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    • 2. 发明申请
    • Immunogenic compositions comprising Liver Stage Malarial Antigens
    • 包含肝阶段疟疾抗原的免疫原性组合物
    • US20070196394A1
    • 2007-08-23
    • US11524550
    • 2006-09-21
    • Joe CohenPierre Druilhe
    • Joe CohenPierre Druilhe
    • A61K39/015
    • A61K39/39A61K39/015Y02A50/412
    • A vaccine composition comprising a Th1-inducing adjuvant in combination with a protecting Liver Stage Antigen or immunological fragment thereof of a human malaria parasite, especially Plasmodium falciparum, with the proviso that when the immunological fragment is an immunological fragment of LSA-3 the Th1-inducing adjuvant is not Montanide. In one preferred aspect the Th1-inducing adjuvant comprises QS21, De-O-acylated monophosphoryl lipid A (3D-MPL) and an oil in water emulsion wherein the oil in water emulsion has the following composition: a metabolisible oil, such a squalene, alpha tocopherol and tween 80. In a further preferred aspect the protecting Liver Stage Antigen is Liver Stage Antigen 3 (LSA-3) or an immunological fragment thereof. A multivalent vaccine composition is also provided comprising the vaccine composition of the invention and in addition at least one other protecting antigen or an immunological fragment thereof, of a malaria parasite.
    • 一种疫苗组合物,其包含与保护性肝阶段抗原组合的Th1诱导佐剂或其疟原虫特别是恶性疟原虫的免疫学片段,条件是当免疫学片段是LSA-3的免疫学片段时,Th1- 诱导性佐剂不是蒙尼奈德。 在一个优选的方面,Th1诱导佐剂包含QS21,De-O-酰化单磷酰脂质A(3D-MPL)和水包油乳液,其中水包油乳液具有以下组成:可代谢的油,如角鲨烯, α-生育酚和吐温80.在另一个优选的方面,保护性肝阶段抗原是肝阶段抗原3(LSA-3)或其免疫学片段。 还提供了多种疫苗组合物,其包含本发明的疫苗组合物,另外还包含疟疾寄生虫的至少一种其它保护性抗原或其免疫学片段。