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1. 发明申请

US20070079775A1 Welding Forged Steel Single Piece Piston and Its Manufacturing Methods 审中-公开
标题翻译：焊接锻钢单件活塞及其制造方法
公开(公告)号：US20070079775A1
公开(公告)日：2007-04-12
申请号：US11278715
申请日：2006-04-05
申请人： Fenghua Lin , Xuejun Ma , Guohua Zhang , Hongmin Wang , Junkui Zhu , Lixia Wang , Zhanyu Gao , Shushan Zhang
发明人： Fenghua Lin , Xuejun Ma , Guohua Zhang , Hongmin Wang , Junkui Zhu , Lixia Wang , Zhanyu Gao , Shushan Zhang
IPC分类号： F02F3/00
CPC分类号： F02F3/003
摘要： The present invention has provided a welding forged steel single piece piston and its manufacturing methods. A semi-finished head and a semi-finished skirt are forged respectively; the semi-finished head and semi-finished skirt are heat-treated respectively; rough machining is carried out respectively to the semi-finished head and the semi-finished skirt, and a face of weld between the two adjacent ring grooves is higher than the one under the combustion chamber; the head and the skirt are welded together through friction welding; an annular groove, a combustion chamber, a ring groove, a pinhole, an outer annulus and oil inlet/outlet holes are manufactured respectively; and the surface of the piston is phosphorized and graphitized. Compared with one-piece forged piston, it has better processing technology, because the head and skirt are forged respectively and then welded together. Over-all structural rigidity of the piston has been increased, and distortion of the ring groove in high temperature is slight because the cooling oil recess is sealed through welding. As the annular groove is located on the upper part of skirt, the weight of body of the piston is lowered and this kind of structure can accelerate engine oil returning on, decrease the clearance between the piston and the cylinder and reduce the engine oil consumption.
摘要翻译：本发明提供了一种焊接锻钢单片活塞及其制造方法。分别锻造半成品头和半成品裙; 半成品头和半成品裙分别进行热处理; 分别对半成品头和半成品裙部进行粗加工，两个相邻环形槽之间的焊接面高于燃烧室下面的焊接面; 头部和裙部通过摩擦焊接焊接在一起; 分别制造环状槽，燃烧室，环槽，针孔，外环和油入口/出口孔; 并且活塞的表面被磷化并石墨化。与单件锻造活塞相比，它具有更好的加工技术，因为头部和裙部分别锻造，然后焊接在一起。增加了活塞的全部结构刚度，并且由于冷却油凹部通过焊接而密封，高温环形槽的变形很小。当环形槽位于裙部上部时，活塞体的重量降低，这种结构可以加速发动机油的返回，减少活塞与气缸之间的间隙，减少发动机机油消耗。

2. 发明申请

US20070079948A1 Manufacturing Method of Semi-Finished Piston with Inner Cooling Channel through Liquid Extrusion Process 审中-公开
标题翻译：通过液体挤出工艺制造内冷却通道的半成品活塞的制造方法
公开(公告)号：US20070079948A1
公开(公告)日：2007-04-12
申请号：US11278746
申请日：2006-04-05
申请人： Guohua Zhang , Xiao Sun , Xiaobo Gao , Shibo Zhao , Yanpeng Liu , Hongmin Wang , Xuejun Ma , Zengjian Feng
发明人： Guohua Zhang , Xiao Sun , Xiaobo Gao , Shibo Zhao , Yanpeng Liu , Hongmin Wang , Xuejun Ma , Zengjian Feng
IPC分类号： B22D19/08 , B22C9/10
CPC分类号： B22D19/0027 , B22C9/105 , B22C9/108 , B22D17/24
摘要： This invention has provided a manufacturing method of semi-finished piston with inner cooling channel through liquid extrusion process, including the following steps: a) produce a wear-resistant cast iron ring with coupling hooks and a common salt and corundum dissoluble core with convex edges; b) fix the wear-resistant cast iron ring in the casting moulds after being aluminized; c) fix the dissoluble core after being pre-heated on the wear-resistant cast iron ring with coupling hooks and convex edges; d) fill in the casting mould with aluminum alloy liquid, compressing and molding. The dissoluble core can be accurately fixed in the casting mould through coupling hooks and convex edges. When the semi-finished piston has been manufactured into finished product, it shall be characterized by high compactness and high mechanical property resulted from liquid extrusion technology. Meanwhile, because of the cooling channel, the temperature in the combustion chamber of the head and ring groove is reduced, the load capacity of the piston is greatly improved, and the manufacturability becomes better.
摘要翻译：本发明提供了一种通过液体挤出工艺制造具有内部冷却通道的半成品活塞的制造方法，其包括以下步骤：a）制造具有连接钩的耐磨铸铁环和具有凸缘的普通盐和刚玉可溶芯 ; b）镀铝后在铸模中固定耐磨铸铁环; c）在具有连接钩和凸边的耐磨铸铁环上预热后固定可溶性芯; d）用铝合金液体填充铸模，压缩成型。可以通过连接钩和凸边缘将可溶性芯体精确地固定在铸模中。当半成品活塞已经制成成品时，其特点是液体挤出技术产生的紧凑性和机械性能很高。同时，由于冷却通道，头环和环槽的燃烧室中的温度降低，活塞的负载能力大大提高，制造性变好。

3. 发明申请

US20110166206A1 UBIQUILIN REGULATION OF PRESENILIN ENDOPROTEOLYSIS, AND SUPPRESSION OF POLYGLUTAMINE-INDUCED TOXICITY IN CELLS 审中-公开
标题翻译：尿白蛋白内啡肽调节，抑制多糖诱导的细胞毒性
公开(公告)号：US20110166206A1
公开(公告)日：2011-07-07
申请号：US11911779
申请日：2006-04-19
申请人： Mervyn J. Monteiro , Hongmin Wang
发明人： Mervyn J. Monteiro , Hongmin Wang
IPC分类号： A61K31/7088 , C12Q1/68 , C12N5/06
CPC分类号： C07K14/00 , A01K67/0336 , A01K2217/05 , A01K2227/703 , A01K2267/0312 , A01K2267/0356 , A61K48/005 , C12N15/8509
摘要： Use of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate γ-secretase components, Pen-2 and Nicastrin, as well as utilization for inducing increased levels of ubiquilin to reduce aggregation of polyglutamine expansion proteins known to cause cell toxicity and cell death in subjects suffering from neurodegenerative diseases, such as Huntington's and Alzheimer's diseases.
摘要翻译：描述了泛蛋白的使用，包括用于减少早老素1和2的断裂并调节γ-分泌酶组分，Pen-2和Nicastrin的用途，以及用于诱导增加水平的泛蛋白以减少已知引起的聚谷氨酰胺膨胀蛋白聚集的用途细胞毒性和患有神经退行性疾病如亨廷顿舞蹈症和阿尔茨海默氏病的受试者的细胞死亡。

4. 发明申请

US20100099747A1 REDUCTION OF POLYALANINE-INDUCED PROTEIN AGGREGATES AND TOXICITY BY UBIQUILIN 审中-公开
标题翻译：尿素诱导的蛋白质聚集体和UBIQUILIN的毒性减少
公开(公告)号：US20100099747A1
公开(公告)日：2010-04-22
申请号：US12520492
申请日：2007-12-21
申请人： Mervyn J. Monteiro , Hongmin Wang
发明人： Mervyn J. Monteiro , Hongmin Wang
IPC分类号： A61K31/7088 , C12N5/071 , A61P25/28
CPC分类号： C07K14/4702 , A61K38/1709 , A61K48/005
摘要： A method for decreasing cell death in a cell exhibiting aggregation of polyalanine-containing proteins. The method includes introduction of an expression vector to a host cell comprising a nucleotide sequence encoding ubiquilin, followed by maintaining the transformed host cell under biological conditions sufficient for expression and accumulation of the ubiquilin in the host cell, wherein overexpression of ubiquilin reduces sensitivity of cell stress induced by expanded polyalanine proteins.
摘要翻译：一种降低细胞死亡的方法，该细胞显示含聚丙氨酸蛋白质的聚集。该方法包括将表达载体导入宿主细胞，该宿主细胞包含编码泛蛋白的核苷酸序列，然后将转化的宿主细胞保持在足以在宿主细胞中表达和积累泛蛋白的生物学条件下，泛素的过量表达降低了细胞的敏感性膨胀聚丙氨酸蛋白酶诱导的应激。

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