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1. 发明申请

US20060173039A1 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative 失效
标题翻译： 4-（取代的芳基）-5-羟基异喹啉酮衍生物
公开(公告)号：US20060173039A1
公开(公告)日：2006-08-03
申请号：US10521565
申请日：2003-07-23
申请人： Futoshi Shiga , Takahiro Kanda , Tetsuya Kimura , Yasuo Takano , Jyunichi Ishiyama , Tomoyuki Kawai , Tsuyoshi Anraku , Kumi Ishikawa
发明人： Futoshi Shiga , Takahiro Kanda , Tetsuya Kimura , Yasuo Takano , Jyunichi Ishiyama , Tomoyuki Kawai , Tsuyoshi Anraku , Kumi Ishikawa
IPC分类号： A61K31/47
CPC分类号： C07D401/10 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/5377 , C07D217/24 , C07D409/04
摘要： The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase. 4-Substituted aryl-5-hydroxyisoquinolinone derivatives, represented by a general formula (1) and their pharmacologically acceptable addition salts.
摘要翻译：本发明提供对聚（ADP-核糖）合成酶具有优异抑制作用的4-取代芳基-5-羟基异喹啉酮衍生物及其药理学上可接受的加成盐。 4-取代的由通式（1）表示的芳基-5-羟基异喹啉酮衍生物及其药理学上可接受的加成盐。

2. 发明授权

US07425563B2 4-(Substituted aryl)-5-hydroxyisoquinolinone derivative 失效
标题翻译： 4-（取代的芳基）-5-羟基异喹啉酮衍生物
公开(公告)号：US07425563B2
公开(公告)日：2008-09-16
申请号：US10521565
申请日：2003-07-23
申请人： Futoshi Shiga , Takahiro Kanda , Tetsuya Kimura , Yasuo Takano , Jyunichi Ishiyama , Tomoyuki Kawai , Tsuyoshi Anraku , Kumi Ishikawa
发明人： Futoshi Shiga , Takahiro Kanda , Tetsuya Kimura , Yasuo Takano , Jyunichi Ishiyama , Tomoyuki Kawai , Tsuyoshi Anraku , Kumi Ishikawa
IPC分类号： C07D217/24 , C07D401/12 , A61K31/47
CPC分类号： C07D401/10 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/5377 , C07D217/24 , C07D409/04
摘要： The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase.4-Substituted aryl-5-hydroxyisoquinolinone derivatives, represented by a general formula (1) and their pharmacologically acceptable addition salts.
摘要翻译：本发明提供对聚（ADP-核糖）合成酶具有优异抑制作用的4-取代芳基-5-羟基异喹啉酮衍生物及其药理学上可接受的加成盐。 4-取代的由通式（1）表示的芳基-5-羟基异喹啉酮衍生物及其药理学上可接受的加成盐。

3. 发明申请

US20110240618A1 LASER PROCESSING METHOD FOR TRANSPARENT MATERIAL 审中-公开
标题翻译：透明材料的激光加工方法
公开(公告)号：US20110240618A1
公开(公告)日：2011-10-06
申请号：US13041124
申请日：2011-03-04
申请人： Takahiro Kanda
发明人： Takahiro Kanda
IPC分类号： B23K26/38
CPC分类号： B41M5/24 , B23K26/361 , B23K26/40 , B23K2103/50
摘要： Laser processing methods are provided that are capable of processing a surface to be processed of a transparent material with a high accuracy even if the transparent material has a rear surface with a large roughness or has defects therein. The laser processing methods for processing a transparent material using a laser light, can include: attaching a laser light absorbing substance having an absorption coefficient for the laser light of 1 μm−1 or more to a surface to be processed of the transparent material, the laser light having an oscillation wavelength in a range of 193 to 11000 nm, and the transparent material having an absorption coefficient for the laser light of 1 cm−1 or lower; and, emitting the laser light from a front surface side of the laser light absorbing substance attached to the transparent material to process the surface to be processed of the transparent material.
摘要翻译：提供了即使透明材料具有大的粗糙度的背面或具有缺陷，也能够高精度地加工透明材料的表面的激光加工方法。使用激光处理透明材料的激光加工方法可以包括：将具有1μm-1以上的激光的吸收系数的激光吸收物质附着到透明材料的被处理面上，振荡波长为193〜11000nm的激光，激光的吸收系数为1cm -1以下的透明材料，并且从附着在透明材料上的激光吸收物质的表面侧发射激光，以处理透明材料的待处理表面。

4. 发明申请

US20110077427A1 METHOD FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL DERIVATIVE 审中-公开
标题翻译：生产光学活性氨基醇衍生物的方法
公开(公告)号：US20110077427A1
公开(公告)日：2011-03-31
申请号：US12993665
申请日：2009-05-19
申请人： Takeshi Tsubuki , Ichiro Araya , Takahiro Kanda , Shintaro Kanazawa
发明人： Takeshi Tsubuki , Ichiro Araya , Takahiro Kanda , Shintaro Kanazawa
IPC分类号： C07C321/30 , C07C319/28
CPC分类号： C07B57/00 , C07B2200/07 , C07C319/20 , C07C323/32
摘要： Disclosed is a preparation method which makes it possible to produce an aminoalcohol derivative having a high optical purity and to enable the large scale synthesis thereof at a low price.For instance, a compound represented by the following general formula (8) is recrystallized in the course of the production process thereof: In this case, R1 represents, for instance, a trihalomethyl group; R2 represents, for instance, a hydrogen atom; R3 represents, for instance, a halogen atom; R4 represents, for instance, a lower alkyl group; X represents, for instance, a sulfur atom; n represents an integer ranging from 1 to 4; and W represents hydrogen chloride or hydrogen bromide.
摘要翻译：公开了一种制备方法，其可以制备具有高光学纯度的氨基醇衍生物，并且能够以低价格进行大规模合成。例如，由以下通式（8）表示的化合物在其制造方法中重结晶：在这种情况下，R 1表示例如三卤代甲基; R2表示例如氢原子; R3表示例如卤素原子; R4表示例如低级烷基; X表示例如硫原子; n表示1〜4的整数， W表示氯化氢或溴化氢。

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