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1. 发明授权

US08143308B2 Synthesis of oligo/poly(catechins) and methods of use 有权
标题翻译：寡聚/聚（儿茶素类）的合成和使用方法
公开(公告)号：US08143308B2
公开(公告)日：2012-03-27
申请号：US11978540
申请日：2007-10-29
申请人： Ferdinando F. Bruno , Jayant Kumar , Subhalakshmi Nagarajan , Susan J. Braunhut , Ramaswamy Nagarajan , Lynne A. Samuelson , Donna McIntosh , Klaudia Foley
发明人： Ferdinando F. Bruno , Jayant Kumar , Subhalakshmi Nagarajan , Susan J. Braunhut , Ramaswamy Nagarajan , Lynne A. Samuelson , Donna McIntosh , Klaudia Foley
IPC分类号： A61K31/352 , A61P35/00 , C07D407/02 , C12P17/16
CPC分类号： A61K36/82 , A61K31/353 , C08G83/00 , C08H6/00
摘要： A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
摘要翻译：用于合成生物相容性的水溶性寡聚/类黄酮的方法包括在生物相容性聚合增溶剂的存在下用聚合剂聚合任选取代的黄酮类化合物，从而产生生物相容性的可溶性寡聚/多形黄烷。还包括生物相容性，可溶性，寡聚/多形黄烷或其药学上可接受的盐，溶剂合物或复合物。还包括治疗受试者癌症，心脏损伤，病毒感染和肥胖症的方法。

2. 发明申请

US20090170928A1 Synthesis of oligo/poly(catechins) and methods of use 有权
标题翻译：寡聚/聚（儿茶素类）的合成和使用方法
公开(公告)号：US20090170928A1
公开(公告)日：2009-07-02
申请号：US11978540
申请日：2007-10-29
申请人： Ferdinando F. Bruno , Jayant Kumar , Subhalakshmi Nagarajan , Susan J. Braunhut , Ramaswamy Nagarajan , Lynne A. Samuelson , Donna McIntosh , Klaudia Foley
发明人： Ferdinando F. Bruno , Jayant Kumar , Subhalakshmi Nagarajan , Susan J. Braunhut , Ramaswamy Nagarajan , Lynne A. Samuelson , Donna McIntosh , Klaudia Foley
IPC分类号： A61K31/352 , C07D407/02 , C12P17/16 , A61P35/00
CPC分类号： A61K36/82 , A61K31/353 , C08G83/00 , C08H6/00
摘要： A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
摘要翻译：用于合成生物相容性的水溶性寡聚/类黄酮的方法包括在生物相容性聚合增溶剂的存在下用聚合剂聚合任选取代的黄酮类化合物，从而产生生物相容性的可溶性寡聚/多形黄烷。还包括生物相容性，可溶性，寡聚/多形黄烷或其药学上可接受的盐，溶剂合物或复合物。还包括治疗受试者癌症，心脏损伤，病毒感染和肥胖症的方法。

3. 发明授权

US07230071B1 Methods for polymerization of electronic and photonic polymers 失效
公开(公告)号：US07230071B1
公开(公告)日：2007-06-12
申请号：US10775580
申请日：2004-02-09
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
IPC分类号： C08G73/06
CPC分类号： C07D487/22 , C08F4/00
摘要： A method for polymerizing electronic and photonic polymers, wherein an aromatic monomer is combined with a hematin catalyst derivatized with at least one non-proteinaceous amphipathic group, and a peroxide initiator, and employing a template, wherein the aromatic monomer aligns along the template and polymerizes to form a complex comprising the polymerized monomer and the template.

4. 发明授权

US07186791B2 Methods for polymerization of electronic and photonic polymers 失效
公开(公告)号：US07186791B2
公开(公告)日：2007-03-06
申请号：US11120031
申请日：2005-05-02
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
IPC分类号： C08G73/66
CPC分类号： C07D487/22 , C08F4/00
摘要： A method for polymerizing electronic and photonic polymers, wherein an aromatic monomer is combined with a hematin catalyst derivatized with at least one non-proteinaceous amphipathic group, and a peroxide initiator, and employing a template, wherein the aromatic monomer aligns along the template and polymerizes to form a complex comprising the polymerized monomer and the template.

5. 发明授权

US07022420B1 Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same 失效
公开(公告)号：US07022420B1
公开(公告)日：2006-04-04
申请号：US10775579
申请日：2004-02-09
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
IPC分类号： B32B15/00
CPC分类号： C08F12/30 , B82Y30/00 , C07D487/22 , C08F4/00 , C08F12/24 , C08F12/28 , C08G73/0266 , C08L25/18 , G01N33/531 , Y10T428/12861 , Y10T428/12951 , Y10T428/12958 , C08F4/80 , C08L2666/02
摘要： An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.

6. 发明授权

US07344751B2 Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same 失效
公开(公告)号：US07344751B2
公开(公告)日：2008-03-18
申请号：US11111570
申请日：2005-04-21
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
IPC分类号： B05D5/12 , C08F2/00 , C08F4/00 , B32B15/00 , C07D487/22
CPC分类号： C08F12/30 , B82Y30/00 , C07D487/22 , C08F4/00 , C08F12/24 , C08F12/28 , C08G73/0266 , C08L25/18 , G01N33/531 , Y10T428/12861 , Y10T428/12951 , Y10T428/12958 , C08F4/80 , C08L2666/02
摘要： An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.

7. 发明授权

US07510739B2 Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same 失效
标题翻译：组装的血红蛋白，其形成方法和使用其聚合芳族单体的方法
公开(公告)号：US07510739B2
公开(公告)日：2009-03-31
申请号：US11111567
申请日：2005-04-21
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
IPC分类号： B05D5/12 , C08F2/00 , C08F4/00 , B32B15/00 , C07D487/22 , C08G73/06
CPC分类号： C08F12/30 , B82Y30/00 , C07D487/22 , C08F4/00 , C08F12/24 , C08F12/28 , C08G73/0266 , C08L25/18 , G01N33/531 , Y10T428/12861 , Y10T428/12951 , Y10T428/12958 , C08F4/80 , C08L2666/02
摘要： An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.
摘要翻译：通过将沉积在一个或多个层中的带电衬底上的血红蛋白形成，所述层与一层或多层聚电解质，优选阳离子聚合物交替。在芳族单体聚合的方法中，将组装的血红素与单体和模板（优选阴离子聚合物）接触。在苯胺聚合的方法中，将苯胺磺化多壁碳纳米管，PEG血红素和反应引发剂分散在水中。

8. 发明授权

US07358327B2 Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same 失效
标题翻译：组装的血红蛋白，其形成方法和使用其聚合芳族单体的方法
公开(公告)号：US07358327B2
公开(公告)日：2008-04-15
申请号：US11111566
申请日：2005-04-21
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar , Michael Sennett
IPC分类号： C08F2/00 , C08F4/00 , B32B15/00 , C07D487/22
CPC分类号： C08F12/30 , B82Y30/00 , C07D487/22 , C08F4/00 , C08F12/24 , C08F12/28 , C08G73/0266 , C08L25/18 , G01N33/531 , Y10T428/12861 , Y10T428/12951 , Y10T428/12958 , C08F4/80 , C08L2666/02
摘要： An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.
摘要翻译：通过将沉积在一个或多个层中的带电衬底上的血红蛋白形成，所述层与一层或多层聚电解质，优选阳离子聚合物交替。在芳族单体聚合的方法中，将组装的血红素与单体和模板（优选阴离子聚合物）接触。在苯胺聚合的方法中，将苯胺磺化多壁碳纳米管，PEG血红素和反应引发剂分散在水中。

9. 发明授权

US07186792B2 Methods for polymerization of electronic and photonic polymers 失效
标题翻译：电子和光子聚合物的聚合方法
公开(公告)号：US07186792B2
公开(公告)日：2007-03-06
申请号：US11120032
申请日：2005-05-02
申请人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
发明人： Ferdinando Bruno , Lynne A. Samuelson , Ramaswamy Nagarajan , Jayant Kumar
IPC分类号： C08G73/06
CPC分类号： C07D487/22 , C08F4/00
摘要： A method for polymerizing electronic and photonic polymers, wherein an aromatic monomer is combined with a hematin catalyst derivatized with at least one non-proteinaceous amphipathic group, and a peroxide initiator, and employing a template, wherein the aromatic monomer aligns along the template and polymerizes to form a complex comprising the polymerized monomer and the template.
摘要翻译：一种用于聚合电子和光子聚合物的方法，其中芳族单体与用至少一种非蛋白质两亲性基团衍生的血红素催化剂和过氧化物引发剂结合，并使用模板，其中芳族单体沿模板对齐并聚合以形成包含聚合单体和模板的复合物。

10. 发明授权

US06569651B1 Enzymatic polymerization of anilines or phenols around a template 失效
标题翻译：苯胺或酚类在模板周围的酶聚合
公开(公告)号：US06569651B1
公开(公告)日：2003-05-27
申请号：US09334105
申请日：1999-06-16
申请人： Lynne A. Samuelson , Sukant K. Tripathy , Ferdinando Bruno , Ramaswamy Nagarajan , Jayant Kumar , Wei Liu
发明人： Lynne A. Samuelson , Sukant K. Tripathy , Ferdinando Bruno , Ramaswamy Nagarajan , Jayant Kumar , Wei Liu
IPC分类号： C12P1300
CPC分类号： C12P13/001 , C12P7/22 , Y10S435/817 , Y10S977/898
摘要： The micelle contains multiple units, each of which contains a hydrophobic part and a hydrophilic part. A preferred unit is dodecyl benzene sulfonic acid. Borate-containing electrolytes include trifluoroborate, trimethylborate and hydrobis(pyridine)boron. Enzymes include peroxidases such as horseradish peroxidase or lignin peroxidase, and laccase. Monomers include unsubstituted and substituted anilines and unsubstituted and substituted phenols. A method is provided for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to align along the template and polymerize to form a polymer-template complex. The template can be a micelle, a borate-containing electrolyte, or lignin sulfonate. The polymer-template complex may be conductive, and possesses exceptional electrical and optical stability, water solubility, and processibility, and can be used in applications such as light-weight energy storage devices (e.g., rechargeable batteries), electrolytic capacitors, anti-static and anti-corrosive coatings for smart windows, and biological sensors.
摘要翻译：胶束含有多个单元，每个单元含有疏水部分和亲水部分。优选的单元是十二烷基苯磺酸。含硼酸盐的电解质包括三氟硼酸盐，硼酸三甲酯和氢化双（吡啶）硼。酶包括过氧化物酶如辣根过氧化物酶或木质素过氧化物酶，以及漆酶。单体包括未取代的和取代的苯胺和未取代的和取代的酚。提供了一种用于酶促聚合的方法，其包括（1）获得包含单体，模板和酶的反应混合物; 和（2）将反应混合物温育一段时间并在足以使单体沿着模板排列的聚合物形成聚合物 - 模板复合物的条件下。模板可以是胶束，含硼酸盐的电解质或木质素磺酸盐。聚合物 - 模板复合物可以是导电的，并且具有优异的电和光学稳定性，水溶性和可加工性，并且可以用于诸如轻量储能装置（例如可再充电电池），电解电容器，防静电以及智能窗户和生物传感器的防腐涂料。

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