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1. 发明授权

US06750213B2 Estrogen receptor modulators 失效
公开(公告)号：US06750213B2
公开(公告)日：2004-06-15
申请号：US10120723
申请日：2002-04-11
申请人： Frank P. DiNinno , Jane Y. Wu , Seongkon Kim , Helen Y. Chen
发明人： Frank P. DiNinno , Jane Y. Wu , Seongkon Kim , Helen Y. Chen
IPC分类号： A61K31395
CPC分类号： C07D327/06 , C07D339/08 , C07D411/04
摘要： The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

2. 发明申请

US20100009957A1 NOVEL INHIBITORS OF BETA-LACTAMASE 审中-公开
标题翻译： β-LACTAMASE的新型抑制剂
公开(公告)号：US20100009957A1
公开(公告)日：2010-01-14
申请号：US12442816
申请日：2007-09-24
申请人： Timothy A. Blizzard , Helen Y. Chen , Jane Yang Wu , Seongkon Kim , Sookhee Ha , Christopher J. Mortko , Narayan Variankaval , Anna Chiu
发明人： Timothy A. Blizzard , Helen Y. Chen , Jane Yang Wu , Seongkon Kim , Sookhee Ha , Christopher J. Mortko , Narayan Variankaval , Anna Chiu
IPC分类号： A61K31/397 , C07D205/12 , A61P31/04
CPC分类号： C07D487/04
摘要： A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.
摘要翻译：在双环的两个位置被杂环基氨基羰基或碳环基氨基羰基取代的一类7-氧代-2,6-二氮杂双环[3.2.0] - 庚烷-6-磺酸化合物是β-内酰胺酶抑制剂。化合物及其前药和药学上可接受的盐可用于与β-内酰胺抗生素联合治疗细菌感染。特别地，由于β-内酰胺酶的存在，这些化合物适用于β-内酰胺抗生素（例如亚胺培南和头孢他啶）对抗β-内酰胺抗生素的微生物。

3. 发明授权

US10654160B2 Nail gun recoil bumper 有权
公开(公告)号：US10654160B2
公开(公告)日：2020-05-19
申请号：US15628506
申请日：2017-06-20
申请人： Helen Y. Chen , Kevin J. Stanger
发明人： Helen Y. Chen , Kevin J. Stanger
IPC分类号： B25F5/00 , B25C1/04 , B25C1/00 , B25C1/06
摘要： A recoil bumper for a nail gun having a body, an axially elongated cylinder disposed within the body of the nail gun, a piston slidably movable in the cylinder, and a driver having a multi-sided cross-sectional configuration, in plan, axially extending along at least a lengthwise portion thereof. The recoil bumper includes a hollow elastomeric member through which the lengthwise portion of the driver endwise passes. The elastomeric member has first and second end faces axially spaced from each other. The first end abuts with the nail gun body while the piston impacts against the second end face during operation of the nail gun. The first end face of said elastomeric member defines a first opening. The second end face of the elastomeric member defines a closed marginal edge for a second opening. The closed marginal edge of the second opening generally corresponds in size and shape to the multi-sided cross-sectional configuration of the lengthwise portion of the driver passing therethrough such that an impact area defined by the second end face of the bumper is optimized to absorb energy imparted thereto by the piston during operation of the nail gun.

4. 发明授权

US06251944B1 Para-substituted phenylene derivatives 失效
标题翻译：对位取代亚苯衍生物
公开(公告)号：US06251944B1
公开(公告)日：2001-06-26
申请号：US09288742
申请日：1999-04-08
申请人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
发明人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
IPC分类号： A61K3119
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α-角蛋白3整联蛋白的方法。

5. 发明授权

US5773644A Cyclopropyl alkanoic acid derivatives 失效
标题翻译：环丙基链烷酸衍生物
公开(公告)号：US5773644A
公开(公告)日：1998-06-30
申请号：US825040
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
IPC分类号： C07D239/14 , A61K31/00 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/505 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C279/18 , C07C279/24 , C07D239/42 , C07C241/00 , C07C229/00 , C07D239/00
CPC分类号： C07D239/42 , C07C279/18 , C07C279/24 , C07C2101/02
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

6. 发明授权

US08733744B2 Multipiece cushioning assembly for a telescoping shock absorbing assembly 有权
标题翻译：用于伸缩式减震组件的多功能缓冲组件
公开(公告)号：US08733744B2
公开(公告)日：2014-05-27
申请号：US13136824
申请日：2011-08-11
申请人： Ronald W. Kerr , Helen Y. Chen , Richard J. Beranek
发明人： Ronald W. Kerr , Helen Y. Chen , Richard J. Beranek
IPC分类号： B60G15/00
CPC分类号： F16F9/58 , F16F9/3271 , F16F2230/0023 , F16F2230/24
摘要： A multipiece cushioning assembly adapted to be arranged in combination with a shock absorbing apparatus. The multipiece cushioning assembly is disposed between a pair of radial shoulders on first and second members telescoping members of the shock absorbing apparatus arranged in operable combination relative to each other. The radial shoulders on the first and second members limit travel of the shock absorbing apparatus, and with the multipiece cushioning assembly including a plurality of elastomeric bumpers arranged in a generally circular array for absorbing over-travel of the first and second members relative to each other and for readily permitting replacement of the multipiece cushioning assembly while maintaining the first and second members in operable combination relative to each other.
摘要翻译：一种适于与减震装置组合设置的多体缓冲组件。多片缓冲组件设置在相对于彼此可操作组合地布置在冲击吸收装置的第一和第二构件伸缩构件上的一对径向肩部之间。第一和第二构件上的径向肩部限制了冲击吸收装置的移动，并且多体缓冲组件包括多个弹性缓冲器，其布置成大致圆形阵列，用于吸收第一和第二构件相对于彼此的过度行进并且容易地允许更换多片缓冲组件，同时保持第一和第二构件相对于彼此可操作地组合。

7. 发明申请

US20130038005A1 Multipiece cushioning assembly for a telescoping shock absorbing assembly 有权
标题翻译：用于伸缩式减震组件的多功能缓冲组件
公开(公告)号：US20130038005A1
公开(公告)日：2013-02-14
申请号：US13136824
申请日：2011-08-11
申请人： Ronald W. Kerr , Helen Y. Chen , Richard J. Beranek
发明人： Ronald W. Kerr , Helen Y. Chen , Richard J. Beranek
IPC分类号： F16F15/02
CPC分类号： F16F9/58 , F16F9/3271 , F16F2230/0023 , F16F2230/24
摘要： A multipiece cushioning assembly adapted to be arranged in combination with a shock absorbing apparatus. The multipiece cushioning assembly is disposed between a pair of radial shoulders on first and second members telescoping members of the shock absorbing apparatus arranged in operable combination relative to each other. The radial shoulders on the first and second members limit travel of the shock absorbing apparatus, and with said multipiece cushioning assembly including a plurality of elastomeric bumpers arranged in a generally circular array for absorbing over-travel of the first and second members relative to each other and for readily permitting replacement of the multipiece cushioning assembly while maintaining the first and second members in operable combination relative to each other.
摘要翻译：一种适于与减震装置组合设置的多体缓冲组件。多片缓冲组件设置在相对于彼此可操作组合地布置在冲击吸收装置的第一和第二构件伸缩构件上的一对径向肩部之间。第一和第二构件上的径向肩部限制了冲击吸收装置的移动，并且所述多体缓冲组件包括多个弹性缓冲器，其布置成大致圆形的阵列，用于吸收第一和第二构件相对于彼此的过度行进并且容易地允许更换多片缓冲组件，同时保持第一和第二构件相对于彼此可操作地组合。

8. 发明授权

US5852210A Cinnamic acid derivatives 失效
标题翻译：肉桂酸衍生物
公开(公告)号：US5852210A
公开(公告)日：1998-12-22
申请号：US825080
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Stephen H. Docter , Ish Kumar Khanna , Francis Jan Koszyk , James W. Malecha , Julie Marion Miyashiro , Thomas D. Penning , Joseph G. Rico , Peter G. Ruminski , Mark A. Russell , Richard Mathias Weier , Xiangdong Xu , Stella S. Yu , Yi Yu
IPC分类号： A61K31/00 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/275 , A61K31/277 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/54 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/14 , A61P19/00 , A61P19/10 , A61P35/00 , A61P35/04 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D231/06 , C07D233/50 , C07D233/54 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12 , C07C241/00 , C07C205/00 , C07D233/44 , C07D239/02
CPC分类号： C07D231/06 , C07C205/34 , C07C205/35 , C07C205/37 , C07C205/44 , C07C205/45 , C07C205/56 , C07C205/57 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07D233/50 , C07D233/64 , C07D239/14 , C07D239/42 , C07D263/32 , C07D279/06 , C07D401/12 , C07D403/12
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

9. 外观设计

USD859116S1 Nailgun recoil bumper 有权
公开(公告)号：USD859116S1
公开(公告)日：2019-09-10
申请号：US29608277
申请日：2017-06-20
申请人： Helen Y. Chen , Kevin J. Stanger
设计人： Helen Y. Chen , Kevin J. Stanger

10. 发明授权

US5952381A Para-substituted phenylene derivatives 失效
标题翻译：对位取代亚苯衍生物
公开(公告)号：US5952381A
公开(公告)日：1999-09-14
申请号：US826244
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
发明人： Barbara B. Chen , Helen Y. Chen , Glen J. Gesicki , Richard A. Haack , James W. Malecha , Thomas D. Penning , Joseph G. Rico , Thomas E. Rogers , Peter G. Ruminski , Mark A. Russell , Stella S. Yu
IPC分类号： A61K31/155 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/4168 , A61K31/4192 , A61K31/4453 , A61K31/505 , A61K31/5375 , A61P9/14 , A61P19/08 , A61P19/10 , A61P27/02 , A61P35/00 , C07C257/18 , C07C259/18 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/47 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D233/50 , C07D233/88 , C07D239/14 , C07D249/14 , C07D271/06 , C07D271/07 , C07D295/20 , C07D295/215 , C07D521/00 , C07C229/00 , A61K31/19 , C07C205/00
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

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