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1. 发明授权

US5318596A Activity sensing pacemaker 失效
标题翻译：活动感应起搏器
公开(公告)号：US5318596A
公开(公告)日：1994-06-07
申请号：US791423
申请日：1991-11-13
申请人： Francisco J. Barreras , Oscar Jimenez
发明人： Francisco J. Barreras , Oscar Jimenez
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： The activity sensing pacemaker comprises: a heart pulse sensing device for sensing heart pulses; pulse generating circuitry for generating pacing pulses; activity sensing structure and circuitry for sensing activity/movement of a patient wearing the pacemaker in one or more of three directions/dimensions, x, y, z, and for causing the pulse generating circuitry to generate pacing pulses at a rate/frequency related to the movements sensed; and, control circuitry coupled to the heart pulse sensing device, to the pulse generating circuitry and to the activity sensing structure and circuitry for controlling the pulse generating circuitry in response to the heart pulses sensed or in response to the patient movements sensed, the activity sensing structure and circuitry causing generation of control pulses related to the movements of the patient and the control circuitry including frequency sensing circuitry for sensing the frequency of the control pulses generated and for controlling the rate/frequency of the pacing pulses generated by the pulse generating circuitry relative to the frequency of the control pulses generated by the movements of the patient in one or more directions/dimensions, x, y, z, independent of the duration or amplitude of the control pulses.
摘要翻译：活动感测起搏器包括：用于感测心脏脉搏的心脏脉搏感测装置; 产生起搏脉冲的脉冲发生电路; 活动感测结构和用于感测佩戴起搏器的患者在三个方向/尺寸x，y，z中的一个或多个中的活动/运动的电路，并且用于使脉冲发生电路以与/ 感觉到运动; 以及耦合到心脏脉冲感测装置的控制电路到脉冲发生电路以及响应于感测到的心脏脉冲或响应于感测到的患者运动而控制脉冲发生电路的活动感测结构和电路，活动感测导致产生与患者和控制电路的移动相关的控制脉冲的结构和电路，包括用于感测产生的控制脉冲的频率的频率感测电路，并且用于控制由脉冲发生电路相对产生的起搏脉冲的速率/频率与由控制脉冲的持续时间或振幅无关的一个或多个方向/维度x，y，z中由患者的运动产生的控制脉冲的频率。

2. 发明授权

US4558702A Cardiac pacer having input/output circuit programmable for use with unipolar and bipolar pacer leads 失效
标题翻译：具有输入/输出电路的心脏起搏器可编程以用于单极和双极引脚
公开(公告)号：US4558702A
公开(公告)日：1985-12-17
申请号：US459806
申请日：1983-01-21
申请人： Francisco J. Barreras , James P. Martucci
发明人： Francisco J. Barreras , James P. Martucci
IPC分类号： A61N1/368 , A61N1/372 , A61N1/36
CPC分类号： A61N1/368 , Y10S128/902
摘要： An implantable cardiac pacer having atrial and ventricular electrodes includes an input/output circuit which can be programmed for use with either unipolar or bipolar pacer leads. The circuit can be reprogrammed by the physician after implant to accommodate physiological changes in the patient or chronic changes in pacer lead characteristics, and can be utilized with single channel or dual channel cardiac pacers.
摘要翻译：具有心房和心室电极的可植入心脏起搏器包括输入/输出电路，其可被编程为与单极或双极起搏器引线一起使用。植入后电路可以由医生进行重新编程，以适应患者的生理变化或起搏器特征的慢性变化，并可用于单通道或双通道心脏呼吸器。

3. 发明授权

US5807397A Implantable stimulator with replenishable, high value capacitive power source and method therefor 失效
公开(公告)号：US5807397A
公开(公告)日：1998-09-15
申请号：US672328
申请日：1996-08-01
申请人： Francisco J. Barreras
发明人： Francisco J. Barreras
IPC分类号： A61N1/36 , A61N1/372 , A61N1/378 , H02J7/02 , A61N1/18
CPC分类号： A61N1/37223 , A61N1/3787 , H02J7/025
摘要： The implantable stimulator in accordance with the principles of the present invention utilizes a high value, small sized capacitor having at least a capacitive rating of 0.1 farads which is completely contained within the implantable stimulator. This high value, small size capacitor or series of capacitors enables the implantable stimulator to deliver, on a controlled and continual basis, electric stimulation pulses to targeted tissues over at least an 8 hour period. Further, the capacitive power source is replenished via an external, RF coupled device on a daily or other long term periodic basis. During the replenishing cycle, the energy contained in the battery of the external transmitter is transferred to the internal capacitive power source in the implantable stimulator. The method includes providing, on an exclusive basis, power to an implantable stimulator via a high value capacitive source during at least an 8 hour cycle of substantially continual delivery of electric stimulation pulses to targeted tissue. The method includes incorporating and containing a capacitive device in the implantable stimulator wherein the capacitive device has a capacitive rating of at least 0.1 farads. The capacitive device captures and stores a pre-determined amount of coulombs of electrical energy. This electrical energy is utilized to power the implantable stimulator during at least an 8 hour cycle during substantial continual delivery of electric stimulation pulses, all based upon energy stored by the capacitive device. Longer cycles (exceeding 24 hours) may be possible. The replenishment unit can be programmed to interrogate the implant and reprogram the implant upon detection of a lower power status signal. Also, automatic as well as manually commanded replenishment routines are established between the replenishment unit and the implant. Data transmission, error detection routines are established for the programming of the implant.

4. 发明授权

US5591217A Implantable stimulator with replenishable, high value capacitive power source and method therefor 失效
标题翻译：具有可补充，高价值电容电源的可植入刺激器及其方法
公开(公告)号：US5591217A
公开(公告)日：1997-01-07
申请号：US368326
申请日：1995-01-04
申请人： Francisco J. Barreras
发明人： Francisco J. Barreras
IPC分类号： A61N1/36 , A61N1/372 , A61N1/378 , H02J7/02 , A61N1/18
CPC分类号： A61N1/37223 , A61N1/3787 , H02J7/025
摘要： The implantable stimulator in accordance with the principles of the present invention utilizes a high value, small sized capacitor having at least a capacitive rating of 0.1 farads which is completely contained within the implantable stimulator. This high value, small size capacitor or series of capacitors enables the implantable stimulator to deliver, on a controlled and continual basis, electric stimulation pulses to targeted tissues over at least a 8 period. Further, the capacitive power source is recharged or replenished via an external, RF coupled device on a daily or other long term periodic basis. The method includes providing, on an exclusive basis, power to an implantable stimulator via a high value capacitive source during at least a twenty-four cycle of substantially continual delivery of electric stimulation pulses to targeted tissue. The method includes incorporating and containing a capacitive device in the implantable stimulator wherein the capacitive device has a capacitive rating of at least 0.1 farads. The capacitive device captures and stores a pre-determined amount of coulombs of electrical energy. This electrical energy is utilized to power the implantable stimulator during the 8 hour cycle during substantial continual delivery of electric stimulation pulses, all based upon energy stored by the capacitive device.
摘要翻译：根据本发明的原理的可植入式刺激器利用了具有至少具有0.1个法拉的电容额定值的高价值小型电容器，其完全包含在可植入刺激器内。这种高价值，小尺寸电容器或一系列电容器使得可植入的刺激器能够在受控和持续的基础上在至少8个周期内向目标组织传递电刺激脉冲。此外，电容性电源通过外部RF耦合器件以每天或其他长期周期性的基础被再充电或补充。该方法包括在至少二十四个周期内将电刺激脉冲基本上连续递送到目标组织，在独占的基础上提供经由高价值电容源的可植入刺激器的功率。该方法包括在可植入刺激器中并入和容纳电容性装置，其中电容性装置具有至少0.1个法拉的电容额定值。电容器件捕获并存储预定量的电能库仑。这种电能被用于在电刺激脉冲的基本持续传递期间的8小时循环期间为所述可植入刺激器供电，全部基于由电容性装置存储的能量。

5. 发明授权

US4556061A Cardiac pacer with battery consumption monitor circuit 失效
标题翻译：心脏起搏器与电池消耗监测电路
公开(公告)号：US4556061A
公开(公告)日：1985-12-03
申请号：US710531
申请日：1985-03-12
申请人： Francisco J. Barreras , Ira R. Baker
发明人： Francisco J. Barreras , Ira R. Baker
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/3708
摘要： A battery powered implantable cardiac pacer includes a battery consumption monitor circuit which develops within an internal counter a cumulative count of battery consumption in milliampere hours. The consumption count may be read out to an external indicator by a multiplex circuit to provide to the user an indication of battery life remaining. An over-current feature within the monitor circuit provides an alarm signal in the event that battery consumption exceeds a predetermined maximum level.
摘要翻译：电池供电的可植入心脏起搏器包括电池消耗监测电路，其在内部计数器内开发以毫安小时计的电池消耗的累积计数。可以通过多路复用电路将消耗计数读出到外部指示器，以向用户提供剩余电池寿命的指示。在电池消耗超过预定最大电平的情况下，监视器电路内的过流特征提供报警信号。

6. 发明授权

US4510945A P Wave detection system 失效
标题翻译： P波检测系统
公开(公告)号：US4510945A
公开(公告)日：1985-04-16
申请号：US397026
申请日：1982-07-12
申请人： Francisco J. Barreras
发明人： Francisco J. Barreras
IPC分类号： A61B5/04
CPC分类号： A61B5/04012
摘要： A system for detecting P waves samples a cardiac signal during first and second time periods set by a clock signal. Comparators determine whether the signal increases in voltage during the time periods by a predetermined value, testing whether the slew rate of the signal falls within a range corresponding to the slew rate of a P wave. Latches responsive to the comparators provide input to a logic circuit whose output clocks a counter. Three successive positive samples input into the counter will cause the counter to generate a signal indicating a P wave has been detected.
摘要翻译：用于检测P波的系统在由时钟信号设置的第一和第二时间段期间对心脏信号进行采样。比较器确定该信号在该时间段期间是否以电压增加一预定值，测试信号的转换速率是否落在与P波的转换速率相对应的范围内。响应于比较器的锁存器向输出计时器的逻辑电路提供输入。输入到计数器中的三个连续的正样本将导致计数器产生指示已经检测到P波的信号。

7. 发明授权

US4594565A Clock oscillator for a cardiac pacer having frequency compensation for temperature and voltage fluctuations 失效
标题翻译：心脏起搏器的时钟振荡器具有温度和电压波动的频率补偿
公开(公告)号：US4594565A
公开(公告)日：1986-06-10
申请号：US646222
申请日：1984-08-30
申请人： Francisco J. Barreras
发明人： Francisco J. Barreras
IPC分类号： A61N1/362 , A61N1/372 , H03K3/011 , H03K3/0231 , H03K3/03 , H03K3/57 , H03L1/02
CPC分类号： A61N1/37229 , A61N1/025 , A61N1/362 , H03K3/011 , H03K3/0231 , H03K3/0307 , A61N1/37211
摘要： A temperature and voltage stable clock circuit for use in implantable cardiac pacers employs CMOS devices to minimize current drain. The circuit includes a timing capacitor which is alternately charged to and discharged between two established threshold voltages during respective charge and discharge cycles, the periods of which determine the clock frequency. To render the frequency of the clock circuit independent of changes in capacitor charge and discharge currents brought about by changes in temperature, the threshold voltage is increased with temperature so that the charge and discharge cycles remain constant. To render the frequency of the clock circuit independent of changes in the power supply voltage, a Wilson current source is used to maintain a constant charge and discharge current to the timing capacitor.
摘要翻译：用于可植入心脏安培器的温度和电压稳定的时钟电路采用CMOS器件来最小化电流消耗。电路包括定时电容器，其在相应的充电和放电周期期间交替地充电到两个建立的阈值电压之间并在其周期中放电，其周期确定时钟频率。为了使时钟电路的频率独立于由温度变化引起的电容器充电和放电电流的变化，阈值电压随温度升高，使得充电和放电周期保持不变。为了使时钟电路的频率独立于电源电压的变化，威尔逊电流源用于保持恒定的充电和放电电流到定时电容器。

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