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1. 发明授权

US06277843B1 Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment 失效
标题翻译：碳青霉烯抗菌化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US06277843B1
公开(公告)日：2001-08-21
申请号：US09421078
申请日：1999-10-19
申请人： Frank P. Dininno , Helen Chen
发明人： Frank P. Dininno , Helen Chen
IPC分类号： C07D47714
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D477/14
摘要： The present invention relates to carbapenem antibacterial agents of the formula I: as well as salts and hydrates thereof. Pharmaceutical compositions and methods of treatment are also included wherein X is present or absent, when present, represents a members selected from the group consisting of: CH2, C(R)2, C═CR2, O, S(O)x, with x equal to 0, 1 or 2; C(O), C(O)O, OC(O) and NR—.
摘要翻译：本发明涉及式I的碳青霉烯类抗生素及其盐和水合物。还包括药物组合物和治疗方法，其中X存在或不存在，当存在时，表示选自以下的成员：CH 2，C（R）2，C = CR 2，O，S（O）x，与 x等于0,1或2; C（O），C（O）O，OC（O）和NR-。

2. 发明申请

US20070128695A1 NOVEL INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR ACTIVITY, THEIR USES AND PROCESSES FOR THEIR PRODUCTION 审中-公开
标题翻译：血管内皮生长因子活性的新型抑制剂，其生产用途及其制备方法
公开(公告)号：US20070128695A1
公开(公告)日：2007-06-07
申请号：US11537623
申请日：2006-09-30
申请人： Terri Davis-Smyth , Helen Chen , Leonard Presta , Napoleone Ferrara
发明人： Terri Davis-Smyth , Helen Chen , Leonard Presta , Napoleone Ferrara
IPC分类号： C07K14/71 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/71 , A61K38/00 , C07K16/2863 , C07K2319/00 , C07K2319/30 , C07K2319/31
摘要： The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial cell proliferative and angiogenic activity thereof. The present invention is also directed to nucleic acids and expression vectors encoding these chimeric VEGF receptor proteins, host cells harboring such expression vectors, pharmaceutically acceptable compositions comprising such proteins, methods of preparing such proteins and to methods utilizing such proteins for the treatment of conditions associated with undesired vascularization.
摘要翻译：本发明涉及包含衍生自血管内皮生长因子（VEGF）受体flt-1和KDR的氨基酸序列的新型嵌合VEGF受体蛋白，包括人KDR受体FLK-1的鼠同源物，其中所述嵌合VEGF受体蛋白质结合VEGF并拮抗其内皮细胞增殖和血管生成活性。本发明还涉及编码这些嵌合VEGF受体蛋白质的核酸和表达载体，含有这种表达载体的宿主细胞，包含这种蛋白质的药学上可接受的组合物，制备这种蛋白质的方法以及利用这些蛋白质治疗相关病症的方法具有不希望的血管形成。

3. 发明授权

US09918590B2 Food preparation device 有权
公开(公告)号：US09918590B2
公开(公告)日：2018-03-20
申请号：US14171578
申请日：2014-02-03
申请人： Haidee Chen , Helen Chen
发明人： Haidee Chen , Helen Chen
IPC分类号： A47J43/04 , A47J27/08 , A47J36/32
CPC分类号： A47J43/04 , A47J27/08 , A47J27/0802 , A47J36/32
摘要： A food preparation device or system which includes the following: (i) a base dimensioned to hold food containers and includes a first opening to receive the food containers and a second opening; (ii) an extraction mechanism to extract food items from each container in the base, through the second opening and to a preparation receptacle; (iii) a heating mechanism in the preparation receptacle; and (iv) one or more processors and memory containing instructions that, when executed cause the food preparation device or system to prepare the food items for consumption.

4. 发明授权

US08440643B2 Inhibitors of beta-lactamase 失效
标题翻译： β-内酰胺酶抑制剂
公开(公告)号：US08440643B2
公开(公告)日：2013-05-14
申请号：US12301797
申请日：2007-05-21
申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
发明人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
IPC分类号： A61K31/675 , A61K31/67 , A61K31/665
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
摘要翻译：本发明提供具有氮基阳离子或季铵基团的芳基 - 和杂芳基 - 磺酰氨基甲基膦酸酯单酯类的新型β-内酰胺酶抑制剂。这些化合物抑制三类β-内酰胺酶，并与β-内酰胺类抗生素（如亚胺培南和头孢他啶）的抗菌作用协同作用，因为β-内酰胺酶的存在对通常对β-内酰胺抗生素有抗性的微生物。

5. 发明申请

US20080084951A1 Systems and methods for receiving multiple input, multiple output signals for test and analysis of multiple-input, multiple-output systems 审中-公开
标题翻译：用于接收多输入多输出信号的系统和方法，用于多输入多输出系统的测试和分析
公开(公告)号：US20080084951A1
公开(公告)日：2008-04-10
申请号：US11544421
申请日：2006-10-06
申请人： Helen Chen , Brian J. Avenell , Gordon R. Strachan , Michael C. Lawton
发明人： Helen Chen , Brian J. Avenell , Gordon R. Strachan , Michael C. Lawton
IPC分类号： H04B7/10
CPC分类号： H04B7/04 , H04B17/0087 , H04L1/06
摘要： Systems and methods for receiving MIMO signals for testing and analyzing operation of MIMO communications devices. Examples of systems and/or methods for receiving MIMO signals include a measuring receiver with N RF paths consisting of N downconverters. Each downconverter achieves a frequency shift of the input MIMO signal equal to a shifting frequency of a first intermediate frequency (IF) plus a delta determined by the signal bandwidth multiplied by an integer number between 1 and N. The shifted N MIMO signals are combined to generate one combined analog MIMO signal. An analog to digital converter converts the combined analog MIMO signal to a stream of digital samples where the samples may be tested and analyzed with metrics on signals communicated in a MIMO environment. Example systems and method for receiving MIMO signals may also be implemented as a MIMO channel emulator such that samples generated by the ADC may be upconverted to output copies of the original signals to a receiver DUT, for example.
摘要翻译：用于接收MIMO信号以测试和分析MIMO通信设备的操作的系统和方法。用于接收MIMO信号的系统和/或方法的示例包括具有由N个下变频器组成的N个RF路径的测量接收机。每个下变频器实现输入MIMO信号的频移等于第一中间频率（IF）的移位频率加上由信号带宽乘以1与N之间的整数确定的增量。移位的N个MIMO信号被组合到生成一个组合的模拟MIMO信号。模数转换器将组合的模拟MIMO信号转换成数字样本流，其中样本可以通过在MIMO环境中传送的信号的度量进行测试和分析。用于接收MIMO信号的示例系统和方法也可以被实现为MIMO信道仿真器，使得例如由ADC生成的采样可以被上变频以将原始信号的副本输出到接收机DUT。

6. 发明授权

US6110944A LTA.sub.4, hydrolase inhibitors 失效
标题翻译： LTA4，水解酶抑制剂
公开(公告)号：US6110944A
公开(公告)日：2000-08-29
申请号：US814899
申请日：1997-03-12
申请人： Barbara Baosheng Chen , Helen Chen , Mark Andrew Russell
发明人： Barbara Baosheng Chen , Helen Chen , Mark Andrew Russell
IPC分类号： C07D295/12 , A61K31/155 , A61K31/4164 , A61K31/4184 , A61K31/445 , A61K31/4453 , A61P1/04 , A61P11/06 , A61P17/06 , A61P29/00 , A61P43/00 , C07C255/12 , C07C257/06 , C07C257/14 , C07C259/14 , C07D211/62 , C07D233/10 , C07D233/18 , C07D233/22 , C07D235/12 , C07D295/185 , C07C69/76 , C07D207/04 , C07D211/60
CPC分类号： C07D295/185 , C07C255/12 , C07C257/06 , C07C257/14 , C07D211/62 , C07D233/22 , C07D235/12 , C07C2103/74
摘要： The present invention provides compounds having the structureAr.sub.1 --Q--Ar.sub.2 --O--(CH.sub.2).sub.n --Zand pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
摘要翻译：本发明提供了具有结构式为Ar1-Q-Ar2-O-（CH2）n-Zand及其药学上可接受的盐和立体异构体的化合物，其可用于治疗由LTB4产生介导的炎性疾病，例如牛皮癣，溃疡性结肠炎， IBD和哮喘。

7. 发明授权

US5925654A LTA.sub.4 , hydrolase inhibitors 失效
标题翻译： LTA4水解酶抑制剂
公开(公告)号：US5925654A
公开(公告)日：1999-07-20
申请号：US815696
申请日：1997-03-12
申请人： Barbara Baosheng Chen , Helen Chen , Mark Andrew Russell , Julie Marion Miyashiro , James Malecha , Thomas Dale Penning
发明人： Barbara Baosheng Chen , Helen Chen , Mark Andrew Russell , Julie Marion Miyashiro , James Malecha , Thomas Dale Penning
IPC分类号： C07D295/08 , A61K31/195 , A61K31/40 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/445 , A61P1/04 , A61P11/06 , A61P17/06 , A61P29/00 , A61P43/00 , C07C229/12 , C07D211/62 , C07D263/32 , C07D277/24 , C07D295/092 , C07D207/08 , C07D207/325
CPC分类号： C07D295/088 , C07C229/12 , C07D211/62 , C07D263/32 , C07D277/24
摘要： The present invention provides compounds having the structure: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
摘要翻译：本发明提供具有以下结构的化合物及其药学上可接受的盐和立体异构体，其可用于治疗由LTB4产生介导的炎性疾病，例如牛皮癣，溃疡性结肠炎，IBD和哮喘。

8. 发明申请

US20170217918A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20170217918A1
公开(公告)日：2017-08-03
申请号：US15328735
申请日：2015-08-06
申请人： Helen CHEN , Steven L. COLLETTI , Duane MONG , Yan GUO , Michael MILLER , Anilkumar NAIR , Christopher W. PLUMMER , Dong XIAO , De-Yi YANG , Merck Sharp & Dohme Corp.
发明人： Helen Chen , Steven L. Colletti , Duane DeMong , Yan Guo , Michael Miller , Anilkumar Nair , Christopher W. Plummer , Dong Xiao , De-Yi Yang
IPC分类号： C07D311/60 , C07D405/14 , C07D471/08 , C07D487/08 , C07D487/04 , C07D491/107 , C07D413/12 , C07D491/08 , C07D405/10 , C07D491/048
CPC分类号： C07D311/60 , A61K31/366 , A61K31/397 , A61K31/4985 , A61K45/06 , C07D405/10 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

9. 发明申请

US20150216362A1 SYSTEM AND METHOD FOR OPERATING A FOOD PREPARATION DEVICE 审中-公开
标题翻译：用于操作食品制备装置的系统和方法
公开(公告)号：US20150216362A1
公开(公告)日：2015-08-06
申请号：US14171539
申请日：2014-02-03
申请人： Helen Chen , Haidee Chen
发明人： Haidee Chen , Helen Chen
IPC分类号： A47J44/00
摘要： A food preparation device or system which utilizes pre-packaged food containers to prepare a food item for consumption.
摘要翻译：一种食物制备装置或系统，其利用预先包装的食物容器来制备用于食物的食品。

10. 发明申请

US20100279983A1 NOVEL INHIBITORS OF BETA-LACTAMASE 失效
标题翻译： β-LACTAMASE的新型抑制剂
公开(公告)号：US20100279983A1
公开(公告)日：2010-11-04
申请号：US12301797
申请日：2007-05-21
申请人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
发明人： Frank Dininno , Milton L. Hammond , Kevin Dykstra , Seongkon Kim , Qiang Tan , Katherine Young , Jeffrey Donald Hermes , Helen Chen , Stephane Raeppel , Michael Mannion , Frederic Gaudette , Arkadii Vaisburg , Jubrail Rahil , Nafsika Georgopapadakou , Nancy Z. Zhou
IPC分类号： A61K31/675 , A61K31/67 , A61K31/665 , C07D409/12 , C07D277/80 , C07D277/36 , C07D333/72 , C07D307/83 , A61P31/04
CPC分类号： C07F9/655354 , C07F9/65395 , C07F9/6541 , C07F9/6553 , C07F9/6558 , C07F9/6561
摘要： This invention provides novel β-lactamase inhibitors of the aryl- and heteroarylsulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammonium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazidime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases. Formula (I) or pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有氮基阳离子或季铵基团的芳基 - 和杂芳基磺酰氨基甲基膦酸酯单酯类的新颖的β-内酰胺酶抑制剂。这些化合物抑制三种类型的β-内酰胺酶，并且与通常对β-内酰胺抗生素具有抗性的那些微生物相互作用可促进β-内酰胺类抗生素（如亚胺培南和头孢他啶）对抗生素的抗菌作用。＆bgr;内酰胺酶。式（I）或其药学上可接受的盐。

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