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1. 发明授权

US09801846B2 Composition comprising EPA and DHA ethylester for parenteral administration 有权
公开(公告)号：US09801846B2
公开(公告)日：2017-10-31
申请号：US15114937
申请日：2015-01-28
申请人： Fresenius Kabi Deutschland GmbH
发明人： Edmundo Brito De La Fuente , Crispulo Gallegos-Montes , Lida A. Quinchia-Bustamente
IPC分类号： A61K31/232 , A61K9/00 , A61K47/12 , A61K47/24 , A61K9/107 , A61K47/10
CPC分类号： A61K31/232 , A61K9/0029 , A61K9/107 , A61K47/10 , A61K47/12 , A61K47/24
摘要： Described herein are compositions for parenteral administration that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil phase comprises the omega-3 fatty acid ethylesters eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester, and mixtures thereof. The composition further comprises at least one anionic surfactant and at least one amphoteric surfactant, and less than 0.05% by weight of oleic acid, based on the total weight of the composition. Also described is a method for preparing such a composition as well as such compositions for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Also featured are methods of treating these conditions by parenterally administering a composition to a patient in need thereof and methods of providing parenteral nutrition to such patients by administering to them a composition as described herein.

2. 发明申请

US20210290526A1 LIPID EMULSION FOR PARENTERAL ADMINISTRATION 有权
公开(公告)号：US20210290526A1
公开(公告)日：2021-09-23
申请号：US17257229
申请日：2019-07-01
申请人： Fresenius Kabi Deutschland GmbH
发明人： Melanie DENKINGER , Ewald SCHLOTZER , Edmundo BRITO DE LA FUENTE , Lida A. Quinchia-Bustamante , Crispulo Gallegos-Montes
IPC分类号： A61K9/00 , A61K9/107 , A61K36/48 , A61K36/63 , A61K35/60 , A61K31/575 , A61K31/202 , A61K36/06 , A61K31/197 , A61K31/355 , A61K31/14 , A61P29/00 , A61P1/16
摘要： The present disclosure relates to lipid emulsions for parenteral administration, comprising 10 to 30% of a lipid phase comprising soybean oil, medium-chain triglycerides (MCT), olive oil and fish oil and less than 25 mg, preferably less than 20 mg, campesterol, less than 30 mg, preferably less than 25 mg, stigmasterol and less than 120 mg, preferably less than 100 mg, betasitosterol per 100 g of the lipid phase. The present disclosure also relates to the lipid emulsions according to the present disclosure for providing parenteral nutrition, in particular to neonates, as well as to methods for manufacturing the lipid emulsions according to the present disclosure.

3. 发明授权

US10143674B2 Composition comprising EPA and DHA triglycerides for parenteral administration 有权
公开(公告)号：US10143674B2
公开(公告)日：2018-12-04
申请号：US15114988
申请日：2015-01-28
申请人： Fresenius Kabi Deutschland GmbH
发明人： Edmundo Brito De La Fuente , Crispulo Gallegos-Montes , Lida A. Quinchia-Bustamente
IPC分类号： A61K31/232 , A61K9/00 , A61K47/10 , A61K47/12 , A61K47/24 , A61K9/107 , A23L33/12
摘要： Described herein are compositions that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil phase comprises the omega-3 fatty acid triglyceride eicosapentaenoic acid triglyceride, docosahexaenoic acid triglyceride, or mixtures thereof. The composition further comprises at least one amphoteric surfactant, at least one co-surfactant, and at least one co-solvent. The compositions comprise less than 0.03% by weight of sodium oleate, based on the total weight of the composition. Also described are methods for preparing such compositions as well as such compositions for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Also featured are methods of treating these conditions by parenterally administering a composition to a patient in need and methods of providing parenteral nutrition to such patients by administering to them a composition as described herein.

4. 发明申请

US20160346242A1 COMPOSITION COMPRISING EPA AND DHA ETHYLESTER FOR PARENTERAL ADMINISTRATION 有权
标题翻译：包含EPA和DHA ETHYLESTER的组合物用于住院管理
公开(公告)号：US20160346242A1
公开(公告)日：2016-12-01
申请号：US15114937
申请日：2015-01-28
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Edmundo Brito De La Fuente , Crispulo Gallegos-Montes , Lida A. Quinchia-Bustamente
IPC分类号： A61K31/232 , A61K47/12 , A61K47/10 , A61K47/24
CPC分类号： A61K31/232 , A61K9/0029 , A61K9/107 , A61K47/10 , A61K47/12 , A61K47/24
摘要： Described herein are compositions for parenteral administration that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil phase comprises the omega-3 fatty acid ethylesters eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester, and mixtures thereof. The composition further comprises at least one anionic surfactant and at least one amphoteric surfactant, and less than 0.05% by weight of oleic acid, based on the total weight of the composition. Also described is a method for preparing such a composition as well as such compositions for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Also featured are methods of treating these conditions by parenterally administering a composition to a patient in need thereof and methods of providing parenteral nutrition to such patients by administering to them a composition as described herein.
摘要翻译：本文描述的是用于肠胃外给药的组合物，其包含基于组合物的总重量的水相和5至30重量％的油相。油相包含ω-3脂肪酸乙酯二十碳五烯酸乙酯，二十二碳六烯酸乙酯及其混合物。基于组合物的总重量，组合物还包含至少一种阴离子表面活性剂和至少一种两性表面活性剂和小于0.05重量％的油酸。还描述了制备这种组合物以及用作药物，特别是用于治疗中风，败血症，阿尔茨海默病或癌症的组合物的方法。还特征在于通过向有需要的患者肠胃外施用组合物来治疗这些病症的方法以及通过向其施用本文所述的组合物向这些患者提供胃肠外营养的方法。

5. 发明申请

US20160044946A1 COMPOSITIONS FOR USE IN NUTRITION OF DYSPHAGIA PATIENTS 审中-公开
标题翻译：用于营养不良患者的组合物
公开(公告)号：US20160044946A1
公开(公告)日：2016-02-18
申请号：US14780026
申请日：2014-03-27
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Crispulo Gallegos-Montes , Edmundo Brito-De-La Fuente , Lida A. Quinchia-Bustamante , Ericka A. Pestana , Nadège Staudinger-Prévost , Getachew Assegehegn
IPC分类号： A23L1/29 , A23L1/0534 , A23L1/053 , A23L1/0522 , A23L1/0532
CPC分类号： A23L29/212 , A23L29/219 , A23L29/25 , A23L29/256 , A23L29/262 , A23L33/105 , A23L33/24 , A23L33/40 , A23V2002/00
摘要： Dysphagia is a common health problem, the term describing a range of mechanical disorders that affect the safety, efficiency, or quality of eating and drinking. In dysphagia, every swallowing attempt bears the danger of choking and aspiration of liquids or food particles into the lung. Generally, when patients experience difficulties in swallowing, food thickeners are used to comply with clinically required levels of viscosity of liquid/semisolid products for use in nutrition for such patients. Herein, food thickening compositions as well as their use and applications are disclosed.
摘要翻译：吞咽障碍是一个常见的健康问题，该术语描述影响饮食和饮水安全性，效率或质量的一系列机械性疾病。吞咽困难时，每次吞咽的尝试都会有窒息和吸入液体或食物颗粒进入肺部的危险。通常，当患者吞咽困难时，使用食品增稠剂来满足临床要求的液体/半固体产品的粘度，用于这种患者的营养。本文中公开了食品增稠组合物及其用途和应用。

6. 发明申请

US20200306215A1 COMPOSITION COMPRISING EPA AND DHA FOR AN ENHANCED EFFICACY OF ANTICANCER AGENTS 审中-公开
公开(公告)号：US20200306215A1
公开(公告)日：2020-10-01
申请号：US16341118
申请日：2017-10-05
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Westphal , Edmundo BRITO DE LA FUENTE , Crispulo Gallegos-Montes , Silke Baasner , Stefanie HONNDORF , Lida Quinchia
IPC分类号： A61K31/202 , A61K47/12 , A61K31/4745 , A61P35/00 , A61K31/513
摘要： The present invention relates to the enhancement of the efficacy of anticancer agents by a composition comprising an aqueous phase, an oil phase, EPA and DHA for use in the treatment of solid tumors, wherein EPA and DHA are present in an amount of at least 65% based on the total weight of the oil phase wherein the composition comprises EPA and DHA in a weight ratio between 1:2 and 1:4, or wherein the composition comprises EPA and DHA in a weight ratio between 6:1 and 4:1 and wherein the treatment comprises administering the composition and administering at least one anticancer agent.

7. 发明授权

US10206884B2 Microcapsules with polymeric coating comprising a lipid and an active agent 有权
公开(公告)号：US10206884B2
公开(公告)日：2019-02-19
申请号：US15106476
申请日：2014-12-19
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Michael Betz , Edmundo Brito De La Fuente , Crispulo Gallegos-Montes
IPC分类号： A61K9/50 , A61K9/16 , A23L29/231 , A23L33/115 , A23P10/35 , B01J13/14 , A23L29/10 , A61K31/19 , B65B7/28 , B65D47/06 , B65D51/28
摘要： The present invention relates to microcapsules and to methods for them. The microcapsules comprise a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. In the matrix, a lipid and an active agent or a prodrug or salt thereof are embedded, the lipid preferably having a melting point of at least 30° C. The microcapsules can be used as a medicament, dietary supplement or food additive, the microcapsules comprising a polymeric coating that is at least partly crosslinked with a polymeric matrix comprising a polysaccharide. As above, a lipid and an active agent or a prodrug or salt thereof are embedded in the matrix, with the lipid preferably having a melting point of at least 30° C. Methods for treating diarrhea or preventing colon cancer comprising administering such microcapsules are also disclosed.

8. 发明申请

US20180147174A1 VITAMIN A FOR PARENTERAL ADMINSTRATION 审中-公开
公开(公告)号：US20180147174A1
公开(公告)日：2018-05-31
申请号：US15575984
申请日：2016-05-20
申请人： Fresenius Kabi Deutschland GmbH
发明人： Edmundo Brito De La Fuente , Crispulo Gallegos-Montes , Lida A. Quinchia-Bustamente , Telli Hekmatara , Michael Betz
IPC分类号： A61K31/215 , A61K9/107 , A61P3/02 , A61K47/10 , A61K47/34 , A61K47/02 , A61K47/24 , A61K47/12
CPC分类号： A61K31/215 , A61K9/0019 , A61K9/1075 , A61K31/07 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/24 , A61K47/34 , A61K47/44 , A61P3/02
摘要： The present disclosure relates to emulsions for parenteral administration comprising 1000 to 5000, preferably 1500 to 3000 IU, vitamin A per ml, wherein the emulsions are free of polysorbates and polyoxyethylen/polyoxypropylene block copolymers. The present disclosure further relates to a method for manufacturing the compositions of the disclosure as well as to the use of the compositions of the disclosure.

9. 发明申请

US20180000732A1 EMULSIONS FOR PARENTERAL ADMINISTRATION 审中-公开
公开(公告)号：US20180000732A1
公开(公告)日：2018-01-04
申请号：US15545503
申请日：2016-03-31
申请人： Fresenius Kabi Deutschland GmbH
发明人： Edmundo Brito De La Fuente , Getachew Assegehegn , Crispulo Gallegos-Montes , Telli Hekmatara , Lida A. Quinchia-Bustamente
IPC分类号： A61K9/107 , A61K9/00 , A61K47/44 , A61K47/46
摘要： A method for manufacturing oil-in-water emulsions for parenteral administration as well as to the use of such emulsions in the treatment or prevention of malnutrition and/or a deficiency in essential fatty acids and/or EPA and DHA and or stroke, sepsis, Alzheimer's disease or cancer.

10. 发明授权

US11975102B2 All-in-one lyophilized multivitamin emulsion for parenteral application 有权
公开(公告)号：US11975102B2
公开(公告)日：2024-05-07
申请号：US16759310
申请日：2018-10-22
申请人： Fresenius Kabi Deutschland GmbH
发明人： Getachew Assegehegn , Edmundo Brito De La Fuente , Crispulo Gallegos-Montes , Lida A. Quinchia Bustamante
IPC分类号： A61K9/19 , A61K9/00 , A61K9/107 , A61K31/07 , A61K31/122 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/4188 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/525 , A61K31/593 , A61K31/714 , A61K47/44
CPC分类号： A61K9/19 , A61K9/0029 , A61K31/07 , A61K31/122 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/4188 , A61K31/4415 , A61K31/455 , A61K31/51 , A61K31/525 , A61K31/593 , A61K31/714 , A61K47/44 , A61K9/107
摘要： The invention relates to lyophilized products and reconstituted emulsions for parenteral application, which comprise all the 13 essential vitamins (A, D, E, K1, C, B1, B2, B3, B5, B6, B7, B9, and B12) in a single container, as well as to methods for preparing them.

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