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1. 发明申请

US20220154293A1 METHOD FOR DETECTING THE METHYLATION OF COLORECTAL-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLORECTAL CANCER DIAGNOSIS 有权
公开(公告)号：US20220154293A1
公开(公告)日：2022-05-19
申请号：US17587365
申请日：2022-01-28
申请人： GENOMICTREE, INC.
发明人： SUNG WHAN AN , Tae Jeong OH
IPC分类号： C12Q1/6886
摘要： The present disclosure relates to a method for detecting CpG methylation of SDC2 (Syndecan 2) gene, a kit for detecting CpG methylation of SDC2 (Syndecan 2) gene, and a method for detecting CpG methylation of SDC2 (Syndecan 2) gene for a colorectal cancer diagnosis.

2. 发明申请

US20130123116A1 DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE 有权
公开(公告)号：US20130123116A1
公开(公告)日：2013-05-16
申请号：US13627474
申请日：2012-09-26
申请人： GENOMICTREE, INC.
发明人： Sung Whan AN , Young Ho MOON , Tae Jeong OH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.

3. 发明申请

US20190390283A1 METHOD FOR DETECTING THE METHYLATION OF COLORECTAL-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLORECTAL CANCER DIAGNOSIS 审中-公开
公开(公告)号：US20190390283A1
公开(公告)日：2019-12-26
申请号：US16543151
申请日：2019-08-16
申请人： GENOMICTREE, INC.
发明人： Sung Whan AN , Tae Jeong OH
IPC分类号： C12Q1/6886
摘要： The present disclosure relates to a method for detecting CpG methylation of SDC2 (Syndecan 2) gene, a kit for detecting CpG methylation of SDC2 (Syndecan 2) gene, and a method for detecting CpG methylation of SDC2 (Syndecan 2) gene for a colorectal cancer diagnosis.

4. 发明申请

US20130122495A1 DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE 有权
标题翻译：使用刮刀癌特异性甲基标记基因的刀片诊断工具包和芯片
公开(公告)号：US20130122495A1
公开(公告)日：2013-05-16
申请号：US13627519
申请日：2012-09-26
申请人： Genomictree, Inc.
发明人： Sung Whan AN , Young Ho MOON , Tae Jeong OH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.
摘要翻译：本发明涉及一种用于使用膀胱癌特异性标志物基因诊断膀胱癌的试剂盒和核酸芯片。更具体地，本发明涉及用于诊断膀胱癌的试剂盒和核酸芯片，其可以检测膀胱癌特异性基因的启动子甲基化，其启动子或外显子区域在膀胱癌的转化细胞中特异性甲基化。使用本发明的诊断试剂盒或核酸芯片能够在转化的早期阶段诊断膀胱癌，从而能够早期诊断膀胱癌，并且可以以比传统方法更准确和更快速地诊断膀胱癌。

5. 发明申请

US20160040244A1 METHOD FOR DETECTING GASTRIC POLYP AND GASTRIC CANCER MARKER GENE OF GASTRIC POLYP AND GASTRIC CANCER-SPECIFIC METHYLATION 审中-公开
标题翻译：检测胃肠道多糖和胃癌标记基因多态性和胃癌特异性甲基化的方法
公开(公告)号：US20160040244A1
公开(公告)日：2016-02-11
申请号：US14438825
申请日：2013-09-26
申请人： GENOMICTREE, INC.
发明人： Sung Whan AN , Tae Jeong OH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： The present invention relates to the novel use of syndecan-2 (SDC2; NM_002998) gene as a gastric polyp- and gastric cancer-specific methylation biomarker, and more particularly, to the use of the syndecan-2 gene as a biomarker that enables gastric polyp and gastric cancer to be diagnosed in an early stage by measuring the methylation level thereof. The present invention has an effect in that the methylation of the CpG island of the gastric polyp- and gastric cancer-specific marker gene can be detected to thereby provide information for diagnosing gastric cancer. The use of the methylation detection method according to the present invention or the diagnostic composition, kit or nucleic acid chip according to the present invention makes it possible to diagnose gastric cancer at an early transformation stage, thus enabling the early diagnosis of gastric cancer. In addition, the method of the present invention enables gastric cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods.
摘要翻译：本发明涉及syndecan-2（SDC2; NM_002998）基因作为胃息肉和胃癌特异性甲基化生物标志物的新用途，更具体地说，涉及使用syndecan-2基因作为生物标志物，息肉和胃癌通过测量其甲基化水平在早期诊断。本发明的效果在于可以检测胃息肉和胃癌特异性标记基因的CpG岛的甲基化，从而提供诊断胃癌的信息。根据本发明的甲基化检测方法或根据本发明的诊断组合物，试剂盒或核酸芯片的使用使得能够在早期转化阶段诊断胃癌，从而能够早期诊断胃癌。此外，与常规方法相比，本发明的方法能够以准确和快速的方式有效地诊断胃癌。

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