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1. 发明授权

US4798789A cDNA clones coding for polypeptides exhibiting murine interleukin-2 activity 失效
标题翻译：编码表达鼠白介素-2活性的多肽的cDNA克隆
公开(公告)号：US4798789A
公开(公告)日：1989-01-17
申请号：US942600
申请日：1986-12-17
申请人： Frank D. Lee , Takashi Yokota , Ken-ichi Arai
发明人： Frank D. Lee , Takashi Yokota , Ken-ichi Arai
IPC分类号： C07K14/55 , C12N15/10 , C12N15/81 , C12P21/00 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C07K14/55 , C12N15/1096 , C12N15/81 , Y10S930/141
摘要： Plasmid vectors are provided that carry complementary DNA (cDNA) clones cng for polypeptides exhibiting murine interleukin-2 activity. One of these polypeptides is 168 amino acids in length, including a potential leader sequence of about 19 amino acids. The cDNA is derived from messenger RNA isolated from a mouse T-cell line after activation with concanavalin A. The cDNA was cloned by incorporation into a plasmid vector, which is then transformed into E. coli. The plasmid vector also contained DNA segments from the SV40 virus, permitting expression of the cDNA after transfection into a mammalian host cell, such as monkey COS-7 cells.
摘要翻译：提供携带编码表达鼠白介素-2活性的多肽的互补DNA（cDNA）克隆的质粒载体。这些多肽之一长度为168个氨基酸，包括约19个氨基酸的潜在前导序列。 cDNA是从刀豆素A活化后从小鼠T细胞系分离的信使RNA得到的。通过掺入到质粒载体中克隆cDNA，然后将其转化到大肠杆菌中。质粒载体还含有来自SV40病毒的DNA片段，其在转染到哺乳动物宿主细胞如猴COS-7细胞后能够表达cDNA。

2. 发明授权

US5955315A Nucleic acids encoding human interleukin-4 失效
标题翻译：编码人白细胞介素-4的核酸
公开(公告)号：US5955315A
公开(公告)日：1999-09-21
申请号：US468817
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N1/21 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , C12N15/63
CPC分类号： C07K14/5406 , C07K16/247 , C12N15/66 , C12N15/70 , C12N15/86 , A61K38/00 , C07K2319/00 , C07K2319/02 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译：提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。

3. 发明授权

US5552304A CDNA Clones coding for human protein exhibiting a broad cellular activity spectrum (human interleukin-4) 失效
标题翻译： CDNA编码人类蛋白质的克隆显示出广泛的细胞活性谱（人白细胞介素-4）
公开(公告)号：US5552304A
公开(公告)日：1996-09-03
申请号：US843958
申请日：1986-03-25
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , C12P21/02 , C12N1/19 , C12N1/21 , C12N5/16 , C12N15/19
CPC分类号： C12N15/70 , C07K14/5406 , C07K16/247 , C12N15/66 , A61K38/00 , C07K2319/02 , Y10S514/825 , Y10S514/885
摘要： Plasmid vectors are provided that carry cDNA clones coding for polypeptides exhibiting B-cell, T-cell and mast cell stimulatory activities, all of which are enhanced in the presence of other immune-reactive agents. The polypeptides also augment the activity of various CSF's, such as G-CSF and G/M-CSF, and depress proliferation of macrophages in the presence of M-CSF. The cDNA is derived from mRNA isolated from a mammalian cell source, such as T-cells typically after activation with a mitogen. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA after transfection into a mammalian host cell, such as COS cells. Two expressed polypeptides of the present invention from different mammals are about 140 and 150 amino acids in length, including potential leader sequences. An E. coli culture containing a plasmid (pcD-2A-E3) carrying a mouse cDNA insert of the present invention was deposited with the American Type Culture Collection (A.T.C.C.) on Nov. 18, 1985, and designated accession number 53,330. Two additional E. coli cultures, each carrying plasmids with different human cDNA inserts of the present invention, were deposited with the A.T.C.C. as follows: pcD-2Fl-13 (pcD-46) was deposited on Nov. 26, 1985 and designated accession number 53,337 and pcD-125 was deposited on Mar. 7, 1986 and designated accession number 67,029.
摘要翻译：提供携带编码表现出B细胞，T细胞和肥大细胞刺激活性的多肽的cDNA克隆的质粒载体，所有这些都在其它免疫反应剂存在下增强。多肽还增加各种CSF的活性，例如G-CSF和G / M-CSF，并且在M-CSF存在下抑制巨噬细胞的增殖。 cDNA源自哺乳动物细胞来源的mRNA，例如通常用丝裂原活化后的T细胞。质粒载体还含有来自SV40病毒的DNA片段，其在转染到哺乳动物宿主细胞如COS细胞后能够表达cDNA。来自不同哺乳动物的本发明的两种表达的多肽的长度为约140和150个氨基酸，包括潜在的前导序列。含有携带本发明的小鼠cDNA插入片段的质粒（pcD-2A-E3）的大肠杆菌培养物于1985年11月18日保藏于美国典型培养物保藏中心（A.T.C.C.），指定登记号为53,330。每个携带本发明不同人cDNA插入片段的质粒的两个另外的大肠杆菌培养物与A.T.C.C. 如下：pcD-2Fl-13（pcD-46）于1985年11月26日保藏，指定登记号为53,337，pcD-125于1986年3月7日保藏，指定登记号为67,029。

4. 发明授权

US5017691A Mammalian interleukin-4 失效
标题翻译：哺乳动物白介素-4
公开(公告)号：US5017691A
公开(公告)日：1991-05-21
申请号：US908215
申请日：1986-09-17
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869
CPC分类号： C12N15/86 , C07K14/5406 , C12N15/66 , C12N15/70 , A61K38/00 , C07K2319/02 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译：提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。

5. 发明授权

US5730970A Pharmaceutical compositions comprising human interleukin-4 (IL-4) 失效
标题翻译：包含人白细胞介素-4（IL-4）
公开(公告)号：US5730970A
公开(公告)日：1998-03-24
申请号：US469267
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , A61K38/20
CPC分类号： C12N15/70 , C07K14/5406 , C07K16/247 , C12N15/66 , A61K38/00 , C07K2319/02 , Y10S514/825 , Y10S514/885
摘要： A pharmaceutical composition comprising human Interleukin-4 (IL-4).
摘要翻译：包含人白细胞介素-4（IL-4）的药物组合物。

6. 发明授权

US5013824A Human interleukin-4 peptides and conjugates thereof 失效
标题翻译：人白细胞介素-4肽及其缀合物
公开(公告)号：US5013824A
公开(公告)日：1991-05-07
申请号：US909520
申请日：1986-09-19
申请人： John S. Abrams , Takashi Yokota , Frank Lee , Ken-ichi Arai
发明人： John S. Abrams , Takashi Yokota , Frank Lee , Ken-ichi Arai
IPC分类号： A61K38/00 , C07K14/54 , C12N15/66 , C12N15/70 , C12N15/869
CPC分类号： C12N15/70 , C07K14/5406 , C12N15/66 , A61K38/00 , C07K2319/02
摘要： Peptides derived from human interleukin-4 are provided comprising from 6 to 40 amino acids. Conjugates of the peptides and carriers are also provided for the production of polyclonal and/or monoclonal antisera to human interleukin-4.
摘要翻译：提供衍生自人白细胞介素-4的肽包含6至40个氨基酸。还提供肽和载体的缀合物用于生产人白介素-4的多克隆和/或单克隆抗血清。

7. 发明授权

US5951973A Use of interleukin-4 (IL-4) to treat rheumatoid arthritis 失效
标题翻译：使用白介素-4（IL-4）治疗类风湿关节炎
公开(公告)号：US5951973A
公开(公告)日：1999-09-14
申请号：US466543
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , A61K38/20
CPC分类号： C12N15/70 , C07K14/5406 , C07K16/247 , C12N15/66 , A61K38/00 , C07K2319/02 , Y10S514/825 , Y10S514/885
摘要： A method of treating rheumatoid arthritis comprising administering human Interleukin-4 (IL-4) to an individual afflicted with the disease. The IL-4 is administered with a pharmaceutically acceptable carrier in a dose ranging from 1 .mu.g to 100 mg.
摘要翻译：一种治疗类风湿性关节炎的方法，包括给患有该疾病的个体施用人白细胞介素-4（IL-4）。 IL-4以1μg至100mg的剂量施用药学上可接受的载体。

8. 发明授权

US5807996A Fused polypeptides comprising interleukin-4 polypeptide fragments 失效
标题翻译：包含白细胞介素-4多肽片段的融合多肽
公开(公告)号：US5807996A
公开(公告)日：1998-09-15
申请号：US468735
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N1/21 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , C07K14/00
CPC分类号： C07K14/5406 , C07K16/247 , C12N15/66 , C12N15/70 , C12N15/86 , A61K38/00 , C07K2319/00 , C07K2319/02 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译：提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。

9. 发明授权

US4695542A cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity 失效
标题翻译：编码显示多谱系细胞生长因子活性的多肽的cDNA克隆
公开(公告)号：US4695542A
公开(公告)日：1987-09-22
申请号：US590867
申请日：1984-03-19
申请人： Takashi Yokota , Frank Lee , Donna Rennick , Ken-ichi Arai
发明人： Takashi Yokota , Frank Lee , Donna Rennick , Ken-ichi Arai
IPC分类号： A61K38/00 , C07H21/04 , C07K14/52 , C12N15/27 , C12P21/00 , C07H15/12 , C12N1/00 , C12N15/00
CPC分类号： C07K14/52 , A61K38/00 , Y10S930/12 , Y10S930/14 , Y10S930/141 , Y10S930/30
摘要： Plasmid vectors are provided that carry complementary DNA (cDNA) clones coding for polypeptides exhibiting mammalian multi-lineage growth cell activity. One of these polypeptides is 166 amino acids in length, including a potential leader sequence of about 19 amino acids. The cDNA is derived from messenger RNA isolated from a mouse T-cell line after activation with concanavalin A. The cDNA was cloned by incorporation into a plasmid vector, which was then transformed into E. coli. The plasmid vector also contains DNA segments from the SV40 virus, permitting expression of the cDNA after transfection into a mammalian host cell, such as monkey COS-7 cells.
摘要翻译：提供携带编码显示哺乳动物多谱系生长细胞活性的多肽的互补DNA（cDNA）克隆的质粒载体。这些多肽之一长度为166个氨基酸，包括约19个氨基酸的潜在前导序列。该cDNA源自用刀豆球蛋白A活化后从小鼠T细胞系分离的信使RNA。通过掺入到质粒载体中克隆cDNA，然后将其转化到大肠杆菌中。质粒载体还含有来自SV40病毒的DNA片段，其在转染到哺乳动物宿主细胞如猴COS-7细胞后能够表达cDNA。

10. 发明授权

US5656266A Method of using interleukin-4 失效
标题翻译：使用白细胞介素-4的方法
公开(公告)号：US5656266A
公开(公告)日：1997-08-12
申请号：US468734
申请日：1995-06-06
申请人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
发明人： Frank Lee , Takashi Yokota , Ken-ichi Arai , Timothy Mosmann , Donna Rennick
IPC分类号： A61K38/00 , C07K14/54 , C07K16/24 , C12N1/21 , C12N15/24 , C12N15/66 , C12N15/70 , C12N15/869 , A61K38/20
CPC分类号： C07K14/5406 , C07K16/247 , C12N15/66 , C12N15/70 , C12N15/86 , A61K38/00 , C07K2319/00 , C07K2319/02 , C12N2710/16243
摘要： Mammalian proteins and muteins thereof, designated interleukin-4s (IL-4s), are provided which exhibit both B cell growth factor activity and T cell growth factor activity. Compounds of the invention include native human and murine IL-4s, muteins thereof, and nucleic acids which are effectively homologous to disclosed cDNAs, and/or which are capable of coding for mammalian IL-4s and their muteins.
摘要翻译：提供了表达B细胞生长因子活性和T细胞生长因子活性的哺乳动物蛋白质和其突变蛋白，称为白细胞介素-4（IL-4s）。本发明的化合物包括天然人和鼠IL-4，其突变蛋白和与公开的cDNA有效同源的核酸，和/或能编码哺乳动物IL-4及其突变蛋白的核酸。

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