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1. 发明申请

US20100310205A1 Hybrid Coupling Structure of the short Range Plasmon Polariton and Conventional Dielectric Waveguide, A Coupling Structure of the Long Range Plasmon Polariton and Conventional Dielectric Waveguide, and Applications Thereof 有权
标题翻译：短距离等离子体极化和常规介质波导的混合耦合结构，长距离等离子体极化和常规介质波导的耦合结构及其应用
公开(公告)号：US20100310205A1
公开(公告)日：2010-12-09
申请号：US12639549
申请日：2009-12-16
申请人： Fan Liu , Rui-Yuan Wan , Yi-Dong Huang , Xue Feng , Wei Zhang , Jiang De Peng , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi
发明人： Fan Liu , Rui-Yuan Wan , Yi-Dong Huang , Xue Feng , Wei Zhang , Jiang De Peng , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi
IPC分类号： G02B6/26 , G02F1/01
CPC分类号： G01N21/553 , B82Y20/00 , G01N21/43 , G01N21/7703 , G02B6/1226 , G02F1/035 , G02F2001/0144 , G02F2203/10
摘要： The present invention provides a hybrid coupling structure of a short range surface plasmon polariton and a conventional dielectric waveguide, including a dielectric substrate layer, a dielectric waveguide layer positioned on the said dielectric substrate layer, a coupling matching layer positioned on the said dielectric waveguide layer and a short range surface plasmon waveguide portion, formed on the said coupling matching layer, for conducting the short range surface plasmon polariton. The present invention also provides a coupling structure of a long range surface plasmon polariton and a dielectric waveguide, including a dielectric substrate layer, a dielectric waveguide layer, a coupling matching layer and a long range surface plasmon waveguide portion upward from below respectively.
摘要翻译：本发明提供了一种短距离表面等离子体激元和传统电介质波导的混合耦合结构，包括电介质基底层，位于所述电介质基底层上的电介质波导层，位于所述电介质波导层上的耦合匹配层以及形成在所述耦合匹配层上的用于传导短距离表面等离子体激元的短距离表面等离子体波导部分。本发明还提供了一种远距离表面等离子体激元和介质波导的耦合结构，其中包括电介质基底层，电介质波导层，耦合匹配层和远距离表面等离子体激元波导部分。

2. 发明授权

US08358880B2 Hybrid coupling structure of the short range plasmon polariton and conventional dielectric waveguide, a coupling structure of the long range plasmon polariton and conventional dielectric waveguide, and applications thereof 有权
标题翻译：短距离等离子体激元和常规电介质波导的混合耦合结构，远距离等离子体激元和常规电介质波导的耦合结构及其应用
公开(公告)号：US08358880B2
公开(公告)日：2013-01-22
申请号：US12639549
申请日：2009-12-16
申请人： Fang Liu , Rui-Yuan Wan , Yi-Dong Huang , Xue Feng , Wei Zhang , Jiang De Peng , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi
发明人： Fang Liu , Rui-Yuan Wan , Yi-Dong Huang , Xue Feng , Wei Zhang , Jiang De Peng , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi
IPC分类号： G02F1/035
CPC分类号： G01N21/553 , B82Y20/00 , G01N21/43 , G01N21/7703 , G02B6/1226 , G02F1/035 , G02F2001/0144 , G02F2203/10
摘要： The present invention provides a hybrid coupling structure of a short range surface plasmon polariton and a conventional dielectric waveguide, including a dielectric substrate layer, a dielectric waveguide layer positioned on the said dielectric substrate layer, a coupling matching layer positioned on the said dielectric waveguide layer and a short range surface plasmon waveguide portion, formed on the said coupling matching layer, for conducting the short range surface plasmon polariton. The present invention also provides a coupling structure of a long range surface plasmon polariton and a dielectric waveguide, including a dielectric substrate layer, a dielectric waveguide layer, a coupling matching layer and a long range surface plasmon waveguide portion upward from below respectively.
摘要翻译：本发明提供了一种短距离表面等离子体激元和传统电介质波导的混合耦合结构，包括电介质基底层，位于所述电介质基底层上的电介质波导层，位于所述电介质波导层上的耦合匹配层以及形成在所述耦合匹配层上的用于传导短距离表面等离子体激元的短距离表面等离子体波导部分。本发明还提供了一种远距离表面等离子体激元和介质波导的耦合结构，其中包括电介质基底层，电介质波导层，耦合匹配层和远距离表面等离子体激元波导部分。

3. 发明授权

US08748111B2 Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
标题翻译：基于多重嗅觉受体的微表面等离子体激元检测器
公开(公告)号：US08748111B2
公开(公告)日：2014-06-10
申请号：US13015851
申请日：2011-01-28
申请人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
发明人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
IPC分类号： G01N33/53 , C07K2/00 , B82Y30/00 , G01N33/00 , G01N21/55
CPC分类号： G01N21/553 , B82Y30/00 , C07K2/00 , G01N21/554 , G01N33/0031 , G01N2201/06113 , G01N2201/08
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

4. 发明申请

US20090209028A1 Sensing Chip 有权
标题翻译：感应芯片
公开(公告)号：US20090209028A1
公开(公告)日：2009-08-20
申请号：US12346950
申请日：2008-12-31
申请人： Huang Yi Dong , Rao Yi , Liu Fang , Zhang Wei , Peng Jiang De , Dai Ohnishi , Daisuke Niwa , Atsushi Tazuke , Yoshikatsu Miura
发明人： Huang Yi Dong , Rao Yi , Liu Fang , Zhang Wei , Peng Jiang De , Dai Ohnishi , Daisuke Niwa , Atsushi Tazuke , Yoshikatsu Miura
IPC分类号： C12M1/34 , G01N21/41
CPC分类号： G01N21/553 , G01N21/41 , G01N21/7703
摘要： There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.
摘要翻译：提供了一种能够通过利用远程表面等离子体激元测量折射率的感测芯片，精确地测量宽范围内的累积折射率，并且更容易实现测量密封。本发明涉及一种感测芯片，其具有在底层上生长的薄金属膜或带状金属，并且具有限制薄膜的上表面和下表面上的折射率和介电缓冲层的电介质金属膜或带状金属。介电缓冲层附着在薄金属膜或带状金属上。金属薄膜或带状金属和缓冲层夹在两个电介质层之间。在上部电介质层的表面形成孔作为测量槽。

5. 发明申请

US20090195783A1 SURFACE PLASMON RESONANCE SENSOR CHIP 有权
标题翻译：表面等离子体共振传感器芯片
公开(公告)号：US20090195783A1
公开(公告)日：2009-08-06
申请号：US12365307
申请日：2009-02-04
申请人： Atsushi Tazuke , Daisuke Niwa , Yoshikatsu Miura , Dai Ohnishi
发明人： Atsushi Tazuke , Daisuke Niwa , Yoshikatsu Miura , Dai Ohnishi
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/7703 , G01N33/54373 , G01N2021/7776 , G01N2021/7783
摘要： A surface plasmon resonance sensor chip includes: a first dielectric layer; a metal layer disposed on the first dielectric layer; and a second dielectric layer covering the metal layer, the chip being provided with an opening that makes a part of a surface on the side of the second dielectric layer of the metal layer be exposed, and allows a measurement sample and the surface on the side of the second dielectric layer to contact each other, wherein an organic molecule film is provided at least one of between the first dielectric layer and the metal layer, and between the metal layer and the second dielectric layer.
摘要翻译：表面等离子体共振传感器芯片包括：第一介电层; 设置在所述第一电介质层上的金属层; 以及覆盖所述金属层的第二电介质层，所述芯片设置有使金属层的第二电介质层侧的表面的一部分露出的开口，并且允许测量样品和侧面上的表面的第二电介质层彼此接触，其中在所述第一介电层和所述金属层之间以及所述金属层和所述第二介电层之间的至少一个上设置有机分子膜。

6. 发明申请

US20120021932A1 Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector 有权
标题翻译：多重嗅觉受体基微表面等离子体极谱探测器
公开(公告)号：US20120021932A1
公开(公告)日：2012-01-26
申请号：US13015851
申请日：2011-01-28
申请人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
发明人： Andreas Mershin , Brian Cook , Liselotte Kaiser , Johanna F. Bikker , Yoshikatsu Miura , Daisuke Niwa , Dai Ohnishi , Atsushi Tazuke , Shuguang Zhang
IPC分类号： C40B30/04 , C40B40/10 , G01N21/75 , G01N21/55 , G01N24/08
CPC分类号： G01N21/553 , B82Y30/00 , C07K2/00 , G01N21/554 , G01N33/0031 , G01N2201/06113 , G01N2201/08
摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.
摘要翻译：本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。本发明还提供了制备hOR17-4嗅觉受体的方法。

7. 发明授权

US08048385B2 Sensing chip 有权
标题翻译：感应芯片
公开(公告)号：US08048385B2
公开(公告)日：2011-11-01
申请号：US12346950
申请日：2008-12-31
申请人： Huang Yi Dong , Rao Yi , Liu Fang , Zhang Wei , Peng Jiang De , Dai Ohnishi , Daisuke Niwa , Atsushi Tazuke , Yoshikatsu Miura
发明人： Huang Yi Dong , Rao Yi , Liu Fang , Zhang Wei , Peng Jiang De , Dai Ohnishi , Daisuke Niwa , Atsushi Tazuke , Yoshikatsu Miura
IPC分类号： G01N21/75
CPC分类号： G01N21/553 , G01N21/41 , G01N21/7703
摘要： There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.
摘要翻译：提供了一种能够通过利用远程表面等离子体激元测量折射率的感测芯片，精确地测量宽范围内的累积折射率，并且更容易实现测量密封。本发明涉及一种感测芯片，其具有在底层上生长的薄金属膜或带状金属，并且具有限制薄膜的上表面和下表面上的折射率和介电缓冲层的电介质金属膜或带状金属。介电缓冲层附着在薄金属膜或带状金属上。金属薄膜或带状金属和缓冲层夹在两个电介质层之间。在上部电介质层的表面形成孔作为测量槽。

8. 发明授权

US08035810B2 Surface plasmon resonance sensor chip 有权
标题翻译：表面等离子体共振传感器芯片
公开(公告)号：US08035810B2
公开(公告)日：2011-10-11
申请号：US12365307
申请日：2009-02-04
申请人： Atsushi Tazuke , Daisuke Niwa , Yoshikatsu Miura , Dai Ohnishi
发明人： Atsushi Tazuke , Daisuke Niwa , Yoshikatsu Miura , Dai Ohnishi
IPC分类号： G01N21/01
CPC分类号： G01N21/553 , G01N21/7703 , G01N33/54373 , G01N2021/7776 , G01N2021/7783
摘要： A surface plasmon resonance sensor chip includes: a first dielectric layer; a metal layer disposed on the first dielectric layer; and a second dielectric layer covering the metal layer, the chip being provided with an opening that makes a part of a surface on the side of the second dielectric layer of the metal layer be exposed, and allows a measurement sample and the surface on the side of the second dielectric layer to contact each other, wherein an organic molecule film is provided at least one of between the first dielectric layer and the metal layer, and between the metal layer and the second dielectric layer.
摘要翻译：表面等离子体共振传感器芯片包括：第一介电层; 设置在所述第一电介质层上的金属层; 以及覆盖所述金属层的第二电介质层，所述芯片设置有使金属层的第二电介质层侧的表面的一部分露出的开口，并且允许测量样品和侧面上的表面的第二电介质层彼此接触，其中在所述第一介电层和所述金属层之间以及所述金属层和所述第二介电层之间的至少一个上设置有机分子膜。

9. 发明申请

US20090066962A1 SURFACE PLASMON RESONANCE SENSOR AND BIOCHIP 失效
标题翻译：表面等离子体共振传感器和生物技术
公开(公告)号：US20090066962A1
公开(公告)日：2009-03-12
申请号：US12206022
申请日：2008-09-08
申请人： Daisuke Niwa , Dai Ohnishi
发明人： Daisuke Niwa , Dai Ohnishi
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/554 , G01N21/7703
摘要： The present invention relates to a surface plasmon resonance sensor which has a first dielectric layer, a metal layer disposed on the first dielectric layer, and a second dielectric layer covering the metal layer. The surface plasmon resonance sensor includes: a sensor main body provided with an opening for exposing a part of a surface of the metal layer on a side facing the second dielectric layer, and for allowing a measurement sample to be brought into contact with this surface; a light source for introducing a beam into the metal layer from one end of the metal layer in a longitudinal direction of the metal layer; and a detection unit detecting a beam emitted from the other end of the metal layer, has high sensitivity in measurement, is downsized, and is usable in a simple manner.
摘要翻译：表面等离子体共振传感器本发明涉及一种表面等离子体共振传感器，其具有第一电介质层，设置在第一电介质层上的金属层和覆盖该金属层的第二电介质层。所述表面等离子体共振传感器包括：传感器主体，其设置有用于暴露所述金属层的面对所述第二介电层的一侧表面的一部分的开口，并且用于使所述测量样品与所述表面接触; 用于从所述金属层的所述金属层的纵向方向的一端引入光束到所述金属层的光源; 检测从金属层的另一端发射的光束的检测单元，测量灵敏度高，尺寸小，可以简单的使用。

10. 发明授权

US07671996B2 Surface plasmon resonance sensor and biochip 失效
标题翻译：表面等离子体共振传感器和生物芯片
公开(公告)号：US07671996B2
公开(公告)日：2010-03-02
申请号：US12206022
申请日：2008-09-08
申请人： Daisuke Niwa , Dai Ohnishi
发明人： Daisuke Niwa , Dai Ohnishi
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N21/554 , G01N21/7703
摘要： The present invention relates to a surface plasmon resonance sensor which has a first dielectric layer, a metal layer disposed on the first dielectric layer, and a second dielectric layer covering the metal layer. The surface plasmon resonance sensor includes: a sensor main body provided with an opening for exposing a part of a surface of the metal layer on a side facing the second dielectric layer, and for allowing a measurement sample to be brought into contact with this surface; a light source for introducing a beam into the metal layer from one end of the metal layer in a longitudinal direction of the metal layer; and a detection unit detecting a beam emitted from the other end of the metal layer, has high sensitivity in measurement, is downsized, and is usable in a simple manner.
摘要翻译：表面等离子体共振传感器本发明涉及一种表面等离子体共振传感器，其具有第一电介质层，设置在第一电介质层上的金属层和覆盖该金属层的第二电介质层。所述表面等离子体共振传感器包括：传感器主体，其设置有用于暴露所述金属层的面对所述第二介电层的一侧表面的一部分的开口，并且用于使所述测量样品与所述表面接触; 用于从所述金属层的所述金属层的纵向方向的一端引入光束到所述金属层的光源; 检测从金属层的另一端发射的光束的检测单元，测量灵敏度高，尺寸小，可以简单的使用。

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