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1. 发明申请

US20120283168A1 TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY 有权
标题翻译：具有CCR10拮抗活性的模板固定化肽
公开(公告)号：US20120283168A1
公开(公告)日：2012-11-08
申请号：US13510864
申请日：2010-11-18
申请人： Francoise Jung , Frank Otto Gombert , Daniel Obrecht , Christian Bisang , Sophie Barthélémy , Alexander Lederer , Eric Chevalier
发明人： Francoise Jung , Frank Otto Gombert , Daniel Obrecht , Christian Bisang , Sophie Barthélémy , Alexander Lederer , Eric Chevalier
IPC分类号： A61K38/12 , A61P3/00 , A61P29/00 , A61P25/00 , A61P11/00 , C07K1/12 , A61P27/02 , A61P35/00 , A61P7/00 , A61P11/06 , A61P37/06 , C07K7/64 , A61P1/00
CPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64
摘要： Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
摘要翻译：通式（I）的新型模板固定型和平滑型肽模拟物，其中单元素T或P是沿任一方向连接的α-氨基酸残基，其取决于其在链中的位置如说明书中所定义，权利要求书及其盐具有拮抗受体CCR10的性质。它们可以用作治疗或预防皮肤病和皮肤疾病，炎症，过敏性疾病，呼吸系统疾病，胃肠道疾病，眼科疾病，血液学和癌症领域的疾病或病症的药物。这些可以通过基于混合固相和溶液相合成策略的方法制造。

2. 发明授权

US08754038B2 Template-fixed peptidomimetics with CCR10 antagonistic activity 有权
标题翻译：模板固定肽模拟物与CCR10拮抗活性
公开(公告)号：US08754038B2
公开(公告)日：2014-06-17
申请号：US13510864
申请日：2010-11-18
申请人： Françoise Jung , Frank Otto Gombert , Daniel Obrecht , Christian Bisang , Sophie Barthélémy , Alexander Lederer , Eric Chevalier
发明人： Françoise Jung , Frank Otto Gombert , Daniel Obrecht , Christian Bisang , Sophie Barthélémy , Alexander Lederer , Eric Chevalier
IPC分类号： A61K38/00 , A61P11/06 , C07K7/06 , C07K7/08
CPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K7/64
摘要： Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
摘要翻译：通式（I）的新型模板固定型和平滑型肽模拟物，其中单元素T或P是沿任一方向连接的α-氨基酸残基，其取决于其在链中的位置如说明书中所定义，权利要求书及其盐具有拮抗受体CCR10的性质。它们可以用作治疗或预防皮肤病和皮肤疾病，炎症，过敏性疾病，呼吸系统疾病，胃肠道疾病，眼科疾病，血液学和癌症领域的疾病或病症的药物。这些可以通过基于混合固相和溶液相合成策略的方法制造。

3. 发明申请

US20120316419A1 MULTIMODAL CATHETER 审中-公开
标题翻译：多功能导管
公开(公告)号：US20120316419A1
公开(公告)日：2012-12-13
申请号：US13580116
申请日：2011-02-18
申请人： Eric Chevalier
发明人： Eric Chevalier
IPC分类号： A61B8/06 , A61B5/04 , A61B8/12 , A61B5/027
CPC分类号： A61B5/026 , A61B5/02007 , A61B5/027 , A61B5/6853 , A61B5/6858 , A61B8/06 , A61B8/12
摘要： Catheter based system for providing functional and morphological characterization of arteries, comprising a catheter (1) configured for insertion in an artery (3), and a sensor system (5) for mapping hemodynamic parameters mounted on the catheter (1), the sensor system comprising at least two anemometric probes (7, 8a, 8b, 9a, 9b, 19, 20, 21, 22) spatially arranged in a deployed position and configured to measure flow velocity components (Vx, Vr) in at least two different positions spaced apart in a radial direction R of such that a possible restriction of the artery due for example to a stenosis, plaque, or other local deformation (3a) of the artery is measurable.
摘要翻译：用于提供动脉的功能和形态表征的基于导管的系统，包括构造成用于插入动脉（3）中的导管（1）和用于映射安装在导管（1）上的血液动力学参数的传感器系统（5），传感器系统包括至少两个空间上布置在展开位置的风速测量探头（7,8a，8b，9a，9b，19,20,21,22），并被配置成测量至少两个不同位置间的流速分量（Vx，Vr）在径向方向R上分开，使得可以限制例如动脉狭窄，斑块或其他局部变形（3a）的动脉受到限制。

4. 发明授权

US08746500B2 Assembly having a self-clamping skirt for closing an annular collar or connecting to same, which can be rapidly positioned and removed, and used in the biopharmaceutical field 有权
标题翻译：具有用于封闭环形套圈或连接到其上的自夹紧裙部的组件，其可快速定位和移除，并用于生物药物领域
公开(公告)号：US08746500B2
公开(公告)日：2014-06-10
申请号：US13254917
申请日：2010-03-05
申请人： Frederic Bernard , Eric Chevalier
发明人： Frederic Bernard , Eric Chevalier
IPC分类号： B65D43/02 , B65D41/16
CPC分类号： B65D43/0216 , B65D41/16 , B65D43/0218 , B65D88/26 , B65D88/54 , B65D88/68 , B65D90/00 , B65D90/046 , B65D90/56 , B65D2590/046 , F16J13/06 , Y10T29/49826
摘要： A mounting assembly is provided including a first piece mounted in a fixed, detachable, and sealed manner, on a rigid, annular collar of a second piece having an end opening. The first piece includes an annular peripheral wall having an inner face configured to contact an outer face of the collar. The first piece includes a transverse wall that can enter the opening, and an annular wall forming a skirt, the inner face of the skirt including a larger diameter part, a smaller diameter part, and an intermediate part configured to contact with conjugated parts of the outer face by clamping. The transverse wall and the skirt form one component and are made of a highly flexible material enabling the first piece to be brought into an intermediate state in which the first piece is enlarged to be removed from the second piece, while retaining elastic deformation.
摘要翻译：提供一种安装组件，其包括以固定的，可拆卸和密封的方式安装在具有端部开口的第二部件的刚性环形套环上的第一件。第一件包括环形周壁，其具有构造成接触套环的外表面的内表面。第一部件包括可以进入开口的横向壁和形成裙部的环形壁，裙部的内表面包括较大直径部分，较小直径部分和中间部分，其构造成与外面通过夹紧。横壁和裙部形成一个部件并且由高度柔性的材料制成，使得第一件可以进入中间状态，其中第一件被放大以从第二件中移除，同时保持弹性变形。

5. 发明申请

US20120037633A1 ASSEMBLY HAVING A HOLDING TORIC BODY FOR CLOSING AN ANNULAR COLLAR, OR CONNECTING TO SAME, WHICH CAN BE RAPIDLY POSITIONED AND REMOVED AND USED IN THE BIOPHARAMACEUTICAL FIELD 有权
标题翻译：具有用于闭合环形胶片或与之连接的保持性体温组件的组件可以被快速定位和移除并用于生物麻醉领域
公开(公告)号：US20120037633A1
公开(公告)日：2012-02-16
申请号：US13254945
申请日：2010-03-05
申请人： Frederic Bernard , Eric Chevalier
发明人： Frederic Bernard , Eric Chevalier
IPC分类号： B65D55/00
CPC分类号： F16J13/065 , B65D88/26 , B65D88/54 , B65D88/68 , B65D90/00 , B65D90/046 , B65D90/56 , B65D2590/046 , F16J15/46
摘要： The invention relates to a piece (1) mounted in a fixed and rigid manner on a rigid annular collar (8) of a second piece (2) having an end opening (3). Said piece (1) comprises a transversal wall (14); an annular wall forming a skirt (15), the inner face (15a) of said skirt including a part (39a) having a larger diameter and a part (39b) having a smaller diameter; a holding toric body (45) adjacent to the inner face (15a), deformable between a retracted state and an expanded state, and filled with a swelling medium; and at least one inlet/outlet port (46) for the swelling media, communicating with the holding body (45). The dimensions of the first piece are selected in relation to those of the collar (8), in such a way as to enable the first piece to be able to be slipped onto, or removed from, the second piece (2), when the holding body (45) is in the retracted state, and to be mounted onto the collar (8) in a fixed, rigid and tight manner, when the holding body (45) is in the expanded state.
摘要翻译：本发明涉及一种以固定和刚性方式安装在具有端部开口（3）的第二件（2）的刚性环形套环（8）上的件（1）。所述片（1）包括横向壁（14）; 形成裙部（15）的环形壁，所述裙部的内表面（15a）包括具有较大直径的部分（39a）和具有较小直径的部分（39b）; 相对于内表面（15a）的保持复曲面体（45），在缩回状态和膨胀状态之间可变形，并且填充有溶胀介质; 和用于溶胀介质的至少一个入口/出口（46），与保持体（45）连通。第一件的尺寸相对于套环（8）的尺寸选择为使得第一件能够被滑动到第二件（2）上或从第二件（2）移除时，当第保持体（45）处于缩回状态，并且当保持体（45）处于展开状态时，以固定，刚性和紧密的方式安装到轴环（8）上。

6. 发明申请

US20110158037A1 MIXING IN A CONTAINER OF CONTENT HAVING A BASE COMPONENT AND A COMPONENT TO BE MIXED 有权
标题翻译：在含有基础组分和混合组分的容器内混合
公开(公告)号：US20110158037A1
公开(公告)日：2011-06-30
申请号：US13054234
申请日：2009-06-16
申请人： Frederic Bernard , Eric Chevalier
发明人： Frederic Bernard , Eric Chevalier
IPC分类号： B01F3/12
CPC分类号： B01F5/20 , B01F3/1207 , B01F3/1221 , B01F7/162 , B01F15/0085
摘要： A mixing process, a spraying and dispersing device, and a mixing device for implementing the process. In the process, components are introduced into a container equipped with introduction elements and mixing elements and the contents are mixed. A mixing facilitator is provided, a spraying and dispersing device that can be connected to the container at one of its introduction element is provided, able to be in an active functional state in which it makes it possible to spray and to disperse a liquid in the container, and then, in a first phase, the base of the contents and then the components to be mixed are introduced into the container, without filling the latter, and in a second phase, the mixing facilitator is introduced into the container via an introduction element, and it is sprayed and dispersed to the components to be mixed by the spraying and dispersing device that is put into the active functional state.
摘要翻译：混合方法，喷雾和分散装置以及用于实施该方法的混合装置。在该过程中，将组分引入装有引入元件和混合元件的容器中，并将内容物混合。提供了一种混合辅助器，提供了可以在其引入元件之一连接到容器的喷射和分散装置，其能够处于活动功能状态，其中其可以喷射和分散液体中的液体容器，然后，在第一阶段，将内容物的底部，然后将要混合的组分引入容器中，而不填充容器，并且在第二阶段中，通过介绍将混合促进剂引入容器并通过被投入到活性功能状态的喷雾分散装置喷雾分散到要混合的成分中。

7. 发明申请

US20110044567A1 3D CONTAINER WITH RIGID FRAME, DEFORMABLE CONTAINER, AND FUNCTIONAL MEANS FOR PROCESSING THE CONTENT, AND INCLUDING AN INTERNAL MEMBER FOR BIOPHARMACEUTICAL APPLICATIONS 有权
标题翻译：具有刚性框架的3D容器，可变容器和用于处理内容的功能手段，并且包括用于生物应用的内部构件
公开(公告)号：US20110044567A1
公开(公告)日：2011-02-24
申请号：US12920888
申请日：2009-02-27
申请人： Magali Dominique Corinne Barbaroux , Eric Chevalier , Isabelle Valerie Christine Gay
发明人： Magali Dominique Corinne Barbaroux , Eric Chevalier , Isabelle Valerie Christine Gay
IPC分类号： B65D30/20
CPC分类号： B65D77/06 , A61J1/05 , B01F7/163 , B01F15/00831 , B01F15/0085 , B65D21/086 , B65D37/00 , B65D88/16 , B65D88/68 , B65D90/205
摘要： A frame delimits an inside space and includes a peripherally closed side wall and two transverse openings or one transverse opening and a transverse end wall. It is capable of allowing the airtight engagement of the open free edge of a side wall in film form of a receptacle that is at least partially deformable. It is specially designed for the creation of a 3D container. The frame is also able to act as a support for at least one functional port or attachment port of a functional element. Its axial size is adequate for delimiting a space of a size that is at least equal to the axial dimension of the functional element, so that the latter can be completely housed within the inside space.
摘要翻译：框架限定内部空间并且包括外围封闭的侧壁和两个横向开口或一个横向开口和横向端壁。它能够允许侧壁的敞开的自由边缘以至少部分可变形的容器的薄膜形式的气密接合。它专为创建3D容器而设计。框架还能够用作对功能元件的至少一个功能端口或附接端口的支持。其轴向尺寸足以限定至少等于功能元件的轴向尺寸的尺寸的空间，使得后者可以完全容纳在内部空间内。

8. 发明授权

US08845182B2 Vessel for processing a biopharmaceutical product including protection means 有权
标题翻译：用于加工包括保护装置在内的生物制药产品的容器
公开(公告)号：US08845182B2
公开(公告)日：2014-09-30
申请号：US12681419
申请日：2008-10-01
申请人： Frederic Bernard , Eric Chevalier
发明人： Frederic Bernard , Eric Chevalier
IPC分类号： B01F7/16 , B65D30/20
CPC分类号： B01F15/0085 , B01F7/162 , B01F15/00831 , B01F2215/0032 , B65D83/0055 , C12M23/00 , C12M23/14 , C12M27/02
摘要： A vessel includes: a pocket capable of assuming a folded state and an expanded state, processing element including an active inner portion; protection element including a side wall, a lower portion and an upper portion defining an inner space, the lower portion being attached to the upper portion of the pocket, the active inner portion being provided in the inner space when the pocket is in the folded state, the peripheral portion of the inner space about the processing element defining a protection chamber; at least one insertion and/or draining opening. The active inner portion is provided inside the pocket adjacent to the lower end portion thereof, the processing element and the protection element are independent in terms of their movements, and the height of the protection chamber is variable and automatically adapts itself based on respectively, the flat-folded, unfolded and expanded states or any intermediate state of the pocket.
摘要翻译：容器包括：能够承受折叠状态和膨胀状态的袋，包括主动内部的处理元件; 保护元件包括侧壁，下部和限定内部空间的上部，所述下部附接到所述凹部的上部，所述主动内部在所述口袋处于折叠状态时设置在所述内部空间中围绕处理元件的内部空间的周边部分限定保护室; 至少一个插入和/或排出开口。主动内部部分设置在与其下端部分相邻的口袋内部，处理元件和保护元件在它们的移动方面是独立的，并且保护室的高度是可变的并且基于分别自动适应自身平折，展开和展开状态或口袋的任何中间状态。

9. 发明申请

US20120208039A1 MULTILAYER FILM OF A WALL OF A BAG HAVING SEAMS AND INTENDED FOR A BIOPHARMACEUTICAL PRODUCT 审中-公开
标题翻译：一个有海绵的袋子的多层薄膜，并用于生物制品
公开(公告)号：US20120208039A1
公开(公告)日：2012-08-16
申请号：US13501912
申请日：2010-10-29
申请人： Magali Barbaroux , Eric Chevalier , Steve Wasterlain
发明人： Magali Barbaroux , Eric Chevalier , Steve Wasterlain
IPC分类号： B32B37/18 , B32B27/08 , B29C47/06
CPC分类号： B32B27/08 , B32B2307/7242 , B32B2439/46 , B65D65/40 , Y10T428/31913
摘要： Monolayer contact film, designed, once made integral with a multilayer functional film, to constitute a final multilayer film of a pouch wall; the pouch having seams, and designed to be filled with biopharmaceutical product, and composed of a selected material that can be part of the composition of the final multilayer film, be in contact with the biopharmaceutical product, without degradation of the film and biopharmaceutical product, be sealable on itself, with a thickness that is less than the thickness of a single contact layer of the final multilayer film suitable for the production of seams of the single contact layer on itself, of which one surface functions as an interface for interlocking with a first interface for making the multilayer functional film integral, and whose other surface has as its final function to constitute the contact surface of the final multilayer film with the biopharmaceutical product.
摘要翻译：设计成与多层功能膜一体形成的单层接触膜构成袋壁的最终多层膜; 设计成填充有生物制药产品的袋，并且由可以作为最终多层膜的组合物的一部分的选定材料组成的袋与生物药物产物接触，而不会降解膜和生物药物产品，可以自身密封，其厚度小于最终多层膜的单个接触层的厚度，其适用于生产单个接触层本身的接缝，其中一个表面用作与互锁的接口用于使多层功能膜成为一体的第一界面，并且其另一表面具有构成最终多层膜与生物药物产品的接触表面的最终功能。

10. 发明申请

US20070056515A1 High density plasma reactor 有权
标题翻译：高密度等离子体反应器
公开(公告)号：US20070056515A1
公开(公告)日：2007-03-15
申请号：US10557695
申请日：2004-05-18
申请人： Eric Chevalier , Philippe Guittienne
发明人： Eric Chevalier , Philippe Guittienne
IPC分类号： C23C16/00
CPC分类号： H05H1/46
摘要： The high density RF plasma source of this invention uses a special antenna configuration to launch waves at frequency such as 13,56 MHz. The tunability of this antenna allows to adapt actively the coupling of the RF energy into an evolutive plasma as found in plasma processings in semiconductor manufacturing. This plasma source can be used for the following applications: plasma etching, deposition, sputtering systems, space propulsion, plasma-based sterilization, plasma abatement system. In another embodiment, the plasma source is in conjunction with one or several process chambers, which comprise an array of magnets and RF coils too . These elements can be used, on one hand, for plasma confinement or the active plasma control (Plasma rotation) thanks to feedback control approach, and one the other hand, for in situ NMR Monitoring or analysis such as moisture monitoring inside a process chamber, before or after the plasma process, or for in situ NMR Inspection of wafers or others workpieces.
摘要翻译：本发明的高密度RF等离子体源使用特殊的天线配置来发射诸如13,56MHz频率的波。该天线的可调性允许主动适应RF能量耦合到等离子体中，如在半导体制造中的等离子体处理中所发现的。该等离子体源可用于以下应用：等离子体蚀刻，沉积，溅射系统，空间推进，基于等离子体的灭菌，等离子体消除系统。在另一个实施例中，等离子体源与一个或多个处理室结合，该处理室也包括一组磁体和RF线圈。一方面，这些元件可以一方面用于等离子体约束或主动等离子体控制（等离子体旋转），这是由于反馈控制方法，另一方面，对于原位NMR监测或分析，例如处理室内的水分监测，在等离子体处理之前或之后，或用于晶片或其他工件的原位NMR检查。

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