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1. 发明授权

US07718701B2 Antipruritic agent 失效
标题翻译：止痒剂
公开(公告)号：US07718701B2
公开(公告)日：2010-05-18
申请号：US10493693
申请日：2003-08-07
申请人： Fumie Sato , Iwao Arai , Norikazu Takano , Tohru Tanami , Makoto Yagi
发明人： Fumie Sato , Iwao Arai , Norikazu Takano , Tohru Tanami , Makoto Yagi
IPC分类号： A01N53/00 , C07C59/00 , C07C69/74
CPC分类号： A61K31/5575 , Y10S514/861 , Y10S514/887
摘要： A method of treating atopy-evoked pruritic symptoms by administering a prostaglandin derivative.
摘要翻译：通过施用前列腺素衍生物治疗特应性诱发的瘙痒症状的方法。

2. 发明申请

US20050009917A1 Antipruritic agent 失效
标题翻译：止痒剂
公开(公告)号：US20050009917A1
公开(公告)日：2005-01-13
申请号：US10493693
申请日：2003-08-07
申请人： Fumie Sato , Iwai Arai , Norikazu Takano , Tohru Tanami , Makoto Yagi
发明人： Fumie Sato , Iwai Arai , Norikazu Takano , Tohru Tanami , Makoto Yagi
IPC分类号： A61K31/5575 , A61P17/00 , A61P17/02 , A61P17/04 , A61P27/02 , A61P37/08 , A61K31/557
CPC分类号： A61K31/5575 , Y10S514/861 , Y10S514/887
摘要： A pharmaceutical preparation for preventing or treating pruritic symptoms which contains as an effective ingredient a prostaglandin derivative represented by formula [1] wherein X1 and X2 which are different from each other represent a hydrogen atom, a halogen atom or a hydroxyl group; Y is an ethylene group, a vinylene group or an ethynylene group; Z is the formula (CH2)kA(CH2)hB(CH2)q, (CH2)kA(CH2)rA′(CH2)t (CH2)kB(CH2)hB′(CH2)q or (CH2)k-1B′(CH2)q-1A′wherein k is an integer of 1 to 4, h is an integer of 0 to 4, q is an integer 1 to 4, r is an integer of 0 to 4, and t is an integer of 0 to 2; A and A′ which may be the same or different represent an ethylene group, a vinylene group or an ethynylene group; B and B′ which may be the same or different represent an oxygen atom or a group represented by the formula S(O)u wherein u is an integer of 0 to 2; W1 is a hydroxyl group, a C1-10 alkyloxy group, a C3-10 cycloalkyloxy group, an aryloxy group or an arylalkyloxy group; W2 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, a C3-10 cycloalkyl group, a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s), or a group represented by the formula wherein W4 is a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group or a C1-5 alkyl group substituted by C3-10 cycloalkyl group(s); v is an integer of 0 to 4; W3 is a hydrogen atom or a methyl group, or W3 when taken together with W2 and the adjacent carbon atom forms a C3-10 cycloalkyl group; m is 0 or 1, a pharmaceutically acceptable salt thereof or a hydrate thereof.
摘要翻译：用于预防或治疗瘙痒症状的药物制剂，其含有作为有效成分的由式[1]表示的前列腺素衍生物，其中X 1和X 2彼此不同，表示氢原子，卤素原子或羟基; Y是亚乙基，亚乙烯基或亚乙炔基; Z是式（CH2）kA（CH2）hB（CH2）q，（CH2）kA（CH2）rA'（CH2）t（CH2）kB（CH2）hB'（CH2）q或（CH2） '（CH 2）q-1A'其中k为1〜4的整数，h为0〜4的整数，q为1〜4的整数，r为0〜4的整数，t为 0〜2; A和A'可以相同或不同，表示亚乙基，亚乙烯基或亚乙炔基; B和B'可以相同或不同，表示氧原子或由式S（O）u表示的基团，其中u为0-2的整数; W 1是羟基，C 1-10烷氧基，C 3-10环烷氧基，芳氧基或芳基烷氧基; W 2是C 1-10烷基，C 2-10烯基，C 2-10炔基，C 3-10环烷基，被C 3-10环烷基取代的C 1-5烷基，或由下式表示的基团，其中W 4是C 1-10烷基，C 2-10烯基，C 2-10炔基或被C 3-10环烷基取代的C 1-5烷基， ; v为0〜4的整数; W 3为氢原子或甲基时，W 3与W 2一起形成，相邻碳原子形成C3-10环烷基; m为0或1，其药学上可接受的盐或其水合物。

3. 发明申请

US20100003210A1 EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION 有权
标题翻译：包含改性粘土以防止炎症的外用皮肤试剂
公开(公告)号：US20100003210A1
公开(公告)日：2010-01-07
申请号：US11722338
申请日：2005-11-25
申请人： Yasuhiro Ohara , Masashi Suzuki , Norikazu Takano , Shunpei Mitsuyama
发明人： Yasuhiro Ohara , Masashi Suzuki , Norikazu Takano , Shunpei Mitsuyama
IPC分类号： A61K31/78 , A61K31/74 , A61P17/00 , A61K31/80
CPC分类号： A61K31/695 , A61K8/26 , A61K8/416 , A61K8/891 , A61K9/0014 , A61K31/56 , A61K33/06 , A61K35/02 , A61K47/32 , A61K47/34 , A61K2800/75 , A61Q17/00 , A61K2300/00
摘要： To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.
摘要翻译：提供防止特应性皮肤炎症发作的皮肤外用剂，对皮肤的刺激性低，其特征在于包括：1）由具有季氨基的化合物改性的粘土; 和2）具有包含类似于生物组分的结构的侧链的聚合物或共聚物。

4. 发明授权

US08741323B2 External skin agent comprising modified clay for preventing inflammation 有权
标题翻译：包含用于预防炎症的改性粘土的外用皮肤剂
公开(公告)号：US08741323B2
公开(公告)日：2014-06-03
申请号：US11722338
申请日：2005-11-25
申请人： Yasuhiro Ohara , Masashi Suzuki , Norikazu Takano , Shunpei Mitsuyama
发明人： Yasuhiro Ohara , Masashi Suzuki , Norikazu Takano , Shunpei Mitsuyama
IPC分类号： A61Q19/00
CPC分类号： A61K31/695 , A61K8/26 , A61K8/416 , A61K8/891 , A61K9/0014 , A61K31/56 , A61K33/06 , A61K35/02 , A61K47/32 , A61K47/34 , A61K2800/75 , A61Q17/00 , A61K2300/00
摘要： To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component.
摘要翻译：提供防止特应性皮肤炎症发作的皮肤外用剂，对皮肤的刺激性低，其特征在于包括：1）由具有季氨基的化合物改性的粘土; 和2）具有包含类似于生物组分的结构的侧链的聚合物或共聚物。

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