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1. 发明申请

US20180292398A1 IMMUNOCHROMATOGRAPHIC KIT 审中-公开
公开(公告)号：US20180292398A1
公开(公告)日：2018-10-11
申请号：US16008050
申请日：2018-06-14
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA , Akira WAKABAYASHI , Keiji SHIGESADA
IPC分类号： G01N33/543 , G01N33/577 , G01N33/569
摘要： A housing case that includes an inspection strip, a first pot in which a first amplification liquid is sealed, and a second pot in which a second amplification liquid is sealed, includes a lower case, an upper case, and an intermediate member disposed therebetween, in which the upper case includes, on a part facing the first pot, a first protrusive deforming portion that deforms towards a side of the first pot when applied with pressing force from outside, whereby a tearing portion of the intermediate member tears a sheet member of the first pot, and includes, at a part facing the second pot, a second protrusive deforming portion that deforms towards a side of the second pot when applied with pressing force from outside, whereby a sheet member of the second pot is torn.

2. 发明申请

US20130084580A1 CHROMATOGRAPHIC KIT AND CHROMATOGRAPHY METHOD 审中-公开
标题翻译：色谱盒和色谱法
公开(公告)号：US20130084580A1
公开(公告)日：2013-04-04
申请号：US13625542
申请日：2012-09-24
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA , Mikinaga MORI
IPC分类号： G01N33/53 , G01N21/78 , G01N21/01
CPC分类号： G01N33/553 , G01N33/54386
摘要： A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance.
摘要翻译：提供了一种色谱试剂盒，其包括具有被测试物质的第一结合物质改性的标记物质的标记物质保存区域和具有测试物质的第二结合物质或第一结合物质的结合物质的标记物质捕获区域从包含测试物质的测试样品的显影方向的上游到下游的顺序，并且还包括具有显色剂的区域，以便检测用于放大信号的两种类型的扩增试剂的第一扩增试剂检测标签物质时的标记物质。

3. 发明申请

US20220334111A1 IMMUNOCHROMATOGRAPHY 有权
公开(公告)号：US20220334111A1
公开(公告)日：2022-10-20
申请号：US17852053
申请日：2022-06-28
申请人： FUJIFILM Corporation
发明人： Yoshihiro ABURAYA , Junichi KATADA , Atsuhiko WADA , Dai UJIHARA
IPC分类号： G01N33/543 , G01N33/532 , G01N33/553
摘要： An immunochromatography includes steps of mixing a specimen capable of containing an antigen and a modified particle, which is a particle modified with a substance having a specific affinity to the antigen, to obtain a mixture containing particle composite bodies; sedimenting the particle composite bodies in the mixture using a centrifuge; dissociating the sedimented particle composite bodies into the particles and the antigen by mixing the sedimented particle composite bodies with a dissociation solution, recovering an antigen-concentrated solution by sedimenting the dissociated particles using a centrifuge; neutralizing the antigen-concentrated solution using a neutralization solution; spreading particle composite bodies for labeling on an insoluble carrier having a reaction site, in a state where the particle composite bodies for labeling, which are composite bodies of the antigen in the neutralized antigen-concentrated solution and a modified particle for labeling, are formed; and capturing the particle composite bodies for labeling at the reaction site.

4. 发明申请

US20170307603A1 IMMUNOCHROMATOGRAPHIC KIT 审中-公开
公开(公告)号：US20170307603A1
公开(公告)日：2017-10-26
申请号：US15649009
申请日：2017-07-13
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , G01N33/54366 , G01N33/558
摘要： The immunochromatographic kit includes an inspection strip which includes an insoluble carrier spreading the specimen liquid, a label-holding pad including a label substance modified with a first substance bondable to a test substance, a liquid-sending pad sending a first amplification liquid to the insoluble carrier, and an absorption pad disposed in contact with the other end of the insoluble carrier and sequentially has an inspection region including a second substance being bonded to the test substance, a confirmation region including a substance bondable to the first substance, and an amplification index region including a substance being reacted with the first amplification liquid between the label-holding pad and the absorption pad of the insoluble carrier, a first pot being disposed below the liquid-sending pad and enclosing the first amplification liquid, and a second pot being disposed above the absorption pad and enclosing a second amplification liquid in a housing case.

5. 发明申请

US20220196643A1 IMMUNOLOGICAL TEST METHOD AND CONCENTRATION JIG 有权
公开(公告)号：US20220196643A1
公开(公告)日：2022-06-23
申请号：US17690101
申请日：2022-03-09
申请人： FUJIFILM Corporation
发明人： Yoshihiro ABURAYA , Naoyuki NISHIKAWA , Junichi KATADA , Atsuhiko WADA , Dai UJIHARA
IPC分类号： G01N33/543
摘要： The immunological test method includes a concentration step of concentrating an antigen-containable solution by mixing the antigen-containable solution with a superabsorbent polymer to obtain an antigen-concentrated solution, and a detection step of detecting an antigen in the antigen-concentrated solution using an antigen-antibody reaction, in which a swelling ratio of the superabsorbent polymer is more than 0.2 g/g and less than 800 g/g, and an antibody that is used in the antigen-antibody reaction is a monoclonal antibody.

6. 发明申请

US20220196523A1 IMMUNOCHROMATOGRAPHY 有权
公开(公告)号：US20220196523A1
公开(公告)日：2022-06-23
申请号：US17690854
申请日：2022-03-09
申请人： FUJIFILM Corporation
发明人： Yoshihiro ABURAYA , Naoyuki NISHIKAWA , Junichi KATADA , Atsuhiko WADA , Dai UJIHARA
IPC分类号： G01N1/40 , G01N33/543
摘要： An immunochromatography including steps of mixing an antigen-containable specimen and modified magnetic particles, which are magnetic particles modified with a substance having a specific affinity to the antigen; collecting the magnetic particles using magnetism; dissociating the modified magnetic particles to obtain an antigen-concentrated solution by mixing the collected magnetic particles with a dissociation solution, an amount of which is smaller than the antigen-containable specimen; obtaining a neutralized antigen-concentrated solution; spreading gold particle composite bodies on an insoluble carrier having a reaction site at which a second binding substance has been immobilized, in a state where the gold particle composite bodies which are composite bodies of an antigen in the neutralized antigen-concentrated solution and modified gold particles which are gold particles modified with a first binding substance are formed; capturing the gold particle composite bodies at the reaction site; and silver-amplifying the gold particle composite body.

7. 发明申请

US20140093868A1 CHROMATOGRAPHY METHOD 审中-公开
标题翻译：色谱法
公开(公告)号：US20140093868A1
公开(公告)日：2014-04-03
申请号：US14098798
申请日：2013-12-06
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA , Mikinaga MORI
IPC分类号： G01N33/553
CPC分类号： G01N33/553 , G01N33/54386
摘要： A chromatographic kit is provided including a labeling substance holding area having a labeling substance modified with a first binding substance of a test substance, and a labeling substance capturing area having a second binding substance of the test substance or a binding substance of the first binding substance in this order from upstream to downstream of a development direction of a test sample including the test substance, and further including an area having a color developing reagent in order to detect a first amplification reagent of two types of amplification reagents used to amplify the signal of the labeling substance when detecting the labeling substance.
摘要翻译：提供了一种色谱试剂盒，其包括具有被测试物质的第一结合物质改性的标记物质的标记物质保存区域和具有测试物质的第二结合物质或第一结合物质的结合物质的标记物质捕获区域从包含测试物质的测试样品的显影方向的上游到下游的顺序，并且还包括具有显色剂的区域，以便检测用于放大信号的两种类型的扩增试剂的第一扩增试剂检测标签物质时的标记物质。

8. 发明公开

US20240319189A1 ASSAY KIT AND CHROMATOGRAPHIC METHOD 审中-公开
公开(公告)号：US20240319189A1
公开(公告)日：2024-09-26
申请号：US18677260
申请日：2024-05-29
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA
IPC分类号： G01N33/569 , B01D15/38 , G01N33/543
CPC分类号： G01N33/56983 , B01D15/3809 , G01N33/54388 , G01N2333/11 , G01N2333/165 , G01N2469/10
摘要： An object of the present invention is to provide an assay kit for performing a chromatographic method, combined with a nasal mucus receiving medium in which a sample is easily visible and the sample is easily collected, and a chromatographic method including detecting presence or absence of a test substance in nasal mucus by using the above-descried assay kit. According to the present invention, there is provided an assay kit including (a) a nasal mucus receiving medium that includes a medium in which a visibility of a portion in contact with nasal mucus is changed in a case where nasal mucus is brought into contact with the portion, and an impermeable sheet, and (b) a chromatographic kit that includes a label substance modified with a first binding substance for a test substance, and a porous carrier having a second binding substance for the test substance or a binding substance for the first binding substance.

9. 发明申请

US20230015388A1 IMMUNOCHROMATOGRAPHIC KIT AND IMMUNOCHROMATOGRAPHIC METHOD 有权
公开(公告)号：US20230015388A1
公开(公告)日：2023-01-19
申请号：US17951170
申请日：2022-09-23
申请人： FUJIFILM Corporation
发明人： Ko YAMAMOTO , Atsuhiko WADA
IPC分类号： G01N33/543 , G01N33/558
摘要： An object of the present invention is to provide a chromatographic kit and a chromatographic method which have high-sensitivity and in which occurrence of false positives is inhibited. According to the present invention, an immunochromatographic kit is provided, the immunochromatographic kit including: a label substance modified with a first antibody having binding properties with respect to a test substance; a porous carrier having a reaction site holding a second antibody having binding properties with respect to the test substance; an amplification reagent; and a third antibody having an immune host which is the same as that of at least one antibody of the first antibody or the second antibody and not recognizing the test substance.

10. 发明申请

US20140242572A1 CHROMATOGRAPHY METHOD, CHROMATOGRAPHY KIT, AND METHOD OF PRODUCING AN INSOLUBLE CARRIER FOR CHROMATOGRAPHY 审中-公开
标题翻译：色谱方法，色谱套件和生产用于色谱的不溶性载体的方法
公开(公告)号：US20140242572A1
公开(公告)日：2014-08-28
申请号：US14189497
申请日：2014-02-25
申请人： FUJIFILM Corporation
发明人： Atsuhiko WADA
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , B01D15/32 , G01N33/538 , G01N33/543 , G01N33/54393 , G01N33/558
摘要： A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive site on the insoluble carrier, a step of washing the reactive site on the insoluble carrier using a washing liquid, a step of detecting the specimen which is captured at the reactive site after a signal of the labeled substance is amplified by an amplification liquid, in which the reactive site on the insoluble carrier includes (i) a second bondable substance which can be bonded to the specimen or a substance having affinity to the first bondable substance which can be bonded to the specimen, and (ii) polyethylene glycol having the molecular weight from 1,500 to 10,000.
摘要翻译：一种色谱分离方法，其特征在于，包括：将可与被检体的第一可结合物质进行了改性的试样和标记物的复合体显影在不溶性载体上的步骤，将样品和标记物质的配合物捕获到在不溶性载体上的反应性位点，使用洗涤液洗涤不溶性载体上的反应部位的步骤，在通过扩增液扩增标记物质的信号后，检测在反应部位捕获的样品的步骤，其中不溶性载体上的反应位点包括（i）可以结合到样品的第二可结合物质或与可与试样结合的第一可结合物质具有亲和力的物质，和（ii）具有分子量为1,500至10,000。

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