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1. 发明授权

US08480663B2 Apparatus and methods for cryogenically ablating tissue and adjusting cryogenic ablation regions 有权
标题翻译：用于低温消融组织和调节低温消融区域的装置和方法
公开(公告)号：US08480663B2
公开(公告)日：2013-07-09
申请号：US12432538
申请日：2009-04-29
申请人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
发明人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2017/22054 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011
摘要： Apparatus and methods for performing cryogenic ablation of tissue and adjusting the size and/or location of a cryogenic cooling region. A cooling assembly may include tubes for dispensing and exhausting a coolant or refrigerant. One or both of the tubes may be moved, e.g., slidably adjusted, in order to adjust the location or size of a cryogenic ablation region. The cooling assembly may be integrated into cryogenic ablation devices including a cryogenic balloon device that includes an inner inflatable balloon and another balloon that is at least partially wrapped around the inner balloon and carries refrigerant for performing cryo-ablation. Electrodes permit electrical mapping of tissue before or after cryo-ablation to verify success of the procedure.
摘要翻译：用于对组织进行低温消融并调节低温冷却区域的尺寸和/或位置的装置和方法。冷却组件可以包括用于分配和排出冷却剂或制冷剂的管。一个或两个管可以被移动，例如可滑动地调节，以便调节低温消融区域的位置或尺寸。冷却组件可以集成到低温消融装置中，包括低温球囊装置，其包括内部可充气球囊和至少部分地缠绕在内球囊周围并承载用于进行低温消融的制冷剂的另一球囊。电极允许在低温消融之前或之后对组织进行电气测绘，以验证该程序的成功。

2. 发明申请

US20090287202A1 APPARATUS AND METHODS FOR CRYOGENICALLY ABLATING TISSUE AND ADJUSTING CRYOGENIC ABLATION REGIONS 有权
标题翻译：冷冻组织和调节低温消退区的装置和方法
公开(公告)号：US20090287202A1
公开(公告)日：2009-11-19
申请号：US12432538
申请日：2009-04-29
申请人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
发明人： Frank W. Ingle , Robert F. Bencini , Josef V. Koblish , Jonathan A. Wohlgemuth , Paul Roche
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22051 , A61B2017/22054 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61M25/1011
摘要： Apparatus and methods for performing cryogenic ablation of tissue and adjusting the size and/or location of a cryogenic cooling region. A cooling assembly may include tubes for dispensing and exhausting a coolant or refrigerant. One or both of the tubes may be moved, e.g., slidably adjusted, in order to adjust the location or size of a cryogenic ablation region. The cooling assembly may be integrated into cryogenic ablation devices including a cryogenic balloon device that includes an inner inflatable balloon and another balloon that is at least partially wrapped around the inner balloon and carries refrigerant for performing cryo-ablation. Electrodes permit electrical mapping of tissue before or after cryo-ablation to verify success of the procedure.
摘要翻译：用于对组织进行低温消融并调节低温冷却区域的尺寸和/或位置的装置和方法。冷却组件可以包括用于分配和排出冷却剂或制冷剂的管。一个或两个管可以被移动，例如可滑动地调节，以便调节低温消融区域的位置或尺寸。冷却组件可以集成到低温消融装置中，包括低温球囊装置，其包括内部可充气球囊和至少部分地缠绕在内球囊周围并承载用于进行低温消融的制冷剂的另一球囊。电极允许在低温消融之前或之后对组织进行电气测绘，以验证该程序的成功。

3. 发明授权

US09320564B2 Steerable catheter and method for performing medical procedure adjacent pulmonary vein ostia 有权
公开(公告)号：US09320564B2
公开(公告)日：2016-04-26
申请号：US11418757
申请日：2006-05-05
申请人： Boaz Avitall , Josef V. Koblish
发明人： Boaz Avitall , Josef V. Koblish
IPC分类号： A61B18/14 , A61M25/01 , A61B6/06 , A61B17/00 , A61B18/00 , A61B19/00
CPC分类号： A61B18/1492 , A61B6/06 , A61B2017/003 , A61B2018/00375 , A61B2034/2051 , A61M25/0144 , A61M25/0147 , A61M25/0152 , A61M2025/0161
摘要： Catheters, systems, and methods are provided for performing medical procedures, such as tissue ablation, adjacent the ostia of anatomical vessels, such as pulmonary veins. The catheter comprises an elongated flexible catheter body including a proximal shaft portion and a distal shaft portion, which has a proximal section pre-shaped to form a curve having an apex sized to be inserted into an anatomical vessel, such as a pulmonary vein, and a distal section configured to contact an ostium of the vessel when the curve apex is inserted within the vessel ostium. The catheter further comprises a steering mechanism configured for decreasing a radius of curvature of the curve.

4. 发明授权

US09125668B2 Ablation device with multiple ablation modes 有权
标题翻译：消融装置具有多种消融模式
公开(公告)号：US09125668B2
公开(公告)日：2015-09-08
申请号：US13613931
申请日：2012-09-13
申请人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
发明人： Raj Subramaniam , Josef V. Koblish , Zaya Tun , Guy R. Harvey , Minhchau N. Cao , Kurt D. Sparks
IPC分类号： A61B18/18 , A61B17/20 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00065 , A61B2018/00232 , A61B2018/00238 , A61B2018/00345 , A61B2018/00351 , A61B2018/00577 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00839
摘要： Devices, systems, and methods for performing ablation therapy on body tissue are disclosed. An example ablation device for treating body tissue includes an ionically conductive balloon and a radio-frequency electrode that delivers RF energy into a distal section of the balloon. The balloon is configured to transmit the RF energy in a direction distally towards a leading end of the ablation device. Multiple ablation electrodes on the device can be used for providing lesions of different size or shape.
摘要翻译：公开了用于对身体组织进行消融治疗的装置，系统和方法。用于治疗身体组织的示例性消融装置包括离子导电球囊和将RF能量递送到气囊的远端部分的射频电极。气囊被配置为在远离消融装置的前端的方向上传送RF能量。器件上的多个消融电极可用于提供不同大小或形状的病灶。

5. 发明授权

US07435248B2 Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel 有权
标题翻译：用于创建和诊断血管口内或周围周围损伤的医用探针
公开(公告)号：US07435248B2
公开(公告)日：2008-10-14
申请号：US10672457
申请日：2003-09-26
申请人： Miriam H. Taimisto , Josef V. Koblish
发明人： Miriam H. Taimisto , Josef V. Koblish
IPC分类号： A61B18/14 , A61B5/042
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2018/00214 , A61B2018/0022 , A61B2018/00375 , A61B2018/00839 , A61B2018/1435
摘要： The present inventions provide assemblies, probes, and methods for creating circumferential lesions in tissue, e.g., the tissue within or around the ostium of a vessel. An ablation probe with an ablative structure can be placed in contact within or around the ostium of the vessel. A diagnostic probe can be introduced through a lumen within the ablation probe and inserted into the vessel. The energy can be provided to the ablative structure to create a circumferential lesion within or around the ostium of the vessel, and the diagnostic structure can be used to diagnose the tissue to determine whether the circumferential lesion can be properly created.
摘要翻译：本发明提供用于在组织中产生周向损伤的组件，探针和方法，例如在血管的口内或周围的组织。具有烧蚀结构的消融探针可以在容器的口中或周围接触放置。诊断探针可以通过消融探针中的内腔引入并插入血管。可以将能量提供给烧蚀结构以在容器的口内或周围形成周缘损伤，并且诊断结构可用于诊断组织以确定是否可以适当地产生周缘损伤。

6. 发明授权

US06837885B2 Surgical probe for supporting inflatable therapeutic devices in contact with tissue in or around body orifices and within tumors 失效
标题翻译：用于支撑可膨胀的治疗装置的手术探针，其与身体孔内或肿瘤周围的组织接触
公开(公告)号：US06837885B2
公开(公告)日：2005-01-04
申请号：US09737176
申请日：2000-12-13
申请人： Josef V. Koblish , Anat V. Hegde , David K. Swanson
发明人： Josef V. Koblish , Anat V. Hegde , David K. Swanson
IPC分类号： A61B17/34 , A61B5/042 , A61B18/04 , A61B18/14 , A61F2/958 , A61B18/18
CPC分类号： A61B18/1492 , A61B5/0422 , A61B2018/00065 , A61B2018/00083 , A61B2018/00095 , A61B2018/00214 , A61B2018/0022 , A61B2018/00238 , A61B2018/00577 , A61B2018/00839 , A61B2090/065 , A61B2218/002
摘要： A probe that facilitates the creation of lesions in bodily tissue. The probe includes a relatively short shaft and an inflatable therapeutic element.

7. 发明授权

US06711444B2 Methods of deploying helical diagnostic and therapeutic element supporting structures within the body 有权
标题翻译：在体内部署螺旋诊断和治疗元件支撑结构的方法
公开(公告)号：US06711444B2
公开(公告)日：2004-03-23
申请号：US09929936
申请日：2001-08-15
申请人： Josef V. Koblish
发明人： Josef V. Koblish
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00077 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/00375 , A61B2018/00797 , A61B2018/00821 , A61B2018/1407 , A61B2018/1435 , A61B2018/1467
摘要： A method of deploying a helical structure having at least one operative element within a bodily structure defining an orifice includes the steps of inserting at least a portion of the helical structure through the orifice in an uncoiled state and returning the helical structure to a coiled state while at least a portion of the helical structure is within the bodily structure such that the coiled helical structure engages the orifice.
摘要翻译：一种部署具有限定孔口的身体结构中的至少一个操作元件的螺旋结构的方法包括以下步骤：将螺旋结构的至少一部分穿过孔口处于未卷绕状态，并将螺旋结构返回到卷绕状态，同时螺旋结构的至少一部分在身体结构内，使得螺旋螺旋结构接合孔。

8. 发明授权

US06610055B1 Surgical method for positioning a diagnostic or therapeutic element on the epicardium or other organ surface 有权
标题翻译：将诊断或治疗元件定位在心外膜或其他器官表面上的手术方法
公开(公告)号：US06610055B1
公开(公告)日：2003-08-26
申请号：US09535120
申请日：2000-03-24
申请人： David K. Swanson , Josef V. Koblish , Russell B. Thompson
发明人： David K. Swanson , Josef V. Koblish , Russell B. Thompson
IPC分类号： A61B1814
CPC分类号： A61B18/1482 , A61B18/1492 , A61B18/1815 , A61B2018/00136 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00797 , A61B2018/00821 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/142
摘要： Surgical methods for positioning diagnostic an therapeutic elements on the epicardium or other organ surface.
摘要翻译：用于将诊断治疗元件定位在心外膜或其他器官表面上的手术方法。

9. 发明授权

US6083222A Deflectable catheter for ablating cardiac tissue 失效
标题翻译：用于消融心脏组织的可挠性导管
公开(公告)号：US6083222A
公开(公告)日：2000-07-04
申请号：US730896
申请日：1996-10-18
申请人： George J. Klein , Josef V. Koblish , Thomas T. Coen
发明人： George J. Klein , Josef V. Koblish , Thomas T. Coen
IPC分类号： A61B10/00 , A61B10/06 , A61B17/00 , A61B18/00 , A61B18/14 , A61N1/05 , A61B17/39 , A61B5/0402
CPC分类号： A61B18/1445 , A61B18/1492 , A61N1/056 , A61B10/06 , A61B18/1402 , A61B18/148 , A61B2017/003 , A61B2018/00279 , A61B2018/00577 , A61B2018/00839 , A61B2018/00916 , A61B2018/126 , A61B2018/162
摘要： A deflectable catheter for ablating tissue in the heart of a patient comprising: an axially elongated catheter shaft sized and constructed to be advanced through the vasculature of a patient into the patient's heart; a deflection wire; and an ablation electrode having first and second opposed electrically conductive surfaces exposable for contact with a selected area of tissue within the patient's heart and movable with respect to each other to apply gripping force to the contacted area of heart tissue for stabilizing the position of the electrically conductive surfaces of the ablation electrode relative to the selected area of heart tissue. The ablation electrode has a first rigid surface exposed for contact with the vasculature of the patient during advancement of the catheter therethrough and has an electrically conductive second rigid surface exposable for contact with a selected area of tissue within the patient's heart, wherein the axially transverse area circumscribed by the first surface of the ablation electrode is less than the tissue-contacting area exposable by the second rigid surface. Therapeutic treatments of the heart of a patient are also disclosed.
摘要翻译： 1.一种用于在患者心脏中烧蚀组织的可偏转导管，包括：轴向细长的导管轴，其大小和构造为通过患者的脉管系统进入患者的心脏; 偏转线; 以及消融电极，其具有可暴露于与患者心脏内的组织的选定区域相对于彼此移动的第一和第二相对的导电表面，以可相对于彼此移动以向心脏组织的接触区域施加夹紧力，以稳定电气位置消融电极的导电表面相对于心脏组织的选定区域。消融电极具有暴露于与导管穿过其中的患者的脉管系统接触的第一刚性表面，并且具有可暴露于与患者心脏内的组织的选定区域接触的导电的第二刚性表面，其中轴向横向区域由消融电极的第一表面限定的面积小于由第二刚性表面可暴露的组织接触面积。还公开了患者心脏的治疗方法。

10. 发明授权

US5910129A Catheter distal assembly with pull wires 失效
公开(公告)号：US5910129A
公开(公告)日：1999-06-08
申请号：US960850
申请日：1997-10-30
申请人： Josef V. Koblish , Sidney D. Fleischman
发明人： Josef V. Koblish , Sidney D. Fleischman
IPC分类号： A61B18/14 , A61M25/00 , A61M25/01 , A61M37/00
CPC分类号： A61M25/0043 , A61B18/1492 , A61M25/01 , A61M25/0144 , A61M25/0147 , A61M25/0152 , A61B2017/00867 , A61B2018/00065 , A61B2018/00553 , A61B2018/00577 , A61B2018/00797 , A61B2018/1407 , A61B2018/142 , A61B2018/1467 , A61B2018/1861 , A61M2025/015 , A61M2025/0163 , C08L2201/12
摘要： A catheter assembly having a sheath, which includes a side wall enclosing an interior bore, and a distal region. The assembly also has a bendable catheter tube, which is carried for sliding movement in the interior bore. A pull wire also runs through the interior bore of the sheath, preferably within a lumen. The catheter tube has a distal portion with a coupling which joins the distal portion of the catheter tube and the distal portion of the pull wire. Relative movement of the pull wire and the sheath causes bending of the catheter tube outwardly through the opening, in response to sliding movement of the catheter tube within the interior bore toward the distal region of the sheath.

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