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1. 发明授权

US07172603B2 Deployable constrictor for uterine artery occlusion 失效
标题翻译：子宫动脉闭塞可部分收缩
公开(公告)号：US07172603B2
公开(公告)日：2007-02-06
申请号：US10300495
申请日：2002-11-19
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Ed Olson
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/1227 , A61B5/026 , A61B8/06 , A61B8/12 , A61B17/1285 , A61B17/42
摘要： Devices, systems and methods for occluding blood vessels include a deployable constrictor having opposed pressure-applying portions, a delivery shaft configured to intravaginally advance the constrictor to the patient's cervix, a location sensor configured to detect a blood vessel, a deployment member for deploying the constrictor about the patient's cervix, and optionally a guide. The constrictor has a first configuration to receive a cervix and a second configuration to apply pressure to the cervical area to occlude a uterine artery by compression from the pressure-applying members. The pressure-applying members may be released from the cervix after a limited therapeutically effective time. The constrictor is for treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries, such as uterine fibroids, dysfunctional uterine bleeding, post-partum hemorrhage, and bleeding associated with caesarian sections.
摘要翻译：用于闭塞血管的装置，系统和方法包括具有相对的压力施加部分的可展开的收缩器，配置成将阴囊推进到患者的子宫颈的输送轴，配置成检测血管的位置传感器，用于部署关于患者的子宫颈的收缩，以及可选的导引。收缩器具有接收子宫颈的第一构造和第二构造，以通过压力从压力施加构件压迫宫颈区域以阻塞子宫动脉。压力施加构件可在有限的治疗有效时间后从子宫颈释放。压缩器用于治疗可通过闭塞子宫动脉（例如子宫肌瘤），功能障碍性子宫出血，产后出血以及与切片相关的出血治疗的子宫疾病和病症。

2. 发明授权

US07875036B2 Short term treatment for uterine disorder 失效
标题翻译：短期治疗子宫功能障碍
公开(公告)号：US07875036B2
公开(公告)日：2011-01-25
申请号：US11256768
申请日：2005-10-24
申请人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
发明人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B17/12 , A61B17/282
摘要： A method and device for treating a female patient's uterine disorder by occluding one or both of the patient's uterine artery. The treatment involves occluding one or both of the patient's uterine arteries with an intravaginal device to form a thrombus within the occluded artery or arteries and administering an agent which will prolong the occlusion of the artery or arteries after removal of the occluding device or initiate or accelerate fibroid cell apoptosis (programmed cell death). The intravaginal device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member.
摘要翻译：一种用于通过闭塞患者的子宫动脉中的一者或两者来治疗女性患者的子宫疾病的方法和装置。该治疗涉及用阴道内装置阻塞患者的子宫动脉中的一者或两者，以在闭塞的动脉或动脉内形成血栓并施用一种药剂，其将在移除闭塞装置之后延长动脉或动脉的闭塞，或启动或加速纤维细胞凋亡（程序性细胞死亡）。阴道内装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。

3. 发明授权

US07686817B2 Occlusion device for asymmetrical uterine artery anatomy 失效
标题翻译：用于不对称子宫动脉解剖的闭塞装置
公开(公告)号：US07686817B2
公开(公告)日：2010-03-30
申请号：US10721857
申请日：2003-11-25
申请人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
发明人： Fred H. Burbank , Greig E. Altieri , Michael L. Jones , Ed Olson
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B17/12 , A61B2017/2927 , A61B2017/2944 , A61B2017/4216 , A61B2017/4225
摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.
摘要翻译：公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。封闭元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调节，以适应不对称的子宫动脉解剖。闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。构造成固定在患者子宫颈内的十字形引导元件可被设置成将闭塞装置引导到病人的子宫颈。

4. 发明授权

US07479145B2 Tenaculum-like device for intravaginal instrument delivery 失效
标题翻译：用于阴道内仪器输送的Tenaculum式装置
公开(公告)号：US07479145B2
公开(公告)日：2009-01-20
申请号：US10716329
申请日：2003-11-18
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , R. J. Serra , Ed Olson , Yu-Tung Wong
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , R. J. Serra , Ed Olson , Yu-Tung Wong
IPC分类号： A61B17/42 , A61B17/46 , A61D1/10
CPC分类号： A61B17/4241 , A61B17/282 , A61B17/42
摘要： The invention is directed to tenaculum-like devices and systems for the intravaginal delivery of therapeutic or diagnostic devices and particularly for occluding a female patient's uterine arteries in order to treat uterine disorders. Included are methods for grasping, manipulating and retaining tissue. The tenaculum-type device has a distal portion with a sound configured to enter a cervical os without causing undue trauma or discomfort to the patient, and a retention or tissue grasping mechanism with a grasping element such as a spike configured to engage and retain a patient's cervix. The tenaculum-type devices embodying features of the invention may have an expandable distal tip to more securely be engaged within the patient's uterine cervical canal.
摘要翻译：本发明涉及用于治疗或诊断装置的阴道内输送的特定用途的器械和系统，特别是用于阻塞女性患者的子宫动脉以治疗子宫疾病。包括用于抓握，操纵和保持组织的方法。所述牵引式装置具有远端部分，其具有构造成进入颈部口的声音，而不会对患者造成不适当的创伤或不适;以及保持或组织夹持机构，其具有抓握元件，例如尖峰，其构造成接合并保持患者的宫颈。体现本发明的特征的憩室型装置可以具有可扩张的远端，以更可靠地接合在患者的子宫颈管内。

5. 发明授权

US08052718B2 Method and apparatus for the detection and occlusion of blood vessels 有权
公开(公告)号：US08052718B2
公开(公告)日：2011-11-08
申请号：US10300115
申请日：2002-11-19
申请人： Fred H. Burbank , Michael L. Jones , R. J. Serra , Greig E. Altieri , Jill Uyeno , Yu-Tung Wong , Randy Werneth
发明人： Fred H. Burbank , Michael L. Jones , R. J. Serra , Greig E. Altieri , Jill Uyeno , Yu-Tung Wong , Randy Werneth
IPC分类号： A61B17/00
摘要： A non-invasive blood vessel occlusion device includes a pair of pressure-applying members with opposed tissue-contacting surfaces, a supporting shaft configured to adjust the distance between tissue-contacting surfaces, and at least one sensor for locating a blood vessel disposed on at least one pressure-applying member. Blood vessels may be occluded by indirectly compressing the artery by compressing tissue near to an artery. The occlusion device finds use in, for example, treating uterine disorders and conditions which may be treated by occlusion of the uterine arteries. A uterine artery may be accessed via a body cavity, such as a patient's vagina, and may be occluded by compressing a portion of the vaginal wall around a portion of a uterine artery.

6. 发明授权

US07651511B2 Vascular clamp for caesarian section 有权
标题翻译：剖宫产血管夹
公开(公告)号：US07651511B2
公开(公告)日：2010-01-26
申请号：US10359386
申请日：2003-02-05
申请人： Fred H. Burbank , Michael L. Jones , R. J. Serra , Greig E. Altieri , Jill Uyeno
发明人： Fred H. Burbank , Michael L. Jones , R. J. Serra , Greig E. Altieri , Jill Uyeno
IPC分类号： A61B17/08
CPC分类号： A61B17/122 , A61B5/026 , A61B5/489 , A61B8/06 , A61B8/12 , A61B2017/2825 , A61B2017/4216 , A61B2090/08021
摘要： The invention provides devices, systems and methods for clamping arteries which are useful in reducing or abolishing blood flow in an artery, and may be used to control hemorrhage following a caesarian delivery. A clamping device embodying features of the invention includes a pair of clamping members with opposed pressure-applying members having facing pressure-applying surfaces, at least one of which is a yieldable pressure-applying surface. The yieldable pressure-applying surface is preferably resilient. The clamping members are configured to adjust the distance between pressure-applying surfaces, and a blood flow sensor is disposed on at least one of the pressure-applying members to aid in locating the target artery and also to monitor blood flow through the artery. The clamping device is particularly suitable for occluding uterine arteries by compressing the broad ligament which contains the uterine artery and which is connected to the patient's uterus with the arterial clamp.
摘要翻译：本发明提供用于夹紧动脉的装置，系统和方法，其用于减少或消除动脉中的血液流动，并且可用于控制在切片递送之后的出血。体现本发明特征的夹紧装置包括一对夹紧构件，其具有相对的施加压力的构件，其具有面对的压力施加表面，其中至少一个是可屈服的施加压力表面。可屈服的施加压力的表面优选是弹性的。夹紧构件构造成调节压力施加表面之间的距离，并且血压传感器设置在至少一个压力施加构件上，以帮助定位目标动脉并且还监测通过动脉的血流。夹紧装置特别适用于通过压缩包含子宫动脉的宽韧带并用动脉夹连接到患者的子宫来闭塞子宫动脉。

7. 发明授权

US07616979B2 Uterine tissue monitoring device and method 失效
标题翻译：子宫组织监测装置及方法
公开(公告)号：US07616979B2
公开(公告)日：2009-11-10
申请号：US11413260
申请日：2006-04-28
申请人： Michael L. Jones , Jill Uyeno , Fred H. Burbank , Greig E. Altieri
发明人： Michael L. Jones , Jill Uyeno , Fred H. Burbank , Greig E. Altieri
IPC分类号： A61B5/05 , A61B19/00 , A61B17/42 , A61M31/00
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/1473 , A61B5/4325
摘要： The invention provides a devices, methods and systems to measure and record uterine tissue environment components such as pH during the course of uterine artery occlusion. The uterus becomes ischemic due to the occlusion thereof, and its pH drops sharply within minutes of uterine artery occlusion and remains relatively low for a period of time. The return of normal pH is an indicator of return of blood to the ischemic tissue. In use, a catheter with a pH measuring tip is advanced through the patient's vaginal canal and into the patient's uterine cavity until the pH measuring active electrode on the distal end of the catheter contacts or penetrates the uterine fundus. The active electrode detects the pH and a signal representing pH is transmitted to a pH recording and monitoring device which preferably displays the pH. The signal may be transmitted through a conductor or by a radio transmitter. Components other than pH may be monitored such a pCO2, and pO2.
摘要翻译：本发明提供了在子宫动脉闭塞过程中测量和记录子宫组织环境组分如pH的装置，方法和系统。子宫由于其闭塞而变得缺血，并且其pH在子宫动脉阻塞的几分钟内急剧下降，并且在一段时间内保持相对较低。正常pH值的返回是血液向缺血组织返回的指标。在使用中，具有pH测量尖端的导管通过患者的阴道通道进入患者的子宫腔，直到导管远端的pH测量有源电极接触或穿透子宫底。活性电极检测pH，将表示pH的信号传输到pH记录和监测装置，其优选显示pH值。信号可以通过导体或无线电发射机传输。可以监测除pH以外的成分，例如pCO 2和pO 2。

8. 发明授权

US07329265B2 Uterine artery occlusion clamp 失效
标题翻译：子宫动脉闭塞钳
公开(公告)号：US07329265B2
公开(公告)日：2008-02-12
申请号：US10430880
申请日：2003-05-06
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri
IPC分类号： A61B17/08
CPC分类号： A61B17/12 , A61B17/2812 , A61B17/42 , A61B2017/00057 , A61B2017/2837 , A61B2090/064 , A61B2090/378
摘要： The invention is directed to a uterine artery clamp and the relatively non-invasive treatment procedure utilizing this clamp. The uterine clamp includes a clamping member having a jaw with tissue-contacting surfaces for applying pressure to target tissue and a stabilizing member which is configured to be inserted into the patient's uterine cervical canal. The clamp may be provided with elongated handles to manually adjust the spacing between the jaw and stabilizer and thereby apply pressure to a uterine artery beneath a bundle of tissue held between the jaw and stabilizer. Uterine clamps embodying features of the invention by be used in procedures for treating uterine disorders such as fibroids, DUB, PPH and the like.
摘要翻译：本发明涉及一种子宫动脉钳和利用该钳夹的相对非侵入性治疗方法。子宫夹具包括具有钳口的夹持构件，其具有用于向目标组织施加压力的组织接触表面和被构造成插入到患者子宫颈管中的稳定构件。夹具可以设置有细长的手柄，以手动调节钳口和稳定器之间的间隔，从而对保持在钳口和稳定器之间的组织束下面的子宫动脉施加压力。通过用于治疗子宫疾病如子宫肌瘤，DUB，PPH等的程序中使用体现本发明特征的子宫夹钳。

9. 发明申请

US20090287088A1 LUMINAL CLIP APPLICATOR WITH SENSOR AND METHODS FOR OCCLUDING BODY LUMENS 审中-公开
标题翻译：具有传感器的LUMINAL CLIP APPLICATOR和用于监测身体灯的方法
公开(公告)号：US20090287088A1
公开(公告)日：2009-11-19
申请号：US12510909
申请日：2009-07-28
申请人： Fred H. Burbank , Michael L. Jones , R.J. Serra , Greig E. Altieri , Jill Ulyeno , Yu-Tung Wong , Randy Werneth
发明人： Fred H. Burbank , Michael L. Jones , R.J. Serra , Greig E. Altieri , Jill Ulyeno , Yu-Tung Wong , Randy Werneth
IPC分类号： A61B17/08 , A61B5/0215 , A61B8/14 , A61B17/10
CPC分类号： A61B8/06 , A61B5/026 , A61B5/415 , A61B5/418 , A61B8/12 , A61B17/00234 , A61B17/12 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B17/2812 , A61B17/42 , A61B2017/0046 , A61B2017/4216
摘要： A method for occluding a body lumen includes providing a clamping device having a pair of opposed pressure applying jaws, providing a sensor on one of the pressure applying jaws for sensing blood flow through a body lumen, and releasably securing a luminal clip between the pressure applying jaws. The method includes using the sensor for detecting blood flow through the body lumen for locating the body lumen, positioning the luminal clip adjacent the located body lumen, and closing the pressure applying jaws for clamping the luminal clip over the body lumen for at least partially occluding blood flow through the body lumen.
摘要翻译：用于闭塞体腔的方法包括提供具有一对相对的压力施加钳口的夹持装置，在压力施加钳口中的一个上提供传感器，用于感测通过体腔的血液流动，以及可释放地将腔夹固定在压力施加颚。该方法包括使用传感器来检测通过体腔的血液流动以定位体腔，将管腔夹定位在邻近定位的体腔的位置，并且闭合压力施加钳口以将管腔夹持件夹持在身体腔上至少部分闭塞血流通过体腔。

10. 发明授权

US07325546B2 Uterine artery occlusion device with cervical receptacle 失效
标题翻译：子宫颈动脉闭塞装置
公开(公告)号：US07325546B2
公开(公告)日：2008-02-05
申请号：US10718222
申请日：2003-11-20
申请人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Guillermo Elizondo-Riojas
发明人： Fred H. Burbank , Michael L. Jones , Greig E. Altieri , Guillermo Elizondo-Riojas
IPC分类号： A61B17/08 , A61B17/42 , A61F6/14 , A61F6/06
CPC分类号： A61B5/6834 , A61B5/026 , A61B5/489 , A61B8/06 , A61B17/12 , A61B17/42 , A61B2017/4216
摘要： An intravaginal uterine artery occlusion device is used for treating uterine disorders such as fibroids, dysfunctional uterine bleeding, postpartum hemorrhage and the like. A occlusion device has a cervical receptacle with an open distal end for receiving the patients uterine cervix, an elongated shaft having a distal end secured to the closed proximal end of the cervical receptacle, and an inner lumen extending to the distal end of the shaft. The patient's uterine cervix is held within the interior of the receptacle by the application of a vacuum to the interior of the receptacle through the inner lumen of the shaft while the leading edge(s) of the cervical receptacle press against the patient's vaginal fornix to occlude the uterine artery. A blood flow sensor may be provided on the leading edge of the receptacle to aid in locating a uterine artery and to monitor blood flow through the uterine artery.
摘要翻译：阴道内子宫动脉闭塞装置用于治疗子宫肌瘤，功能障碍性子宫出血，产后出血等。闭塞装置具有颈部插座，其具有用于接收患者子宫颈的开放远端，具有固定到颈部容纳件的封闭近端的远端的细长轴以及延伸到轴的远端的内腔。患者的子宫颈通过穿过轴的内腔通过真空施加到容器的内部而保持在容器的内部，而颈部容器的前缘压靠患者的阴道穹窿阻塞子宫动脉。可以在容器的前缘上设置血流传感器，以帮助定位子宫动脉并监测通过子宫动脉的血流。

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