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1. 发明申请

US20110074381A1 SENSORS USING HIGH ELECTRON MOBILITY TRANSISTORS 有权
标题翻译：传感器使用高电子移动晶体管
公开(公告)号：US20110074381A1
公开(公告)日：2011-03-31
申请号：US12966531
申请日：2010-12-13
申请人： Fan REN , Stephen John PEARTON , Tanmay LELE
发明人： Fan REN , Stephen John PEARTON , Tanmay LELE
IPC分类号： G01N27/26 , H01L29/778
CPC分类号： G01N33/54306 , G01N27/4145 , G01N33/0045 , H01L29/2003 , H01L29/7787
摘要： Embodiments of the invention include sensors comprising high electron mobility transistors (HEMTs) with capture reagents on a gate region of the HEMTs. Example sensors include HEMTs with a thin gold layer on the gate region and bound antibodies; a thin gold layer on the gate region and chelating agents; a non-native gate dielectric on the gate region; and nanorods of a non-native dielectric with an immobilized enzyme on the gate region. Embodiments including antibodies or enzymes can have the antibodies or enzymes bound to the Au-gate via a binding group. Other embodiments of the invention are methods of using the sensors for detecting breast cancer, prostate cancer, kidney injury, glucose, metals or pH where a signal is generated by the HEMT when a solution is contacted with the sensor. The solution can be blood, saliva, urine, breath condensate, or any solution suspected of containing any specific analyte for the sensor.
摘要翻译：本发明的实施例包括在HEMT的栅极区域上具有捕获试剂的高电子迁移率晶体管（HEMT）的传感器。示例传感器包括在栅极区域上具有薄金层的HEMT和结合的抗体; 栅区上的薄金层和螯合剂; 栅极区域上的非天然栅极电介质; 以及在栅极区域上具有固定化酶的非天然电介质的纳米棒。包括抗体或酶的实施方案可以具有通过结合基团结合到Au-门的抗体或酶。本发明的其它实施方案是使用传感器检测乳腺癌，前列腺癌，肾损伤，葡萄糖，金属或pH的方法，当溶液与传感器接触时，HEMT产生信号。解决方案可以是血液，唾液，尿液，呼吸冷凝液或任何怀疑含有传感器特定分析物的溶液。

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