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1. 发明授权

US06646120B1 Dextran derivatives, preparation and medicinal applications 失效
标题翻译：葡聚糖衍生物，制剂和药物应用
公开(公告)号：US06646120B1
公开(公告)日：2003-11-11
申请号：US09367111
申请日：2000-09-26
申请人： Frederic Chaubet , Remi Huynh , Latifa Dahri , Jose Correia , Marcel Jozefowicz , Jacqueline Jozefonvicz
发明人： Frederic Chaubet , Remi Huynh , Latifa Dahri , Jose Correia , Marcel Jozefowicz , Jacqueline Jozefonvicz
IPC分类号： C08B3702
CPC分类号： C08B37/0021
摘要： The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.1 provided that when d=0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.
摘要翻译：本发明涉及葡聚糖衍生物，它们作为具有特定生物作用的药物的应用及其制备方法。所述衍生物对应于通式DMCaBbSUcSd，其中：D表示多糖链，优选由葡萄糖苷单元序列组成，MC表示甲基羧酸酯基，B表示羧甲基苄基酰胺基，Su表示硫酸基，S表示磺酸酯基，a，b， c和d分别代表组，MC，B，Su和S的取代度（ds）; a等于0或> = 0.3，b等于0或> = 0.1，c等于0或> = 0.1，d等于0或> = 0.1，条件是当d = 0时，a和/或 b不等于0，所述产物具有链尺寸分布的均匀性，由高效空间排阻色谱中对称的高斯洗脱曲线所示，以及带电化学基团分布的均匀性，通过具有单个对称峰的洗脱曲线在低压离子交换层析中。

2. 发明授权

US06946443B2 Biomaterial based on an insolubilized dextran derivative and a growth factor 失效
标题翻译：基于不溶性葡聚糖衍生物和生长因子的生物材料
公开(公告)号：US06946443B2
公开(公告)日：2005-09-20
申请号：US10016706
申请日：2001-12-11
申请人： Cinderella Blanchat , Delphine Logeart-Avramoglou , Hervé Petite , Alain Meunier , Frédéric Chaubet , Jacqueline Jozefonvicz , Marcel Jozefowicz , Laurent Sedel , José Correia
发明人： Cinderella Blanchat , Delphine Logeart-Avramoglou , Hervé Petite , Alain Meunier , Frédéric Chaubet , Jacqueline Jozefonvicz , Marcel Jozefowicz , Laurent Sedel , José Correia
IPC分类号： A61L27/00 , A61K6/097 , A61L27/20 , A61L27/22 , A61L27/26 , A61L27/46 , A61L27/48 , A61L27/54 , A61K38/18 , A61K31/721
CPC分类号： A61L27/54 , A61L27/20 , A61L27/227 , A61L27/26 , A61L27/46 , A61L27/48 , A61L2300/414 , C08L5/02
摘要： The invention concerns a biologically active material essentially comprising at least an insolubilized dextran derivative of general formula DMCaBbSUcSd and at least a growth factor having an activity on osteoarticular, dental and/or maxillofacial tissues, and the method for preparing same. The invention also concerns the uses of said biomaterial for preparing a repair or filing material, such as an implant, for osteoarticular, dental or maxillofacial applications and for preparing an orthopaedic, dental or maxillofacial prosthesis, and the prosthesis coated with said biologically active material.
摘要翻译：本发明涉及一种生物活性物质，其基本上包含至少一种通式DMC的不溶性葡聚糖衍生物，其中S 和至少一种对骨关节炎，牙齿和/或颌面组织具有活性的生长因子及其制备方法。本发明还涉及所述生物材料用于制备用于骨关节炎，牙齿或颌面应用的修复或填充材料（例如植入物）以及用于制备矫形器，牙科或颌面假体以及用所述生物活性材料涂覆的假体的用途。

3. 发明授权

US07101863B2 Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative 失效
标题翻译：具有伤口愈合或抗互补活性的药物组合物，其包含葡聚糖衍生物
公开(公告)号：US07101863B2
公开(公告)日：2006-09-05
申请号：US10020044
申请日：2001-12-13
申请人： Latifa Dahricorreia , Jacqueline Jozefonvicz , Marcel Jozefowicz , José Correia , Rémi Huynh
发明人： Latifa Dahricorreia , Jacqueline Jozefonvicz , Marcel Jozefowicz , José Correia , Rémi Huynh
IPC分类号： A61K31/721 , C08B37/02
CPC分类号： A61K31/721 , C08B37/0021
摘要： The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising, (1) at least a dextran derivative of general formula DMCaBbSuc, a, b, and c respectively representing the degrees of substitution in the groups MC, B and Su, wherein a≧0.6, b=0 or ≧0.1, and c=0 or ranges widely between 0.1 and 0.5 for a wound healing composition, and a≧0.3, b≧0.1 and c=0 or ranges widely between 0.1 and 0.4 for a composition with anti-complementary activity; (2) and at least a pharmaceutically acceptable carrier, said dextran derivative being present in a single unit dose or at a concentration adapted to the desired wound healing or anti-complementary activity.
摘要翻译：本发明涉及具有伤口愈合或抗互补活性的药物组合物及其用途，所述组合物包含：（1）至少一种通式DMC的一种葡聚糖衍生物，分别代表组MC，B和Su中取代度的a，b和c，其中a> = 0.6，b = 0或> = 0.1，c = 0 或对于伤口愈合组合物，范围广泛在0.1至0.5之间，对于具有抗互补活性的组合物，≥0.3，b> = 0.1和c = 0或广泛范围在0.1至0.4范围内; （2）和至少一种药学上可接受的载体，所述葡聚糖衍生物以单一单位剂量或以适合于所需伤口愈合或抗互补活性的浓度存在。

4. 发明授权

US06028191A Method for obtaining sulphated polysaccharides 失效
标题翻译：获得硫酸化多糖的方法
公开(公告)号：US06028191A
公开(公告)日：2000-02-22
申请号：US11750
申请日：1998-05-06
申请人： Alain Nardella , Frederic Chaubet , Corinne Sinquin , Sylvia Colliec Jouault , Catherine Boisson-Vidal , Patrick Durand , Jacqueline Jozefonvicz
发明人： Alain Nardella , Frederic Chaubet , Corinne Sinquin , Sylvia Colliec Jouault , Catherine Boisson-Vidal , Patrick Durand , Jacqueline Jozefonvicz
IPC分类号： C08B37/00
CPC分类号： C08B37/006
摘要： A method for obtaining sulphated polysaccharides using the free radical depolymerization of a fucan from Phaeophyceae in the presence of a metal catalyst and of hydrogen peroxide is described. The method of the invention provides polysaccharide fractions with a molecular weight of 10,000 g/mol or less, with anticoagulant properties.
摘要翻译： PCT No.PCT / FR96 / 01314 Sec。 371日期：1998年5月6日 102（e）日期1998年5月6日PCT提交1996年8月23日PCT公布。出版物WO97 / 08206 日期1997年3月6日描述了在金属催化剂和过氧化氢存在下，使用从Phaeophyceae获得的福克斯的自由基解聚获得硫酸化多糖的方法。本发明的方法提供分子量为10,000g / mol以下的具有抗凝血性质的多糖级分。

5. 发明授权

US5693625A Method of regenerating cells and tissues using functionalized dextrans 失效
标题翻译：使用功能化葡聚糖再生细胞和组织的方法
公开(公告)号：US5693625A
公开(公告)日：1997-12-02
申请号：US216859
申请日：1994-03-24
申请人： Denis Barritault , Jacqueline Jozefonvicz , Michele Tardieu , Faouzi Slaoui , Jean-Pierre Caruelle , Jose Courty
发明人： Denis Barritault , Jacqueline Jozefonvicz , Michele Tardieu , Faouzi Slaoui , Jean-Pierre Caruelle , Jose Courty
IPC分类号： A61K9/00 , A61K31/721 , A61K47/36 , A61K31/715 , C08B37/02
CPC分类号： A61K31/721 , A61K47/36 , A61K9/0014
摘要： Compositions useful for regenerating cells and tissues comprise at least one functionalized dextran which has been substituted with carboxymethyl, benzylamide, or benzylamide sulfonate. These dextrans can be used alone or in combination with acid or basic fibroblast growth factors to enhance tissue or cell regeneration. Additionally, these dextrans enhance the stability of acid or basic fibroblast growth factors.
摘要翻译：用于再生细胞和组织的组合物包含已被羧甲基，苄基酰胺或苄基酰胺磺酸取代的至少一种官能化的葡聚糖。这些葡聚糖可以单独使用或与酸性或碱性成纤维细胞生长因子组合使用以增强组织或细胞再生。此外，这些葡聚糖增强了酸或碱性成纤维细胞生长因子的稳定性。

6. 发明授权

US07022775B2 Resins based on polystyrene-functionalized methyl esters groups of L-tyrosine and their uses 失效
标题翻译：基于聚苯乙烯官能化的L-酪氨酸甲酯基团的树脂及其用途
公开(公告)号：US07022775B2
公开(公告)日：2006-04-04
申请号：US10415775
申请日：2001-11-06
申请人： Rosa Siali , Hamid Lakhiari , Catherine Boisson-Vidal , Jacqueline Jozefonvicz
发明人： Rosa Siali , Hamid Lakhiari , Catherine Boisson-Vidal , Jacqueline Jozefonvicz
IPC分类号： C08F112/08 , C08F212/08
CPC分类号： C08F8/38 , C08F8/32 , C08F212/08
摘要： The present invention relates to resins based on functionalized polystyrene, to the method for the production thereof, to the use thereof for producing columns for purifying anti-factor VIII antibodies, and also to a method for purifying anti-factor VIII antibodies ex vivo.
摘要翻译：本发明涉及基于官能化聚苯乙烯的树脂，其制备方法，其用于生产用于纯化抗因子VIII抗体的柱的用途，以及离体纯化抗因子VIII抗体的方法。

7. 发明授权

US06828307B1 Low molecular weight sulphated polysaccharide to obtain a medicine with antithrombotic activity 失效
标题翻译：低分子量硫酸多糖获得具有抗血栓活性的药物
公开(公告)号：US06828307B1
公开(公告)日：2004-12-07
申请号：US10069913
申请日：2002-07-12
申请人： Sylvia Colliec-Jouault , Patrick Durand , Anne-Marie Fischer , Jacqueline Jozefonvicz , Didier Letourneur , Jean Millet
发明人： Sylvia Colliec-Jouault , Patrick Durand , Anne-Marie Fischer , Jacqueline Jozefonvicz , Didier Letourneur , Jean Millet
IPC分类号： A61K31726
CPC分类号： A61K31/737 , A61K36/03
摘要： The invention concerns the use of a sulphated polysaccharide capable of being obtained by radical depolymerization of a raw fucan derived from Pheophyceae, said polysaccharide having a molar mass not more than 10,000 g/mol, to obtain a medicine for preventing or treating vascular thrombosis, in particular venous thrombosis, arterial thrombosis and arterial restenosis.
摘要翻译：本发明涉及使用能够通过自由基解聚获得的硫酸化多糖，所述硫酸化多糖来源于白僵菌，所述多糖具有不大于10,000g / mol的摩尔质量，以获得用于预防或治疗血管血栓形成的药物特定静脉血栓形成，动脉血栓形成和动脉再狭窄。

8. 发明授权

US4755379A Polymers substituted by groups conferring anti-coagulant properties on them, process for their preparation, articles and compositions made therefrom and uses thereof 失效
标题翻译：由赋予其抗凝性的基团取代的聚合物，其制备方法，由其制备的制品和组合物及其用途
公开(公告)号：US4755379A
公开(公告)日：1988-07-05
申请号：US781203
申请日：1985-09-27
申请人： Marcel Jozefonvicz , Jacqueline Jozefonvicz , Christine Fougnot , Monique Mauzac
发明人： Marcel Jozefonvicz , Jacqueline Jozefonvicz , Christine Fougnot , Monique Mauzac
IPC分类号： A61L17/00 , A61K31/795 , A61L33/00 , A61L33/06 , A61L33/08 , C08F8/32 , C08J7/14 , A61K31/745 , A61K31/715 , A61K31/725 , C07H5/06
CPC分类号： C08J7/14 , A61K31/795 , A61L33/0041 , A61L33/06 , A61L33/064 , A61L33/08 , C08F8/30 , Y10S514/822
摘要： Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X denotes the group --SO.sub.3 R.sub.1 or --R.sub.3 --SO.sub.3 R.sub.1, R.sub.1 being a hydrogen atom or a physiologically compatible metal, R.sub.3 being a --CH.sub.2 --CO--NH--R.sub.4 group in which R.sub.4 represensts an alkyl aryl or alkylaryl radical, which may or may not be substituted, or substituted or unsubstituted --CH.sub.2 --; Y denotes the group --SO.sub.2 --R.sub.2 or --R.sub.3 --SO.sub.2 --R.sub.2, R.sub.2 being the residue of an amino acid connected to the --SO.sub.2 bridge through its amine function and V denotes the group --CH.sub.2 --CO--NH--CHR--COOH, R being the side chain of an amino acid it being understood that: (a) if X is --SO.sub.3 R.sub.1 it is necessarily accompanied by Y and/or by V, and (b) V is always accompanied by X and/by Y.
摘要翻译：抗凝血剂产品由聚合物（均聚物或共聚物）构成，包括在其可固定的基团中统计学上统计X，和/或Y和/或V，其中X表示基团-SO 3 R 1或-R 3 SO 3 R 1，R 1为氢原子或生理上相容的金属，R3是-CH2-CO-NH-R4基团，其中R4表示烷基芳基或烷基芳基，其可以是或可以不被取代，或取代或未取代的-CH 2 - ; Y表示基团-SO 2 -R 2或-R 3 -SO 2 -R 2，R 2是通过其胺官能团与-SO 2桥连接的氨基酸的残基，V表示基团-CH 2 -CO-NH-CHR-COOH， R是氨基酸的侧链，应理解为：（a）如果X是-SO 3 R 1，则必须伴随有Y和/或V，（b）V总是伴有X和/ Y。

9. 发明授权

US5321133A Sulphated polysaccharides, anticoagulant agent and anticomplementary agent obtained from brown algae fucuses and method of obtaining same 失效
标题翻译：硫酸多糖，抗凝血剂和从褐藻获得的抗补体剂及其获得方法
公开(公告)号：US5321133A
公开(公告)日：1994-06-14
申请号：US778220
申请日：1992-01-16
申请人： Sylvia Colliec , Jacqueline Bretaudiere , Patrick Durand , Anne-Marie Fischer , Jacqueline Jozefonvicz , Bernard Kloareg , Catherine Vidal
发明人： Sylvia Colliec , Jacqueline Bretaudiere , Patrick Durand , Anne-Marie Fischer , Jacqueline Jozefonvicz , Bernard Kloareg , Catherine Vidal
IPC分类号： A61K36/02 , A61K31/715 , A61K31/737 , A61P7/02 , A61P37/06 , C08B37/00 , C12P19/04 , C08B31/00
CPC分类号： A61K31/737 , C08B37/006 , C12P19/04
摘要： The invention relates to sulphated polysaccharides obtained from fucuses extracted from pheophyceae. The molecular weight of these polysaccharides is greater than 5 and less than 40 Kda; their sulphur content is greater than that of the original fucus and they contain less than 0.15% of contaminant proteins. Applications as anticoagulant and anticomplementary agents.
摘要翻译： PCT No.PCT / FR90 / 00420 Sec。 371日期：1992年1月16日 102（e）日期1992年1月16日PCT Filed 1990年6月13日PCT公布。出版物WO90 / 15823 日期1990年12月27日。本发明涉及从从鞘内提取的岩藻中获得的硫酸化多糖。这些多糖的分子量大于5，小于40Kda; 它们的硫含量大于原始灰分，并且含有少于0.15％的污染蛋白。作为抗凝剂和抗补体剂的应用。

10. 发明授权

US4736019A Process for the separation of antifactor VIII:C antibodies, more particularly usable for the purification of the blood plasma of a type a hemophiliac 失效
标题翻译：用于分离抗反应器VIII的方法：C抗体，更特别可用于纯化血友病血型
公开(公告)号：US4736019A
公开(公告)日：1988-04-05
申请号：US865333
申请日：1986-05-21
申请人： Noureddine Bellattar , Danielle Gulino , Jacqueline Jozefonvicz
发明人： Noureddine Bellattar , Danielle Gulino , Jacqueline Jozefonvicz
IPC分类号： G01N33/53 , A61K35/16 , A61K39/395 , A61M1/36 , B01J20/281 , C07K1/16 , C07K1/22 , C07K14/435 , C07K14/755 , C07K16/00 , C07K16/06 , G01N30/88 , G01N33/545
CPC分类号： A61M1/3679 , A61K35/16 , Y10S530/811 , Y10S530/813 , Y10S530/815 , Y10S530/816
摘要： The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies.Preferably use is made of polystyrene, to which have been fixed groups --SO.sub.3 Na and --SO.sub.2 Glu, --SO.sub.2 Threo, --SO.sub.2 OHPro or SO.sub.2 Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.
摘要翻译：用于分离存在于液体中的抗VIII：C抗体的方法包括将所述液体与由其可链可取代基组成的聚合物或共聚物构成的固体支持物接触，所述基团至少部分地被具有对抗VIII的亲和性的基团取代：C抗体和对抗抗VIII：C抗体的选择性与其他免疫球蛋白相比，然后将液体从吸附有抗VIII：C抗体的载体分离。优选使用具有固定基团-SO 3 Na和-SO 2 Glu，-SO 2 Threo，-SO 2 OHPro或SO 2 Lys的聚苯乙烯。这些载体可用于A型血友病血浆的柱中的离体纯化。

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