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1. 发明授权

US06734165B2 Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide 失效
标题翻译：对万古霉素抗性细菌进行再敏化的方法，其选择性地切割细胞壁depipipeptide
公开(公告)号：US06734165B2
公开(公告)日：2004-05-11
申请号：US09938746
申请日：2001-08-23
申请人： Gabriela Chiosis , Ivo G. Boneca , W. Clark Still
发明人： Gabriela Chiosis , Ivo G. Boneca , W. Clark Still
IPC分类号： A61K3816
CPC分类号： A61K31/40 , A61K38/14 , A61K2300/00
摘要： The present invention relates a method for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond in the cell wall peptide precursors of the bacteria which comprises using an antibacterial amount of vancomycin or a homolog of vancomycin and an amount of an agent effective to selectively cleave the ester bond so as to thereby re-sensitize vancomycin resistant bacteria.
摘要翻译：本发明涉及一种对万古霉素抗性的革兰氏阳性菌进行再敏化的方法，其中抗细菌量为万古霉素或细菌的细菌壁肽前体中的酰胺键转变为酯键，万古霉素的同系物和一定量的有效选择性地切割酯键的试剂，从而使万古霉素抗性细菌再敏化。

2. 发明授权

US06953861B2 Method of re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide 失效
标题翻译：对万古霉素抗性细菌进行再敏化的方法，其选择性地切割细胞壁depipipeptide
公开(公告)号：US06953861B2
公开(公告)日：2005-10-11
申请号：US10805624
申请日：2004-03-18
申请人： Gabriela Chiosis , Ivo G. Boneca , W. Clark Still
发明人： Gabriela Chiosis , Ivo G. Boneca , W. Clark Still
IPC分类号： A61K31/40 , A61K38/14 , C07D207/08
CPC分类号： A61K31/40 , A61K38/14 , A61K2300/00
摘要： The present invention relates to pyrrolidine compounds of the general structure: where n is an integer 1-6 and R is hydrogen or a C1 to C6 straight chain or branched alkyl group, and wherein when n=1, R=CH3 or H, useful for re-sensitizing vancomycin resistant Gram-positive bacteria in which resistance results from the conversion of an amide bond to an ester bond on the cell wall peptide precursors of the bacteria.
摘要翻译：本发明涉及通式结构的吡咯烷化合物：其中n为整数1-6，R为氢或C 1至C 6直链或支链烷基并且其中当n = 1时，R = CH 3或H，其可用于对由万古霉素抗性的革兰氏阳性细菌进行再敏化，其中抗性是由酰胺键转化为酯键而导致的细胞壁的肽前体细菌。

3. 发明授权

US5789172A Methods of determining the structure of a compound encoded by identifiers having tags 失效
标题翻译：确定具有标签的标识符编码的化合物的结构的方法
公开(公告)号：US5789172A
公开(公告)日：1998-08-04
申请号：US680716
申请日：1996-07-11
申请人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
发明人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
IPC分类号： G01N33/566 , C07B61/00 , C07C43/225 , C07C205/59 , C07C245/14 , C07C317/28 , C07D243/24 , C07D521/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B70/00 , G01N33/532 , G01N33/543 , G01N33/68 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/68 , C07D243/24 , C07H21/00 , C07K1/047 , C40B50/16 , G01N33/532 , G01N33/54353 , B01J2219/00572 , C07B2200/11 , C40B40/00 , C40B70/00
摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
摘要翻译：提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

4. 发明授权

US5599926A A.sub.4 B.sub.6 macrotricyclic enantioselective receptors for amino acid derivatives, and other compounds 失效
标题翻译：氨基酸衍生物的A4B6大分子对映体选择性受体和其他化合物
公开(公告)号：US5599926A
公开(公告)日：1997-02-04
申请号：US188146
申请日：1994-01-27
申请人： W. Clark Still , Julian A. Simon , Shawn D. Erickson , Seung S. Yoon , Jong-In Hong
发明人： W. Clark Still , Julian A. Simon , Shawn D. Erickson , Seung S. Yoon , Jong-In Hong
IPC分类号： C07B57/00 , C07B63/00 , C07B63/04 , C07D487/18 , C07D487/22 , C07D498/18 , C07D513/18
CPC分类号： C07D487/18 , C07B57/00 , C07B63/00 , C07B63/04 , C07D487/22 , C07D498/18 , C07D513/18 , Y02P20/55
摘要： The subject invention provides chiral receptor molecules having the structure: ##STR1## wherein A has the structure: ##STR2## and R.sub.1 and R.sub.2 are independently the same or different and are H, F, alkyl, aryl, etc.; X is CH.sub.2 or NH; Y is C.dbd.O or SO.sub.2 ; and n is 0 to about 3; which are useful for the purification of enantiomers of amino acid derivatives and other compounds. The subject invention also provides methods of preparing said receptor molecules.
摘要翻译：本发明提供具有以下结构的手性受体分子：其中A具有以下结构：R 1和R 2独立地相同或不同，为H，F，烷基，芳基等; X是CH 2或NH; Y为C = O或SO2; 且n为0至约3; 其可用于纯化氨基酸衍生物和其它化合物的对映异构体。本发明还提供了制备所述受体分子的方法。

5. 发明授权

US06622094B2 Method for determining relative energies of two or more different molecules 失效
标题翻译：确定两个或多个不同分子的相对能量的方法
公开(公告)号：US06622094B2
公开(公告)日：2003-09-16
申请号：US08601734
申请日：1996-02-15
申请人： W. Clark Still , Quentin McDonald
发明人： W. Clark Still , Quentin McDonald
IPC分类号： G06F1750
CPC分类号： C07K1/00 , G06F19/16 , G06F19/701 , G06F19/704
摘要： The present invention provides for a method for selecting a molecule for a population which comprises: a) selecting a first molecule with a conformation characterized by a particular set of coordinates that define the position of each atom in the first molecule; b) determining the energy of the first molecule; c) transforming the coordinates of the first molecule to the coordinates of a second structurally distinct molecule to produce a particular conformation of the second molecule characterized by a particular set of coordinates that define the position of each atom in the second molecule; d) determining the energy of the second molecule; thus, selecting either the first molecule or the second molecule for the population based on their relative energies. The selected molecule may be redefined as the first molecule and the procedure repeated iteratively so as to obtain a population of first molecules and a population of second molecules. Based on the populations, the free energy difference between the first molecule and the second molecule may be determined.
摘要翻译：本发明提供了一种用于选择群体分子的方法，其包括：a）选择具有由定义第一分子中每个原子的位置的特定坐标系表征的构象的第一分子; b）确定第一分子的能量; c）将第一分子的坐标转换为第二结构不同分子的坐标以产生第二分子的特定构象，其特征在于定义第二分子中每个原子的位置的特定坐标系; d）确定第二分子的能量; 因此，基于它们的相对能量，为群体选择第一分子或第二分子。所选择的分子可以被重新定义为第一分子，并且该过程重复地重复以获得第一分子和第二分子群体的群体。基于群体，可以确定第一分子和第二分子之间的自由能差异。

6. 发明授权

US5968736A Methods for recording the reaction history of a solid support 失效
标题翻译：用于记录固体支持物的反应历史的方法
公开(公告)号：US5968736A
公开(公告)日：1999-10-19
申请号：US480821
申请日：1995-06-07
申请人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
发明人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
IPC分类号： G01N33/566 , C07B61/00 , C07C43/225 , C07C205/59 , C07C245/14 , C07C317/28 , C07D243/24 , C07D521/00 , C07H21/00 , C07K1/00 , C07K1/04 , C40B70/00 , G01N33/532 , G01N33/543 , G01N33/68 , G01N33/53
CPC分类号： G01N33/68 , C07D243/24 , C07H21/00 , C07K1/047 , C40B50/16 , G01N33/532 , G01N33/54353 , B01J2219/00572 , C07B2200/11 , C40B40/00 , C40B70/00
摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
摘要翻译：提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

7. 发明授权

US4293422A Flash chromatography 失效
标题翻译：快速色谱
公开(公告)号：US4293422A
公开(公告)日：1981-10-06
申请号：US54982
申请日：1979-07-05
申请人： W. Clark Still
发明人： W. Clark Still
IPC分类号： B01D15/08 , G01N30/60
CPC分类号： G01N30/603 , B01D15/165
摘要： A short vertical column is utilized to confine a short bed of adsorbent horizontally which has vertically defined upper and lower ends. Space in the column is provided to define a zone for horizontally defined liquid above and in contact with the bed. Liquid solvent is then placed in the column above bed to wet the bed, and positive gas pressure is applied to the liquid above the bed to drive entraped gases out of the bed. The solvent level is then lowered to the upper level of the bed. The sample is then added and gas pressure is used to drive the solvent and sample into the bed. The bed is eluted with fresh solvent in the same manner.
摘要翻译：使用短的垂直柱来限制水平的具有垂直限定的上端和下端的吸附剂。提供柱中的空间来限定在床上方并与床接触的水平定义的液体的区域。然后将液体溶剂置于床上方的柱中以使床层湿润，并将床上的液体施加正气体压力以将夹带的气体驱出床。然后将溶剂水平降至床的上部水平。然后加入样品，使用气体压力将溶剂和样品驱入床中。以相同的方式用新鲜溶剂洗脱床。

8. 发明授权

US6001579A Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags 失效
标题翻译：由非可序列标签编码的支持体和组合化学文库
公开(公告)号：US6001579A
公开(公告)日：1999-12-14
申请号：US485018
申请日：1995-06-07
申请人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
发明人： W. Clark Still , Michael H. Wigler , Michael H. J. Ohlmeyer , Lawrence W. Dillard , John C. Reader
IPC分类号： C07D243/16 , G01N33/53 , G01N33/543 , G01N33/546 , G01N33/566 , G01N33/58
CPC分类号： C07D243/28 , C07D491/048 , C40B40/04 , C40B50/16 , C40B70/00 , G01N33/54313 , G01N33/54353 , C07B2200/11
摘要： Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
摘要翻译：提供了编码的组合化学，其中使用有机分子记录顺序合成方案，其定义了反应物的选择和阶段，作为相同或不同的信息位。可以在多级合成中产生各种产物，例如低聚物和合成的非重复有机分子。方便地，化合物的嵌套族可以用作标识符，其中取代基的数目和/或位置定义了选择。或者，可以使用可检测的官能团，例如放射性同位素，荧光剂，卤素等，其中两个不同基团的存在和比例可用于限定阶段或选择。特别地，可以使用多个标识符来提供二进制或更高代码，以便仅限定几个可拆卸标签来定义多个选择。可以筛选颗粒以获得感兴趣的特征，特别是结合亲和力，其中产物可以与颗粒分离或保留在颗粒上。对特征呈阳性的颗粒的反应历程可以通过标签的释放和分析来确定以确定颗粒的反应历程。

9. 发明授权

US5804563A Synthetic receptors, libraries and uses thereof 失效
标题翻译：合成受体，文库及其用途
公开(公告)号：US5804563A
公开(公告)日：1998-09-08
申请号：US628972
申请日：1996-04-08
申请人： W. Clark Still , Ge Li
发明人： W. Clark Still , Ge Li
IPC分类号： G01N33/566 , C07C237/10 , C07C271/22 , C07J9/00 , C07J41/00 , C07J51/00 , C07K1/04 , C07K5/12 , C07K7/06 , C07K7/23 , C07K17/04 , C12Q1/25 , C12Q1/68 , C40B70/00 , A01N45/00
CPC分类号： C07J9/005 , C07J41/0055 , C07J41/0061 , C07K1/047 , C07K5/123 , C12Q1/6811 , B01J2219/0054 , B01J2219/00572 , B01J2219/00592 , C40B70/00
摘要： The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain or branched. The template may be linked to an identifier which uniquely defines the synthetic receptor. The identifier is a stable chemical molecule or a plurality of stable chemical molecules distinguishable and detectable to picomolar levels or may be an oligonucleotide. In an preferred embodiment, the template is covalently linked to a solid support which is linked to an identifier.
摘要翻译：本发明涉及合成受体，其包含共价连接到两个或多个低聚物的多官能有机模板，其可以独立地相同或不同，并且可以独立地是直链或支链的。模板可以链接到唯一地限定合成受体的标识符。标识符是稳定的化学分子或多个稳定的化学分子，其可分辨和可检测到皮摩尔水平，或可以是寡核苷酸。在优选实施方案中，模板共价连接到与标识符连接的固体支持物。

10. 发明授权

US5740072A Rapidly convergent method for boltzmann-weighted ensemble generation in free energy simulations 失效
标题翻译：在自由能模拟中的螺旋加权集合生成的快速收敛方法
公开(公告)号：US5740072A
公开(公告)日：1998-04-14
申请号：US320255
申请日：1994-10-07
申请人： W. Clark Still , Frank Guarnieri , Hanoch Senderowitz
发明人： W. Clark Still , Frank Guarnieri , Hanoch Senderowitz
IPC分类号： C07K1/00 , G06F17/50 , G06F19/00 , G01N37/00
CPC分类号： C07K1/00 , G06F19/701
摘要： The invention is directed to a method for generating possible conformations of a molecule comprising the steps of: a) selecting a first conformation of the molecule characterized by a first set of coordinates associated with each atom in the molecule by the presence of a pattern of forces among such atoms and by a series of intrinsic forces associated with each atom; b) varying the pattern of forces among such atoms in a non-random manner and randomly varying the series of intrinsic forces associated with each atom so as to generate a second conformation of the molecule characterized by a second set of coordinates associated with each atom in the molecule, by a second pattern of forces among each atom and by a second series of intrinsic forces associated with each atom; and c) randomly varying the second set of coordinates so as to obtain a third set of coordinates and thereby generating such possible conformations of the molecule.
摘要翻译：本发明涉及一种用于产生分子的可能构象的方法，包括以下步骤：a）选择分子的第一构象，所述第一构象的特征在于通过存在力图形的分子中与每个原子相关联的第一组坐标在这些原子之间以及与每个原子相关联的一系列内在力; b）以非随机方式改变这些原子之间的力的模式并且随机地改变与每个原子相关联的一系列内在力，从而产生分子的第二构象，其特征在于与每个原子相关联的第二组坐标分子，通过每个原子之间的第二个力图案和与每个原子相关联的第二系列内在力; 以及c）随机地改变所述第二组坐标以获得第三组坐标，从而产生所述分子的这种可能的构象。

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