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1. 发明授权

US06169092A 3-Ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes 失效
标题翻译： 3-脲基 - 吡哆醛和吡咯并噻吩，用于治疗炎症过程
公开(公告)号：US06169092A
公开(公告)日：2001-01-02
申请号：US09214370
申请日：1999-01-05
申请人： Gabriele Br{umlaut over (a)}unlich , Mazen Es-Sayed , R{umlaut over (u)}diger Fischer , Rolf Henning , Burkhard Fugmann , Stephan Schneider , Michael Sperzel , Graham Sturton , Mary Fitzgerald , Barbara Briggs , Arnel Concepcion
发明人： Gabriele Br{umlaut over (a)}unlich , Mazen Es-Sayed , R{umlaut over (u)}diger Fischer , Rolf Henning , Burkhard Fugmann , Stephan Schneider , Michael Sperzel , Graham Sturton , Mary Fitzgerald , Barbara Briggs , Arnel Concepcion
IPC分类号： A61K31495
CPC分类号： C07D491/04 , C07D495/04 , C07F9/6561
摘要： 3-Urea-pyridofurans and -pyridothiophenes are prepared by reacting appropriately substituted 3-amino-pyridofurans or -pyridothiophenes with isocyanates or isothiocyanates. The 3-urea-pyridofurans and -pyridothiophenes can be used as active ingredients in medicaments, particularly in medicaments for the treatment of acute and chronic inflammatory processes.
摘要翻译：通过将适当取代的3-氨基 - 呋喃呋喃或吡咯并噻吩与异氰酸酯或异硫氰酸酯反应制备3-脲 - 吡哆醛和吡咯并噻吩。 3-脲 - 吡哆醛和吡咯并噻吩可用作药物中的活性成分，特别是用于治疗急性和慢性炎症过程的药物。

2. 发明申请

US20050065153A1 Novel heterocycles 3 审中-公开
标题翻译：新的杂环3
公开(公告)号：US20050065153A1
公开(公告)日：2005-03-24
申请号：US10964380
申请日：2004-10-12
申请人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Maria Niewohner
IPC分类号： C07D253/06 , A61K31/53 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/02 , C07D253/07 , C07D487/04
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译：本发明涉及7-（4-叔丁基 - 环己基） - 咪唑并三嗪酮，其制备方法及其在药物中的应用，用于治疗和/或预防炎症过程和/或免疫疾病。

3. 发明申请

US20050272732A1 5-ethyl-imidazo (5,1-F) (1,2,4,) triazin-4 (3h)-ones as phosphodiesterase inhibitors 审中-公开
标题翻译：作为磷酸二酯酶抑制剂的5-乙基咪唑并（5,1-F）（1,2,4）三嗪-4（3h） - 酮
公开(公告)号：US20050272732A1
公开(公告)日：2005-12-08
申请号：US10513115
申请日：2003-04-22
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： C07D253/06 , A61K31/53 , A61P11/00 , A61P11/06 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译：本发明涉及新的5-乙基 - 咪唑并三嗪酮，其制备方法及其在药物中的用途，用于治疗和/或预防炎症过程和/或免疫疾病。

4. 发明申请

US20060293326A1 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases 审中-公开
标题翻译： 2-杂芳基 - 咪唑并三嗪酮及其在治疗炎症或免疫疾病中的应用
公开(公告)号：US20060293326A1
公开(公告)日：2006-12-28
申请号：US10480949
申请日：2002-05-21
申请人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Maria Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton
发明人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Maria Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D487/04
摘要： The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10-membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C1-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3- to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3- to 10-membered carbocyclyl and oxo.
摘要翻译：本发明涉及2-杂芳基 - 咪唑并三嗪酮，其制备方法及其在药物中的应用，用于治疗和/或预防炎症过程和/或免疫疾病。本发明涉及通式（I）的化合物，其中R 1表示5至10元杂芳基，其任选被相同或不同的选自以下的残基所取代：卤素，（C 1 -C 4 - ） - 烷基，三氟甲基，氰基，硝基和三氟甲氧基，表示3-至10-元碳环基或碳键合，4-至10- 其中碳环基和杂环基任选被相同或不同的选自（C 1 -C 6 -C 6） - 烷基，（C 1 -C 6）（C 1 -C 6 -C 6） - 羟基，羟基，卤素，三氟甲基和氧代，或表示（C 2 -C 10） - 烷基，其任选被相同或不同的残基选择，所述残基选自（C 1 -C 6 -C 6） - 烷氧基，羟基，卤素，至10元碳环基和氧代。

5. 发明申请

US20060040942A1 5-ethylimidarotriazones 失效
公开(公告)号：US20060040942A1
公开(公告)日：2006-02-23
申请号：US10514672
申请日：2003-05-05
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

6. 发明申请

US20060040941A1 7-Aminoimidazotriazones 审中-公开
标题翻译： 7-氨基咪唑三唑
公开(公告)号：US20060040941A1
公开(公告)日：2006-02-23
申请号：US10513116
申请日：2003-04-22
申请人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen-Haertwig , Martin Michels , Dagmar Karthaus , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Ulrich Niewohner , Maria Niewohner
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04 , C07D253/07 , C07D401/12 , C07D403/12
摘要： The invention relates to novel 7-amino-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译：本发明涉及新型7-氨基 - 咪唑并三嗪酮，其制备方法及其在药物中的应用，用于治疗和/或预防炎症过程和/或免疫疾病。

7. 发明申请

US20080318912A1 Medicaments for Treating Chronic Respiratory Disease 审中-公开
标题翻译：治疗慢性呼吸道疾病的药物
公开(公告)号：US20080318912A1
公开(公告)日：2008-12-25
申请号：US11659458
申请日：2005-08-03
申请人： Craig Fox , Harry Finch , Mary Fitzgerald
发明人： Craig Fox , Harry Finch , Mary Fitzgerald
IPC分类号： A61K31/58 , A61P11/00
CPC分类号： A61K31/52 , A61K31/573 , A61K2300/00
摘要： There is provided the use of a methylxanthine compound and a steroid in a synergistic combination for the treatment of a respiratory disease, wherein the methylxanthine compound is administered at a dose, which, in isolation, is not effective to treat said disease.
摘要翻译：提供了用于治疗呼吸系统疾病的协同组合中的甲基黄嘌呤化合物和类固醇的用途，其中所述甲基黄嘌呤化合物以分开的方式施用，所述剂量不能有效地治疗所述疾病。

8. 发明申请

US20090191217A1 Anti-IL-1R1 Single Domain Antibodies And Therapeutic Uses 审中-公开
标题翻译：抗IL-1R1单域抗体和治疗用途
公开(公告)号：US20090191217A1
公开(公告)日：2009-07-30
申请号：US11791781
申请日：2005-12-01
申请人： Ruud M. de Wildt , Philip D. Drew , Ian M. Tomlinson , Mary Fitzgerald , Craig Fox , Steve Holmes
发明人： Ruud M. de Wildt , Philip D. Drew , Ian M. Tomlinson , Mary Fitzgerald , Craig Fox , Steve Holmes
IPC分类号： A61K39/395 , A61M5/178 , A61K9/48 , A61K9/20 , A61M37/00 , A61M25/00 , A61M15/00
CPC分类号： A61K39/3955 , A61K47/60 , A61K47/643 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K2039/555 , C07K14/70578 , C07K14/7155 , C07K16/18 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/569 , C07K2317/626 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/31 , C12N15/62
摘要： Disclosed is the use of an antagonist of Interleukin 1 receptor type 1 (IL-1R1) for the manufacture of a medicament treating, preventing or suppressing lung inflammation or a respiratory disease. In some embodiments of the described invention, the medicament is for local administration to pulmonary tissue. Also disclosed are methods for treating lung inflammation or a respiratory disease.
摘要翻译：披露了1型白细胞介素1受体拮抗剂（IL-1R1）用于制备治疗，预防或抑制肺部炎症或呼吸系统疾病的药物的用途。在所述发明的一些实施方案中，药物用于局部施用于肺组织。还公开了治疗肺部炎症或呼吸系统疾病的方法。

9. 发明申请

US20060185234A1 Corsage holder 审中-公开
标题翻译：胸花架
公开(公告)号：US20060185234A1
公开(公告)日：2006-08-24
申请号：US11343448
申请日：2006-01-31
申请人： Mary Fitzgerald
发明人： Mary Fitzgerald
IPC分类号： A01G5/00
CPC分类号： A01G5/04 , A45F5/08 , A47G7/02
摘要： A holder and method of securing a decorative object, e.g., a corsage, to a surface, e.g., clothing of a wearer, without damaging the decorative object or the surface are provided. The holder includes a vessel having at least one side wall configured to define a cavity, the vessel including an open top end for receiving the object and a closed bottom end for supporting the object in the cavity, the vessel being from of a material having magnetic properties; and a magnetic member for securing the vessel to the surface, wherein the vessel is placed on one side of the surface and the magnetic member is placed adjacent to the vessel on an opposite side of the surface gripping the surface therebetween.
摘要翻译：提供了将装饰物例如胸衣固定到例如穿着者的衣服的表面上的保持器和方法，而不损坏装饰物体或表面。所述支架包括具有至少一个侧壁的容器，所述至少一个侧壁被配置为限定空腔，所述容器包括用于接收所述物体的敞开的顶端和用于将所述物体支撑在所述空腔中的封闭的底端，所述容器由具有磁性的材料属性; 以及用于将容器固定到表面的磁性构件，其中容器放置在表面的一侧上，并且磁性构件被放置在与容器相邻的表面上，夹着其表面之间的表面。

10. 发明申请

US20060100207A1 Dihydropyridinone derivatives 失效
标题翻译：二氢吡啶酮衍生物
公开(公告)号：US20060100207A1
公开(公告)日：2006-05-11
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译：本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。

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