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1. 发明授权

US4770185A Method and apparatus for endoscopic blood flow detection by the use of ultrasonic energy 失效
标题翻译：通过使用超声能量进行内窥镜血流检测的方法和装置
公开(公告)号：US4770185A
公开(公告)日：1988-09-13
申请号：US828496
申请日：1986-02-11
申请人： Fred E. Silverstein , Roy W. Martin , David A. Gilbert
发明人： Fred E. Silverstein , Roy W. Martin , David A. Gilbert
IPC分类号： A61B1/012 , A61B1/015 , A61B1/018 , A61B1/273 , A61B8/06 , A61B8/12 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B10/00
CPC分类号： A61B17/22 , A61B1/00177 , A61B1/018 , A61B1/2736 , A61B8/06 , A61B8/12 , A61B8/445 , A61B17/3478 , A61B2017/320084 , A61B2018/1407 , A61B5/489
摘要： A system for endoscopic detection of blood flow is disclosed. A catheter is sized to pass through the biopsy channel of an endoscope and includes an elongated catheter tube of flexible material and an ultrasonic probe carried by the catheter tube adjacent its tip. Depending on the application, the ultrasonic field provided by the ultrasonic probe may be either transverse or parallel to the longitudinal axis of the catheter tube and may be either highly directional, omnidirectional, or sectorial. The ultrasonic probe is coupled to a pulsed Doppler circuit (FIG. 16) by an isolation circuit (FIG. 20) that provides electrical isolation and RFI suppression. The Doppler circuit is designed to enhance close proximity detection of blood flow, to limit the range of the probe's ultrasonic field, and to distinguish between arterial blood flow, venous blood flow, and vessel wall motion.
摘要翻译：公开了一种内窥镜检测血流的系统。导管的尺寸设置成穿过内窥镜的活检通道，并且包括柔性材料的细长导管和由导管邻近其尖端承载的超声波探头。根据应用，由超声波探头提供的超声波场可以是横向的或平行于导管的纵向轴线，并且可以是高度定向的，全向的或扇形的。超声波探头通过提供电隔离和RFI抑制的隔离电路（图20）耦合到脉冲多普勒电路（图16）。多普勒电路设计用于增强血流的近距离检测，限制探头的超声波场的范围，并区分动脉血流，静脉血流和血管壁运动。

2. 发明授权

US4582067A Method for endoscopic blood flow detection by the use of ultrasonic energy 失效
标题翻译：通过使用超声能量进行内窥镜血流检测的方法
公开(公告)号：US4582067A
公开(公告)日：1986-04-15
申请号：US466123
申请日：1983-02-14
申请人： Fred E. Silverstein , Roy W. Martin , David A. Gilbert
发明人： Fred E. Silverstein , Roy W. Martin , David A. Gilbert
IPC分类号： A61B1/015 , A61B1/018 , A61B1/273 , A61B8/06 , A61B8/12 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B10/00
CPC分类号： A61B8/06 , A61B1/015 , A61B1/018 , A61B1/2736 , A61B17/22 , A61B8/12 , A61B8/445 , A61B17/3478 , A61B2017/320084 , A61B2018/1407 , A61B5/489
摘要： Various forms of a catheter that is sized to pass through the biopsy channel of an endoscope include an elongated catheter tube of flexible material and an ultrasonic probe carried by the catheter tube adjacent its tip. The forms include: a papillotome catheter (FIGS. 1 and 3); catheters for general endoscopic and nonendoscopic applications (FIGS. 4, 7A through 7C, 8A through 8B, 10A through 10B, and 11); and, a sclerosing catheter (FIGS. 13 through 15). These catheters may be used to determine the location of the retroduodenal artery in endoscopic papillotomy (FIGS. 2, 5, and 6), to evaluate and treat esophageal varices (FIGS. 9 and 12), or generally to detect blood flow in a biological structure within the body. Depending on the application, the ultrasonic field provided by the ultrasonic probe may be either transverse or parallel to the longitudinal axis of the catheter tube and may be either highly directional, omnidirectional, or sectorial. The ultrasonic probe is coupled to a pulsed Doppler circuit (FIG. 16) by an isolation circuit (FIGS. 17 through 20) that provides electrical isolation and RFI suppression. The Doppler circuit is designed to enhance close proximity detection of blood flow, to limit the range of the probe's ultrasonic field, and to distinguish between arterial blood flow, venous blood flow, and vessel wall motion.
摘要翻译：尺寸适于穿过内窥镜的活检通道的导管的各种形式包括：柔性材料的细长导管和由导管邻近其末端承载的超声波探头。形式包括：乳头切开导管（图1和3）; 用于一般内窥镜和非内窥镜应用的导管（图4,7A至7C，8A至8B，10A至10B和11）; 和硬化导管（图13至15）。这些导管可用于确定内视乳头切开术中再二十二指肠动脉的位置（图2，图5和图6），以评估和治疗食管静脉曲张（图9和12），或通常用于检测生物中的血液流动体内结构。根据应用，由超声波探头提供的超声波场可以是横向的或平行于导管的纵向轴线，并且可以是高度定向的，全向的或扇形的。超声波探头通过提供电隔离和RFI抑制的隔离电路（图17至20）耦合到脉冲多普勒电路（图16）。多普勒电路设计用于增强血流的近距离检测，限制探头的超声波场的范围，并区分动脉血流，静脉血流和血管壁运动。

3. 发明授权

US4802487A Endoscopically deliverable ultrasound imaging system 失效
标题翻译：内窥镜可交付超声成像系统
公开(公告)号：US4802487A
公开(公告)日：1989-02-07
申请号：US30898
申请日：1987-03-26
申请人： Roy W. Martin , Fred E. Silverstein
发明人： Roy W. Martin , Fred E. Silverstein
IPC分类号： A61B8/12 , A61M25/00 , A61M25/01 , A61B10/00
CPC分类号： A61M25/0122 , A61B8/12 , A61B8/445 , A61M25/005
摘要： An endoscopically deliverable ultrasound imaging system having an ultrasound probe mounted at the end of an endoscopically deliverable catheter. The catheter connects the probe to an ultrasound imaging system. The axial or radial position of the ultrasound probe is measured by a position transducer mounted on the endocscope adjacent the biopsy port from which the catheter extends. The output of the position measuring transducer is applied to the ultrasound imaging system so that the imaging system provides an image of the tissue depth as a function of the position of the ultrasound probe.

4. 发明授权

US5247938A Method and apparatus for determining the motility of a region in the human body 失效
标题翻译：用于确定人体内区域的运动性的方法和装置
公开(公告)号：US5247938A
公开(公告)日：1993-09-28
申请号：US463548
申请日：1990-01-11
申请人： Fred E. Silverstein , Roy W. Martin , Michael B. Kimmey , Michael D. Schuffler , Andrew H. Proctor , Geoffrey C. Jiranek
发明人： Fred E. Silverstein , Roy W. Martin , Michael B. Kimmey , Michael D. Schuffler , Andrew H. Proctor , Geoffrey C. Jiranek
IPC分类号： A61B1/018 , A61B1/273 , A61B1/31 , A61B5/03 , A61B5/07 , A61B8/12
CPC分类号： A61B8/0858 , A61B1/018 , A61B1/2736 , A61B1/31 , A61B5/036 , A61B5/07 , A61B5/076 , A61B5/4255 , A61B5/4519 , A61B5/6834 , A61B8/12 , A61B8/445
摘要： Devices are described which can be used to study the physiological function of the intestinal wall. These devices include an ultrasonic transducer that can be attached to a region of the intestinal wall. The transducer interrogates the wall and echoes are obtained from the different wall layers. The echoes are processed to produce an M-mode display of the wall. This allows monitoring how the wall changes with time. For example, as the wall contracts the muscle layer thickens and this action may be observed with the device. Other sensors and electrodes can be combined with this probe to correlate various physiological action. Finally, several such probes can be combined into a common introducible probe but which will monitor several regions along the intestinal wall. The major advantage of the disclosed device is that it provides a measurement of intestinal motility previously unattainable and it is introducible by endoscopy. This makes it a suitable tool for studying patient disease.
摘要翻译：描述了可用于研究肠壁生理功能的装置。这些装置包括可连接到肠壁的区域的超声换能器。换能器询问墙壁，回波是从不同的墙层获得的。处理回波以产生墙的M模式显示。这样可以监控墙壁随时间的变化。例如，当壁收缩时，肌肉层变厚，并且可以用该装置观察到该动作。其他传感器和电极可以与该探头组合，以使各种生理作用相关联。最后，几个这样的探针可以组合成通用的可引入的探针，但是它将监测沿着肠壁的几个区域。所公开的装置的主要优点是其提供了先前无法实现的肠动力的测量，并且其可通过内窥镜检查来引入。这使它成为研究患者疾病的合适工具。

5. 发明授权

US6035229A Method and apparatus for detecting Barrett's metaplasia of the esophagus 失效
标题翻译：检测食管的Barrett化生的方法和装置
公开(公告)号：US6035229A
公开(公告)日：2000-03-07
申请号：US878227
申请日：1997-06-17
申请人： Fred E. Silverstein , Roy W. Martin , Darik Taniguchi , John A. Myers
发明人： Fred E. Silverstein , Roy W. Martin , Darik Taniguchi , John A. Myers
IPC分类号： A61B1/267 , A61B1/273 , A61B5/00
CPC分类号： A61B1/2733 , A61B1/00082 , A61B1/00165 , A61B1/0607 , A61B1/07 , A61B5/0084 , A61B5/4233 , A61B1/00009 , A61B1/0638 , A61B5/0075
摘要： A system for detecting Barrett's metaplasia utilizes an illumination and imaging probe at the end of a catheter. The probe illuminates the wall of the esophagus and returns reflected light to be processed to provide a visual indication of the color of the esophageal wall. The position of the probe along the length of the esophagus is also measured to allow a medical practitioner to determine the location of the transition from the pink stomach lining to the white esophageal lining.
摘要翻译：用于检测巴雷特氏化学的系统在导管的末端使用照明和成像探针。探头照亮食道的壁，并返回待处理的反射光，以提供食管壁颜色的视觉指示。探测器沿食道长度的位置也被测量，以允许医生确定从粉红色胃衬里到白色食管衬里的过渡位置。

6. 发明公开

US20230249996A1 METHOD AND SYSTEM FOR THE REMEDIATION OF AQUATIC FACILITIES 审中-公开
公开(公告)号：US20230249996A1
公开(公告)日：2023-08-10
申请号：US18111656
申请日：2023-02-20
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： C02F1/76 , C02F1/32 , C02F1/00 , C02F1/467 , C02F1/68
CPC分类号： C02F1/76 , C02F1/008 , C02F1/32 , C02F1/686 , C02F1/766 , C02F1/4674 , C02F2103/42 , C02F2209/02 , C02F2209/06 , C02F2209/006 , C02F2209/29 , C02F2303/04
摘要： The invention relates to a method and system for the continuous treatment of the water of an aquatic facility using an integrated process control system to control a mixed halogen-based treatment comprising chlorine dioxide and a free halogen. The integrated process control system provides versatile control the chlorine dioxide and/or free halogen while employing in-situ generation of chlorine dioxide.

7. 发明申请

US20120207852A1 Biocide compositions and related methods 审中-公开
标题翻译：杀菌剂成分及相关方法
公开(公告)号：US20120207852A1
公开(公告)日：2012-08-16
申请号：US12932469
申请日：2011-02-25
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： A01N59/00 , A01P1/00
CPC分类号： A01N59/00 , A01N37/16 , A01N2300/00
摘要： Compositions for producing a biocide solution upon contact with water, the composition comprises at least an acid anhydride and polyoxychlorine donor. The biocide solution forms reactive oxygen species that releases oxygen gas when contacted by microorganisms, proteinaceous substances, and oxidizable organic based contaminants. The biocide solution is free of chlorine dioxide.
摘要翻译：用于在与水接触时生产杀生物剂溶液的组合物，所述组合物至少包含酸酐和聚氯乙烯供体。杀生物剂溶液形成当与微生物，蛋白质物质和可氧化的有机基污染物接触时释放氧气的活性氧物质。杀生物剂溶液不含二氧化氯。

8. 发明申请

US20100178356A1 Composition and method for enhanced sanitation and oxidation of aqueous systems 有权
标题翻译：用于增强水系统的卫生和氧化的组合物和方法
公开(公告)号：US20100178356A1
公开(公告)日：2010-07-15
申请号：US12460734
申请日：2009-07-23
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： A61K33/40 , A61K33/24 , A61K33/38 , A61K33/34 , A61K33/32 , A61K33/26 , A61K33/04
CPC分类号： C02F1/76 , C02F1/725 , C02F1/766 , C02F2103/42 , Y02A50/488
摘要： This invention relates to a method for enhanced sanitation and oxidation of aqueous solutions at aquatic facilities. The method provides a means for the in-situ generation of chlorine dioxide from dilute solutions of chlorite anions at near neutral pH, and enhanced inactivation rates of microbiological organisms including cryptosporidium.
摘要翻译：本发明涉及一种在水生设施中增强水溶液的卫生和氧化的方法。该方法提供了在接近中性pH下从亚氯酸盐阴离子的稀释溶液中原位生成二氧化氯的方法，以及增强的微生物生物体（包括隐孢子虫）的灭活速率。

9. 发明授权

US07465411B2 Catalyst-mediated in-situ generation of dioxirane 失效
标题翻译：催化剂介导的原位生成二环氧乙烷
公开(公告)号：US07465411B2
公开(公告)日：2008-12-16
申请号：US11378889
申请日：2006-03-16
申请人： Roy W. Martin
发明人： Roy W. Martin
IPC分类号： C01B15/08 , C11D3/39 , C11D3/395 , A62D3/38 , A61L101/14 , A61L101/44 , D06L3/00
CPC分类号： C11D3/3947 , C01B15/08 , C01B15/16 , C11D3/0031
摘要： A composition capable of expedited in-situ generation of dioxirane and a method of preparing the composition are presented. The composition includes a transition metal catalyst, peracid donor, and carbonyl donor, and forms an effective multi-purpose oxidizing (e.g., bleaching) solution. Methods of using the bleaching solutions and their application are also presented. The composition provides a cost-effective means of producing a dioxirane-based multi-purpose bleaching solution for use on laundries, carpets, hard surfaces, bathroom surfaces, floors and the like.
摘要翻译：提出了能够加速原位生成二环氧环的组合物和制备该组合物的方法。组合物包括过渡金属催化剂，过酸供体和羰基供体，并形成有效的多用途氧化（例如漂白）溶液。还提出了使用漂白溶液的方法及其应用。该组合物提供了生产用于洗衣店，地毯，硬表面，浴室表面，地板等的基于二环氧乙烷的多用途漂白溶液的成本有效的方法。

10. 发明授权

US06500133B2 Apparatus and method for producing high intensity focused ultrasonic energy for medical applications 有权
标题翻译：用于医疗应用的用于生产高强度聚焦超声波能量的装置和方法
公开(公告)号：US06500133B2
公开(公告)日：2002-12-31
申请号：US09728100
申请日：2000-12-01
申请人： Roy W. Martin , Mark D. Brentnall , Andrew H. Proctor
发明人： Roy W. Martin , Mark D. Brentnall , Andrew H. Proctor
IPC分类号： A61N702
CPC分类号： A61N7/00 , A61B8/4272 , A61B8/4444 , A61B17/22004 , A61B17/2251 , A61B17/320068 , A61B17/3203 , A61B18/14 , A61B18/22 , A61B2090/0813 , B06B3/00
摘要： A medical instrument uses solid tapered cones mounted to a preferably concave, spherically curved, piezoelectric ultrasound transducer which focuses and concentrates the ultrasound energy to a narrow tip so very high levels of ultrasound can be delivered to the tissue adjacent to the tip. Ultrasound matching layers or variable curvature geometries are employed at the tip aid in transferring the energy from the tip to the tissue.
摘要翻译：医疗器械使用安装到优选凹形的球形弯曲的压电超声换能器的固体锥形锥体，其将超声能量聚焦并集中到窄尖端，使得非常高水平的超声波可以被递送到与尖端相邻的组织。超声波匹配层或可变曲率几何形状在尖端处用于将能量从尖端传递到组织。

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