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1. 发明授权

US06524837B1 Hydantoinase variants with improved properties and their use for the production of amino acids 有权
标题翻译：具有改进性质的乙内酰脲酶变体及其用于生产氨基酸的用途
公开(公告)号：US06524837B1
公开(公告)日：2003-02-25
申请号：US09497585
申请日：2000-02-03
申请人： Frances H. Arnold , Oliver May , Karlheinz Drauz , Andreas Bommarius
发明人： Frances H. Arnold , Oliver May , Karlheinz Drauz , Andreas Bommarius
IPC分类号： C12N986
CPC分类号： C12P13/12 , C07H21/04 , C12N9/86 , C12P13/04 , C12P13/06 , C12P13/08 , C12P41/009
摘要： Hydantoinase enzymes which are mutants of a previously isolated hydantoinase having the amino acid SEQ. ID. NO. 2. The mutants include amino acid substitutions at positions 95, 154, 180, 251 and/or 255 of the wild type hydantoinase (SEQ. ID. NO. 2). The mutant hydantoinases, like the parent hydantoinase, are used in the production of optically pure amino acids.
摘要翻译：乙内酰脲酶，其是具有氨基酸SEQ ID NO：1的先前分离的乙内酰脲酶的突变体。 ID。没有。突变体包括野生型乙内酰脲酶（SEQ ID NO：2）的95,54,180,251和/或255位的氨基酸取代。突变的乙内酰脲酶，如亲水乙内酰脲酶，用于生产光学纯氨基酸。

2. 发明授权

US06800464B2 Arthrobacter D-carbamoylase and methods of preparing enantiomerically enriched D-amino acids 有权
标题翻译：节杆菌D-氨基甲酰酶和制备对映异构体富集的D-氨基酸的方法
公开(公告)号：US06800464B2
公开(公告)日：2004-10-05
申请号：US10105294
申请日：2002-03-26
申请人： Karlheinz Drauz , Oliver May , Andreas Bommarius , Christoph Syldatk , Josef Altenbuchner , Markus Werner , Martin Siemann-Herzberg
发明人： Karlheinz Drauz , Oliver May , Andreas Bommarius , Christoph Syldatk , Josef Altenbuchner , Markus Werner , Martin Siemann-Herzberg
IPC分类号： C12P1304
CPC分类号： C12N9/80 , C12N2310/111 , C12P13/04 , C12P41/009 , G01N2333/195
摘要： The present invention relates to a new D-carbamoylase and the gene sequences which code for this from the organism Arthrobacter crystallopoietes DSM 20117. Plasmids, vectors, microorganisms, particular primers and specific possible uses of the enzymes according to the invention are also mentioned. The invention moreover describes a new process for the discovery of enzymes which can be employed in a process for the preparation of D-amino acids starting from 5′-substituted hydantoins.
摘要翻译：本发明涉及一种新的D-氨基甲酰基酶和从生物体节杆菌结晶洗脱剂DSM 20117中为此编码的基因序列。还提及了根据本发明的酶的质粒，载体，微生物，特定引物和具体可能的用途。本发明还描述了用于发现酶的新方法，其可用于从5'-取代的乙内酰脲开始制备D-氨基酸的方法。

3. 发明申请

US20050101813A1 Molecular weight-enlarged ligands for asymmetric, homogeneously soluble hydrogenation catalysts, process for the production thereof and use 审中-公开
标题翻译：用于不对称，均相可溶的氢化催化剂的分子量扩大配体，其生产方法和用途
公开(公告)号：US20050101813A1
公开(公告)日：2005-05-12
申请号：US10656220
申请日：2003-09-08
申请人： Hans-Peter Krimmer , Jens Woeltinger , Olaf Burkhardt , Ingo Klement , Hans Henniges , Karlheinz Drauz , Andreas Bommarius , Jean-Louis Philippe , Andreas Karau
发明人： Hans-Peter Krimmer , Jens Woeltinger , Olaf Burkhardt , Ingo Klement , Hans Henniges , Karlheinz Drauz , Andreas Bommarius , Jean-Louis Philippe , Andreas Karau
IPC分类号： C07C5/02
CPC分类号： B01J31/1683 , B01J31/1805 , B01J31/1815 , B01J31/2291 , B01J31/2404 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/0266 , B01J2531/0272 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845
摘要： A molecular weight-enlarged, homogeneously soluble ligand, useful in catalysts, particularly for the synthesis of enantiomerically enriched organic compounds, includes: a weight average molecular weight of at least 1000 g/mol; a molecular weight-enlarging polymer; optionally, a polymer linker; and at least one homochiral active center; wherein the active center is bound to the molecular weight-enlarging polymer through the polymer linker or is bound directly to the molecular weight-enlarging polymer.
摘要翻译：可用于催化剂，特别是用于合成对映异构体富集的有机化合物的分子量增大的均匀可溶性配体包括：重均分子量至少为1000g / mol; 分子量增大的聚合物; 任选地，聚合物接头; 和至少一个同义词活性中心; 其中活性中心通过聚合物接头与分子量增加的聚合物结合，或直接结合到分子量增加的聚合物上。

4. 发明授权

US06624248B2 Polymeric diphosphine ligands for homogeneously soluble hydrogenation catalysts, process for the production thereof and use 失效
标题翻译：用于均相可溶性氢化催化剂的聚合二膦配体，其制备方法和用途
公开(公告)号：US06624248B2
公开(公告)日：2003-09-23
申请号：US09767873
申请日：2001-01-24
申请人： Olaf Burkhardt , Jens Woltinger , Andreas Bommarius , Juan Jose Almena Perea , Hans Henniges , Karlheinz Drauz , Andreas Karau , Jean-Louis Philippe , Hans-Peter Krimmer , Gunther Oehme
发明人： Olaf Burkhardt , Jens Woltinger , Andreas Bommarius , Juan Jose Almena Perea , Hans Henniges , Karlheinz Drauz , Andreas Karau , Jean-Louis Philippe , Hans-Peter Krimmer , Gunther Oehme
IPC分类号： C08L8502
CPC分类号： C08F8/40 , B01J31/1675 , B01J31/1683 , B01J31/181 , B01J31/24 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00
摘要： Molecular weight-enlarged, homogeneously soluble ligands are provided that are especially useful for hydrogenation catalysts, wherein the ligands contain homochiral active centers of bis(3,4-diarylphosphinyl)pyrrolidines, and their use in producing cataylsts for enantioselective reactions, as well as the catalysts thus produced.
摘要翻译：提供了分子量增大的均匀可溶性配体，其特别可用于氢化催化剂，其中配体含有双（3,4-二芳基氧膦基）吡咯烷的同基因活性中心，以及它们在制备用于对映选择性反应的催化剂中的用途，以及催化剂。

5. 发明授权

US06333176B1 Process for obtaining microorganisms containing peptide amidase, microorganisms obtained therewith, peptide amidases contained in them and use thereof 失效
标题翻译：用于获得含有肽酰胺酶的微生物，由其获得的微生物，其中包含的肽酰胺酶和其用途的方法
公开(公告)号：US06333176B1
公开(公告)日：2001-12-25
申请号：US09382590
申请日：1999-08-25
申请人： Ursula Stelkes-Ritter , Maria-Regina Kula , Klaudia Wyzgol , Andreas Bommarius , Michael Schwarm , Karlheinz Drauz
发明人： Ursula Stelkes-Ritter , Maria-Regina Kula , Klaudia Wyzgol , Andreas Bommarius , Michael Schwarm , Karlheinz Drauz
IPC分类号： C12N902
CPC分类号： C12R1/64 , C12N9/80
摘要： A plant peptide amidase from the flavedo of oranges is known; this can be obtained only in small quantities and is seasonal. The proposed new enzymes are microbial peptide amidases which can be obtained from micro-organisms recovered from soil samples in a “double screening” and grown. These microbial peptide amidases are particularly useful for (a) the production of peptides and N-terminal-protected amino acids, (b) racemate splitting of N-protected amino acid amides, (c) obtaining non-proteinogenous D-amino acids, and (d) obtaining new N&agr;-protected D-amino acid amides.
摘要翻译：来自桔梗的植物肽酰胺酶是已知的; 这只能以少量获得，并且是季节性的。所提出的新酶是微生物肽酰胺酶，其可以从“双重筛选”中从土壤样品中回收的微生物获得并生长。这些微生物肽酰胺酶特别可用于（a）肽和N-末端保护的氨基酸的产生，（b）N-保护的氨基酸酰胺的外消旋物分裂，（c）获得非蛋白质性的D-氨基酸，和（d）获得新的Nalpha保护的D-氨基酸酰胺。

6. 发明授权

US6114163A Process for obtaining active L-.alpha.-amino carboxylic acids from corresponding racemic d, L-.alpha.-amino carboxylic acids 失效
标题翻译：从相应的外消旋d，L-α-氨基羧酸获得活性的L-α-氨基羧酸的方法
公开(公告)号：US6114163A
公开(公告)日：2000-09-05
申请号：US94321
申请日：1998-06-16
申请人： Karlheinz Drauz , Andreas Bommarius , Michael Karrenbauer , Gunter Knaup
发明人： Karlheinz Drauz , Andreas Bommarius , Michael Karrenbauer , Gunter Knaup
IPC分类号： C07C227/34 , C07C227/36 , C07C319/20 , C07C323/60 , C12P13/04 , C12P41/00 , C07C1/00
CPC分类号： C12P41/007 , C07C227/34 , C07C227/36 , C07C319/20 , C12P13/04
摘要： The disclosure relates to a process for obtaining optically active L-.alpha.-aminocarboxylic acids from the corresponding racemic D,L,.alpha.-aminocarboxylic acids. The following steps are involved: (a) the D,L,.alpha.-aminocarboxylic acids are acetylated; (b) the N-acetyl-L-.alpha.-aminocarboxylic acid present in the mixture of N-acetyl-D,L,.alpha.-aminocarboxylic acids thus obtained is broken down enzymatically into the L-.alpha.-aminocarboxylic acid; (c) the L-.alpha.-aminocarboxylic acid is separated from the mixture, a quantity of a solution of N-acetyl-D(L)-.alpha.-aminocarboxylic acids and a quantity of acetate equivalent to the L-.alpha.-aminocarboxylic acid being retained; and (d) the N-acetyl-D(L)-.alpha.-aminocarboxylic acid is racemized and recycled for enzymatic breakdown. Known extraction processes involving steps (a) to (d) have the disadvantage of producing large quantities of salt. Specifically, the processes are far removed from the ideal equation, according to which one hundred percent of the acetic anhydride and the D,L,.alpha.-aminocarboxylic acids are converted to L-.alpha.-aminocarboxylic acids and acetic acid. Adjusting the retained solution from step (c) in such a way as to obtain a solution consisting essentially of N-acetyl-D-(L)-.alpha.-aminocarboxylic acid salt and free acetic acid in equilibrium with acetate and free N-acetyl-D(L)-.alpha.-aminocarboxylic acid and from which acetic acid is extracted by distillation makes it surprisingly easy to feed the solution formed as "mother liquor" following separation of the L-.alpha.-aminocarboxylic acid in the circuit and to achieve a materials balance as close as possible to the ideal.
摘要翻译：本公开涉及从相应的外消旋D，L，α-氨基羧酸获得光学活性的L-氨基羧酸的方法。涉及以下步骤：（a）D，L，α-氨基羧酸被乙酰化; （b）将由此获得的N-乙酰基-D，L，α-氨基羧酸的混合物中存在的N-乙酰基-L-α-氨基羧酸酶促分解成L-氨基羧酸; （c）从混合物中分离出L-α-氨基羧酸，一定量的N-乙酰基-D（L）-α-氨基羧酸溶液和一定量的乙酸钠相当于L-氨基羧酸为保留和（d）N-乙酰基-D（L）-α-氨基羧酸被外消旋化并再循环用于酶分解。涉及步骤（a）至（d）的已知提取方法具有产生大量盐的缺点。具体来说，这些方法远远不能从理想方程中去除，根据其中百分之百的乙酸酐和D，L，α-氨基羧酸被转化成L-α-氨基羧酸和乙酸。调节步骤（c）中保留的溶液，以获得基本上由N-乙酰基-D-（L）-α-氨基羧酸盐和游离乙酸与乙酸酯和游离N-乙酰基 - D（L）-α-氨基羧酸，通过蒸馏萃取乙酸，使得在电路中分离出L-α-氨基羧酸之后，使得形成为“母液”的溶液容易进料，并获得材料平衡尽可能接近理想。

7. 发明授权

US5827717A Microorganisms their use and method of producing L-.alpha.-amino acids 失效
标题翻译：微生物的用途和生产L-α-氨基酸的方法
公开(公告)号：US5827717A
公开(公告)日：1998-10-27
申请号：US595214
申请日：1996-02-01
申请人： Fritz Wagner , Dirk Volkel , Andreas Bommarius , Karlheinz Drauz
发明人： Fritz Wagner , Dirk Volkel , Andreas Bommarius , Karlheinz Drauz
IPC分类号： C12N1/20 , C12N1/21 , C12N9/86 , C12N15/09 , C12P13/04 , C12P41/00 , C12R1/06 , C12N9/14 , C07H21/04 , C12N5/00 , C12N9/90
CPC分类号： C12P41/009 , C12P13/04 , Y10S435/83
摘要： The invention relates to novel microorganisms, their use and method of producing L-.alpha.-amino acids. In particular, microorganisms DSM 7329 and 7330 are suitable for the production of L-.alpha.-amino acids from corresponding hydantoins or carbamoyl-.alpha.-amino acids. These novel microorganisms are simple to cultivate and make possible high L-.alpha.-amino acid yields from different substrates.
摘要翻译：本发明涉及新的微生物，其用途和生产L-氨基酸的方法。特别地，微生物DSM 7329和7330适用于从相应的乙内酰脲或氨基甲酰基-α-氨基酸生产L-α-氨基酸。这些新颖的微生物很容易培养，并使不同底物产生高的α-α-氨基酸。

8. 发明授权

US06372459B1 N-acetyl amino acid racemase 失效
标题翻译： N-乙酰氨基酸消旋酶
公开(公告)号：US06372459B1
公开(公告)日：2002-04-16
申请号：US09624390
申请日：2000-07-27
申请人： Stefan Verseck , Maria-Regina Kula , Andreas Bommarius , Karlheinz Drauz
发明人： Stefan Verseck , Maria-Regina Kula , Andreas Bommarius , Karlheinz Drauz
IPC分类号： C12P1304
CPC分类号： C12P41/007 , C12N9/90
摘要： The present invention is directed to an N-acetyl amino acid racemase (AAR) as well as the gene coding for it, to a plasmid, vector and microroganism containing the gene. A method of producing enantiomer-enriched amino acids, and derivatives thereof, is also provided.
摘要翻译：本发明涉及N-乙酰氨基酸消旋酶（AAR）以及编码它的基因，涉及含有该基因的质粒，载体和微团聚体。还提供了产生对映体富集的氨基酸及其衍生物的方法。

9. 发明授权

US06251625B1 Process for preparing peptides and N-carbamoyl-protected peptides 失效
标题翻译：制备肽和N-氨基甲酰保护肽的方法
公开(公告)号：US06251625B1
公开(公告)日：2001-06-26
申请号：US09011859
申请日：1998-04-03
申请人： Andreas Bommarius , Karlheinz Drauz , Uwe Eichhorn , Hans-Dieter Jakubke , Matthias Kottenhahn
发明人： Andreas Bommarius , Karlheinz Drauz , Uwe Eichhorn , Hans-Dieter Jakubke , Matthias Kottenhahn
IPC分类号： C12P2106
CPC分类号： C12P21/02 , C07K1/063 , Y02P20/55
摘要： The invention concerns a process for the enzymatic preparation of protected di- and oligopeptides and the separation of the protective groups used. The process according to the invention enables peptides to be synthesized simply and economically and the protective group to be separated carefully. The process comprises three reaction steps: 1. Preparation of N-carbamoyl amino acid or N-carbamoyl amino acid derivatives; 2. Formation of the peptide bond between the carbamoyl-protected electrophile and nucelophile; and 3. Separation of the carbamoyl-protective group.
摘要翻译：本发明涉及用于酶制备受保护的二肽和寡肽以及所用保护基的分离的方法。根据本发明的方法使得肽可以简单和经济地合成，并且保护基被仔细分离。该方法包括三个反应步骤：1.制备N-氨基甲酰基氨基酸或N-氨基甲酰基氨基酸衍生物; 氨基甲酰基保护的亲电子和生物素之间的肽键的形成; 和3.氨基甲酰基保护基的分离。

10. 发明授权

US06180551B2 Process for preparing MeO-Peg-protected dihydroquinine or dihydroquinidine derivatives, new dihydroquinine or dihydroquinidine derivatives and their use 失效
标题翻译：制备MeO-Peg-保护的二氢奎尼丁或二氢奎尼丁衍生物的方法，新的二氢喹啉或二氢奎尼丁衍生物及其用途
公开(公告)号：US06180551B2
公开(公告)日：2001-01-30
申请号：US09504183
申请日：2000-02-15
申请人： Carsten Bolm , Arne Gerlach , Karlheinz Drauz , Andreas Bommarius
发明人： Carsten Bolm , Arne Gerlach , Karlheinz Drauz , Andreas Bommarius
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07B53/00 , C07D453/04
摘要： Process for the formation of MeO-Peg-protected dihydroquinine or dihydro quinindine derivatives, new dihydroquinine-or dihyroquinidine derivatives as well as the use thereof. It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands, can be recycled after enantioselective dihydroxylation by precipitating and filtering the reaction medium, and be reused in the reaction medium. Also disclosed are the ligand systems (I) and (IV), process for preparing the same and their use in the enantioselective dihydroxiation of double bonds.
摘要翻译：形成MeO-Peg-保护的二氢喹啉或二氢喹啉衍生物，新的二氢喹啉或二氢喹啉衍生物的方法及其用途。已知二氢奎尼丁或二氢奎尼丁衍生物可以成功地用作对映选择性二羟基化的配体。与现有技术的配体不同，新公开的基于二氢喹啉/奎尼丁的配体体系可以通过沉淀和过滤反应介质在对映选择性二羟基化之后再循环，并在反应介质中重新使用。还公开了配体体系（I）和（IV），其制备方法及其在双键对映体选择性二氢化中的用途。

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