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1. 发明申请

US20210283314A1 METHOD FOR PRODUCING POROUS SUBSTRATE COMPRISING BIOABSORBABLE POLYMER THAT CONTAINS HEPARIN, POROUS SUBSTRATE COMPRISING BIOABSORBABLE POLYMER THAT CONTAINS HEPARIN, AND ARTIFICIAL BLOOD VESSEL 有权
公开(公告)号：US20210283314A1
公开(公告)日：2021-09-16
申请号：US16334578
申请日：2017-08-31
申请人： GUNZE LIMITED
发明人： Hidetaka NAKAYAMA , Toshiharu SHINOKA , Shuhei TARA , Tadahisa SUGIURA
IPC分类号： A61L27/56 , A61L27/54 , A61L27/50 , A61L27/58 , A61L27/14 , B29C67/20
摘要： The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.

2. 发明申请

US20180221132A1 ARTIFICIAL BLOOD VESSEL, METHOD FOR PRODUCING ARTIFICIAL BLOOD VESSEL, AND METHOD FOR PRODUCING POROUS TISSUE REGENERATION SUBSTRATE 审中-公开
公开(公告)号：US20180221132A1
公开(公告)日：2018-08-09
申请号：US15747815
申请日：2016-08-02
申请人： GUNZE LIMITED
发明人： Hidetaka NAKAYAMA , Kosuke SAWAI , Toshiharu SHINOKA , Shuhei TARA , Hirotsugu KUROBE
IPC分类号： A61F2/06 , A61L27/50 , A61L27/56
CPC分类号： A61F2/06 , A61L27/507 , A61L27/56 , A61L27/58 , C08J9/28 , C08J2201/0484 , C08J2201/0522 , C08J2205/022 , C08J2205/024 , C08J2205/044 , C08J2207/10 , C08J2300/16 , C08J2367/04
摘要： The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.

3. 发明申请

US20160074023A1 MEDICAL MATERIAL 审中-公开
标题翻译：医用材料
公开(公告)号：US20160074023A1
公开(公告)日：2016-03-17
申请号：US14784465
申请日：2014-04-22
申请人： GUNZE LIMITED
发明人： Yuki SAKAMOTO , Kensuke TAKI , Hidetaka NAKAYAMA , Noriko KAWADA
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12113 , A61B17/12172 , A61B17/12177 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00942
摘要： There is provided a defect hole closing material which achieves minimally invasive medical treatment for Atrial Septal Defect, and poses little possibility of occurrence of a failure in the body in some distant future.The defect hole closing material (100) comprises two bioabsorbable material-made cylindrical bodies (the first cylindrical section (110) and the second cylindrical section (120)) having a mesh-like structure in the form of an hourglass shape, a numeral “8” shape, a double spindle shape, or a peanut shape. With the first end (112) kept held securely, the second end, or the other end (122) is pulled toward the first end (112) by operating the string (140), whereupon the cylinder diameter is increased, and also the first cylindrical section (110) and the second cylindrical section (120) move close to each other with respect to the substantially central section (130) serving as a center.
摘要翻译：提供了一种缺陷闭孔材料，其实现了心房间隔缺损的微创治疗，并且在不久的将来几乎不会发生身体失败的可能性。缺陷孔闭合材料（100）包括两个生物可吸收材料制造的圆柱体（第一圆柱形部分（110）和第二圆柱形部分（120）），其具有沙漏形状的网状结构，数字“ 8“形，双锭形或花生形。在第一端（112）保持牢固地保持的情况下，通过操作串（140）将第二端或另一端（122）拉向第一端（112），于是缸直径增加，而第一端圆柱形部分（110）和第二圆柱形部分（120）相对于用作中心的大致中心部分（130）彼此靠近移动。

4. 发明申请

US20210283058A1 METHOD FOR PRODUCING SUSTAINED-RELEASE DRUG, AND SUSTAINED-RELEASE DRUG 有权
公开(公告)号：US20210283058A1
公开(公告)日：2021-09-16
申请号：US16334587
申请日：2017-08-31
申请人： GUNZE LIMITED
发明人： Hidetaka NAKAYAMA
IPC分类号： A61K9/16 , A61K9/19 , A61K31/727
摘要： The present invention aims to provide a method for producing a sustained-release drug which includes allowing a medicinal ingredient to be supported on a porous body containing a bioabsorbable polymer and which can control the releasing rate of the medicinal ingredient. The present invention also aims to provide a sustained-release drug. The present invention is directed to a method for producing a sustained-release drug, including: a solution preparing step of preparing a medicinal ingredient-bioabsorbable polymer solution having a medicinal ingredient uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the medicinal ingredient, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the medicinal ingredient-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the medicinal ingredient; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the medicinal ingredient to provide a sustained-release drug containing a porous body supporting the medicinal ingredient, wherein one or two or more common solvents 3 are used, and a releasing rate of the medicinal ingredient of the resulting sustained-release drug is controlled by adjusting a type and a mixing ratio of the one or two or more common solvents 3.

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