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1. 发明授权

US11386993B2 Plasma collection with remote programming 有权
公开(公告)号：US11386993B2
公开(公告)日：2022-07-12
申请号：US17078824
申请日：2020-10-23
申请人： Fenwal, Inc.
发明人： Brian C. Case , Lan T. Nguyen , Amit J. Patel , Samantha M. Planas , Walter T. Watts , Kyungyoon Min , Daniel R. Boggs
IPC分类号： G16H40/60 , G16H10/60 , A61M1/34 , A61B34/10 , G06F21/31 , G08B3/10 , G08B5/22
摘要： A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.

2. 发明授权

US10919049B2 Convertible fluid processing assemblies 有权
公开(公告)号：US10919049B2
公开(公告)日：2021-02-16
申请号：US16226740
申请日：2018-12-20
申请人： Fenwal, Inc.
发明人： Lan T. Nguyen , Zahra R. Ali , Angela N. Carlson , Korri Hershenhouse , Molly Erickson
IPC分类号： B04B5/04 , A61M1/36 , A61M1/30 , A61M1/02
摘要： Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination.

3. 发明申请

US20210043316A1 PLASMA COLLECTION WITH REMOTE PROGRAMMING 有权
公开(公告)号：US20210043316A1
公开(公告)日：2021-02-11
申请号：US17078824
申请日：2020-10-23
申请人： Fenwal, Inc.
发明人： Brian C. Case , Lan T. Nguyen , Amit J. Patel , Samantha M. Planas , Walter T. Watts , Kyungyoon Min , Daniel R. Boggs
IPC分类号： G16H40/60 , G16H10/60 , A61M1/34 , A61B34/10 , G06F21/31 , G08B3/10 , G08B5/22
摘要： A system and method for collecting plasma includes drawing whole blood from a donor, combining anticoagulant with the whole blood from the donor, separating the whole blood into a plasma product and a second blood component and sending the plasma product to a collection container. A controller receives parameters over a network from a remote computer, receives a user input to confirm the a parameter and/or procedure, determines a target volume for plasma product and/or raw plasma based on the parameters and, in response to confirming the donor, controls the system to collect the plasma using draw and return phases.

4. 发明申请

US20190193091A1 Convertible Fluid Processing Assemblies 审中-公开
公开(公告)号：US20190193091A1
公开(公告)日：2019-06-27
申请号：US16226740
申请日：2018-12-20
申请人： Fenwal, Inc.
发明人： Lan T. Nguyen , Zahra R. Ali , Angela N. Carlson , Korri Hershenhouse , Molly Erickson
IPC分类号： B04B5/04 , A61M1/36 , A61M1/30
CPC分类号： B04B5/0442 , A61M1/02 , A61M1/30 , A61M1/304 , A61M1/36 , A61M1/3672 , A61M1/3683 , A61M1/3693 , A61M1/3696
摘要： Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination.

5. 发明申请

US20180099080A1 PERFORMING AN APHERESIS PROCEDURE ON A HUMAN SUBJECT WITH IDENTITY INPUT DATA 审中-公开
公开(公告)号：US20180099080A1
公开(公告)日：2018-04-12
申请号：US15836227
申请日：2017-12-08
申请人： Fenwal, Inc.
发明人： Brian C. Case , Lan T. Nguyen
IPC分类号： A61M1/34
CPC分类号： A61M1/3403 , A61B34/10 , A61M2205/33 , A61M2205/3334 , G06F19/00 , G16H10/60
摘要： A system for performing an apheresis procedure on a human subject includes an apheresis device having a communication channel in communication with a data storage device remote from the apheresis treatment device, an input device configured to receive an identity input data, wherein the identity input data comprises a combination of data, and a processing circuit. The processing circuit is configured to compare the identity input data to an identity of a human subject downloaded from the data storage device and, if the combination of data is consistent with two or more subject-specific information for a subject data entry, to provide access to an apheresis procedure operated according to the pre-programmed parameters on the apheresis device. The processing circuit is configured to derive an operating parameter for the apheresis procedure based on at least one of the subject-specific information of the human subject and to operate the apheresis procedure using the derived operating parameter.

6. 发明申请

US20180078699A1 SYSTEM AND METHOD FOR PLATELET REMOVAL DURING MONONUCLEAR CELL COLLECTION 审中-公开
公开(公告)号：US20180078699A1
公开(公告)日：2018-03-22
申请号：US15693799
申请日：2017-09-01
申请人： Fenwal, Inc.
发明人： Jonathan W. Prendergast , Lan T. Nguyen , Katherine N. Radwanski
IPC分类号： A61M1/36 , A61M1/38 , B01D63/16
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3496 , A61M1/361 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2202/0427 , A61M2202/0439 , A61M2202/0443 , B01D63/16
摘要： A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

7. 发明授权

US09861736B2 Methods for extracting platelet-rich plasma for therapeutic injection 有权
公开(公告)号：US09861736B2
公开(公告)日：2018-01-09
申请号：US13907311
申请日：2013-05-31
申请人： Fenwal, Inc.
发明人： John W. Barry, Jr. , Brian C. Case , Jonathan Prendergast , Lan T. Nguyen , John Foley
IPC分类号： A61M1/36 , A61M1/02 , A61M1/34
CPC分类号： A61M1/3693 , A61M1/02 , A61M1/3496 , A61M1/3696 , A61M2202/0415
摘要： Methods are provided for collecting platelet-rich plasma. A disposable flow circuit is mounted to a fluid processing device having a fluid separation chamber and an injection device. A fluid containing plasma and platelets is continuously conveyed from a fluid source into the fluid separation chamber and processed to produce platelet-rich plasma. At least a portion of the platelet-rich plasma is automatically conveyed from the fluid separation chamber into the injection device, which is directly connected to a pump device such that at least a portion of the platelet-rich plasma from the fluid separation chamber is automatically conveyed into the pump device prior to being conveyed into the injection device. The injection device with the platelet-rich plasma is then detached from the disposable flow circuit.

8. 发明授权

US09119914B2 Methods for automated blood prime 有权
标题翻译：自动化血型的方法
公开(公告)号：US09119914B2
公开(公告)日：2015-09-01
申请号：US13778474
申请日：2013-02-27
申请人： Fenwal, Inc.
发明人： Lan T. Nguyen , John T. Foley , Jonathan Prendergast , Matthew Schoonover
IPC分类号： A61M1/16 , A61M1/36 , A61M1/34 , A61M1/30
CPC分类号： A61M1/16 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3609 , A61M1/3643 , A61M1/3644 , A61M2202/0429 , A61M2205/12 , A61M2205/50 , A61M2240/00
摘要： A method is disclosed for priming a kit for use in a therapeutic apheresis procedure with previously-collected blood prior to flowing the patient's whole blood into the inlet line of the kit, as part of a procedure in which a selected blood component is separated from a patient's whole blood, and replaced with a previously-collected blood component. The operator enters into the controller of the separation device the hematocrit value of the previously-collected blood. Then, in response to prompts by the controller, the operator enters a target hematocrit value for the previously-collected blood and an identification of the portion of the kit to be primed. The identified portion of the kit is automatically primed with the previously-collected blood. The patient is then connected to the inlet line of the kit in response to a prompt from the controller and the therapeutic procedure is commenced.
摘要翻译：公开了一种用于在将患者的全血流入试剂盒的入口管线之前用先前收集的血液引发用于治疗性分离术的试剂盒的方法，作为将选择的血液成分与患者的全血，并用以前收集的血液成分代替。操作者将分离装置的控制器输入先前收集的血液的血细胞比容值。然后，响应于控制器的提示，操作者输入先前收集的血液的目标血细胞比容值和待引发的试剂盒的部分的标识。试剂盒的识别部分会自动使用以前收集的血液进行预处理。然后响应于来自控制器的提示将患者连接到试剂盒的入口管线，并且治疗程序开始。

9. 发明申请

US20150115180A1 METHOD AND APPARATUS TO VERIFY CORRECT REPLACEMENT FLUID IN A THERAPEUTIC EXCHANGE PROCEDURE 有权
标题翻译：在治疗交换程序中验证正确替代液的方法和装置
公开(公告)号：US20150115180A1
公开(公告)日：2015-04-30
申请号：US14068241
申请日：2013-10-31
申请人： FENWAL, INC.
发明人： Matthew Schoonover , Lan T. Nguyen , David Stude , Elizabeth Nelson
IPC分类号： G01N21/84 , G01N33/49 , G01N33/487
CPC分类号： G01N21/84 , A61M1/342 , A61M1/3437 , A61M1/3455 , A61M1/3496 , A61M2205/18 , A61M2205/27 , A61M2205/3306 , A61M2205/60 , A61M2205/6009 , G01N33/487 , G01N33/49
摘要： A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.
摘要翻译：提供了一种方法和装置，用于在治疗交换过程期间自动检测由操作者加载的替换流体的类型，并且如果使用不正确的流体，则提供警告报警。在操作人员将替换流体的容器连接到一次性使用试剂盒的更换流体管线之后，将要执行的交换程序的标识输入到控制器中，更换的流体通过套件的一部分流过传感器与检测流过该段的流体类型的硬件组件相关联。控制器验证在段中检测到的替换流体是否对应于所选择的交换过程的替换流体，并且在已经加载不正确的替换流体的情况下通知操作者。

10. 发明授权

US11938259B2 Systems and methods for use and control of an automated separator with adsorption columns 有权
公开(公告)号：US11938259B2
公开(公告)日：2024-03-26
申请号：US16529901
申请日：2019-08-02
申请人： Fenwal, Inc.
发明人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C Case
IPC分类号： A61M1/36
CPC分类号： A61M1/362 , A61M1/362227 , A61M1/36224 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/3693 , A61M1/3696 , A61M1/362266
摘要： Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

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