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    • 2. 发明授权
    • Integral multilayer element for glucose analysis
    • 用于葡萄糖分析的整体多层元件
    • US5183741A
    • 1993-02-02
    • US603243
    • 1990-10-22
    • Fuminori AraiHarumi Katsuyama
    • Fuminori AraiHarumi Katsuyama
    • C12Q1/26
    • C12Q1/26Y10S435/805
    • An integral multilayer element for chemical analysis utilizing an oxidase enzyme reaction system is prepared having in the following order:(a) a porous spreading layer;(b) an oxygen-permeable, protein-impermeable light-blocking layer;(c) an oxidase-containing layer;(d) an indicator layer containing peroxidase and a hydrogen peroxide indicator showing detectable change in the presence of peroxidase and hydrogen peroxide; and(e) a water-impermeable, light-transmissive support. The oxidase in the oxidase-containing layer is preferably glucose oxidase to provide a multilayer element for glucose determination. This multilayer element shortens the analytical time, widens the measurable concentration range of the analyte and improves accuracy.
    • 按照以下顺序制备用于利用氧化酶反应体系的化学分析的整体多层元件:(a)多孔扩散层; (b)透氧的蛋白质不透过的遮光层; (c)含氧化酶层; (d)包含过氧化物酶和过氧化氢指示剂的指示剂层,显示过氧化物酶和过氧化氢存在下可检测的变化; 和(e)不透水的透光支架。 氧化酶层中的氧化酶优选为葡萄糖氧化酶,以提供用于葡萄糖测定的多层元件。 该多层元件缩短了分析时间,扩大了分析物的可测量浓度范围,提高了精度。
    • 9. 发明授权
    • Analysis material sheet
    • 分析材料表
    • US4783315A
    • 1988-11-08
    • US758562
    • 1985-07-23
    • Fuminori AraiKenichiro YazawaHideaki TakeuchiMasao Kitajima
    • Fuminori AraiKenichiro YazawaHideaki TakeuchiMasao Kitajima
    • G01N31/22G01N33/52G01N33/66
    • G01N33/525Y10T428/31736Y10T428/3175
    • An analysis material sheet is disclosed which is comprised of layers of material with strong adhesion for one another. The sheet includes a water-impermeable support having provided directly or indirectly thereon a layer of fabric. The fabric contains a hydrophobic organic polymer fiber and is physically activated on at least one surface thereof, with the physically activated surface being adhered directly or indirectly to the support. A reagent layer can be provided directly or indirectly on the liquid sample-spreading layer of fabric. By utilizing a fabric containing a hydrophobic organic polymer fiber, body fluids to be analyzed can be quickly and uniformly spread and by utilizing the physically activated surface of the fabric, strong adhesion between the layers can be obtained.
    • 公开了一种分析材料片,其由彼此具有强粘合性的材料层组成。 片材包括直接或间接地在其上提供织物层的不透水支撑体。 织物含有疏水性有机聚合物纤维,并在其至少一个表面上物理活化,物理活化表面直接或间接地粘附到载体上。 试剂层可以直接或间接地提供在织物的液体样品铺展层上。 通过使用含有疏水性有机聚合物纤维的织物,可以快速且均匀地分散待分析的体液,并且通过利用织物的物理活化表面,可以获得层间的强粘合性。
    • 10. 发明授权
    • Integral multilayer analytical element
    • 整体多层分析元件
    • US4895704A
    • 1990-01-23
    • US117355
    • 1987-10-27
    • Fuminori AraiTakeshi Igarashi
    • Fuminori AraiTakeshi Igarashi
    • G01N31/22G01N33/52
    • G01N33/525Y10S435/805
    • An integral multilayer analytical element which comprises a water-impermeable light-transmissive support, a hydrophilic layer containing a water-absorptive hydrophilic polymer binder and a spreading layer superposed in this order, and contains at least one reagent capable of reacting with a component of a sample to produce a detectable species capable of detecting by light, which is characterized in that light-scattering particulates in an amount to make light transmittance to 10 to 2.5% are contained in the above hydrophilic layer and/or a layer located on the side of the support therefrom. This element may decrease the influence of a conventional reagent layer up to the extent being negligible without lowering the sensitivity. Precision of the measurement at a low concentration range is also high, and reproducibility of the meaurement is well. Manufacture of this element is easy.
    • 一种整体多层分析元件,其包含不透水的透光性支撑体,含有吸水性亲水性聚合物粘合剂的亲水层和依次叠加的扩散层,并且含有至少一种能够与 样品以产生能够被光检测的可检测物质,其特征在于将上述亲水层和/或位于上述亲水层侧的层中含有使光透射率达到10至2.5%的量的光散射微粒 其支撑。 该元件可以降低常规试剂层的影响,直到可忽略的程度,而不降低灵敏度。 在低浓度范围内的测量精度也很高,测量的重现性好。 制造这个元素很容易。