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1. 发明授权

US12070539B2 Extracorporeal blood treatment method 有权
公开(公告)号：US12070539B2
公开(公告)日：2024-08-27
申请号：US17948833
申请日：2022-09-20
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Katty Ferrari
IPC分类号： A61M1/16 , A61M1/30 , A61M1/34 , A61M1/36 , A61M60/113
CPC分类号： A61M1/1656 , A61M1/1605 , A61M1/165 , A61M1/303 , A61M1/34 , A61M1/3643 , A61M60/113 , A61M2205/50
摘要： An extracorporeal blood treatment apparatus comprises: a blood treatment device (2) comprising a blood chamber (3) and a fluid chamber (4) separated from one another by a semipermeable membrane (5); an extracorporeal blood circuit (17) comprising a blood withdrawal line (6) connected to an inlet port (3a) of the blood chamber (3) and a blood return line (7) connected to an outlet port (3b) of the blood chamber (3); a blood pump (21) configured to be coupled to the blood withdrawal line (6); a hydraulic circuit (100) connectable to the fluid chamber (4), wherein the hydraulic circuit (100) comprises a fluid preparation device (9) connected to a water network (14) and configured to dilute concentrates in water to prepare a treatment fluid; a control unit (12) connected to the preparation device (9) and to the blood pump (21). The control unit (12) is configured to execute the following procedure: setting the hydraulic circuit (100) so that the fluid preparation device (9) bypasses the fluid chamber (4); controlling the fluid preparation device (9) to prepare the treatment fluid while bypassing the fluid chamber (4); and simultaneously controlling the blood pump (21) to perform pure ultrafiltration of a patient (P) connected to the extracorporeal blood circuit (17).

2. 发明授权

US11383012B2 Apparatus for extracorporeal blood treatment 有权
公开(公告)号：US11383012B2
公开(公告)日：2022-07-12
申请号：US16463788
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： Anders Wallenborg , Anders Nilsson , Kristian Solem , Thomas Hertz , Paolo Rovatti , Carlo Alberto Lodi , Alessandro Surace , Jan Sternby
IPC分类号： A61M1/34 , A61M1/16 , A61M1/36
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

3. 发明授权

US11883571B2 Apparatus for extracorporeal blood treatment 有权
公开(公告)号：US11883571B2
公开(公告)日：2024-01-30
申请号：US16849456
申请日：2020-04-15
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus includes a filtration unit (2) connected to a blood circuit (17) and a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating of the dialysis fluid up to the calculating of the initial plasma conductivity performed by maintaining the dialysis fluid conductivity substantially constant.

4. 发明申请

US20230014488A1 EXTRACORPOREAL BLOOD TREATMENT METHOD 有权
公开(公告)号：US20230014488A1
公开(公告)日：2023-01-19
申请号：US17948833
申请日：2022-09-20
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Katty Ferrari
IPC分类号： A61M1/16 , A61M1/30 , A61M1/34 , A61M1/36 , A61M60/113
摘要： An extracorporeal blood treatment apparatus comprises: a blood treatment device (2) comprising a blood chamber (3) and a fluid chamber (4) separated from one another by a semipermeable membrane (5); an extracorporeal blood circuit (17) comprising a blood withdrawal line (6) connected to an inlet port (3a) of the blood chamber (3) and a blood return line (7) connected to an outlet port (3b) of the blood chamber (3); a blood pump (21) configured to be coupled to the blood withdrawal line (6); a hydraulic circuit (100) connectable to the fluid chamber (4), wherein the hydraulic circuit (100) comprises a fluid preparation device (9) connected to a water network (14) and configured to dilute concentrates in water to prepare a treatment fluid; a control unit (12) connected to the preparation device (9) and to the blood pump (21). The control unit (12) is configured to execute the following procedure: setting the hydraulic circuit (100) so that the fluid preparation device (9) bypasses the fluid chamber (4); controlling the fluid preparation device (9) to prepare the treatment fluid while bypassing the fluid chamber (4); and simultaneously controlling the blood pump (21) to perform pure ultrafiltration of a patient (P) connected to the extracorporeal blood circuit (17).

5. 发明授权

US10218411B2 Method for providing operation data to a fluid processing medical apparatus using a medical accessory 有权
公开(公告)号：US10218411B2
公开(公告)日：2019-02-26
申请号：US15519013
申请日：2015-10-15
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti
IPC分类号： H04B7/00 , H04B5/00 , H04W4/80 , A61M1/14 , G06F19/00 , H04W4/02 , H04W12/02 , G16H40/63 , H04W76/38 , G06F3/041 , G06K7/10 , G06K19/06 , H04M1/02
摘要： A method for providing operation data to a fluid processing medical apparatus and a medical accessory have been provided. The method comprises the steps of providing the medical apparatus (10) with a readable element (12); acquiring configuration data associated to the readable element (12) of the medical apparatus (10) by relatively approaching a data acquisition unit (22) of a medical accessory (20) and the readable element (12) of the medical apparatus (10); establishing a wireless communication between medical accessory (20) and the medical apparatus (10) based on the configuration data; providing a medical component (40) having a readable element (42); acquiring operation data associated to the readable element (42) of the medical component (40) by relatively approaching the data acquisition unit (22) of the medical accessory (20) and the readable element (42) of the medical component (40), the medical component (40) being destined to be operatively coupled to the medical apparatus (10); and providing the operation data to the medical apparatus (10) using the wireless communication.

6. 发明授权

US12029555B2 Sensor and apparatus for determining at least one parameter of blood circulating in an extracorporeal blood circuit 有权
公开(公告)号：US12029555B2
公开(公告)日：2024-07-09
申请号：US16982317
申请日：2019-03-20
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Enrico Ravagli , Stefano Severi
IPC分类号： A61B5/145 , A61B5/00 , A61B5/02 , A61B5/026 , A61B5/1455 , A61B8/00 , A61M1/16 , A61M1/36
CPC分类号： A61B5/14535 , A61B5/0071 , A61B5/0075 , A61B5/0261 , A61B5/1455 , A61B5/6866 , A61B8/00 , A61M1/1603 , A61M1/1619 , A61M1/3601 , A61M1/3609 , A61M1/3612 , A61M1/3669 , A61B2562/00 , A61B2562/04 , A61B2562/146 , A61B2562/16 , A61B2562/164 , A61B2562/166 , A61B2562/228 , A61M1/1605 , A61M1/1613 , A61M2205/3306 , A61M2205/3334
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit (2), a blood withdrawal line (6), a blood return line (7), a preparation line (19) and a spent dialysate line (13); a non-invasive blood volume sensor (50) for determining an additional property of blood is active on a tube segment (61) of the blood withdrawal line or of the blood return line; the sensor includes one source (53) for directing a signal towards the blood, a plurality of detectors (57) for receiving the signal, and a controller (65) receiving the output signals from the detectors (57) and determining a blood volume variation and a value of sodium concentration in the blood (Napl) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.

7. 发明申请

US20220249025A1 NON-INVASIVE SENSOR FOR DETERMINING A HEARTBEAT AND/OR HEART RATE IN A SEGMENT OF AN EXTRACORPOREAL BLOOD CIRCUIT 有权
公开(公告)号：US20220249025A1
公开(公告)日：2022-08-11
申请号：US17761318
申请日：2020-09-18
申请人： Gambro Lundia AB
发明人： Paolo Rovatti , Mariano Ruffo , David Stefani
IPC分类号： A61B5/00 , A61B5/024 , A61M60/113 , A61M60/279 , A61M60/37 , A61M1/36
摘要： Non-invasive heartbeat sensor for determining a heart rate in a conduit of an extracorporeal blood treatment apparatus, comprising one source for directing an optical signal towards the blood flowing in the segment; one detector for receiving an optical informative signal comprising the signal emitted by said source after passing the blood, and emitting respective output signal; a controller receiving the respective output signal and retrieving a heartbeat frequency and a heart rate value, based on the output signal, wherein the informative signal is altered by flow perturbation of the blood partially generated by the flow impulses originated by the heart.

8. 发明申请

US20220143284A1 APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND METHOD FOR DETERMINING A PARAMETER INDICATIVE OF THE PROGRESS OF AN EXTRACORPOREAL BLOOD TREATMENT 有权
公开(公告)号：US20220143284A1
公开(公告)日：2022-05-12
申请号：US17429271
申请日：2020-01-23
申请人： Gambro Lundia AB
发明人： Paolo Rovatti , Marco Salsa
IPC分类号： A61M1/16 , A61M1/34 , G16H20/40
摘要： An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. An upstream variation of the value of the characteristic (Cdin) is caused in the fresh treatment liquid with respect to a prescription baseline (Cdset) thereby causing a corresponding and timely delayed downstream variation of the same characteristic (Cdout) in the spent liquid flowing in the spent dialysate line (13). An amplitude (ΔCin) and/or a duration over time (ΔT) of the upstream variation are/is computed as a function of the flow rate (Qdial) of the fresh treatment liquid in a preparation line (19) or of the parameter correlated to the flow rate (Qdial).

9. 发明授权

US10646632B2 Apparatus for extracorporeal blood treatment 有权
公开(公告)号：US10646632B2
公开(公告)日：2020-05-12
申请号：US15574956
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace , Carlo Alberto Lodi , Anders Wallenborg , Anders Nilsson , Kristian Solem , Jan Sternby , Thomas Hertz
IPC分类号： A61M1/16 , A61M1/36
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood through the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

10. 发明授权

US10485912B2 Extracorporeal blood treatment system for individualized treatment 有权
公开(公告)号：US10485912B2
公开(公告)日：2019-11-26
申请号：US15103174
申请日：2014-12-10
申请人： GAMBRO LUNDIA AB
发明人： Paolo Rovatti , Alessandro Surace
IPC分类号： A61M1/16
CPC分类号： A61M1/1611 , A61M1/1601 , A61M1/1652 , A61M1/1613 , A61M2205/3576 , A61M2205/3584 , A61M2205/52 , A61M2205/6018 , A61M2205/6054
摘要： A method of operating an extracorporeal blood treatment includes, prior to commencing an extracorporeal blood treatment, reading from a storage device (4a, 5a) stored values of a patient-specific prescription parameter. These stored values relate to a sequence of previous extracorporeal blood treatments. In addition, the method includes processing the stored values of the parameter read from the storage device (4a, 5a) according to a predetermined algorithm to determine a current value of the patient-specific prescription parameter. The current value is then available for the subsequent extracorporeal blood treatment.

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