. A memory stores a correlation which provides the relative chromophore concentration as a function of the scaled, 2d derivative spectrum value. Finally, the relative concentration of the first form of the chromophore in the tissue sample is determined from the 2d derivative spectrum values and the correlation.
    • 一种用于测量具有第一形式和第二形式的发色团的第一形式的相对浓度的测量系统和方法。 该方法包括用波长范围内的多个波长的光照射组织样本,其中发色团的第一和第二形式提供重叠的光谱响应。 提供检测器,其检测从组织发射的光谱数据。 此外,该方法包括分别在所述波长范围内的第一和第二波长处确定第一和第二2D导数光谱值,在该范围内第一2d衍生光谱值随发色团的第一形式的相对浓度而变化。 从第一和第二2D导数光谱值导出缩放的二维导数光谱值。 存储器存储提供相对发色团浓度作为缩放的二维导数谱值的函数的相关性。 最后,从2d衍生光谱值和相关性确定组织样品中发色团的第一形式的相对浓度。