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1. 发明授权

US10368834B2 Bone surface image reconstruction using ultrasound 有权
公开(公告)号：US10368834B2
公开(公告)日：2019-08-06
申请号：US14113672
申请日：2012-04-25
申请人： F. William Mauldin, Jr. , John A. Hossack , Kevin Owen
发明人： F. William Mauldin, Jr. , John A. Hossack , Kevin Owen
IPC分类号： A61B8/08 , A61B8/00 , G01S7/52 , G01S15/60 , G01S15/89 , A61B34/20 , A61B17/34 , A61B90/00
摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.

2. 发明申请

US20140046186A1 BONE SURFACE IMAGE RECONSTRUCTION USING ULTRASOUND 审中-公开
标题翻译：使用超声波的骨表面图像重建
公开(公告)号：US20140046186A1
公开(公告)日：2014-02-13
申请号：US14113672
申请日：2012-04-25
申请人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
发明人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/0875 , A61B8/0841 , A61B8/4245 , A61B8/4254 , A61B8/4433 , A61B8/4455 , A61B8/4466 , A61B8/4483 , A61B8/466 , A61B8/483 , A61B34/20 , A61B2017/3413 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2090/378 , A61B2090/3937 , G01S7/52073 , G01S7/5208 , G01S15/60 , G01S15/8915 , G01S15/899
摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
摘要翻译：超声波换能器元件可以被配置为产生被引导到对象的组织中的超声能量，并且被配置为接收由位于组织内的目标反射的超声能量的一部分。超声波换能器可以包括被配置为提供或接收超声能量的表面，该表面包括大于或等于约4λ2的面积，或者超声波换能器元件可以被包括在具有至少两个相邻超声波之间的间隔的阵列中小于或等于约1/2的元件，并且该阵列包括在两个轴线上至少近似对称的孔。可以经由显示器呈现目标的至少一部分的位置，形状或取向中的一个或多个的三维表示。

3. 发明申请

US20180035979A1 ULTRASOUND CONTRAST AGENT DECORRELATION-BASED SIGNAL SEPARATION 审中-公开
公开(公告)号：US20180035979A1
公开(公告)日：2018-02-08
申请号：US15668404
申请日：2017-08-03
申请人： Elizabeth Bronwyn Herbst , John A. Hossack , Shiying Wang , F. William Mauldin, JR.
发明人： Elizabeth Bronwyn Herbst , John A. Hossack , Shiying Wang , F. William Mauldin, JR.
IPC分类号： A61B8/08 , A61B8/00 , A61K49/22 , A61B8/14
CPC分类号： A61B8/481 , A61B8/085 , A61B8/14 , A61B8/4483 , A61B8/461 , A61B8/5207 , A61K49/221 , A61K49/223
摘要： An apparatus can be used to generate acoustic imaging pulse sequences and receive corresponding echoes elicited by the acoustic imaging pulse sequences. An acoustic radiation force (ARF) pulse sequence can be generated to agitate a contrast medium in a tissue region between the acoustic imaging pulse sequences. A decorrelation between images corresponding to the received echoes can be determined. A weighting map can be applied to an image to weight a region of the image corresponding to a spatial location of the contrast medium using the determined decorrelation. In an example, the receiving of corresponding echoes elicited by the acoustic imaging pulse sequences can include receiving acoustic energy having a range of frequencies offset from a fundamental frequency associated with the acoustic imaging pulse sequences. An acoustic imaging pulse sequence can include a pulse having an inverted amplitude envelope with respect to another pulse included in the sequence.

4. 发明申请

US20150150534A1 SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES 有权
标题翻译：用于绑定微量元素动力学的系统和方法
公开(公告)号：US20150150534A1
公开(公告)日：2015-06-04
申请号：US14559422
申请日：2014-12-03
申请人： F. William Mauldin, JR. , Shiying Wang , John A. Hossack , Alexander L. Klibanov
发明人： F. William Mauldin, JR. , Shiying Wang , John A. Hossack , Alexander L. Klibanov
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/481 , A61B8/0891 , A61B8/587 , G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.
摘要翻译：一种超声系统和方法，其可以包括：接收波束形成器，被配置为从换能器接收信号; 耦合到所述接收波束形成器的处理器，所述处理器被配置为：分析从感兴趣区域反射的回波数据，所述回波数据由所发射的脉冲序列引起; 使用回波数据，确定在感兴趣区域内随时间的粘附微泡区域的信号幅度的集中趋势; 确定信号幅度的时间序列; 使用时间序列，确定初始信号幅度参数; 使用时间序列获得饱和信号参数和残差信号参数; 并确定指示残留信号幅度与饱和信号幅度相关的信息的相对指示。

5. 发明授权

US09002080B2 Singular value filter for imaging or detection 有权
标题翻译：用于成像或检测的奇异值滤波器
公开(公告)号：US09002080B2
公开(公告)日：2015-04-07
申请号：US13650821
申请日：2012-10-12
申请人： F. William Mauldin, Jr. , John A. Hossack , Abhay V. Patil
发明人： F. William Mauldin, Jr. , John A. Hossack , Abhay V. Patil
IPC分类号： G06K9/00 , G06K9/62 , A61B8/08
CPC分类号： G06K9/6247 , A61B8/0891 , A61B8/481 , A61B8/485 , A61B8/5207 , G01S7/52039 , G01S7/52041 , G01S7/52042 , G01S7/52046 , G01S15/8915 , G01S15/8981
摘要： Apparatus or techniques can include obtaining information indicative of energy, such as ultrasonic energy, reflected from a tissue region, forming respective input matrices representative of the obtained information, the input matrices respectively comprising an ensemble-of-interest and at least one ensemble corresponding to a spatial location nearby a spatial location corresponding to the ensemble-of-interest, performing respective singular value decompositions on the respective input matrices to obtain respective sets of singular values corresponding to respective sets of singular vectors, obtaining respective output matrices including weighting a respective projection of a respective ensemble-of-interest onto at least one of the singular vectors included in a respective set of singular vectors, and, using the respective output matrices, at least one of determining a characteristic, or constructing an image, of at least a portion of the tissue region.
摘要翻译：设备或技术可以包括获得指示诸如超声波能量的信息的信息，例如从组织区域反射，形成表示所获得信息的相应输入矩阵，输入矩阵分别包括感兴趣集合和至少一个对应于相邻于感兴趣集合的空间位置附近的空间位置，在各个输入矩阵上执行各自的奇异值分解，以获得对应于各组奇异矢量的各组奇异值，获得各自的输出矩阵，包括对相应投影加权将相关的感兴趣整体集合到包含在相应的一组奇异矢量中的奇异矢量中的至少一个，并且使用相应的输出矩阵，确定至少一个部分组织区域。

6. 发明申请

US20100168578A1 System and Method for Combined ECG-Echo for Cardiac Diagnosis 审中-公开
标题翻译：用于心脏诊断的组合ECG回波的系统和方法
公开(公告)号：US20100168578A1
公开(公告)日：2010-07-01
申请号：US12664146
申请日：2008-06-12
申请人： Arthur Garson, JR. , William F. Walker , John A. Hossack , Travis N. Blalock
发明人： Arthur Garson, JR. , William F. Walker , John A. Hossack , Travis N. Blalock
IPC分类号： A61B8/14 , A61B5/0402
CPC分类号： A61B8/0858 , A61B8/0883 , A61B8/483
摘要： A system and related method for obtaining volumetric cardiac data of a subject. The data is generated by forming a plurality of focused ultrasound images corresponding to a series of ranges, generating myocardial boundary data for each of the plurality of ultrasound images, calculating the area of the region defined by said myocardial boundary data for each of the plurality of ultrasound images, multiplying the area for each of the plurality of ultrasound images by a slice depth corresponding to said ultrasound image to obtain the slice volume of each slice, and summing the slice volumes to obtain a total volume. In an alternative embodiment the system and related method combine an automated volumetric ultrasound system for finding chamber volumes and myocardial thicknesses, with a diagnostic electrocardiogram system to enable simultaneous diagnosis of mechanical and electrical cardiac problems.
摘要翻译：用于获得受试者体积心脏数据的系统和相关方法。通过形成对应于一系列范围的多个聚焦超声图像来生成数据，为多个超声图像中的每一个生成心肌边界数据，计算由多个超声图像中的每一个的所述心肌边界数据定义的区域的面积超声图像，将所述多个超声图像中的每一个的面积乘以对应于所述超声图像的切片深度，以获得每个切片的切片体积，并且对切片体积求和以获得总体积。在替代实施例中，系统和相关方法结合了用于发现腔室体积和心肌厚度的自动化体积超声系统与诊断心电图系统，以实现机电和电心脏问题的同时诊断。

7. 发明授权

US06780152B2 Method and apparatus for ultrasound imaging of the heart 有权
标题翻译：心脏超声成像的方法和装置
公开(公告)号：US06780152B2
公开(公告)日：2004-08-24
申请号：US10180386
申请日：2002-06-26
申请人： Kutay F. Üstüner , Thilaka S. Sumanaweera , Sevig Ayter , Kenneth M. Fowkes , John A. Hossack , John W. Allison
发明人： Kutay F. Üstüner , Thilaka S. Sumanaweera , Sevig Ayter , Kenneth M. Fowkes , John A. Hossack , John W. Allison
IPC分类号： A61B800
CPC分类号： A61B8/5284 , A61B8/08 , A61B8/0883 , A61B8/4245 , A61B8/483 , G01S7/52074 , G01S15/8993 , G01S15/8995
摘要： Images of the heart are formed by using multiple sets of ultrasound data. Each set of data is acquired and processed responsive to a different set of imaging parameters. The imaging parameter sets differ in at least one parameter, such as array position, temporal frequency response or transmit focal depth, so that the images formed using these data sets have, either laterally or axially, different spatial spectra. A set of images is formed responsive to a first imaging parameter set for a first cardiac cycle. Another set of images is formed responsive to a second imaging parameter set for a second cardiac cycle. The two sets of images are temporally aligned so that they correspond to the same set of phases of the cardiac cycle. Since the data acquisition and processing are distributed over multiple cycles of the motion, assuming regular periodic heart cycle, temporal resolution is maintained.
摘要翻译：通过使用多组超声数据形成心脏的图像。响应于不同的成像参数集，获取和处理每组数据。成像参数集在至少一个参数（例如阵列位置，时间频率响应或发射焦深）上不同，使得使用这些数据集形成的图像具有横向或轴向不同的空间光谱。响应于为第一心动周期设置的第一成像参数形成一组图像。响应于为第二心动周期设置的第二成像参数形成另一组图像。这两组图像在时间上对准，使得它们对应于心动周期的相同的一组相位。由于数据采集和处理分布在运动的多个周期上，假设定期周期性的心脏周期，维持时间分辨率。

8. 发明授权

US06755787B2 Medical diagnostic ultrasound system and method for versatile processing 有权
公开(公告)号：US06755787B2
公开(公告)日：2004-06-29
申请号：US10299179
申请日：2002-11-19
申请人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
发明人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： G01S15/899 , A61B8/483 , A61B8/5276 , G01S7/52034 , G01S7/52077 , G01S15/8981 , G01S15/8993 , G01S15/8995
摘要： A method and system for reducing speckle for two and three-dimensional images is disclosed. For two-dimensional imaging, a one and a half or a two-dimensional transducer is used to obtain sequential, parallel or related frames of elevation spaced data. The frames are compounded to derive a two-dimensional image. For three-dimensional imaging, various pluralities of two-dimensional frames of data spaced in elevation are compounded into one plurality of spaced two-dimensional frames of data. The frames of data are then used to derive a three dimensional set of data, such as by interpolation. Alternatively, the various pluralities are used to derive a three-dimensional set of data. An anisotropic filter is applied to the set of data. The anisotropic filter filters at least along the elevation dimension. In either situation, various displays may be generated from the final three-dimensional set of data. A method and system for adjustably generating two and three-dimensional representations is also disclosed. For three-dimensional imaging, at least two sets of three-dimensional data corresponding respectively to two types of Doppler or B-mode data are generated. The sets of data are then combined. An image or a quantity may be obtained from the combined data. By combining after generating the three-dimensional sets of data, the same data (sets of data) may be combined multiple times pursuant to different relationships. Thus, a user may optimize the image or quantity. Likewise, frames of data may be combined pursuant to different persistence parameters, such as different finite impulse response filter size and coefficients. The frames of data may then be re-combined pursuant to different persistence parameters. Original ultrasound data may also be used to re-generate an imaging using the same ultrasound image processes as used for a previous image. APPENDIX A ⁢ Filter at Plane ⁢ Y = - 2 ⁢ X ⁢ ⁢ → ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] ⁢ Z ↓ Filter at Plane ⁢ Y = - 1 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = 0 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = + 1 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] Filter at Plane ⁢ Y = + 2 ⁢ [ 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ] The filter perform no filtering in the X, Z plane. It filters (low pass) contributions from neighboring elements in only the Y direction. The filter may be implemented as a 1-D low pass filter in the Y-direction [0.2, 0.4, 1.0, 0.4, 0.2]=(a 1×5×1 anisotropic filter).

9. 发明授权

US06679846B2 Diagnostic ultrasound imaging method and system with improved frame rate 有权
公开(公告)号：US06679846B2
公开(公告)日：2004-01-20
申请号：US10081978
申请日：2002-02-21
申请人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
发明人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
IPC分类号： B60R2500
CPC分类号： G01S15/8963 , A61B8/00 , G01S7/52039 , G01S7/52046 , G01S7/52085 , G01S7/52095 , G01S15/8927 , G01S15/8959 , G01S15/8977
摘要： A medical diagnostic ultrasonic imaging system acquires receive beams from spatially distinct transmit beams. The receive beams alternate in type between at least first and second types across the region being imaged. The first and second types of receive beams differ in at least one scan parameter other than transmit and receive line geometry, and can for example differ in transmit phase, transmit or receive aperture, system frequency, transmit focus, complex phase angle, transmit code or transmit gain. Receive beams associated with spatially distinct ones of the transmit beams (including at least one beam of the first type and at least one beam of the second type) are then combined. In this way, many two-pulse techniques, including, for example, phase inversion techniques, synthetic aperture techniques, synthetic frequency techniques, and synthetic focus techniques, can be used while substantially reducing the frame rate penalty normally associated with such techniques.

10. 发明授权

US06517488B1 Medical diagnostic ultrasound system and method for identifying constrictions 有权
标题翻译：医学诊断超声系统和识别收缩的方法
公开(公告)号：US06517488B1
公开(公告)日：2003-02-11
申请号：US09606515
申请日：2000-06-29
申请人： John A. Hossack
发明人： John A. Hossack
IPC分类号： A61B806
CPC分类号： G01S15/8981 , A61B8/06 , G01S15/584 , G01S15/8993 , Y10S128/916
摘要： A method and system for identifying constrictions in a vessel are provided. Total blood volume flow is measured at various locations along the vessel. The total volume flow must be conserved. Regions with a different volume flow than expected (e.g. areas associated with a lower volume that violates conservation of flow) are identified as suspicious. Suspicious regions are likely associated with dropout artifact. Actual constrictions are determined from the geometry of images where the region is not suspicious.
摘要翻译：提供了用于识别容器中的收缩部的方法和系统。在血管的不同位置测量总体积血流量。总体积流量必须保守。具有不同于预期的体积流量的区域（例如，与较低体积相关的区域违反流动的保护）被识别为可疑的。可疑地区可能与辍学神器有关。实际收缩是根据区域不可疑的图像几何确定的。

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