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1. 发明授权

US09061003B2 Therapeutic or preventive agent for diabetes 有权
标题翻译：糖尿病的治疗或预防剂
公开(公告)号：US09061003B2
公开(公告)日：2015-06-23
申请号：US13981258
申请日：2012-01-25
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
IPC分类号： A61K38/39 , A61K38/05 , A61K38/06 , C07K5/062 , C07K5/065 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/093 , C07K5/097
CPC分类号： A61K38/39 , A61K38/05 , A61K38/06 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/0806 , C07K5/0812 , C07K5/0819 , C07K5/0823
摘要： A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modified substances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.
摘要翻译：含有选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，化学修饰物质和药学上可接受的盐的三种或更多种的胶原肽混合物以及至少一种选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，Pro-Hyp-Gly，Leu -Hyp，Ile-Hyp，Ser-Hyp-Gly，Gly-Pro-Hyp，（Pro-Hyp-Gly）5，Pro-Hyp，Hyp-Gly，Pro-Gly，Pro-Pro和Ala-Hyp或化学其改性物质或其药学上可接受的盐具有DPPTV抑制活性和/或GLP-1分泌促进活性，因此作为糖尿病的治疗或预防剂等是有效的。

2. 发明申请

US20130303448A1 Therapeutic or Preventive Agent for Diabetes 有权
标题翻译：糖尿病治疗或预防剂
公开(公告)号：US20130303448A1
公开(公告)日：2013-11-14
申请号：US13981258
申请日：2012-01-25
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
IPC分类号： A61K38/39
CPC分类号： A61K38/39 , A61K38/05 , A61K38/06 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/0806 , C07K5/0812 , C07K5/0819 , C07K5/0823
摘要： A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modified substances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.
摘要翻译：含有选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，化学修饰物质和药学上可接受的盐的三种或更多种的胶原肽混合物以及至少一种选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，Pro-Hyp-Gly，Leu -Hyp，Ile-Hyp，Ser-Hyp-Gly，Gly-Pro-Hyp，（Pro-Hyp-Gly）5，Pro-Hyp，Hyp-Gly，Pro-Gly，Pro-Pro和Ala-Hyp或化学其改性物质或其药学上可接受的盐具有DPPTV抑制活性和/或GLP-1分泌促进活性，因此作为糖尿病的治疗或预防剂等有效。

3. 发明授权

US08410062B2 Collagen peptide, dipeptide and malady inhibitor 有权
标题翻译：胶原肽，二肽和恶性抑制剂
公开(公告)号：US08410062B2
公开(公告)日：2013-04-02
申请号：US13523438
申请日：2012-06-14
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
IPC分类号： A61K38/05
CPC分类号： C07K5/06139 , A61K38/05 , C07K5/06165
摘要： A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
摘要翻译：本发明要解决的问题是提供：对于抑制诸如骨质疏松症，骨关节炎和压力性溃疡等各种疾病的肽分子的主体，特别是容易吸收到体内的二肽肠包含二肽作为必需二肽的胶原肽; 以及包含二肽作为基本有效成分的疾病抑制剂。作为解决上述问题的方法，本发明的胶原肽的特征在于，含有具有Hyp-Gly结构的二肽作为必需二肽的二肽。根据本发明的二肽的特征在于具有Hyp-Gly的结构。根据本发明的疾病抑制剂的特征在于包含具有Hyp-Gly结构作为必需有效成分的二肽。

4. 发明授权

US08227424B2 Collagen peptide, dipeptide and malady inhibitor 有权
公开(公告)号：US08227424B2
公开(公告)日：2012-07-24
申请号：US12443298
申请日：2008-11-14
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
IPC分类号： A61K38/05 , A61P10/02
CPC分类号： C07K5/06139 , A61K38/05 , C07K5/06165
摘要： A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.

5. 发明申请

US20110166365A1 Collagen peptide, dipeptide and malady inhibitor 有权
标题翻译：胶原肽，二肽和恶性抑制剂
公开(公告)号：US20110166365A1
公开(公告)日：2011-07-07
申请号：US12443298
申请日：2008-11-14
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
IPC分类号： C07D207/12
CPC分类号： C07K5/06139 , A61K38/05 , C07K5/06165
摘要： A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
摘要翻译：本发明要解决的问题是提供：对于抑制诸如骨质疏松症，骨关节炎和压力性溃疡等各种疾病的肽分子的主体，特别是容易吸收到体内的二肽肠包含二肽作为必需二肽的胶原肽; 以及包含二肽作为基本有效成分的疾病抑制剂。作为解决上述问题的方法，本发明的胶原肽的特征在于，含有具有Hyp-Gly结构的二肽作为必需二肽的二肽。根据本发明的二肽的特征在于具有Hyp-Gly的结构。根据本发明的疾病抑制剂的特征在于包含具有Hyp-Gly结构作为必需有效成分的二肽。

6. 发明授权

US5223029A Hardening material for medical and dental use 失效
标题翻译：用于医疗和牙科用途的硬化材料
公开(公告)号：US5223029A
公开(公告)日：1993-06-29
申请号：US477864
申请日：1990-04-09
申请人： Hironobu Oonishi , Fumihito Sugihara , Takashi Ishii , Kaneo Suzuki , Seiko Hata , Toshikazu Takano
发明人： Hironobu Oonishi , Fumihito Sugihara , Takashi Ishii , Kaneo Suzuki , Seiko Hata , Toshikazu Takano
IPC分类号： A61F2/00 , A61K6/033 , A61L24/00 , A61L27/12 , A61L27/46
CPC分类号： A61L24/0084 , A61K6/0061 , A61K6/0085 , A61K6/0094 , A61K6/0643 , A61L27/12 , A61L27/46 , A61F2310/00293
摘要： This invention relates to a hardening material for medical and dental use, in which at least either one or both of .alpha.-tricalcium phosphate and tetracalcium phosphate as an essential component and, as a hardening adjuster, the following 1 tannin, 2 tannin and collagen, 3 collagen and an organic acid, 4 tannin, collagen, and an organic acid, 5 tannin and an organic acid, or 6 at least two kinds or organic acids.

7. 发明授权

US5342441A Biologically compatible hardening material for dental or medical applications 失效
标题翻译：用于牙科或医疗应用的生物相容性硬化材料
公开(公告)号：US5342441A
公开(公告)日：1994-08-30
申请号：US902024
申请日：1992-06-22
申请人： Yoshinobu Mandai , Kohji Nagatomi , Kazuhiko Minamigawa , Fumihito Sugihara
发明人： Yoshinobu Mandai , Kohji Nagatomi , Kazuhiko Minamigawa , Fumihito Sugihara
IPC分类号： A61F2/00 , A61K6/00 , A61K6/033 , A61L24/02 , A61L27/12 , A61K6/02
CPC分类号： A61L27/12 , A61K6/033 , A61K6/0643 , A61L24/02 , A61F2310/00293
摘要： A hardenable, biocompatible composition for repairing firm living tissue which includes a powder component containing Ca.sub.4 P.sub.2 O.sub.9 and at least one of CaHPO.sub.4 and CaHPO.sub.4.H.sub.2 O at a molar ratio of Ca:P of 1.16-1.95; and a liquid component containing 1 mM to 2M of a second phosphate ion and 1 mM to 2M of an organic ion. The weight ratio of the powder component to the liquid component is 0.5-4.0.
摘要翻译：一种用于修复固体活组织的可硬化的生物相容性组合物，其包含Ca:P为1.16-1.95的摩尔比的含有Ca4P2O9和CaHPO4和CaHPO4·H2O的至少一种的粉末成分; 和含有1mM至2M的第二磷酸根离子和1mM至2M的有机离子的液体组分。粉末成分与液体成分的重量比为0.5〜4.0。

8. 发明申请

US20100068342A1 COLLAGEN PEPTIDE COMPOSITION AND FOOD OR BEVERAGE CONTAINING THE SAME 审中-公开
标题翻译：胶原蛋白组合物和含有其的食物或饮料
公开(公告)号：US20100068342A1
公开(公告)日：2010-03-18
申请号：US12312513
申请日：2007-11-15
申请人： Hitoshi Matsumoto , Hiroki Ohara , Takanori Nakajima , Fumihito Sugihara , Hajime Takasaki
发明人： Hitoshi Matsumoto , Hiroki Ohara , Takanori Nakajima , Fumihito Sugihara , Hajime Takasaki
IPC分类号： A23L1/305 , A23L1/0562
CPC分类号： C07K14/78 , A23J3/06 , A23J3/341 , A23L2/52 , A23L29/284 , A23L33/18 , A23V2002/00 , A61K38/014 , A23V2200/316 , A23V2250/5422
摘要： An object of the present invention is to elucidate a collagen peptide composed of oligopeptides having ability to enter the blood higher than that of conventional collagen peptides and thus to provide a food or beverage mixed with the collagen peptide. The present invention provides a collagen peptide composition obtainable by digesting a collagen or gelatin with protease, which comprises 70% to 100% by weight of peptides with a molecular weight 500 or more to 3000 or less, less than 10% by weight of peptides with a molecular weight of less than 500, and less than 20% by weight of peptides with a molecular weight of more than 3000, based on the total weight of the composition, wherein the ratio of N-terminal glycine residues to total of the N-terminal amino acid residues of the peptides in the composition is 33 mol % or more to 65 mol % or less.
摘要翻译：本发明的目的是阐明由具有比常规胶原肽更高的进入血液的能力的寡肽构成的胶原肽，从而提供与胶原肽混合的食品或饮料。本发明提供了一种通过用蛋白酶消化胶原蛋白或明胶获得的胶原肽组合物，其包含70％至100％重量的分子量为500或更多至3000或更小，少于10重量％基于组合物的总重量，分子量小于500且小于20重量％的分子量大于3000的肽，其中N-末端甘氨酸残基与N- 组合物中肽的末端氨基酸残基为33摩尔％以上至65摩尔％以下。

9. 发明授权

US5238491A Hardening material for medical and dental use 失效
标题翻译：用于医疗和牙科用途的硬化材料
公开(公告)号：US5238491A
公开(公告)日：1993-08-24
申请号：US474766
申请日：1990-03-21
申请人： Fumihito Sugihara , Takashi Ishii , Tooru Kurihara
发明人： Fumihito Sugihara , Takashi Ishii , Tooru Kurihara
IPC分类号： A61K6/08 , A61K6/00 , A61K6/033 , A61K6/097 , A61L24/00 , A61L27/00 , A61L27/42 , A61L27/46
CPC分类号： A61K6/0643 , A61K6/0085 , A61L24/0063 , A61L27/425 , A61L27/46
摘要： This invention relates to a hardening material for medical and dental use which is composed of a powder of calcium phosphate and a hardening liquid.A subject of the present invention is to provide a hardening material wherein a calcified hard tissue analogous to body hard tissue capable of making chemically a sufficient bond with body hard tissue is formed in a body within relatively short time passage.To attain the above-described objective, the hardening material for medical and dental use relating to the present invention is composed of a calcium phosphate powder and a hardening liquid and also of at least either one of collagen and/or collagen derivatives in a state of powder or solution, and the calcium phosphate powder contains a powder of .alpha.-tricalcium phosphate [.alpha.-Ca.sub.3 (PO.sub.4).sub.2 ]and/or tetracalcium phosphate [Ca.sub.4 (PO.sub.4).sub.2 O] as an essential component and the hardening liquid comprises at least one acid selected from inorganic acids and acetic acid.
摘要翻译： PCT No.PCT / JP89 / 00726 Sec。 371 1990年3月21日 102（e）1990年3月21日PCT PCT 1991年7月20日PCT公布。出版物WO90 / 00892 日本1990年2月8日。本发明涉及由磷酸钙粉末和硬化液构成的用于医疗和牙科用途的硬化材料。本发明的目的是提供一种硬化材料，其中在相对短的时间通过内在身体中形成类似于能够与身体硬组织化学充分结合的身体硬组织的钙化硬组织。为了实现上述目的，本发明的医疗用牙齿用硬化材料由磷酸钙粉末和硬化液体构成，并且还包含胶原和/或胶原衍生物中的至少一种，其状态为粉末或溶液，并且磷酸钙粉末含有α-磷酸三钙[α-Ca 3（PO 4）2]和/或磷酸四钙[Ca 4（PO 4）2 O]作为必需组分的粉末，并且硬化液体包含至少一种酸选自无机酸和乙酸。

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