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1. 发明申请

US20130101520A1 ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：超声对比剂及其制备和使用方法
公开(公告)号：US20130101520A1
公开(公告)日：2013-04-25
申请号：US13612236
申请日：2012-09-12
申请人： Michel SCHNEIDER , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
发明人： Michel SCHNEIDER , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K49/227
摘要： The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
摘要翻译：本发明涉及气体填充微泡的可注射悬浮液，以及制备和使用它们的方法，特别是作为超声造影剂。

2. 发明申请

US20090076477A1 Automatic Liquid Injection System and Method 审中-公开
标题翻译：自动注液系统及方法
公开(公告)号：US20090076477A1
公开(公告)日：2009-03-19
申请号：US12208878
申请日：2008-09-11
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M5/00 , A61B6/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

3. 发明申请

US20120265065A1 Automatic Liquid Injection System and Method 审中-公开
标题翻译：自动注液系统及方法
公开(公告)号：US20120265065A1
公开(公告)日：2012-10-18
申请号：US13467301
申请日：2012-05-09
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M5/20 , A61B6/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

4. 发明授权

US06726650B2 Automatic liquid injection system and method 有权
标题翻译：自动注液系统及方法
公开(公告)号：US06726650B2
公开(公告)日：2004-04-27
申请号：US09204067
申请日：1998-12-03
申请人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
发明人： Michel Schneider , Christophe Golay , Laurent Jakob , Jean Brochot , Feng Yan , Christian Mathieu
IPC分类号： A61M3700
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

5. 发明授权

US5961956A Frozen ultrasonic gas suspensions 失效
标题翻译：冷冻超声波气体悬浮液
公开(公告)号：US5961956A
公开(公告)日：1999-10-05
申请号：US944408
申请日：1997-10-06
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/00 , A61K49/22 , A61K49/04 , A61K9/127 , A61K9/14
CPC分类号： A61K49/223
摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
摘要翻译：公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。还公开了微泡悬浮液的冷藏方法及其用途。

6. 发明授权

US5846518A Gas mixtures useful as ultrasound contrast media contrast agents containing the media and method 失效
标题翻译：用作含有介质和方法的超声造影剂造影剂的气体混合物
公开(公告)号：US5846518A
公开(公告)日：1998-12-08
申请号：US848912
申请日：1997-05-01
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/00 , A61B8/13 , A61K49/18 , A61K49/22 , A61K51/00
CPC分类号： A61K49/223 , A61K49/225
摘要： The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof. Gas mixtures described are found to be very effective as ultrasound contrast media. The invention also comprises a method of making the ultrasound contrast medium, the contrast agent and the ultrasound agent kit.
摘要翻译：本发明涉及以微泡或微球形式的超声波回波成像的可注射介质，其包含至少两种生物相容性物质A和B（在体温下为气体）形成混合物，当与通常的表面活性剂悬浮时，添加剂和稳定剂提供有用的超声对比代理商混合物中组分（B）中的至少一种是分子量大于80道尔顿且在标准条件下其在水中的溶解度低于0.0283ml / ml水的气体。造影剂中第一组分（B）的存在可以在0.5和41体积％之间变化。超声造影剂的另一组分（A）是分子量低于80道尔顿的气体或气体混合物。第二组分以59-99.5体积％的比例存在，优选选自氧气，空气，氮气，二氧化碳或其混合物。发现所描述的气体混合物作为超声波造影剂非常有效。本发明还包括制造超声造影剂，造影剂和超声剂试剂盒的方法。

7. 发明授权

US5556610A Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method 失效
标题翻译：用作超声波造影剂的气体混合物，含有介质和方法的造影剂
公开(公告)号：US5556610A
公开(公告)日：1996-09-17
申请号：US352108
申请日：1994-11-30
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/22 , A61K49/00
CPC分类号： A61K49/225 , A61K49/223
摘要： The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.15 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof. Gas mixtures described are found to be very effective as ultrasound contrast media. The invention also comprises a method of making the ultrasound contrast medium, the contrast agent and the ultrasound agent kit.
摘要翻译：本发明涉及以微泡或微球形式的超声波回波成像的可注射介质，其包含至少两种生物相容性物质A和B（在体温下为气体）形成混合物，当与通常的表面活性剂悬浮时，添加剂和稳定剂提供有用的超声对比代理商混合物中组分（B）中的至少一种是分子量大于80道尔顿且在标准条件下其在水中的溶解度低于0.0283ml / ml水的气体。造影剂中第一组分（B）的存在可以在0.15和41体积％之间变化。超声造影剂的另一组分（A）是分子量低于80道尔顿的气体或气体混合物。第二组分以59-99.5体积％的比例存在，优选选自氧气，空气，氮气，二氧化碳或其混合物。发现所描述的气体混合物作为超声波造影剂非常有效。本发明还包括制造超声造影剂，造影剂和超声剂试剂盒的方法。

8. 发明申请

US20120093732A1 ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：超声对比剂及其制备和使用方法
公开(公告)号：US20120093732A1
公开(公告)日：2012-04-19
申请号：US13224129
申请日：2011-09-01
申请人： Michel Schneider , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
发明人： Michel Schneider , Feng Yan , David Lazarus , Jean Brochot , Jerome Puginier
IPC分类号： A61B8/00 , A61K49/22
CPC分类号： A61K49/223 , A61K49/227
摘要： The invention is directed to injectable suspensions of gas-filled microvesicles, as well as methods of preparing and using the same, especially as ultrasound contrast agents.
摘要翻译：本发明涉及气体填充微泡的可注射悬浮液，以及制备和使用它们的方法，特别是作为超声造影剂。

9. 发明授权

US07534239B1 Automatic liquid injection system and method 有权
标题翻译：自动注液系统及方法
公开(公告)号：US07534239B1
公开(公告)日：2009-05-19
申请号：US09576422
申请日：2000-05-22
申请人： Michel Schneider , Laurent Jakob , Christophe Golay , Jean Brochot , Feng Yan
发明人： Michel Schneider , Laurent Jakob , Christophe Golay , Jean Brochot , Feng Yan
IPC分类号： A61M31/00
CPC分类号： A61M5/1456 , A61B2017/22008 , A61B2090/3925 , A61B2090/3933 , A61M5/007 , A61M2205/6072 , B01F9/0016 , B01F11/0002 , B01F2003/0035
摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.
摘要翻译：一种功率辅助方法和注射器装置，用于可控地向患者输送分散药物或诊断活性剂，其均匀性在整个递送期间保留。所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

10. 发明授权

US5830435A Method of storing frozen microbubble suspensions 失效
标题翻译：储存冷冻微泡悬浮液的方法
公开(公告)号：US5830435A
公开(公告)日：1998-11-03
申请号：US909100
申请日：1997-08-12
申请人： Feng Yan , Michel Schneider , Jean Brochot
发明人： Feng Yan , Michel Schneider , Jean Brochot
IPC分类号： A61K49/00 , A61K49/22 , A61K49/04 , A61K9/127
CPC分类号： A61K49/223
摘要： Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.
摘要翻译：公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液，其中载体液体是生理上可接受的，固定化气体微泡是由ev逝包膜或有形膜结合的微泡。当液体形式时，悬浮液是可注射的，并且可用作血液池和生物组织的超声成像中的造影剂。将气体微泡固定在载体中，将平均尺寸低于50μm，优选低于10μm，更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度， 76℃，并保持该温度较长时间。微泡可以通过表面活性剂如片状磷脂来稳定，或者可以包含由合成或天然聚合物或蛋白质制成的膜。还公开了微泡悬浮液的冷藏方法及其用途。

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