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1. 发明授权

US08246986B2 Drug coating providing high drug loading 失效
标题翻译：药物涂层提供高药物负荷
公开(公告)号：US08246986B2
公开(公告)日：2012-08-21
申请号：US10950003
申请日：2004-09-23
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/24 , A61K9/22 , A61K9/54
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： Aqueous drug coatings including at least one insoluble drug, wherein the insoluble drug accounts for about 85 wt % to about 97 wt % of the drug coatings are described. Such drug coatings may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs.
摘要翻译：描述了包含至少一种不溶性药物的水性药物涂层，其中不溶性药物占药物涂层的约85重量％至约97重量％。这样的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。

2. 发明授权

US08226979B2 Drug coating providing high drug loading and methods for providing the same 有权
标题翻译：药物涂层提供高的药物负荷和提供相同的方法
公开(公告)号：US08226979B2
公开(公告)日：2012-07-24
申请号：US13084462
申请日：2011-04-11
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/24 , A61K9/22 , A61K9/54
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译：本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。

3. 发明申请

US20110318392A1 DRUG COATING PROVIDING HIGH DRUG LOADING AND METHODS FOR PROVIDING THE SAME 有权
标题翻译：提供高剂量药物的药物涂料及其提供方法
公开(公告)号：US20110318392A1
公开(公告)日：2011-12-29
申请号：US13084462
申请日：2011-04-11
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/00 , A61P25/04 , A61P29/00 , A61K31/167 , A61K31/485
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译：本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。

4. 发明申请

US20120165361A1 DRUG COATING PROVIDING HIGH DRUG LOADING AND METHODS FOR PROVIDING THE SAME 审中-公开
标题翻译：提供高剂量药物的药物涂料及其提供方法
公开(公告)号：US20120165361A1
公开(公告)日：2012-06-28
申请号：US13412840
申请日：2012-03-06
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K31/485 , A61P25/04 , A61P29/00 , A61K31/167 , A61K47/38
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译：本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。

5. 发明申请

US20050112195A1 Drug coating providing high drug loading and methods for providing same 失效
标题翻译：药物涂层提供高的药物负荷和提供相同的方法
公开(公告)号：US20050112195A1
公开(公告)日：2005-05-26
申请号：US10950003
申请日：2004-09-23
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48 , A61K9/50 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/485 , A61K31/16
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译：本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。

6. 发明申请

US20070225632A1 HYDRATABLE POLYMERIC ESTER MATRIX FOR DRUG ELECTROTRANSPORT 审中-公开
标题翻译：用于药物电子输送的可压缩聚合物基质
公开(公告)号：US20070225632A1
公开(公告)日：2007-09-27
申请号：US11688630
申请日：2007-03-20
申请人： David Rauser , David Edgren , Janardhanan Subramony , Rama Padmanabhan
发明人： David Rauser , David Edgren , Janardhanan Subramony , Rama Padmanabhan
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0444 , A61N1/0448
摘要： A transdermal electrotransport drug delivery system to an individual. The system has a liquid imbibing polymer with carboxyl groups available for noncovalently associating with a cationic drug. The liquid imbibing polymer is applicable for imbibing liquid before the device is deployed on a patient for electrotransport drug delivery.
摘要翻译：一种透皮电转运药物递送系统给个体。该系统具有可用于非阳离子药物非共价结合的具有羧基的液体吸收性聚合物。液体吸收性聚合物适用于在将装置部署在病人身上进行电输送药物递送之前吸入液体。

7. 发明申请

US20050175690A1 Novel drug compositions and dosage forms 审中-公开
标题翻译：新型药物组合物和剂型
公开(公告)号：US20050175690A1
公开(公告)日：2005-08-11
申请号：US11024330
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K31/35
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译：本发明涉及包含所述药物组合物的新型药物组合物和剂型。本发明的药物组合物包含药剂和增溶剂。本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。本发明还涉及制备所述药物组合物和剂型的方法。本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

8. 发明申请

US20050169992A1 Methods and dosage forms for increasing solubility of drug compositions for controlled delivery 审中-公开
标题翻译：用于增加药物组合物用于受控递送的溶解度的方法和剂型
公开(公告)号：US20050169992A1
公开(公告)日：2005-08-04
申请号：US11023257
申请日：2004-12-22
申请人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
发明人： Frank Jao , David Edgren , Robert Skluzacek , Noymi Yam
IPC分类号： A61K9/00 , A61K9/48 , A61K31/18 , A61K31/7004 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0004 , A61K31/7004
摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of poorly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration.
摘要翻译：描述了通过使用提高药剂的溶解度的药物核心组合物增强药剂的受控递送的剂型和装置。本发明提供了一种在口服药物递送系统中递送高剂量的难溶性药物的方法，其便于吞咽，每天一次给药。

9. 发明申请

US20070243254A1 NOVEL DRUG COMPOSITIONS AND DOSAGE FORMS OF TOPIRAMATE 审中-公开
标题翻译：新型药物组合物及其用量
公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
IPC分类号： A61K9/24 , A61P25/06 , A61P25/08
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译：本发明涉及包含所述药物组合物的新型药物组合物和剂型。本发明的药物组合物包含药剂和增溶剂。本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。本发明还涉及制备所述药物组合物和剂型的方法。本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

10. 发明申请

US20070207204A1 Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
标题翻译：药物递送时间变化模式的剂型
公开(公告)号：US20070207204A1
公开(公告)日：2007-09-06
申请号：US11744999
申请日：2007-05-07
申请人： David Edgren , Patrick Wong , Shu Li
发明人： David Edgren , Patrick Wong , Shu Li
IPC分类号： A61K9/66
CPC分类号： A61K9/0004 , A61K31/277
摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.
摘要翻译：本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。药物涂层在初始无药物释放间隔后释放。在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

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