专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090053792A1 OXYGEN-REGULATED MICROORGANISMS 有权
标题翻译：氧气调节微生物
公开(公告)号：US20090053792A1
公开(公告)日：2009-02-26
申请号：US12065597
申请日：2006-09-08
申请人： Frederick R. Blattner , John Walter Campbell , Nian Shi , Buffy Stahl
发明人： Frederick R. Blattner , John Walter Campbell , Nian Shi , Buffy Stahl
IPC分类号： C12N1/20 , C12N1/16
CPC分类号： C12N1/00 , C12N15/52
摘要： The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and chemicals.
摘要翻译：本发明涉及具有氧调节代谢的微生物新菌株。微生物具有较高的生长速率并且比亲本菌株更有效。微生物可用于产生多种感兴趣的产品，例如重组蛋白质，核酸如DNA，氨基酸和化学品。

2. 发明授权

US08900849B2 Oxygen-regulated microorganisms 有权
标题翻译：氧气调节微生物
公开(公告)号：US08900849B2
公开(公告)日：2014-12-02
申请号：US12065597
申请日：2006-09-08
申请人： Frederick R. Blattner , John Walter Campbell , Nian Shi , Buffy Stahl
发明人： Frederick R. Blattner , John Walter Campbell , Nian Shi , Buffy Stahl
IPC分类号： C12N1/20 , C12N15/00 , C07H21/02 , C07H21/04 , C07K1/00 , C12N15/52 , C12N1/00
CPC分类号： C12N1/00 , C12N15/52
摘要： The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and chemicals.
摘要翻译：本发明涉及具有氧调节代谢的微生物新菌株。微生物具有较高的生长速率并且比亲本菌株更有效。微生物可用于产生多种感兴趣的产品，例如重组蛋白质，核酸如DNA，氨基酸和化学品。

3. 发明申请

US20110165680A1 CLEAN GENOME BACTOFECTION 审中-公开
标题翻译：清洁基因组细菌
公开(公告)号：US20110165680A1
公开(公告)日：2011-07-07
申请号：US13063450
申请日：2009-09-14
申请人： Frederick R. Blattner , Val Burland , Charles Landy , Nian-Qing Shi , Buffy Stahl
发明人： Frederick R. Blattner , Val Burland , Charles Landy , Nian-Qing Shi , Buffy Stahl
IPC分类号： C12N15/85 , C12N1/21 , C07H21/04 , C12N15/63 , C07K14/00
CPC分类号： C12N15/70 , A61K39/00 , C12N15/79 , Y02A50/403 , Y02A50/476
摘要： Methods for introducing and expressing genes in animal cells are provided comprising infecting the animal cells with live invasive reduced-genome bacteria comprising a eukaryotic expression cassette comprising said gene. Also provided are methods for producing a pluripotent stem (iPS) cell from a mammalian somatic cell comprising infecting the somatic cell with live invasive reduced-genome bacteria comprising one or more eukaryotic expression cassettes comprising at least a gene encoding the transcription factor Oct3/4 and a gene encoding a member of the SRY-related HMG-box (Sox) transcription factor family.
摘要翻译：提供了用于在动物细胞中引入和表达基因的方法，包括用包含所述基因的真核表达盒的活侵入性还原基因组细菌感染动物细胞。还提供了用于从哺乳动物体细胞产生多能茎（iPS）细胞的方法，包括用活侵入性减少基因组细菌感染体细胞，所述活体减少基因组细菌包含至少包含编码转录因子Oct3 / 4的基因的一个或多个真核表达盒，编码SRY相关HMG盒（Sox）转录因子家族成员的基因。

4. 发明授权

US07989181B2 Methods and compositions for producing recombinant proteins using a gene for TRNA 有权
标题翻译：使用TRNA基因生产重组蛋白的方法和组合物
公开(公告)号：US07989181B2
公开(公告)日：2011-08-02
申请号：US12294369
申请日：2007-04-23
申请人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
发明人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
IPC分类号： C12P21/04 , C12N5/10 , C12N1/20 , C12N1/19
CPC分类号： C12P21/02 , C12N15/11
摘要： The invention relates to host cells with improved protein expressed properties. The host cells comprise rare tRNA genes within the one or more rRNA operons.
摘要翻译：本发明涉及具有改进的蛋白质表达特性的宿主细胞。宿主细胞在一个或多个rRNA操纵子内包含罕见的tRNA基因。

5. 发明申请

US20110293662A1 COMPOSITIONS COMPRISING REDUCED GENOME BACTERIA FOR USE IN TREATMENT OF SEPSIS 审中-公开
标题翻译：包含减少基因细菌的组合物用于治疗SEPSIS
公开(公告)号：US20110293662A1
公开(公告)日：2011-12-01
申请号：US13148037
申请日：2010-02-10
申请人： Frederick R. Blattner , Valerie Burland , John Walter Campbell , Charles Landry
发明人： Frederick R. Blattner , Valerie Burland , John Walter Campbell , Charles Landry
IPC分类号： A61K39/02 , A61P31/04 , A61P37/04 , A61K39/108 , C12N1/20
CPC分类号： A61K35/74 , Y02A50/473
摘要： Methods for prophylaxis or treatment of sepsis in a subject are provided comprising administering to the subject a therapeutically effective dose of multiple deletion strain bacteria.
摘要翻译：提供了用于预防或治疗受试者败血症的方法，包括向受试者施用治疗有效剂量的多种缺失菌株细菌。

6. 发明授权

US07935505B2 Plasmid DNA preparations and methods for producing same 有权
标题翻译：质粒DNA制剂及其制备方法
公开(公告)号：US07935505B2
公开(公告)日：2011-05-03
申请号：US12294159
申请日：2007-05-24
申请人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
发明人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
IPC分类号： C12N15/64
CPC分类号： C12N15/70
摘要： The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.
摘要翻译：本发明的各种实施方案一般涉及质粒DNA制备物以及生产和使用这些制剂的方法。

7. 发明申请

US20090068707A1 PLASMID DNA PREPARATIONS AND METHODS FOR PRODUCING SAME 有权
标题翻译： PLASMID DNA制备及其生产方法
公开(公告)号：US20090068707A1
公开(公告)日：2009-03-12
申请号：US12294159
申请日：2007-05-24
申请人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
发明人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
IPC分类号： C12P19/34 , C12N1/21 , C12N15/63
CPC分类号： C12N15/70
摘要： The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.
摘要翻译：本发明的各种实施方案一般涉及质粒DNA制备物以及生产和使用这些制剂的方法。

8. 发明申请

US20090053766A1 METHODS AND COMPOSITIONS FOR PRODUCING RECOMBINANT PROTEINS USING A GENE FOR TRNA 有权
标题翻译：使用TRNA基因生产重组蛋白的方法和组合物
公开(公告)号：US20090053766A1
公开(公告)日：2009-02-26
申请号：US12294369
申请日：2007-04-23
申请人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
发明人： Frederick R. Blattner , John Walter Campbell , Guy Plunkett
IPC分类号： C12P21/04 , C12N5/10 , C12N1/20 , C12N1/19
CPC分类号： C12P21/02 , C12N15/11
摘要： The invention relates to host cells with improved protein expressed properties. The host cells comprise rare tRNA genes within the one or more rRNA operons.
摘要翻译：本发明涉及具有改进的蛋白质表达特性的宿主细胞。宿主细胞在一个或多个rRNA操纵子内包含罕见的tRNA基因。

9. 发明授权

US08039243B2 Insertion sequence-free bacteria 有权
标题翻译：插入无序细菌
公开(公告)号：US08039243B2
公开(公告)日：2011-10-18
申请号：US11275094
申请日：2005-12-09
申请人： Frederick R. Blattner
发明人： Frederick R. Blattner
IPC分类号： C12N1/20 , C07H21/04
CPC分类号： C12N15/70
摘要： The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences from a bacterial genome. The methods provide precise deletions and seldom introduces mutations to the genomic DNA sequences around the deletion sites. Thus, the methods can be used to generate a series of deletions in a bacterium without increasing the possibility of undesired homologous recombination within the genome. In addition, some of the methods provided by the present invention can also be used for replacing a region of a bacterial genome with a desired DNA sequence.
摘要翻译：本发明提供了一种具有遗传工程化以小于其天然亲本菌株的基因组的基因组的细菌。具有较小基因组的细菌可以更有效地产生商业产品。本发明还提供从细菌基因组中删除基因和其他DNA序列的方法。该方法提供精确的缺失，很少引入缺失位点周围基因组DNA序列的突变。因此，该方法可用于在细菌中产生一系列缺失，而不增加基因组内不希望的同源重组的可能性。此外，本发明提供的一些方法也可用于用期望的DNA序列替代细菌基因组的区域。

10. 发明授权

US06855814B2 Sequences of E. coli O157 有权
标题翻译：大肠杆菌O157的序列
公开(公告)号：US06855814B2
公开(公告)日：2005-02-15
申请号：US10114170
申请日：2002-04-01
申请人： Frederick R. Blattner , Valerie Burland , Nicole T. Perna , Guy Plunkett , Rod Welch
发明人： Frederick R. Blattner , Valerie Burland , Nicole T. Perna , Guy Plunkett , Rod Welch
IPC分类号： C07K14/245 , C12Q1/68 , C07H21/02
CPC分类号： C07K14/245
摘要： The entire genome of pathogenic E. coli strain 0157:H7 has been sequenced. All of the genomic DNA sequences present in 0157 and absent in the previously sequenced laboratory strain K12 are presented here.
摘要翻译：病原性大肠杆菌菌株0157：H7的整个基因组已被测序。存在于0157中的所有基因组DNA序列和在先前测序的实验室菌株K12中不存在。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式