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1. 发明授权

US07575903B2 CHR and POMC effects on animal growth 有权
标题翻译： CHR和POMC对动物生长的影响
公开(公告)号：US07575903B2
公开(公告)日：2009-08-18
申请号：US11790511
申请日：2007-04-26
申请人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
发明人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
IPC分类号： C12P19/34
CPC分类号： C12Q1/6888 , C07K14/57509 , C12Q2600/156
摘要： The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the knowledge of their CRH, POMC and MC4R genotypes. The predictive value comes from the discovery that certain single nucleotide polymorphisms (SNPs) in these genes are linked to higher growth rate phenotypes. Specifically, the phenotypes that correlated with specific SNP's are end-of-test rib-eye area, adjusted weaning weight, average daily gain, shipping weight and hot carcass weight. The invention also provides novel kits that can be used in making the determination of these genotypes. The invention further provides for methods of screening bovines to predict which animals will have higher growth rate, allowing producers to selectively breed and manage animals based on desired characteristics, thereby maximizing productivity and profitability in commercial meat production operations.
摘要翻译：本发明提供了选择将显示与增长的生长速率相关的表型的牛动物。基于其CRH，POMC和MC4R基因型的知识，这些表型包括热胴体重，平均日增重，运输重量，测试肋眼面积的结束和调整的断奶重量，这是产后生长的量度。预测值来自发现这些基因中的某些单核苷酸多态性（SNPs）与较高生长速率表型相关联。具体来说，与特异性SNP相关的表型是测试结束面积，调整的断奶重量，平均日增重，运输重量和热胴体重。本发明还提供可用于确定这些基因型的新型试剂盒。本发明还提供了筛选牛的方法以预测哪些动物具有较高的生长速率，允许生产者基于期望的特征来选择性繁殖和管理动物，从而最大限度地提高商业肉类生产操作中的生产率和获利能力。

2. 发明申请

US20120004402A1 CRH AND POMC EFFECTS ON ANIMAL GROWTH 有权
标题翻译： CRH和POMC对动物生长的影响
公开(公告)号：US20120004402A1
公开(公告)日：2012-01-05
申请号：US13180617
申请日：2011-07-12
申请人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
发明人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
IPC分类号： C07H21/04
CPC分类号： C12Q1/6888 , C07K14/57509 , C12Q2600/156
摘要： The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the knowledge of their CRH, POMC and MC4R genotypes. The predictive value comes from the discovery that certain single nucleotide polymorphisms (SNPs) in these genes are linked to higher growth rate phenotypes. Specifically, the phenotypes that correlated with specific SNP's are end-of-test rib-eye area, adjusted weaning weight, average daily gain, shipping weight and hot carcass weight. The invention also provides novel kits that can be used in making the determination of these genotypes. The invention further provides for methods of screening bovines to predict which animals will have higher growth rate, allowing producers to selectively breed and manage animals based on desired characteristics, thereby maximizing productivity and profitability in commercial meat production operations.
摘要翻译：本发明提供了选择将显示与增长的生长速率相关的表型的牛动物。基于其CRH，POMC和MC4R基因型的知识，这些表型包括热胴体重，平均日增重，运输重量，测试肋眼面积的结束和调整的断奶重量，这是产后生长的量度。预测值来自发现这些基因中的某些单核苷酸多态性（SNPs）与较高生长速率表型相关联。具体来说，与特异性SNP相关的表型是测试结束面积，调整的断奶重量，平均日增重，运输重量和热胴体重。本发明还提供可用于确定这些基因型的新型试剂盒。本发明还提供了筛选牛的方法以预测哪些动物具有较高的生长速率，允许生产者基于期望的特征来选择性繁殖和管理动物，从而最大限度地提高商业肉类生产操作中的生产率和获利能力。

3. 发明授权

US07993882B2 CRH and POMC effects on animal growth 失效
标题翻译： CRH和POMC对动物生长的影响
公开(公告)号：US07993882B2
公开(公告)日：2011-08-09
申请号：US12510307
申请日：2009-07-28
申请人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
发明人： Fiona Buchanan , Tracey D. Thue , Dianne Winkelman-Sim
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6888 , C07K14/57509 , C12Q2600/156
摘要： The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the knowledge of their CRH, POMC and MC4R genotypes. The predictive value comes from the discovery that certain single nucleotide polymorphisms (SNPs) in these genes are linked to higher growth rate phenotypes. Specifically, the phenotypes that correlated with specific SNP's are end-of-test rib-eye area, adjusted weaning weight, average daily gain, shipping weight and hot carcass weight. The invention further provides for methods of screening bovines to predict which animals will have higher growth rate, allowing producers to selectively breed and manage animals based on desired characteristics, thereby maximizing productivity and profitability in commercial meat production operations.
摘要翻译：本发明提供了选择将显示与增长的生长速率相关的表型的牛动物。基于其CRH，POMC和MC4R基因型的知识，这些表型包括热胴体重，平均日增重，运输重量，测试肋眼面积的结束和调整的断奶重量，这是产后生长的量度。预测值来自发现这些基因中的某些单核苷酸多态性（SNPs）与较高生长速率表型相关联。具体来说，与特异性SNP相关的表型是测试结束面积，调整的断奶重量，平均日增重，运输重量和热胴体重。本发明还提供了筛选牛的方法以预测哪些动物具有较高的生长速率，允许生产者基于期望的特征来选择性繁殖和管理动物，从而最大限度地提高商业肉类生产操作中的生产率和获利能力。

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