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1. 发明申请

US20180340917A1 CHROMATOGRAPHY SYSTEM WITH GUARD COLUMNS 审中-公开
公开(公告)号：US20180340917A1
公开(公告)日：2018-11-29
申请号：US16056339
申请日：2018-08-06
申请人： GE Healthcare Bio-Sciences AB
发明人： Karol Lacki
IPC分类号： G01N30/46 , B01D15/18 , G01N30/88 , B01D15/38
摘要： A chromatography system with a main column comprising a chromatography resin, a first guard column and a second guard column, wherein the first guard column is connected to a first end of the main column, the second guard column is connected to a second end of the main column and the bed volumes of said first and second guard columns are each less than about 50% of the bed volume of the main column.

2. 发明申请

US20200378934A1 Method in a Chromatography System 审中-公开
公开(公告)号：US20200378934A1
公开(公告)日：2020-12-03
申请号：US16995933
申请日：2020-08-18
申请人： GE Healthcare Bio-Sciences AB
发明人： Petra Bangtsson , Erik Estrada , Karol Lacki , Helena Skoglar
IPC分类号： G01N30/88 , G01N30/78 , G01N30/46 , B01D15/18 , G01N30/42 , B01D15/42
摘要： There is provided a method and a corresponding system for determining binding capacities of a chromatography column. The method includes detecting a feed signal representative of the composition of a feed material provided to the inlet of the column. The method further includes detecting an effluent signal representative of the composition of the effluent from the column. The method further includes using the feed signal and the effluent signal to determine binding capacities of the column.

3. 发明授权

US10598638B2 Chromatography lab system including cooling compartment and identifying device 有权
公开(公告)号：US10598638B2
公开(公告)日：2020-03-24
申请号：US16175784
申请日：2018-10-30
申请人： GE Healthcare Bio-Sciences AB
发明人： Bjorn Olovsson , Karol Lacki , Mikael Berg
IPC分类号： G01N30/82 , G01N35/00
摘要： A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.

4. 发明申请

US20190128859A1 CHROMATOGRAPHY LAB SYSTEM FOR ANALYZING SAMPLES INCLUDING A COOLING COMPARTMENT WITH AN IDENTIFYING DEVICE THAT IDENTIFIES A FRACTION COLLECTOR DEVICE 审中-公开
公开(公告)号：US20190128859A1
公开(公告)日：2019-05-02
申请号：US16175784
申请日：2018-10-30
申请人： GE Healthcare Bio-Sciences AB
发明人： Bjorn Olovsson , Karol Lacki , Mikael Berg
IPC分类号： G01N30/82 , G01N35/00
摘要： A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.

5. 发明申请

US20150328563A1 Method for Cleaning of Packed Bed Chromatography Columns 审中-公开
标题翻译：填充床色谱柱清洗方法
公开(公告)号：US20150328563A1
公开(公告)日：2015-11-19
申请号：US14649227
申请日：2013-12-12
申请人： GE Healthcare Bio-Sciences AB
发明人： Karol Lacki , Hans J. Johansson
IPC分类号： B01D15/20 , B01D15/38
CPC分类号： B01D15/20 , B01D15/3809 , C07K1/16 , G01N30/50 , G01N2030/8813 , Y02P20/582
摘要： The invention discloses a process for chromatographic separation of at least one target biomolecule from at least one contaminant, comprising the steps of: a) providing an axial chromatography column comprising a consolidated bed of separation matrix particles, where the consolidated bed is confined between a bottom support net and a movable top adaptor; b) separating a target biomolecule from at least one contaminant on the column; c) raising the adaptor by at least 10% of the height of the consolidated bed; d) flowing a cleaning liquid upwards through the bed under conditions sufficient to liquefy the bed, and; e) repacking the matrix particles of the liquefied bed to create a consolidated bed and lowering the adaptor such that it contacts the packed bed and optionally compresses it, and; f) separating a target biomolecule from at least one contaminant on the column.
摘要翻译：本发明公开了一种用于至少一种目标生物分子与至少一种污染物进行色谱分离的方法，包括以下步骤：a）提供包含分离基质颗粒的固化床的轴向色谱柱，其中固结床被限制在底部支撑网和可移动顶部适配器; b）将靶生物分子与柱上的至少一种污染物分离; c）将适配器提升至合并床的高度的至少10％; d）在足以液化床的条件下将清洁液体向上流动通过床; e）重新包装液化床的基质颗粒以产生固结床并降低适配器，使其接触填充床并任选地压缩它， f）将目标生物分子与柱上的至少一种污染物分离。

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