专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5395977A Process for producing optical active 4-hydroxy-2-cyclopentenone 失效
标题翻译：光学活性4-羟基-2-环戊烯酮的制备方法
公开(公告)号：US5395977A
公开(公告)日：1995-03-07
申请号：US31182
申请日：1993-03-12
申请人： Fumio Toda , Yorihiko Inoue , Masayoshi Minai
发明人： Fumio Toda , Yorihiko Inoue , Masayoshi Minai
IPC分类号： C07B53/00 , C07B57/00 , C07C45/78 , C07C45/85 , C07C49/707
CPC分类号： C07C45/78 , C07C45/85
摘要： A process for producing optically active 4-hydroxy-2-cyclopentenone [1] which comprises reacting 4-hydroxy-2-cyclopentenone represented by the formula: ##STR1## with an optically active propargyl alcohol derivative represented by the general formula: ##STR2## wherein R and R.sup.1 each independently represent a halogenated phenyl group, an alkylphenyl group, or an alkyl group which may be substituted with one or more halogen atom(s), and * indicates an asymmetric carbon atom, to form an optically active complex [3] consisting essentially of optically active 4-hydroxy-2-cyclopentenone represented by the formula [1] ##STR3## wherein * indicates an asymmetric carbon atom, and the optically active propargyl alcohol derivative [2], and then decomposing the optically active complex [3].
摘要翻译：一种制备光学活性的4-羟基-2-环戊烯酮的方法[1]，其包括使由下式表示的4-羟基-2-环戊烯酮与由下列通式表示的光学活性炔丙醇衍生物反应：其中R和R 1各自独立地表示卤代苯基，烷基苯基或可以被一个或多个卤素原子取代的烷基，和*表示不对称碳原子以形成光学活性基本上由式[1]表示的光学活性4-羟基-2-环戊烯酮[3]组成的复合物[3]，其中*表示不对称碳原子和光学活性炔丙醇衍生物[2]，然后分解光学活性复合物[3]。

2. 发明授权

US5041620A Method for producing optically active 2-cyclopenten-4-one-1-ol esters, 2-cyclopenteno-4-one-1-ol ester and complexes thereof with optically active 1,6-diphenyl-2,4-hexadiyne-1,6-diol 失效
标题翻译：光学活性的2-环戊烯-4-酮-1-醇酯，2-环戊烯-4-酮-1-醇酯及其与光学活性的1,6-二苯基-2,4-己二炔-1的配合物的制备方法， 6-二醇
公开(公告)号：US5041620A
公开(公告)日：1991-08-20
申请号：US892103
申请日：1986-08-04
申请人： Fumio Toda , Masayoshi Minai
发明人： Fumio Toda , Masayoshi Minai
IPC分类号： C07C33/48 , C07C69/013 , C07C69/24 , C07C69/63 , C07C69/708
CPC分类号： C07C69/63 , C07C33/48 , C07C69/013 , C07C69/24 , C07C69/708
摘要： A method for producing an optically active 2-cyclopenten-4-one-1-ol ester useful as an intermediate for medicines, agricultural chemicals and represented by the general formula (I), ##STR1## wherein R represents a saturated or unsaturated aliphatic hydrocarbon residue which may or may not be substituted with a halogen atom, and a mark * represents an asymmetric carbon,which comprises bringing a 2-cyclopenten-4-one-1-ol ester represented by the general formula ##STR2## wherein R represents a saturated or unsaturated aliphatic hydrocarbon residue which may or may not be substituted with a halogen atom, into contact with an optically active 1,6-diphenyl-2,4-hexadiyne-1,6-diol derivative represented by the general formula (II), ##STR3## wherein R' represents a halogenated phenyl, lower alkylphenyl, naphthyl or tertiary lower alkyl group, and a mark * represents an asymmetric carbon,in an organic solvent to obtain an optically active cyclopentenone ester complex which is a bound product of the optically active 2-cyclopenten-4-one-1-ol ester represented by the foregoing general formula (I) with the optically active 1,6-diphenyl-2,4-hexadiyne-1,6-diol derivative represented by the foregoing general formula (II), and then decomposing the resulting optically active cyclopentenone ester complex.
摘要翻译：可用作药物，农药中间体的光学活性2-环戊烯-4-酮-1-醇酯的方法，由通式（I）表示，其中R表示饱和或不饱和脂肪族烃残基，其可以被卤素原子取代，也可以不被卤原子取代，标记*表示不对称碳，该方法包括使由通式表示的2-环戊烯-4-酮-1-醇酯 R表示可以或可以不被卤素原子取代的饱和或不饱和脂肪族烃残基，与通式（1）表示的光学活性1,6-二苯基-2,4-己二炔-1,6-二醇衍生物接触，（II），其中R'表示卤代苯基，低级烷基苯基，萘基或叔低级烷基，标记*表示不对称碳，在有机溶剂中得到光学活性环戊烯酮酯络合物，其中是一个有限的亲由上述通式（I）表示的光学活性2-环戊烯-4-酮-1-醇酯与光学活性1,6-二苯基-2,4-己二炔-1,6-二醇衍生物的管道，由前述通式（II），然后分解得到的光学活性环戊烯酮酯络合物。

3. 发明授权

US5306844A Tartaric acid amide derivative and method of producing the same 失效
标题翻译：酒石酸酰胺衍生物及其制备方法
公开(公告)号：US5306844A
公开(公告)日：1994-04-26
申请号：US522065
申请日：1990-05-11
申请人： Fumio Toda , Koichi Tanaka
发明人： Fumio Toda , Koichi Tanaka
IPC分类号： C07D317/32 , C07C67/00 , C07C231/00 , C07C235/06 , C07C235/14 , C07C235/16 , C07D317/22
CPC分类号： C07D317/22
摘要： A d- or l-tartaric acid amide derivative serving as a host compound and a method of producing the amide derivative which combines with a guest compound to form a clathrate compound and which is expressed by the following Formula (A) or (B): ##STR1##
摘要翻译：用作宿主化合物的d-或l-酒石酸酰胺衍生物和与客体化合物结合形成包合物化合物并由下式（A）或（B）表示的酰胺衍生物的制备方法：（*化学结构*）（A）（*化学结构*）（B）

4. 发明授权

US5202504A Optically active biphenyl derivative and process for optical resolution 失效
标题翻译：光学活性联苯衍生物和光学拆分方法
公开(公告)号：US5202504A
公开(公告)日：1993-04-13
申请号：US646096
申请日：1991-01-25
申请人： Fumio Toda
发明人： Fumio Toda
IPC分类号： C07D207/267 , C07B57/00 , C07C33/46 , C07C39/15 , C07C43/23 , C07C205/00 , C07C209/88 , C07C211/00 , C07C211/27 , C07C231/20 , C07C255/12 , C07C311/00 , C07C317/00
CPC分类号： C07B57/00 , C07C33/46
摘要： A biphenyl compound having the formula (I) is newly separated into its optical active compound and useful as an optically separating agent: ##STR1## wherein W, X and Y are each an atom or atomic group selected from among H, F, Cl, Br, I, CH.sub.3, CF.sub.3, OH, OCH.sub.3, NH.sub.2 and N(CH.sub.3).sub.2 and Z is an atom or atomic group selected from among Cl, Br, I, CH.sub.3 and OCH.sub.3, R is an atomic group having 1 to 20 carbon atoms and containing a polar functional group selected from among ##STR2##
摘要翻译：将具有式（I）的联苯化合物新分离成其光学活性化合物，并用作光学分离剂：其中W，X和Y各自为选自H，F ，Cl，Br，I，CH3，CF3，OH，OCH3，NH2和N（CH3）2，Z是选自Cl，Br，I，CH3和OCH3的原子或原子团，R是具有1 至20个碳原子并含有选自中的极性官能团

5. 发明授权

US4962274A Process for separating alkyl-substituted naphthalene derivatives using clathrate complexes 失效
标题翻译：使用包合络合物分离烷基取代的萘衍生物的方法
公开(公告)号：US4962274A
公开(公告)日：1990-10-09
申请号：US403961
申请日：1989-09-07
申请人： Fumio Toda
发明人： Fumio Toda
IPC分类号： C07C7/152 , C07C15/24 , C07C15/28
CPC分类号： C07C15/28 , C07C15/24 , C07C7/152 , C07C2103/24
摘要： A process for the separation of an alkyl-substituted naphthalene from a mixture containing the desired alkyl-substituted naphthalene and at least one isomer thereof comprises placing 9,9'-bianthracene in contact with the mixture to form a clathrate complex of the formula ##STR1## wherein A represents 2-methylnaphthalene, 2-isopropyl-naphthalene of 2,6-diisopropylnaphthalene, collecting the clathrate complex by filtration, subjecting the clathrate complex to thermal decomposition, and then recovering the alkyl-substituted naphthalene derivative.
摘要翻译：从含有所需烷基取代萘和至少一种异构体的混合物中分离烷基取代的萘的方法包括使9,9'-双蒽与该混合物接触以形成下式的包合物络合物：IMA IMA >（I）其中A表示2-甲基萘，2,6-二异丙基萘的2-异丙基萘，通过过滤收集包合络合物，使包合物络合物热分解，然后回收烷基取代的萘衍生物。

6. 发明授权

US5395985A Compound and separating agent 失效
标题翻译：复合分离剂
公开(公告)号：US5395985A
公开(公告)日：1995-03-07
申请号：US206449
申请日：1994-03-04
申请人： Fumio Toda
发明人： Fumio Toda
IPC分类号： C07B57/00 , C07B63/02 , C07C33/28 , C07C33/48 , C07C45/78 , C07C49/643 , C07D307/33
CPC分类号： C07D307/33 , C07B57/00 , C07C33/28 , C07C33/48 , C07C33/486 , C07C45/78 , C07C49/643
摘要： A compound represented by the general formula (I) and a separating agent comprising the same: ##STR1## wherein Ar and Ar' are each an aromatic group; and the positional relationship of the two substituents on the central benzene ring may be any of ortho, meta and para.The above compound is effective in the separation and purification of many compounds to and enables the provision of various compounds (such as intermediates of drugs) which are useful in the field of fine chemicals, particularly optically active substances, at high purities and in large amounts.
摘要翻译：由通式（I）表示的化合物和包含其的分离剂：其中Ar和Ar'各自为芳族基团; 并且中心苯环上的两个取代基的位置关系可以是邻位，间位和对位中的任何一个。上述化合物在许多化合物的分离和纯化中是有效的，并且能够提供在高纯度和大量的精细化学品，特别是光学活性物质领域中有用的各种化合物（例如药物的中间体）。

7. 发明授权

US4898654A Method of producing optically active .beta.-lactam derivatives 失效
标题翻译：光学活性β-内酰胺衍生物的制备方法
公开(公告)号：US4898654A
公开(公告)日：1990-02-06
申请号：US357840
申请日：1989-05-26
申请人： Fumio Toda , Kouichi Tanaka , Masatoshi Taniguchi , Michio Sasaoka
发明人： Fumio Toda , Kouichi Tanaka , Masatoshi Taniguchi , Michio Sasaoka
IPC分类号： C07D205/12 , C07D487/04
CPC分类号： C07D487/04 , C07D205/12
摘要： Disclosed is a method of producing an optically active .beta.-lactam derivative of the formula ##STR1## comprising irradiating with light, in solid phase, an inclusion complex of a compound of the formula ##STR2## with an optically active host compound.
摘要翻译：公开了一种制备式（II）的光学活性β-内酰胺衍生物的方法，包括用固相照射下式的化合物（I）的包合络合物与光学活性物质主体化合物。

8. 发明授权

US4467102A Optically active propargyl alcohol derivative and a method for preparation of the same 失效
标题翻译：光学活性炔丙醇衍生物及其制备方法
公开(公告)号：US4467102A
公开(公告)日：1984-08-21
申请号：US553644
申请日：1983-11-21
申请人： Fumio Toda , Koichi Tanaka
发明人： Fumio Toda , Koichi Tanaka
IPC分类号： C07B31/00 , C07B57/00 , C07C27/00 , C07C29/44 , C07C29/88 , C07C33/28 , C07C33/48 , C07C67/00 , C07D333/16 , C07D333/00
CPC分类号： C07D333/16 , C07C29/44 , C07C33/28 , C07C33/48
摘要： An optically active propargyl alcohol derivative of the formula (I) ##STR1## wherein X=phenyl or thienyl and R=lower alkyl, halogenated methyl, phenyl or substituted phenyl having at least one lower alkyl radical and or halogen atom, is prepared by contacting a racemic modification of l- and d-isomers of the formula (I) with l-brucine in an organic solvent, by separating the resultant deposited diastereomer from a solution containing the resultant other diastereomer in the organic solvent, by decomposing each diastereomer with an aqueous mineral acid solution in the presence of an organic solvent capable of dissolving the corresponding optically active isomer dissociated from the diastereomer and incompatible with water so as to allow the optically active isomer to be dissolved in the water-incompatible organic solvent, and by recovering the optically active isomer from the solution thereof.
摘要翻译：式（I）的光学活性炔丙醇衍生物其中X =苯基或噻吩基，R =低级烷基，卤代甲基，苯基或具有至少一个低级烷基和/或卤素原子的取代苯基是通过在有机溶剂中使式 - （I）的1-和D-异构体的外消旋改性物与1-羧酸接触，通过将所得到的沉积的非对映异构体与含有所得的其它非对映异构体的溶液在有机溶剂中分离，在无机酸溶液存在下，在有机溶剂的存在下，能够溶解与非对映异构体解离的相应的光学活性异构体并且与水不相容，以使光学活性异构体溶解在与水不相容的有机溶剂中，以及通过从其溶液中回收旋光异构体。

9. 发明授权

US4976834A Asymmetric photochemical reaction process 失效
标题翻译：不对称光化学反应过程
公开(公告)号：US4976834A
公开(公告)日：1990-12-11
申请号：US173994
申请日：1988-03-28
申请人： Fumio Toda
发明人： Fumio Toda
IPC分类号： B01J19/12 , C07B31/00 , C07B53/00 , C07C45/00 , C07C45/61 , C07C45/67 , C07C49/753 , C07C67/00 , C07C69/738 , C07C69/78 , C07D205/08 , C07D463/00 , C07D505/00
CPC分类号： C07D505/00 , C07C45/67 , C07C49/753 , C07D205/08 , C07D463/06
摘要： An optically active substance having an optical purity of at least 50% e.e. is obtained by an asymmetric photochemical reaction by converting a starting, achiral material in a chiral crystalline form and irradiating light to the chiral crystalline form to effect the photocyclization of the starting material.

10. 发明授权

US4769502A Alkynol type compounds and alcohol-separating process 失效
标题翻译：炔醇类化合物和醇分离过程
公开(公告)号：US4769502A
公开(公告)日：1988-09-06
申请号：US48495
申请日：1987-05-08
申请人： Fumio Toda , Koichi Tanaka
发明人： Fumio Toda , Koichi Tanaka
IPC分类号： C07C33/28 , C07C27/26 , C07C29/74
CPC分类号： C07C33/28
摘要： Alkynol type compounds of the following formula (I): ##STR1## [wherein R.sub.1 -R.sub.5 and R.sub.6 -R.sub.10 each represent hydrogen atoms or lower alkyl group and R.sub.11 represents a lower alkyl group or a group of the formula: ##STR2## (wherein R.sub.1 -R.sub.5 and R.sub.6 -R.sub.10 are as hereinbefore defined); at least one of R.sub.1 -R.sub.5 and at least one of R.sub.6 -R.sub.10 being lower alkyl grops.] These compounds are capable of forming and precipitating crystalline complexes with alcohols when added to an aqueous solution of alcohol. Thus, these compounds are useful for separating alcohols from aqueous solutions of alcohols.
摘要翻译：下式（I）的炔醇型化合物：其中R 1 -R 5和R 6 -R 10各自表示氢原子或低级烷基，R 11表示低级烷基或下式的基团：其中 R1-R5和R6-R10如上文所定义）; R 1 -R 5中的至少一个和R 6 -R 10中的至少一个为低级烷基。]这些化合物当加入到醇的水溶液中时能够与醇形成和沉淀结晶配合物。因此，这些化合物可用于从醇的水溶液中分离醇。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式