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1. 发明授权

US06411850B1 Method of determining a ventilatory threshold breakpoint for an adaptive rate pacemaker 失效
标题翻译：确定适应性起搏器通气阈值断点的方法
公开(公告)号：US06411850B1
公开(公告)日：2002-06-25
申请号：US09408623
申请日：1999-09-30
申请人： G. Neal Kay , Donald L. Hopper , Jan-Pieter Heemells , Jeff Hall
发明人： G. Neal Kay , Donald L. Hopper , Jan-Pieter Heemells , Jeff Hall
IPC分类号： A61N136
CPC分类号： A61N1/36521
摘要： A method for automatically determining the ventilatory (or “anaerobic”) threshold breakpoint for adaptive rate pacing without the need for directly measuring anaerobic threshold or ventilatory threshold comprises: (a) positioning a first sensing electrode in the heart or superior vena cava of a patient carrying an implanted pacemaker, the first sensing electrode connected to the implanted pacemaker; (b) positioning a second sensing electrode in the thoracic region of the patient and spaced apart from the first sensing electrode; (c) determining the chest wall impedance of the patient between the first sensing electrode and the second sensing electrode; (d) measuring the ventilation (e.g., the minute ventilation) of the subject from the chest wall impedance during submaximal exercise by the patient; and then (e) determining the ventilatory threshold breakpoint of the patient from the measured ventilation. In the pacemaker, the adaptive rate pacing is preferably based on measured chest wall impedance, with pacing rate increasing as exercise or metabolic activity sensed thereby increases. The implanted pacemaker is then preferably programmed, preferably automatically, so that the rate of increase in pacing rate in response to increasing ventilation by the pacemaker is attenuated after the breakpoint is reached. Peak ventilation is preferably also determined so that the maximum pacing rate of the pacemaker output is matched to the peak ventilation during adaptive rate pacing from the pacemaker. Apparatus implementing the method is also disclosed.
摘要翻译：用于自动确定用于自适应速率起搏的通气（或“厌氧”）阈值断点而不需要直接测量厌氧阈值或通气阈值的方法包括：（a）将第一感测电极定位在患者的心脏或上腔静脉中携带植入式心脏起搏器，第一感测电极连接到植入式起搏器; （b）将第二感测电极定位在患者的胸部区域并与第一感测电极间隔开; （c）确定患者在第一感测电极和第二感测电极之间的胸壁阻抗; （d）在患者的次最大运动期间测量受试者从胸壁阻抗的通气（例如，每分通气量）; 然后（e）从所测量的通气中确定患者的通气阈值断点。在起搏器中，自适应速率起搏优选地基于测量的胸壁阻抗，起搏速率随着运动或感知的代谢活动而增加。然后，植入式起搏器优选地被自动地编程，使得响应于由起搏器增加的通气而增加的起搏速率的增加在达到断点之后减弱。优选还确定峰值通气，使得起搏器输出的最大起搏速率与起搏器的适应性起搏期间的峰值通气量匹配。还公开了实现该方法的装置。

2. 发明授权

US06652517B1 Ablation catheter, system, and method of use thereof 有权
标题翻译：消融导管，系统及其使用方法
公开(公告)号：US06652517B1
公开(公告)日：2003-11-25
申请号：US09558478
申请日：2000-04-25
申请人： Jeffrey A. Hall , Bruce H. KenKnight , G. Neal Kay , Gregory P. Walcott , Wade A. Bowe
发明人： Jeffrey A. Hall , Bruce H. KenKnight , G. Neal Kay , Gregory P. Walcott , Wade A. Bowe
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2017/00243 , A61B2017/22038 , A61B2017/22068 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00285 , A61B2018/00375 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/124 , A61B2018/1407 , A61B2018/1435
摘要： A cardiac ablation apparatus for producing a circumferential ablation that electrically isolates a heart chamber wall portion from vessel such as a pulmonary vein extending into a wall portion comprises (a) an elongate centering catheter having a distal end portion; (b) an expandable centering element connected to the centering catheter distal end portion and configured for positioning within the vessel when in a retracted configuration, and for securing the elongate centering catheter in a substantially axially aligned position with respect to the vessel when the centering element is in an expanded configuration; (c) an ablation catheter slidably connected to the centering catheter the ablation element having a distal end portion, and (d) an expandable ablation element connected to the ablation catheter distal end portion.
摘要翻译：一种心脏消融装置，用于产生将心室壁部分与血管延伸到壁部分中的肺静脉电隔离的周缘消融，包括：（a）具有远端部分的细长定心导管; （b）连接到定心导管远端部分并且构造成当处于缩回构型时定位在容器内的可扩张定心元件，并且当中心元件处于扩展配置; （c）消融导管，其可滑动地连接到所述定心导管，所述消融元件具有远端部分，以及（d）可扩展的消融元件，其连接到所述消融导管远端部分。

3. 发明授权

US07136707B2 Recordable macros for pacemaker follow-up 有权
公开(公告)号：US07136707B2
公开(公告)日：2006-11-14
申请号：US10348191
申请日：2003-01-21
申请人： Jeffrey A. Hall , G. Neal Kay
发明人： Jeffrey A. Hall , G. Neal Kay
IPC分类号： A61N1/08
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/37252
摘要： A device and method for programming an implantable pulse generator. In one embodiment, commands are entered designating implantable pulse generator programming variables into programmer memory. At least some of the commands are transformed into an executable macro. The macro is stored in the programmer memory. The macro is executed to transmit the programming variables to the implantable pulse generator.

4. 发明授权

US08417350B2 Recordable macros for pacemaker follow-up 有权
标题翻译：可记录的起搏器跟踪宏
公开(公告)号：US08417350B2
公开(公告)日：2013-04-09
申请号：US13618914
申请日：2012-09-14
申请人： Jeffrey A. Hall , G. Neal Kay
发明人： Jeffrey A. Hall , G. Neal Kay
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/37252
摘要： A device and method for programming an implantable pulse generator. In one embodiment, commands are entered designating implantable pulse generator programming variables into programmer memory. At least some of the commands are transformed into an executable macro. The macro is stored in the programmer memory. The macro is executed to transmit the programming variables to the implantable pulse generator.
摘要翻译：一种用于编程可植入脉冲发生器的装置和方法。在一个实施例中，命令被指定为可植入脉冲发生器编程变量到编程器存储器中。至少一些命令被转换成可执行宏。宏存储在编程器存储器中。执行宏以将编程变量发送到可植入脉冲发生器。

5. 发明授权

US08280518B2 Recordable macros for pacemaker follow-up 有权
标题翻译：可记录的起搏器跟踪宏
公开(公告)号：US08280518B2
公开(公告)日：2012-10-02
申请号：US11467466
申请日：2006-08-25
申请人： Jeffrey A. Hall , G. Neal Kay
发明人： Jeffrey A. Hall , G. Neal Kay
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/37252
摘要： A device and method for programming an implantable pulse generator. In one embodiment, commands are entered designating implantable pulse generator programming variables into programmer memory. At least some of the commands are transformed into an executable macro. The macro is stored in the programmer memory. The macro is executed to transmit the programming variables to the implantable pulse generator.
摘要翻译：一种用于编程可植入脉冲发生器的装置和方法。在一个实施例中，命令被指定为可植入脉冲发生器编程变量到编程器存储器中。至少一些命令被转换成可执行宏。宏存储在编程器存储器中。执行宏以将编程变量发送到可植入脉冲发生器。

6. 发明申请

US20130013021A1 RECORDABLE MACROS FOR PACEMAKER FOLLOW-UP 有权
标题翻译：可追溯到追击者的追随者
公开(公告)号：US20130013021A1
公开(公告)日：2013-01-10
申请号：US13618914
申请日：2012-09-14
申请人： Jeffrey A. Hall , G. Neal Kay
发明人： Jeffrey A. Hall , G. Neal Kay
IPC分类号： A61N1/362
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/37252
摘要： A device and method for programming an implantable pulse generator. In one embodiment, commands are entered designating implantable pulse generator programming variables into programmer memory. At least some of the commands are transformed into an executable macro. The macro is stored in the programmer memory. The macro is executed to transmit the programming variables to the implantable pulse generator.
摘要翻译：一种用于编程可植入脉冲发生器的装置和方法。在一个实施例中，命令被指定为可植入脉冲发生器编程变量到编程器存储器中。至少一些命令被转换成可执行宏。宏存储在编程器存储器中。执行宏以将编程变量发送到可植入脉冲发生器。

7. 发明授权

US06893438B2 Ablation catheter, system, and method of use thereof 失效
标题翻译：消融导管，系统及其使用方法
公开(公告)号：US06893438B2
公开(公告)日：2005-05-17
申请号：US10286548
申请日：2002-11-01
申请人： Jeffrey A. Hall , Bruce H. KenKnight , G. Neal Kay , Gregory P. Walcott , Wade A. Bowe
发明人： Jeffrey A. Hall , Bruce H. KenKnight , G. Neal Kay , Gregory P. Walcott , Wade A. Bowe
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61B18/18
CPC分类号： A61B18/1492 , A61B2017/00243 , A61B2017/22038 , A61B2017/22068 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00285 , A61B2018/00375 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/124 , A61B2018/1407 , A61B2018/1435
摘要： A cardiac ablation apparatus for producing a circumferential ablation that electrically isolates a heart chamber wall portion from vessel such as a pulmonary vein extending into said wall portion comprises (a) an elongate centering catheter having a distal end portion; (b) an expandable centering element connected to said centering catheter distal end portion and configured for positioning within said vessel when in a retracted configuration, and for securing said elongate centering catheter in a substantially axially aligned position with respect to said vessel when said centering element is in an expanded configuration; (c) an ablation catheter slidably connected to said centering catheter said ablation element having a distal end portion, and (d) an expandable ablation element connected to said ablation catheter distal end portion. The ablation element is configured to form a circumferential ablation on the wall around the elongate centering catheter when the centering catheter is axially aligned with respect to the vessel. In a further embodiment, a non-expandable, compliant centering element is employed, such as an elastic finger. Systems incorporating such an apparatus and methods of use thereof are also disclosed.
摘要翻译：一种心脏消融装置，用于产生将心脏室壁部分与血管延伸到所述壁部分中的肺静脉电隔离的周缘消融，包括：（a）具有远端部分的细长定心导管; （b）连接到所述定心导管远端部分并且构造成当处于缩回构型时定位在所述容器内的可扩张定心元件，并且用于当所述定心元件相对于所述容器基本轴向对准的位置时将所述细长定心导管固定处于扩展配置; （c）消融导管，其可滑动地连接到所述定心导管，所述消融元件具有远端部分，以及（d）可扩张的消融元件，其连接到所述消融导管远端部分。消融元件构造成当定心导管相对于血管轴向对准时，在围绕细长定心导管的壁上形成周边消融。在另一个实施例中，使用不可膨胀的柔性定心元件，例如弹性指状物。还公开了包含这种装置及其使用方法的系统。

8. 发明授权

US06493583B1 Implantable cardiac stimulation device and method for treating intrinsic ventricular rhythms associated with loss of atrial transport 有权
标题翻译：植入式心脏刺激装置和治疗与心房运输丧失相关的内在心律的方法
公开(公告)号：US06493583B1
公开(公告)日：2002-12-10
申请号：US09641000
申请日：2000-08-17
申请人： Paul A. Levine , G. Neal Kay
发明人： Paul A. Levine , G. Neal Kay
IPC分类号： A61N1362
CPC分类号： A61N1/3622 , A61N1/3684
摘要： An implantable cardiac stimulation device and method treats intrinsic ventricular rhythms lacking atrial transport to the heart. Once an arrhythmia detector detects an intrinsic ventricular rhythm lacking atrial transport, an atrial pulse generator paces the atria to restore atrial transport. The pacing is maintained at a constant rate for a first time period after which the pacing rate is decreased over a recovery time period. The device and method may also be employed for treating accelerated junctional rhythms, accelerated idioventricular rhythms, and first degree AV block, all of which result in inhibition of a dual-chamber pacemaker.
摘要翻译：可植入心脏刺激装置和方法治疗缺乏心房运输到心脏的内部心室节律。一旦心律失常检测器检测到缺乏心房运输的内在心律，心房脉搏发生器将心房起搏恢复心房运输。起搏在第一时间段内保持恒定速率，之后起搏速率在恢复时间段内减少。该装置和方法也可用于治疗加速的连接节律，加速的室内节律和一级AV阻滞，所有这些都导致双室起搏器的抑制。

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