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1. 发明申请

US20150258188A1 BACTERIAL OUTER MEMBRANE VESICLES 审中-公开
标题翻译：细菌外膜修复
公开(公告)号：US20150258188A1
公开(公告)日：2015-09-17
申请号：US14727248
申请日：2015-06-01
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Mariagrazia PIZZA , Davide SERRUTO , Rino RAPPUOLI
IPC分类号： A61K39/095 , C12N1/20 , C12N13/00
CPC分类号： A61K39/095 , A61K2039/55555 , C07K14/22 , C12N1/06 , C12N1/20 , C12N13/00
摘要： Existing methods of meningococcal OMV preparation involve the use of detergent during disruption of the bacterial membrane. According to the invention, membrane disruption is performed substantially in the absence of detergent. The resulting OMVs which retain important bacterial immunogenic components, particularly (i) the protective NspA surface protein, (ü) protein NMB2132 and (iii) protein NMB 1870. A Typical process involves the following steps: (a) treating bacterial cells in the substantial absence of detergent; (b) centrifuging the composition from step (a) to separate the outer membrane vesicles from treated cells and cell debris, and collecting the supernatant; (c) performing a high speed centrifugation of the supernatant from step (b) and collecting the outer membrane vesicles in a pellet; (d) re-dispersing the pellet from step (c) in a buffer; (e) performing a second high speed centrifugation in accordance with step (c), collecting the outer membrane vesicles in a pellet; (f) re-dispersing the pellet from step (e) in an aqueous medium.
摘要翻译：脑膜炎球菌OMV制剂的现有方法涉及在细菌膜破坏期间使用洗涤剂。根据本发明，膜破坏基本上在没有洗涤剂的情况下进行。特别是（i）保护性NspA表面蛋白质（ü）蛋白质NMB2132和（iii）蛋白质NMB1870）的所得OMVs。一个典型的方法包括以下步骤：（a）处理实质上的细菌细胞不含洗涤剂; （b）将来自步骤（a）的组合物离心以将外膜囊泡与经处理的细胞和细胞碎片分离，并收集上清液; （c）对来自步骤（b）的上清液进行高速离心并将颗粒中的外膜囊泡收集; （d）将来自步骤（c）的沉淀物重新分散在缓冲液中; （e）根据步骤（c）进行第二高速离心，将外膜囊泡收集在颗粒中; （f）将来自步骤（e）的沉淀物重新分散在水性介质中。

2. 发明申请

US20160151476A1 COMBINATION NEISSERIAL COMPOSITIONS 有权
公开(公告)号：US20160151476A1
公开(公告)日：2016-06-02
申请号：US15015041
申请日：2016-02-03
申请人： GlaxoSmithKline Biologicals SA
发明人： Marzia Monica GIULIANI , Mariagrazia PIZZA , Rino RAPPUOLI
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K38/164 , A61K39/00 , A61K39/02 , A61K39/39 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C07K14/22
摘要： Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

3. 发明申请

US20160051658A1 NEISSERIAL ANTIGENIC PEPTIDES 审中-公开
标题翻译： NEISSERIAL抗原肽
公开(公告)号：US20160051658A1
公开(公告)日：2016-02-25
申请号：US14750837
申请日：2015-06-25
申请人： GLAXOSMITHKLINE BIOLOGICALS SA
发明人： Cesira GALEOTTI , Guido GRANDI , Vega MASIGNANI , Marirosa MORA , Mariagrazia PIZZA , Rino RAPPUOLI , Giulio RATTI , Vincenzo SCARLATO , Maria SCARSELLI
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供衍生自脑膜炎奈瑟氏球菌B细菌的蛋白质，多肽和其片段。还提供编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸，例如，反义核酸）。另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了用组合物制备组合物和处理方法的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

4. 发明申请

US20170165346A1 COMBINATION NEISSERIAL COMPOSITIONS 审中-公开
公开(公告)号：US20170165346A1
公开(公告)日：2017-06-15
申请号：US15438584
申请日：2017-02-21
申请人： GlaxoSmithKline Biologicals SA
发明人： Marzia Monica GIULIANI , Mariagrazia PIZZA , Rino RAPPUOLI
IPC分类号： A61K39/095
摘要： Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

5. 发明申请

US20160175422A1 COMBINATION NEISSERIAL COMPOSITIONS 有权
公开(公告)号：US20160175422A1
公开(公告)日：2016-06-23
申请号：US15015004
申请日：2016-02-03
申请人： GlaxoSmithKline Biologicals SA
发明人： Marzia Monica GIULIANI , Mariagrazia PIZZA , Rino RAPPUOLI
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K38/164 , A61K39/00 , A61K39/02 , A61K39/39 , A61K2039/53 , A61K2039/55505 , A61K2039/70 , C07K14/22
摘要： Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nucleic acids. Preferred Neisseria species are N. meningitidis and N. gonorrhoeae.

6. 发明申请

US20160082098A1 OUTER MEMBRANE VESICLE (OMV) VACCINE COMPRISING N. MENINGITIDIS SEROGROUP B OUTER MEMBRANE PROTEINS 审中-公开
标题翻译：外膜蛋白（OMV）包含N. MENINGITIDIS SEROGROUP B外膜蛋白的疫苗
公开(公告)号：US20160082098A1
公开(公告)日：2016-03-24
申请号：US14961725
申请日：2015-12-07
申请人： GlaxoSmithKline Biologicals SA
发明人： Mariagrazia PIZZA , Rino RAPPUOLI , Marzia Monica GIULIANI
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/54 , A61K2039/55505 , A61K2039/6068 , A61K2039/70 , Y02A50/466
摘要： A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.
摘要翻译：一种组合物，其包含（a）脑膜炎奈瑟氏球菌血清群B外膜囊泡（OMV））和（b）选自其他奈瑟氏球菌蛋白质的免疫原性成分或其免疫原性片段。组分（b）优选包括来自与组分（a）的OMV得自其的不同NmB应变的蛋白质。 OMV优选通过脱氧胆酸提取获得。任选地，组合物还可以包含抗其他病原体的保护性抗原。

7. 发明申请

US20160030546A1 OUTER MEMBRANE VESICLE (OMV) VACCINE COMPRISING N. MENINGITIDIS SEROGROUP B OUTER MEMBRANE PROTEINS 审中-公开
公开(公告)号：US20160030546A1
公开(公告)日：2016-02-04
申请号：US14882320
申请日：2015-10-13
申请人： GlaxoSmithKline Biologicals SA
发明人： Mariagrazia PIZZA , Rino RAPPUOLI , Marzia Monica GIULIANI
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/54 , A61K2039/55505 , A61K2039/6068 , A61K2039/70 , Y02A50/466
摘要： A composition comprising (a) Neisseria meningitidis serogroup B outer membrane vesicles (OMVs), and (b) an immunogenic component selected from other Neisseria proteins, or immunogenic fragments thereof. Component (b) preferably includes a protein from a different NmB strain from that from which the OMV of component (a) is derived. The OMVs are preferably obtained by deoxycholate extraction. Optionally, the composition may also comprise a protective antigen against other pathogens.

8. 发明申请

US20160030545A1 NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS 审中-公开
公开(公告)号：US20160030545A1
公开(公告)日：2016-02-04
申请号：US14804756
申请日：2015-07-21
申请人： GlaxoSmithKline Biologicals SA
发明人： Claire FRASER , Cesira GALEOTTI , Guido GRANDI , Erin HICKEY , Vega MASIGNANI , Marirosa MORA , Jeremy PETERSEN , Mariagrazia PIZZA , Rino RAPPUOLI , Giulio RATTI , Vincenzo SCARLATO , Maria SCARSELLI , Herve TETTELIN , J. Craig VENTER
IPC分类号： A61K39/095 , C07K14/22
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

9. 发明申请

US20160024157A1 HAEMOPHILUS INFLUENZAE TYPE B 审中-公开
标题翻译： HAEMOPHILUS INFLUENZAE型B
公开(公告)号：US20160024157A1
公开(公告)日：2016-01-28
申请号：US14876623
申请日：2015-10-06
申请人： GLAXOSMITHKLINE BIOLOGICALS SA , J. CRAIG VENTER INSTITUTE, INC.
发明人： Vega MASIGNANI , Rino RAPPUOLI , Herve TETTELIN
IPC分类号： C07K14/285 , A61K39/102 , C07K16/12
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K39/12 , C07K14/005 , C07K16/1242
摘要： Polypeptides comprising various amino acid sequences derived from Haemophilus influenzae type b, including a number of lipoproteins. These can be used in the development of vaccines for preventing and/or treating bacterial meningitis. They may also be useful for diagnostic purposes, and as targets for antibiotics. Antibodies against the polypeptides are also disclosed, as are the coding nucleic acids.
摘要翻译：包含衍生自b型流感嗜血杆菌的各种氨基酸序列的多肽，包括许多脂蛋白。这些可用于开发用于预防和/或治疗细菌性脑膜炎的疫苗。它们也可用于诊断目的，也可用作抗生素的靶标。编码核酸也公开了抗多肽的抗体。

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