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1. 发明申请

US20050231391A1 Flight timer 失效
标题翻译：飞行计时器
公开(公告)号：US20050231391A1
公开(公告)日：2005-10-20
申请号：US10816972
申请日：2004-04-01
申请人： Frederick Boyns , Craig Kllcourse , Cameron Smith , Blake Stancik , Scott Thielman
发明人： Frederick Boyns , Craig Kllcourse , Cameron Smith , Blake Stancik , Scott Thielman
IPC分类号： G01C23/00 , G08B21/00
CPC分类号： G01C23/00
摘要： A timer usable in navigating and piloting an aircraft, the timer having a plurality of application modes for management of time and numeric data, including an approach mode, a fuel mode, a chronograph mode and a clock mode. Each application mode can drive independent but simultaneous time count sequences for use in flight management and navigation such as counting down approach times, fuel-tank switching intervals and other time sensitive events, as well as providing military time, standard time and UTC time.
摘要翻译：一种可用于导航和驾驶飞行器的定时器，定时器具有用于管理时间和数字数据的多种应用模式，包括进场模式，燃料模式，计时模式和时钟模式。每个应用模式都可以驱动独立但同时的时间计数序列，用于飞行管理和导航，例如倒数接近时间，燃料箱切换间隔和其他时间敏感事件，以及提供军事时间，标准时间和UTC时间。

2. 发明授权

US07187303B2 Flight timer 失效
标题翻译：飞行计时器
公开(公告)号：US07187303B2
公开(公告)日：2007-03-06
申请号：US10816972
申请日：2004-04-01
申请人： Frederick C. Boyns , Craig Kilcourse , Cameron Smith , Blake Stancik , Scott Thielman
发明人： Frederick C. Boyns , Craig Kilcourse , Cameron Smith , Blake Stancik , Scott Thielman
IPC分类号： G08B21/00
CPC分类号： G01C23/00
摘要： A timer usable in navigating and piloting an aircraft, the timer having a plurality of application modes for management of time and numeric data, including an approach mode, a fuel mode, a chronograph mode and a clock mode. Each application mode can drive independent but simultaneous time count sequences for use in flight management and navigation such as counting down approach times, fuel-tank switching intervals and other time sensitive events, as well as providing military time, standard time and UTC time.
摘要翻译：一种可用于导航和驾驶飞行器的定时器，定时器具有用于管理时间和数字数据的多种应用模式，包括进场模式，燃料模式，计时模式和时钟模式。每个应用模式都可以驱动独立但同时的时间计数序列，用于飞行管理和导航，例如倒数接近时间，燃料箱切换间隔和其他时间敏感事件，以及提供军事时间，标准时间和UTC时间。

3. 外观设计

USD981581S1 Arched massage head 有权
公开(公告)号：USD981581S1
公开(公告)日：2023-03-21
申请号：US29772188
申请日：2021-02-26
申请人： William Smith , Cameron Smith , Dominic Rainville
设计人： William Smith , Cameron Smith , Dominic Rainville

4. 发明申请

US20220008284A1 SELF-MASSAGE DEVICE HAVING INTERCHANGEABLE MASSAGE HEADS AND BOARD 有权
公开(公告)号：US20220008284A1
公开(公告)日：2022-01-13
申请号：US17180654
申请日：2021-02-19
申请人： William Smith , Cameron Smith , Dominic Rainville
发明人： William Smith , Cameron Smith , Dominic Rainville
IPC分类号： A61H23/02
摘要： Described is a self-massage device including a massage board with multiple connected indentations formed along the length of the massage board. The self-massage device also includes one or more massage heads having a top portion formed to contact a portion of a user's body, and a bottom portion having a protrusion formed to be removably inserted into one or more of the connected indentations in the massage board via a pressure mechanism.

5. 发明授权

US09555041B2 Neprilysin inhibitors 有权
标题翻译： Neprilysin抑制剂
公开(公告)号：US09555041B2
公开(公告)日：2017-01-31
申请号：US14804407
申请日：2015-07-21
申请人： Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
发明人： Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
IPC分类号： A61K31/5377 , A61K31/4155 , A61K31/454 , A61K31/4196 , A61K31/4192 , A61K31/497 , A61K31/505 , A61K31/426 , A61K31/50 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/24 , C07D239/36 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/18 , C07D263/34 , C07D263/38 , C07D277/56 , C07D401/04 , C07D403/04 , C07D403/06 , C07D413/04 , C07D471/04 , C07D239/28 , C07D239/34 , C07D239/52 , C07D401/06 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/437
CPC分类号： C07D471/04 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/14 , C07D237/24 , C07D239/28 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/38 , C07D277/34 , C07D277/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , Y02P20/55
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R 1 -R 6，a，b和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

6. 发明申请

US20150133658A1 NEPRILYSIN INHIBITORS 有权
标题翻译： NEPRILYSIN抑制剂
公开(公告)号：US20150133658A1
公开(公告)日：2015-05-14
申请号：US14460567
申请日：2014-08-15
申请人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号： C07D471/04 , C07D249/10 , C07D231/14 , C07D261/12 , C07D239/34 , C07D249/04 , C07D249/18
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R1，R2a，R2b，R3-R6，a，b，Z和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

7. 发明申请

US20140011997A1 NEPRILYSIN INHIBITORS 有权
标题翻译： NEPRILYSIN抑制剂
公开(公告)号：US20140011997A1
公开(公告)日：2014-01-09
申请号：US14024974
申请日：2013-09-12
申请人： Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
发明人： Cameron Smith , Melissa Fleury , Roland Gendron , Ryan Hudson , Adam D. Hughes
IPC分类号： C07D231/14 , C07D401/06 , C07D261/18 , C07D249/10 , C07D249/04 , C07D471/04 , C07D249/18 , C07D249/12 , C07D257/04 , C07D263/34 , C07D239/52 , C07D239/28 , C07D239/34 , C07D263/38 , C07D277/56 , C07D413/04 , C07D237/24 , C07D403/06
CPC分类号： C07D471/04 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/14 , C07D237/24 , C07D239/28 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/38 , C07D277/34 , C07D277/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , Y02P20/55
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R 1 -R 6，a，b和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

8. 发明申请

US20120232053A1 QUATERNARY AMMONIUM COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 有权
标题翻译：季铵化合物作为MUSCARINIC受体拮抗剂有用
公开(公告)号：US20120232053A1
公开(公告)日：2012-09-13
申请号：US13473792
申请日：2012-05-17
申请人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
发明人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
IPC分类号： A61K31/4535 , A61K31/4468 , C07D401/12 , A61K31/454 , A61P11/06 , C07D405/12 , A61K31/453 , C07D205/04 , A61K31/397 , A61P11/00 , C07D211/58 , C07D409/12
CPC分类号： C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供下式的化合物：盐或两性离子形式或其药学上可接受的盐，其中R1-6，a，Z和Q如说明书中所定义。这些化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

9. 发明申请

US20120213807A1 NEPRILYSIN INHIBITORS 有权
标题翻译： NEPRILYSIN抑制剂
公开(公告)号：US20120213807A1
公开(公告)日：2012-08-23
申请号：US13398027
申请日：2012-02-16
申请人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号： A61K39/00 , C07D413/06 , C07D401/06 , C07D249/18 , C07D471/04 , C07D261/18 , C07D239/36 , A61K31/4192 , A61K31/4196 , A61K31/415 , A61K31/5377 , A61K31/454 , C07D249/10 , A61K31/437 , A61K31/42 , A61K31/505 , A61K31/56 , A61K31/7048 , A61P7/02 , A61P3/10 , A61P27/06 , C07D249/12 , A61P29/00 , A61P25/24 , A61P9/04 , A61P9/02 , A61P9/10 , C07D231/20 , C07D231/14 , C07D403/06 , A61K31/4155 , C07D403/04 , A61K31/497 , A61K38/22 , C07D319/06 , C07C271/22 , C07D249/04
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中R1，R2a，R2b，R3-R6，a，b，Z和X如说明书中所定义，或其药学上可接受的盐。这些化合物具有去血清抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

10. 发明授权

US07290050B1 Transparent load balancer for network connections 有权
标题翻译：用于网络连接的透明负载均衡器
公开(公告)号：US07290050B1
公开(公告)日：2007-10-30
申请号：US10252061
申请日：2002-09-20
申请人： Cameron Smith , Vilis Ositis
发明人： Cameron Smith , Vilis Ositis
IPC分类号： G06F15/173 , G06F9/46
CPC分类号： H04L67/1008 , H04L67/1002 , H04L67/1006 , H04L69/16 , H04L69/165
摘要： A transparent load balancer receives incoming Ethernet frames having incoming source and destination IP and MAC addresses. The load balancer diverts the incoming frames to one of several multi-application platforms. The incoming frames are communicated across a first TCP connection that terminates on a multi-application platform. The first TCP connection is defined by TCP source and destination ports. The transparent load balancer receives outgoing frames from the multi-application platform and outputs the outgoing frames with source and destination IP and MAC addresses that are identical to the incoming source and destination IP and MAC addresses. The outgoing frames are communicated across a second TCP connection, the second TCP connection being defined by the same TCP source port and TCP destination port of the first TCP connection. The transparent load balancer and multi-application platforms can be inserted into a running network without noticeable interruption to devices on the network.
摘要翻译：透明负载平衡器接收具有传入源和目标IP和MAC地址的入站以太网帧。负载平衡器将进入的帧转移到几个多应用平台之一。传入的帧通过在多应用平台上终止的第一TCP连接进行通信。第一个TCP连接由TCP源端口和目标端口定义。透明负载平衡器从多应用平台接收输出帧，并输出与源IP和MAC地址相同的源IP和MAC地址的出站帧。输出帧通过第二TCP连接进行通信，第二TCP连接由第一TCP连接的相同TCP源端口和TCP目标端口定义。透明负载平衡器和多应用平台可以插入到正在运行的网络中，而不会明显地中断网络上的设备。

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