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1. 发明申请

US20050064010A1 Transscleral delivery 有权
标题翻译：跨收运
公开(公告)号：US20050064010A1
公开(公告)日：2005-03-24
申请号：US10945682
申请日：2004-09-20
申请人： Eugene Cooper , David Kleinman , Thierry Nivaggioli , Philippe Dor , Sreenivasu Mudumba
发明人： Eugene Cooper , David Kleinman , Thierry Nivaggioli , Philippe Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61K31/4745
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译：通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。

2. 发明申请

US20090324688A1 TRANSSCLERAL DELIVERY 审中-公开
公开(公告)号：US20090324688A1
公开(公告)日：2009-12-31
申请号：US12540305
申请日：2009-08-12
申请人： Eugene R. COOPER , David Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.

3. 发明申请

US20070265294A1 Formulations and methods for vascular permeability-related diseases or conditions 有权
标题翻译：血管通透性相关疾病或病症的制剂和方法
公开(公告)号：US20070265294A1
公开(公告)日：2007-11-15
申请号：US11726813
申请日：2007-03-23
申请人： David Kleinman , Thierry Nivaggioli , Mary Gerritsen , David Weber
发明人： David Kleinman , Thierry Nivaggioli , Mary Gerritsen , David Weber
IPC分类号： A61K31/436 , A61P11/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P31/16 , A61P9/00
CPC分类号： A61K31/436 , A61K47/10
摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
摘要翻译：本文描述了用于治疗，抑制，预防，延迟发作或引起与血管通透性有关的疾病或病症消退的制剂和方法。

4. 发明申请

US20050279698A1 Integrated cooker-strainer 审中-公开
标题翻译：集成炊具 - 过滤器
公开(公告)号：US20050279698A1
公开(公告)日：2005-12-22
申请号：US10869773
申请日：2004-06-16
申请人： David Kleinman
发明人： David Kleinman
IPC分类号： A47J36/18 , A47J45/06 , B01D29/88
CPC分类号： A47J36/18 , A47J45/061
摘要： An integrated cooker-strainer system for food preparation. The device includes a pot assembly operatively associated with a strainer assembly. The integrated system has a first position wherein a handle and container of the strainer assembly is substantially engaged in a handle and container of the pot assembly. In both the first and second position, a sealed mating portion between the strainer and pot maintains contact between the surfaces, preventing the leakage of liquid at this point. The integrated system may be used for a variety of other purposes, for example, as a meat strainer, colander, steamer, and produce shaker. The integrated system may be used for baking, microwave or stovetop cooking. A hand-operated pressing mechanism can be employed to accelerate drainage of liquid from food.
摘要翻译：一种用于食物制备的综合炊具过滤系统。该装置包括与过滤器组件可操作地相关联的罐组件。集成系统具有第一位置，其中过滤器组件的手柄和容器基本上接合在锅组件的手柄和容器中。在第一和第二位置中，过滤器和罐之间的密封配合部分保持表面之间的接触，从而防止在此点泄漏液体。集成系统可以用于各种其他目的，例如，作为肉过滤器，漏勺，蒸笼和产生振荡器。集成系统可用于烘烤，微波炉或炉灶烹饪。可以使用手动按压机构来加速食物中液体的排出。

5. 发明申请

US20050021311A1 Remote diagnosis server 审中-公开
标题翻译：远程诊断服务器
公开(公告)号：US20050021311A1
公开(公告)日：2005-01-27
申请号：US10840438
申请日：2004-05-06
申请人： Somnath Deb , Sudipto Ghoshal , Venkata Malepati , David Kleinman , Kevin Cavanaugh
发明人： Somnath Deb , Sudipto Ghoshal , Venkata Malepati , David Kleinman , Kevin Cavanaugh
IPC分类号： G05B23/02 , G06F11/00
CPC分类号： G05B23/0216 , G05B2223/06 , Y10S706/914
摘要： A network-based diagnosis server for monitoring and diagnosing a system, the server being remote from the system it is observing, comprises a sensor for generating signals indicative of a characteristic of a component of the system, a network-interfaced sensor agent coupled to the sensor for receiving signals therefrom, a broker module coupled to the network for sending signals to and receiving signals from the sensor agent, a handler application connected to the broker module for transmitting signals to and receiving signals therefrom, a reasoner application in communication with the handler application for processing, and responding to signals received from the handler application, wherein the sensor agent, broker module, handler application, and reasoner applications operate simultaneously relative to each other, such that the present invention diagnosis server performs continuous monitoring and diagnosing of said components of the system in real time. The diagnosis server is readily adaptable to various different systems.
摘要翻译：一种用于监视和诊断系统的基于网络的诊断服务器，该服务器远离其正在观察的系统，包括用于产生指示系统的部件的特性的信号的传感器，耦合到该系统的网络接口传感器传感器，用于从其接收信号，耦合到网络的代理模块，用于向传感器代理发送信号并从其接收信号;连接到代理模块的处理程序应用程序，用于向其发送信号并从中接收信号;与处理程序通信的推理器应用程序应用程序，以及对来自处理程序应用程序的信号进行响应，其中传感器代理程序，代理模块，处理程序应用程序和推理程序应用程序相对于彼此同时操作，使得本发明诊断服务器执行所述组件的连续监视和诊断的系统。诊断服务器易于适应各种不同的系统。

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