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1. 发明授权

US5271389A Ventilator control system that generates, measures, compares, and corrects flow rates 失效
标题翻译：呼吸机控制系统可以生成，测量，比较和校正流量
公开(公告)号：US5271389A
公开(公告)日：1993-12-21
申请号：US836773
申请日：1992-02-12
申请人： Fernando J. Isaza , Stanley Y. Wong
发明人： Fernando J. Isaza , Stanley Y. Wong
IPC分类号： A61M16/00 , A61M16/20 , G05D7/06 , A62B7/00 , A62B9/02 , F16K31/02
CPC分类号： G05D7/0635 , A61M16/00 , A61M16/204 , A61M2016/0036
摘要： The present invention provides a system and method for providing an improved correction to an input flow control signal to a flow control valve in a ventilator system. The correction as derived from a sum of the error in the flow rate actually delivered as compared with the desired flow rate for each control interval in a breath with the sum of past errors corresponding to control intervals in past breaths to generate a cumulative error signal for application in the control interval in a next breath. The cumulative error signal is stored as the sum of previous sustained errors arising periodically in the system for each control interval of previous breaths, and is integrated with the current error signal for each control interval to generate an integrated correction component signal. The input flow control signal is summed with the integrated correction component to generate a corrected command flow signal to the flow control valve.

2. 发明授权

US5813399A System and method for closed loop airway pressure control during the inspiratory cycle of a breath in a patient ventilator using the exhalation valve as a microcomputer-controlled relief valve 失效
标题翻译：使用呼气阀作为微电脑控制的安全阀，在患者呼吸机的呼吸吸气循环中进行闭环气道压力控制的系统和方法
公开(公告)号：US5813399A
公开(公告)日：1998-09-29
申请号：US782563
申请日：1997-01-10
申请人： Fernando J. Isaza , Stanley Y. Wong
发明人： Fernando J. Isaza , Stanley Y. Wong
IPC分类号： A61M16/00 , A61M16/20 , A62B7/00 , A62B9/02 , F16K31/02
CPC分类号： A61M16/20 , A61M16/00 , A61M16/204 , A61M16/206 , A61M2016/0039 , A61M2016/0042
摘要： The method and system for controlling airway pressure in a ventilator during the inspiratory cycle involves controlling the flow of breathing gas through a flow supply valve venting the breathing gas at a desired rate of outflow through a relief valve to achieve the desired airway pressure. Measurements of the rates of actual supply flow, the actual outflow through the exhalation/relief valve, and the pressure in the airway are compared with desired values for determination the amount of error for feedback control of the ventilator system.
摘要翻译：用于在吸气循环期间控制通气机中的气道压力的方法和系统包括通过流动供应阀控制呼吸气体的流动，该呼吸气体以期望的流出速率通过安全阀排出呼吸气体，以实现所需的气道压力。将实际供应流量，通过呼气/安全阀的实际流量以及气道中的压力进行测量与用于确定呼吸机系统的反馈控制的误差量的期望值进行比较。

3. 再颁专利

USRE39225E1 System and method for adjustable disconnection sensitivity for disconnection and occlusion detection in a patient ventilator 有权
标题翻译：用于患者通气机中断路和闭塞检测的可调断开灵敏度的系统和方法
公开(公告)号：USRE39225E1
公开(公告)日：2006-08-08
申请号：US09811104
申请日：2001-03-16
申请人： Fernando J. Isaza , Stanley Y. Wong , Peter Doyle
发明人： Fernando J. Isaza , Stanley Y. Wong , Peter Doyle
IPC分类号： A61M16/00
CPC分类号： A61M16/0051 , A61M16/024 , A61M16/0833 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2039/1005 , A61M2205/15
摘要： The system and method for detecting disconnection and occlusion of a tubing system of a patient ventilator detects disconnection of the tubing system, opens the exhalation valve, delivers an idle flow of breathing gas to the tubing system, disables breath triggering, and generates an alarm. A reconnection of the tubing system can also be detected, to initiate resumption of pressure supported inspiration. For occlusion detection, the pressure drop in the tubing system is determined by pressure sensors in the inspiratory and expiratory airways of the tubing system. The two pressure drop values are compared, and once occlusion is detected, an alarm is generated, and the ventilator responds to protect the patient from over distension. Abatement of the occlusion can also be monitored in a pressure based occlusion status cycling mode, and the ventilator can revert back to normal ventilation when the circuit occlusion or exhaust port occlusion are not detected.
摘要翻译：用于检测断开的系统和方法<？delete-start id =“DEL-S-00001”date =“20060808”？>和管道系统的闭塞<？delete-end id =“DEL-S-00001”？患者呼吸机检测到管道系统的断开，打开呼气阀，将呼吸气体的空气流输送到管道系统，禁止呼吸触发，并产生警报。还可以检测管道系统的重新连接，以启动压力支持的灵感的恢复。 <？delete-start id =“DEL-S-00002”date =“20060808”？>对于闭塞检测，管道系统中的压降由管道系统的吸气和呼气气道中的压力传感器决定。比较两个压降值，一旦检测到闭塞，则产生报警，呼吸机响应，以保护患者免受过度膨胀。也可以在基于压力的闭塞状态循环模式下监视闭塞的消除，并且当未检测到电路闭塞或排气口遮挡时，呼吸机可以恢复正常通气。<？delete-end id =“DEL-S- 00002“？>

4. 发明授权

US5319540A System and method for controlling a periodically actuated ventilation flow system 失效
标题翻译：用于控制周期性致动的通风流系统的系统和方法
公开(公告)号：US5319540A
公开(公告)日：1994-06-07
申请号：US116917
申请日：1993-09-07
申请人： Fernando J. Isaza , Stanley Y. Wong
发明人： Fernando J. Isaza , Stanley Y. Wong
IPC分类号： A61M16/00 , A61M16/20 , G05D7/06 , G05B13/02
CPC分类号： G05D7/0635 , A61M16/00 , A61M16/204 , A61M2016/0036
摘要： The present invention provides a system and method for providing a correction to a flow control signal to a flow control valve in a ventilator system. The correction component sums the errors in the flow rate actually delivered as compared with the desired flow rate for each control interval in a breath with the sum of past errors corresponding to control intervals in past breaths to generate a corrected command flow signal to the flow control valve.
摘要翻译：本发明提供一种用于向通气机系统中的流量控制阀提供对流量控制信号的校正的系统和方法。校正部件将与呼吸中的每个控制间隔的期望流量相比实际传送的流量的误差与对应于过去呼吸中的控制间隔的过去误差的总和相加，以产生到流量控制的校正的指令流信号阀。

5. 发明授权

US06739337B2 System and method for transient response and accuracy enhancement for sensors with known transfer characteristics 有权
标题翻译：具有已知传输特性的传感器的瞬态响应和精度增强的系统和方法
公开(公告)号：US06739337B2
公开(公告)日：2004-05-25
申请号：US10400958
申请日：2003-03-27
申请人： Fernando J. Isaza
发明人： Fernando J. Isaza
IPC分类号： A61M1600
CPC分类号： G01F25/0007 , A61M16/024 , A61M2016/0039 , G01F1/6965
摘要： A parameter of interest being measured by a sensor is estimated from output response data from the sensor and the known transfer function of the sensor, allowing fast and accurate sensor data from sensors having a dynamic characteristic otherwise precluding assessment of the sensor input. A parameter of breathing gas from a ventilator is determined based upon the known transfer function and a plurality of the sensor output signals at predetermined intervals of time, to provide an estimation of the parameter of interest.
摘要翻译：根据传感器的输出响应数据和传感器的已知传递函数，估计传感器测量的感兴趣的参数，从而具有动态特性的传感器的快速准确的传感器数据，否则可以阻止传感器输入的评估。来自通气机的呼吸气体的参数基于已知的传递函数和多个传感器输出信号以预定的时间间隔来确定，以提供感兴趣的参数的估计。

6. 发明授权

US06553991B1 System and method for transient response and accuracy enhancement for sensors with known transfer characteristics 有权
标题翻译：具有已知传输特性的传感器的瞬态响应和精度增强的系统和方法
公开(公告)号：US06553991B1
公开(公告)日：2003-04-29
申请号：US09231145
申请日：1999-01-15
申请人： Fernando J. Isaza
发明人： Fernando J. Isaza
IPC分类号： A61M1600
CPC分类号： G01F25/0007 , A61M16/024 , A61M2016/0039 , G01F1/6965
摘要： A parameter of interest being measured by a sensor is estimated from output response data from the sensor and the known transfer function of the sensor, allowing fast and accurate sensor data from sensors having a dynamic characteristic otherwise precluding assessment of the sensor input. A parameter of breathing gas from a ventilator is determined based upon the known transfer function and a plurality of the sensor output signals at predetermined intervals of time, to provide an estimation of the parameter of interest.
摘要翻译：根据传感器的输出响应数据和传感器的已知传递函数，估计传感器测量的感兴趣的参数，从而具有动态特性的传感器的快速准确的传感器数据，否则可以阻止传感器输入的评估。来自通气机的呼吸气体的参数基于已知的传递函数和多个传感器输出信号以预定的时间间隔来确定，以提供感兴趣的参数的估计。

7. 发明授权

US06668824B1 System and method for adjustable disconnection sensitivity for disconnection and occlusion detection in a patient ventilator 有权
标题翻译：用于患者通气机中断路和闭塞检测的可调断开灵敏度的系统和方法
公开(公告)号：US06668824B1
公开(公告)日：2003-12-30
申请号：US09518772
申请日：2000-03-03
申请人： Fernando J. Isaza , Stanley Wong , Itzhak Verona , Peter Doyle
发明人： Fernando J. Isaza , Stanley Wong , Itzhak Verona , Peter Doyle
IPC分类号： A61M1600
CPC分类号： A61M16/0051 , A61M16/024 , A61M16/0833 , A61M2016/0027 , A61M2016/0039 , A61M2016/0042 , A61M2039/1005 , A61M2205/15
摘要： The system and method for detecting disconnection and occlusion of a tubing system of a patient ventilator detects disconnection of the tubing system, opens the exhalation valve, delivers an idle flow of breathing gas to the tubing system, disables breath triggering, and generates an alarm. A reconnection of the tubing system can also be detected, to initiate resumption of pressure supported inspiration. For occlusion detection, the pressure drop in the tubing system is determined by pressure sensors in the inspiratory and expiratory airways of the tubing system. The two pressure drop values are compared, and once occlusion is detected, an alarm is generated, and the ventilator responds to protect the patient from over distension. Abatement of the occlusion can also be monitored in a pressure based occlusion status cycling mode, and the ventilator can revert back to normal ventilation when either circuit occlusion or exhaust port occlusion are not detected.
摘要翻译：用于检测患者呼吸机的管道系统的断开和闭塞的系统和方法检测管道系统的断开，打开呼气阀，将呼吸气体的空闲流量输送到管道系统，禁止呼吸触发并产生警报。还可以检测管道系统的重新连接，以启动压力支持的灵感的恢复。对于闭塞检测，管道系统中的压降由管道系统的吸气和呼气气道中的压力传感器确定。比较两个压降值，一旦检测到闭塞，则产生报警，呼吸机响应，以保护患者免受过度膨胀。也可以在基于压力的阻塞状态循环模式下监测闭塞的消除，并且当没有检测到电路闭塞或排气口闭塞时，呼吸机可以恢复到正常通气。

8. 发明授权

US5881717A System and method for adjustable disconnection sensitivity for disconnection and occlusion detection in a patient ventilator 失效
公开(公告)号：US5881717A
公开(公告)日：1999-03-16
申请号：US818173
申请日：1997-03-14
申请人： Fernando J. Isaza
发明人： Fernando J. Isaza
IPC分类号： A61M16/00 , A61M39/10
CPC分类号： A61M16/0051 , A61M2016/0039 , A61M2016/0042 , A61M2039/1005 , A61M2205/15
摘要： The system and method for detecting disconnection and occlusion of a tubing system of a patient ventilator detects disconnection of the tubing system, opens the exhalation valve, delivers an idle flow of breathing gas to the tubing system, disables breath triggering, and generates an alarm. A reconnection of the tubing system can also be detected, to initiate resumption of pressure supported inspiration. For occlusion detection, the pressure drop in the tubing system is determined by pressure sensors in the inspiratory and expiratory airways of the tubing system. The two pressure drop values are compared, and once occlusion is detected, an alarm is generated, and the ventilator responds to protect the patient from over distension. Abatement of the occlusion can also be monitored in a pressure based occlusion status cycling mode, and the ventilator can revert back to normal ventilation when either circuit occlusion or exhaust port occlusion are not detected.

9. 发明授权

US5865168A System and method for transient response and accuracy enhancement for sensors with known transfer characteristics 失效
公开(公告)号：US5865168A
公开(公告)日：1999-02-02
申请号：US818174
申请日：1997-03-14
申请人： Fernando J. Isaza
发明人： Fernando J. Isaza
IPC分类号： A61M16/00 , G01F1/696 , G01F25/00 , A61M15/00
CPC分类号： G01F25/0007 , A61M16/00 , G01F1/6965 , A61M2016/0039
摘要： A parameter of interest being measured by a sensor is estimated from output response data from the sensor and the known transfer function of the sensor, allowing fast and accurate sensor data from sensors having a dynamic characteristic otherwise precluding assessment of the sensor input. A parameter of breathing gas from a ventilator is determined based upon the known transfer function and a plurality of the sensor output signals at predetermined intervals of time, to provide an estimation of the parameter of interest.

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