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1. 发明申请

US20100303820A1 METHODS OF TREATMENT USING IL-17E ANTAGONISTS 审中-公开
标题翻译：使用IL-17E拮抗剂治疗的方法
公开(公告)号：US20100303820A1
公开(公告)日：2010-12-02
申请号：US12787295
申请日：2010-05-25
申请人： Eugene Medlock , Richard Yeh , Scott Michael Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott Michael Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： A61K39/395 , A61P11/00
CPC分类号： A61K39/3955 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0381 , A01K2267/0387 , A61K38/20 , A61K48/00 , C07K14/54 , C07K14/7155 , C07K2319/00 , C07K2319/30 , C12N15/8509
摘要： Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.
摘要翻译：新型IL-17样多肽和编码相同的核酸分子。本发明还提供载体，宿主细胞，选择性结合剂和用于产生IL-17样多肽的方法。还提供用于治疗，诊断，改善或预防具有IL-17类似多肽，激动剂或其拮抗剂的疾病的方法。

2. 发明申请

US20110160438A1 IL-17 RECEPTOR LIKE MOLECULES AND USES THEREOF 审中-公开
标题翻译： IL-17受体类似分子及其用途
公开(公告)号：US20110160438A1
公开(公告)日：2011-06-30
申请号：US12914873
申请日：2010-10-28
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K16/28
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译：本发明提供IL-17受体样多肽和编码该多肽的核酸分子。本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。

3. 发明申请

US20090281287A1 IL-17 receptor like molecules and uses thereof 失效
标题翻译： IL-17受体样分子及其用途
公开(公告)号：US20090281287A1
公开(公告)日：2009-11-12
申请号：US12455553
申请日：2009-06-03
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C07K19/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
摘要翻译：本发明提供IL-17受体样多肽和编码该多肽的核酸分子。本发明还提供载体，宿主细胞，激动剂和拮抗剂（包括选择性结合剂）以及用于产生IL-17受体样多肽的方法。还提供用于治疗，诊断，改善或预防具有IL-17受体样多肽的疾病的方法。

4. 发明授权

US07094566B2 IL-17 receptor like molecules and uses thereof 有权
公开(公告)号：US07094566B2
公开(公告)日：2006-08-22
申请号：US09810927
申请日：2001-03-16
申请人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
发明人： Eugene Medlock , Richard Yeh , Scott M. Silbiger , Gary S. Elliott , Hung Q. Nguyen , Shuqian Jing
IPC分类号： C12N15/12 , C12N5/10 , C12N15/63 , C12P21/02 , C07K14/47
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0368 , A61K38/00 , A61K49/0008 , C07K14/7155 , C12N15/8509 , G01N33/6863 , G01N2500/00 , Y10S435/81
摘要： The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.

5. 发明授权

US08300494B2 Sub volt flash memory system 有权
标题翻译：亚伏闪存系统
公开(公告)号：US08300494B2
公开(公告)日：2012-10-30
申请号：US12980209
申请日：2010-12-28
申请人： Hieu Van Tran , Sang T. Nguyen , Anh Ly , Hung Q. Nguyen
发明人： Hieu Van Tran , Sang T. Nguyen , Anh Ly , Hung Q. Nguyen
IPC分类号： G11C8/00
CPC分类号： G11C16/28 , G11C16/08 , G11C16/30
摘要： Various circuits include MOS transistors that have a bulk voltage terminal for receiving a bulk voltage that is different from a supply voltage and ground. The bulk voltage may be selectively set so that some MOS transistors have a bulk voltage set to the supply voltage or ground and other MOS transistors have a bulk voltage that is different. The bulk voltage may be set to forward or reverse bias pn junctions in the MOS transistor. The various circuits include comparators, operational amplifiers, sensing circuits, decoding circuits and the other circuits. The circuits may be included in a memory system.
摘要翻译：各种电路包括具有用于接收不同于电源电压和接地的体电压的体电压端子的MOS晶体管。可以选择性地设置体电压，使得一些MOS晶体管具有设置为电源电压或地的体电压，并且其它MOS晶体管具有不同的体电压。体电压可以被设置为MOS晶体管中的正向或反向偏置pn结。各种电路包括比较器，运算放大器，感测电路，解码电路和其它电路。电路可以包括在存储器系统中。

6. 发明申请

US20120231006A1 ANTI-ORAI1 ANTIGEN BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：抗ORAI1抗原结合蛋白及其用途
公开(公告)号：US20120231006A1
公开(公告)日：2012-09-13
申请号：US13510926
申请日：2010-11-19
申请人： Hung Q. Nguyen , Fen-Fen Lin , Xiao-juan Bi , Helen J. McBride , Shaw-Fen Sylvia Hu
发明人： Hung Q. Nguyen , Fen-Fen Lin , Xiao-juan Bi , Helen J. McBride , Shaw-Fen Sylvia Hu
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , C12P21/02 , C12N5/16 , A61P37/00 , A61P3/10 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/08 , A61P1/16 , A61P35/00 , A61P31/04 , A61P9/10 , C12N1/21 , C12N1/19 , C12N1/15 , C07K16/18
CPC分类号： C07K16/28 , A61K2039/505 , C07K14/47 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/60
摘要： Disclosed is an isolated antigen binding proteins, such as but not limited to, an antibody or antibody fragment, that specifically bind to SEQ ID NO: 4, the amino acid sequence of extracellular loop 2 (ECL2) of human Orai1. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors and host cells useful in methods of making it, and methods of using it in treating disorders or diseases in patients.
摘要翻译：公开了分离的抗原结合蛋白，例如但不限于特异性结合人Orai1的细胞外环2（ECL2）的氨基酸序列SEQ ID NO：4的抗体或抗体片段。还公开了包含抗原结合蛋白，编码它的分离的核酸，用于制备它的方法中的载体和宿主细胞的药物组合物和药物，以及用于治疗患者疾病或疾病的方法。

7. 发明授权

US07990773B2 Sub volt flash memory system 有权
标题翻译：亚伏闪存系统
公开(公告)号：US07990773B2
公开(公告)日：2011-08-02
申请号：US12623306
申请日：2009-11-20
申请人： Hieu Van Tran , Sang T. Nguyen , Anh Ly , Hung Q. Nguyen
发明人： Hieu Van Tran , Sang T. Nguyen , Anh Ly , Hung Q. Nguyen
IPC分类号： G11C11/34
CPC分类号： G11C16/28 , G11C16/08 , G11C16/30
摘要： Various circuits include MOS transistors that have a bulk voltage terminal for receiving a bulk voltage that is different from a supply voltage and ground. The bulk voltage may be selectively set so that some MOS transistors have a bulk voltage set to the supply voltage or ground and other MOS transistors have a bulk voltage that is different. The bulk voltage may be set to forward or reverse bias pn junctions in the MOS transistor. The various circuits include comparators, operational amplifiers, sensing circuits, decoding circuits and the other circuits. The circuits may be included in a memory system.
摘要翻译：各种电路包括具有用于接收不同于电源电压和接地的体电压的体电压端子的MOS晶体管。可以选择性地设置体电压，使得一些MOS晶体管具有设置为电源电压或地的体电压，并且其它MOS晶体管具有不同的体电压。体电压可以被设置为MOS晶体管中的正向或反向偏置pn结。各种电路包括比较器，运算放大器，感测电路，解码电路和其它电路。电路可以包括在存储器系统中。

8. 发明授权

US07839682B2 Array and pitch of non-volatile memory cells 有权
标题翻译：非易失性存储单元的阵列和间距
公开(公告)号：US07839682B2
公开(公告)日：2010-11-23
申请号：US12362106
申请日：2009-01-29
申请人： Hieu Van Tran , Anh Ly , Hung Q. Nguyen , Thuan T. Vu
发明人： Hieu Van Tran , Anh Ly , Hung Q. Nguyen , Thuan T. Vu
IPC分类号： G11C16/00
CPC分类号： G11C16/10 , G11C16/0408
摘要： An array of non-volatile memory cells is arranged in a plurality of rows and columns, wherein each memory cell has at least three terminals: a first terminal for the read out of the signal from the memory cell, a second terminal to which high voltage is supplied during certain operation, and a third terminal to which low voltage is supplied in all operations. The cells in the same column have a common bit line connected to the first terminal of memory cells in the same column. The array comprises a first and second sub arrays of memory cells arranged adjacent to one another in the same row. A first decoder is positioned to one side of the first sub array in the same row as the first sub array. A second decoder is positioned to another side of the second sub array in the same row as the second sub array. A first high voltage line is connected to the second decoder and to only the second terminal of the memory cells in the same row in the first sub array. A second high voltage line, different from the first high voltage line, is connected to the second decoder and to only the second terminal of the memory cells in the same row in the second sub array. A low voltage line is connected to the first decoder and to the thirds terminal of the memory cells in the same row of the first and second sub arrays.
摘要翻译：一组非易失性存储单元被布置成多个行和列，其中每个存储单元具有至少三个端子：用于从存储单元读出信号的第一端子，高电压的第二端子在一定操作期间提供，并且在所有操作中提供低电压的第三端子。同一列中的单元具有连接到同一列中的存储器单元的第一端的公共位线。阵列包括在同一行中彼此相邻布置的存储单元的第一和第二子阵列。第一解码器位于与第一子阵列相同的行中的第一子阵列的一侧。第二解码器被定位在与第二子阵列相同的行中的第二子阵列的另一侧。第一高压线路连接到第二解码器，并且仅连接到第一子阵列中的同一行中的存储器单元的第二端子。与第一高压线不同的第二高压线路连接到第二解码器，并且仅连接到第二子阵列中同一行中的存储器单元的第二端子。低电压线连接到第一解码器和第一和第二子阵列的同一行中的存储器单元的第三端子。

9. 发明授权

US07834164B2 DNA encoding OSK1 toxin peptide analogs and vectors and cells for combinant expression 有权
标题翻译：编码OSK1毒素肽类似物的DNA和用于组合表达的载体和细胞
公开(公告)号：US07834164B2
公开(公告)日：2010-11-16
申请号：US11978105
申请日：2007-10-25
申请人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr.
发明人： John K. Sullivan , Joseph G. McGivern , Leslie P. Miranda , Hung Q. Nguyen , Kenneth W. Walker , Shaw-Fen Sylvia Hu , Colin V. Gegg, Jr.
IPC分类号： C07H21/04 , C12N1/21 , C12N5/10 , C12N15/63
CPC分类号： C07K14/43522 , A61K38/00 , A61K47/60 , C07K2319/30 , C07K2319/31
摘要： Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.
摘要翻译：公开了包含OSK1肽类似物的物质组合物，并且在一些实施方案中为其药学上可接受的盐。药物组合物包含该组合物和药学上可接受的载体。还公开了编码本发明组合物的DNA，包含DNA的表达载体和包含表达载体的宿主细胞。还公开了治疗自身免疫性疾病和预防或减轻多发性硬化症状的复发的方法。

10. 发明申请

US20100188138A1 Fast Start Charge Pump for Voltage Regulators 有权
标题翻译：用于稳压器的快速启动电荷泵
公开(公告)号：US20100188138A1
公开(公告)日：2010-07-29
申请号：US12726249
申请日：2010-03-17
申请人： Hieu Van Tran , Sang Thanh Nguyen , Anh Ly , Hung Q. Nguyen , Wingfu AAron Lau , Nasrin Jaffari , Thuan Trong Vu , Vishal Sarin , Loc B. Hoang
发明人： Hieu Van Tran , Sang Thanh Nguyen , Anh Ly , Hung Q. Nguyen , Wingfu AAron Lau , Nasrin Jaffari , Thuan Trong Vu , Vishal Sarin , Loc B. Hoang
IPC分类号： G05F1/10
CPC分类号： H02M3/07 , H02M1/36 , H02M1/44
摘要： A digital multilevel memory system includes a charge pump and a voltage regulator for generating regulated high voltages for various memory operations. The charge pump may include a plurality of boost circuits to boost the output of the charge pump during a fast start up. Afterwards, the boost circuits are disabled to allow the charge pump to generate high voltages without boosting. The boost circuits may be successively enabled to boost the voltage. The boost circuits may be loadless. The voltage regulator may operate in an open loop and may include a resistive divider as a reference voltage for regulating the high voltage from the charge pump. The charge pump may include spread spectrum pump clocking to reduce electromagnetic inference for capacitor or inductor on-chip charge pumping.
摘要翻译：数字多电平存储器系统包括电荷泵和用于产生用于各种存储器操作的调节高电压的电压调节器。电荷泵可以包括多个升压电路，以在快速启动期间升高电荷泵的输出。之后，升压电路被禁止，使电荷泵产生高电压而不加速。升压电路可以被连续地使能以升高电压。升压电路可以是无负载的。电压调节器可以在开环中工作，并且可以包括电阻分压器作为用于调节来自电荷泵的高电压的参考电压。电荷泵可以包括扩频泵时钟，以减少用于电容器或电感器片上电荷泵浦的电磁推理。

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