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1. 发明授权

US07585517B2 Transscleral delivery 有权
标题翻译：跨收运
公开(公告)号：US07585517B2
公开(公告)日：2009-09-08
申请号：US10945682
申请日：2004-09-20
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
IPC分类号： A61F2/00 , C12P21/04 , A61K38/00 , A61K31/44 , A61K31/445
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译：通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。

2. 发明授权

US08637070B2 Rapamycin formulations and methods of their use 有权
标题翻译：雷帕霉素配方及其使用方法
公开(公告)号：US08637070B2
公开(公告)日：2014-01-28
申请号：US11352092
申请日：2006-02-09
申请人： Sreenivasu Mudumba , Philippe J M Dor , Thierry Nivaggioli , David A. Weber , Sidiq Farooq
发明人： Sreenivasu Mudumba , Philippe J M Dor , Thierry Nivaggioli , David A. Weber , Sidiq Farooq
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/0048 , A61K31/045 , A61K31/436 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/44
摘要： Described herein are liquid rapamycin formulations. Described herein are methods of treating or preventing diseases or conditions, such as choroidal neovascularization, wet AMD and dry AMD, and preventing transition of dry AMD to wet AMD, using the liquid rapamycin formulations described herein.
摘要翻译：本文描述的是液体雷帕霉素制剂。本文描述了使用本文所述的液体雷帕霉素制剂治疗或预防疾病或病症如脉络膜新生血管形成，湿性AMD和干性AMD的方法，以及防止干性AMD转变为湿性AMD。

3. 发明授权

US08367097B2 Liquid formulations for treatment of diseases or conditions 有权
标题翻译：用于治疗疾病或病症的液体制剂
公开(公告)号：US08367097B2
公开(公告)日：2013-02-05
申请号：US12778872
申请日：2010-05-12
申请人： Sreenivasu Mudumba , Philippe J M Dor , Thierry Nivaggioli , David A. Weber , Sidiq Farooq
发明人： Sreenivasu Mudumba , Philippe J M Dor , Thierry Nivaggioli , David A. Weber , Sidiq Farooq
IPC分类号： A61F2/00 , A01N43/62 , A61K31/55 , A61K38/13
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/0048 , A61K31/045 , A61K31/436 , A61K31/44 , A61K31/4745 , A61K47/10 , A61K47/12 , A61K47/44
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.
摘要翻译：包括但不限于眼睛中的组织的疾病和病症可被有效治疗，预防，抑制，发作延迟或由给予这些组织的治疗剂引起的回归。本文描述的是液体制剂，其将多种治疗剂（包括但不限于雷帕霉素）递送给受试者较长时间; 当被置于受试者的水性介质中时形成非分散物质的液体制剂; 在水性介质中形成凝胶或凝胶状物质的非分散质量形成液体制剂; 液体制剂，包含治疗剂和多种聚合物; 以及使用液体制剂将治疗剂递送给受试者较长时间的方法。液体制剂可以放置在受试者的水性介质中，包括但不限于通过眼内或眼周内施用，或靠近受试者待治疗的疾病或病症的位置放置。可以使用方法来施用雷帕霉素以治疗或预防受试者的血管生成，脉络膜新生血管形成或年龄相关性黄斑变性或湿性年龄相关性黄斑变性。液体制剂可以包含雷帕霉素或其它治疗剂。

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