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1. 发明授权

US06738716B1 Database system for predictive cellular bioinformatics 有权
公开(公告)号：US06738716B1
公开(公告)日：2004-05-18
申请号：US09718766
申请日：2000-11-21
申请人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
发明人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
IPC分类号： G01N3348
CPC分类号： G06K9/00127 , C12M41/36 , C12M41/46 , G06F19/24 , G06T7/0012 , G06T2207/30024 , Y10S707/99933 , Y10S707/99934 , Y10S707/99936
摘要： A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.

2. 发明授权

US06615141B1 Database system for predictive cellular bioinformatics 失效
标题翻译：用于预测细胞生物信息学的数据库系统
公开(公告)号：US06615141B1
公开(公告)日：2003-09-02
申请号：US09718704
申请日：2000-11-21
申请人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
发明人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
IPC分类号： G01N3348
CPC分类号： G06K9/00127 , C12M41/36 , C12M41/46 , G06F19/24 , G06T7/0012 , G06T2207/30024 , Y10S707/99933 , Y10S707/99934 , Y10S707/99936
摘要： A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.
摘要翻译：用于从蜂窝信息获取知识的系统。该系统具有包括数据库管理模块（“DBMS”）的数据库。该系统还具有各种模块，包括耦合到DBMS的群模块，用于从图像采集设备将多个特征（例如，小区大小，小区之间的距离，小区群，小区类型）分类和存储到数据库中。该系统具有耦合到DBMS的翻译模块，用于从多个特征的一组选定特征中定义描述符。在具体实施方案中，描述符是用于已知或未知的化合物，例如药物。预测模块耦合到DBMS，用于基于来自所选化合物的所选择的描述符从数据库中选择来自已知和未知化合物的多个描述符之一。所选择的化合物可以是可用于治疗人类等的化合物。

3. 发明授权

US06631331B1 Database system for predictive cellular bioinformatics 有权
公开(公告)号：US06631331B1
公开(公告)日：2003-10-07
申请号：US09718836
申请日：2000-11-21
申请人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
发明人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
IPC分类号： G01N3348
CPC分类号： G06K9/00127 , C12M41/36 , C12M41/46 , G06F19/24 , G06T7/0012 , G06T2207/30024 , Y10S707/99933 , Y10S707/99934 , Y10S707/99936
摘要： A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.

4. 发明授权

US06743576B1 Database system for predictive cellular bioinformatics 失效
标题翻译：用于预测细胞生物信息学的数据库系统
公开(公告)号：US06743576B1
公开(公告)日：2004-06-01
申请号：US09311890
申请日：1999-05-14
申请人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
发明人： James H. Sabry , Cynthia L. Adams , Eugeni A. Vaisberg , Anne M. Crompton
IPC分类号： C12Q100
CPC分类号： G06K9/00127 , C12M41/36 , C12M41/46 , G06F19/24 , G06T7/0012 , G06T2207/30024 , Y10S707/99933 , Y10S707/99934 , Y10S707/99936
摘要： A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a population module coupled to the DBMS for categorizing and storing a plurality of features (e.g., cell size, distance between cells, cell population, cell type) from an image acquisition device into the database. The system has a translation module coupled to the DBMS for defining a descriptor from a set of selected features from the plurality of features. In a specific embodiment, the descriptor is for a known or unknown compound, e.g., drug. A prediction module is coupled to the DBMS for selecting one of a plurality of a descriptors from known and unknown compounds from the database based upon a selected descriptor from a selected compound. The selected compound may be one that is useful for treatment of human beings or the like.
摘要翻译：用于从蜂窝信息获取知识的系统。该系统具有包括数据库管理模块（“DBMS”）的数据库。该系统还具有各种模块，包括耦合到DBMS的群模块，用于从图像采集设备将多个特征（例如，小区大小，小区之间的距离，小区群，小区类型）分类和存储到数据库中。该系统具有耦合到DBMS的翻译模块，用于从多个特征的一组选定特征中定义描述符。在具体实施方案中，描述符是用于已知或未知的化合物，例如药物。预测模块耦合到DBMS，用于基于来自所选化合物的所选择的描述符从数据库中选择来自已知和未知化合物的多个描述符之一。所选择的化合物可以是可用于治疗人类等的化合物。

5. 发明授权

US06651008B1 Database system including computer code for predictive cellular bioinformatics 有权
标题翻译：数据库系统包括用于预测细胞生物信息学的计算机代码
公开(公告)号：US06651008B1
公开(公告)日：2003-11-18
申请号：US09721154
申请日：2000-11-21
申请人： Eugeni A. Vaisberg , Cynthia L. Adams , James H. Sabry , Anne M. Crompton
发明人： Eugeni A. Vaisberg , Cynthia L. Adams , James H. Sabry , Anne M. Crompton
IPC分类号： G06F1900
CPC分类号： G06F19/28
摘要： According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.
摘要翻译：根据本发明，用于在治疗或药物发现中使用信息技术的基于计算机的技术。在一个示例性实施例中，提供了基于基于关于暴露于物质的生物体或非活细胞结构的信息来确定关于物质属性的信息的基于计算机的技术。根据本发明的计算机软件使研究人员和/或科学家能够使用例如蜂窝信息学数据库来识别有希望的候选人寻找新的和更好的药物或治疗。

6. 发明授权

US07657076B2 Characterizing biological stimuli by response curves 失效
标题翻译：通过响应曲线表征生物刺激
公开(公告)号：US07657076B2
公开(公告)日：2010-02-02
申请号：US11186143
申请日：2005-07-20
申请人： Eugeni A. Vaisberg , Donald R. Oestreicher , Cynthia L. Adams
发明人： Eugeni A. Vaisberg , Donald R. Oestreicher , Cynthia L. Adams
IPC分类号： G06K9/00 , G06K9/20 , G06K9/36 , G06F19/00
CPC分类号： G06K9/6253 , G06F19/70 , G06K9/00127
摘要： A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.
摘要翻译：用于产生刺激响应曲线（例如，剂量反应曲线）的方法示出了一种或多种细胞的表型如何响应于刺激的不同水平而改变。曲线上的每个“点”表示在特定刺激水平（例如治疗剂的剂量）下的细胞的定量表型。定量表型是细胞的多变量表型表达。它们包括通过图像分析获得的细胞的各种特征。这些特征通常包括从基本参数（例如细胞周期状态，有丝分裂指数等）导出的图像（例如，细胞形状，细胞核区域，高尔基体织构）和/或生物学表征获得的基本参数。可以比较刺激反应曲线以允许刺激分类并识别相关刺激的微妙差异。为了便于比较，可能期望在主要分量空间中呈现响应曲线。

7. 发明授权

US07016787B2 Characterizing biological stimuli by response curves 失效
公开(公告)号：US07016787B2
公开(公告)日：2006-03-21
申请号：US09789595
申请日：2001-02-20
申请人： Eugeni A. Vaisberg , Donald R. Oestreicher , Cynthia L. Adams
发明人： Eugeni A. Vaisberg , Donald R. Oestreicher , Cynthia L. Adams
IPC分类号： G01N33/48 , G06K9/00
CPC分类号： G06K9/6253 , G06F19/70 , G06K9/00127
摘要： A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.

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