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1. 发明授权

US06583318B2 Method for synthesis of &agr;-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives 失效
标题翻译： α-亚磺酰氨基酰胺，羧酸和异羟肟酸衍生物的合成方法
公开(公告)号：US06583318B2
公开(公告)日：2003-06-24
申请号：US10146713
申请日：2002-05-15
申请人： Eugene Campian , Boliang Lou , Adnan M. M. Mjalli
发明人： Eugene Campian , Boliang Lou , Adnan M. M. Mjalli
IPC分类号： C07C30300
CPC分类号： C07C303/40 , C07C311/19 , C07C311/29
摘要： A method of synthesizing &agr;-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three reactants to form an array of polymer-bound &agr;-sulfonamido amide-type intermediates and use of such intermediates for the preparation of combinatorial libraries.
摘要翻译：一种合成α-亚磺酰氨基酰胺，羧酸或异羟肟酸衍生物的方法，包括提供一组聚合物结合的反应物（磺酰胺，醛或酮，异氰化物或酸）与三组其他三种反应物反应形成聚合物结合的α-亚磺酰氨基酰胺型中间体阵列以及这种中间体用于制备组合文库的用途。

2. 发明授权

US06620882B1 Solid support template for preparation of highly functionalized heterocycle compounds 失效
标题翻译：用于制备高度官能化杂环化合物的固体支持模板
公开(公告)号：US06620882B1
公开(公告)日：2003-09-16
申请号：US10275058
申请日：2002-10-31
申请人： Eugene Campian , Boliang Lou , Kexin Yang , Jinfang Zhang
发明人： Eugene Campian , Boliang Lou , Kexin Yang , Jinfang Zhang
IPC分类号： C08F832
CPC分类号： C08F283/04 , C08F290/14
摘要： The present invention relates to a novel solid support template of Formula (I) and methods for producing novel highly functionalized imidazoles, pyrazinones and benzodiazepinones through a plurality of chemical reactions utilizing the solid support template
摘要翻译：本发明涉及式（I）的新的固体支持模板和通过使用固体支持模板的多个化学反应来生产新的高官能化的咪唑，吡嗪酮和苯并二氮杂酮的方法

3. 发明授权

US06600016B1 Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same 失效
标题翻译：用于合成组合文库的多功能固体支持树脂及其使用方法
公开(公告)号：US06600016B1
公开(公告)日：2003-07-29
申请号：US09379848
申请日：1999-08-24
申请人： Eugene Campian , Boliang Lu , Jinfang Zhang
发明人： Eugene Campian , Boliang Lu , Jinfang Zhang
IPC分类号： C07K104
CPC分类号： C07K1/047 , C07K1/042
摘要： Multifunctionalized support resin for the solid phase synthesis of combinatorial libraries is disclosed. The support resin comprises a resin backbone to which is attached a template containing at least two more attachment points which carry mutiple functionalized benzyl-type linkers. Each linker displays differing chemical stability under cleavage conditions so that products can be selectively and sequentially cleaved and separated from the reaction vessel. The linkers are independently different benzyl-type moieties, and each product synthesized on the linkers may have a different chemical structure. The support resin may further comprise an additional linker which is directly attached to the resin backbone. This linker can benzyl-type linkers or other traditional cleavable-linkers. The invention is further directed to a method for the production of mutiple combinatorial libraries in a simultaneous fashion utilizing the above described support resin. The products are selectively cleaved under conditions where only one linker site is cleaved so that the product is individually separated from the reaction vessel.
摘要翻译：公开了用于组合文库的固相合成的多官能化支撑树脂。载体树脂包括树脂主链，其连接有含有至少两个另外的连接点的模板，其携带多个官能化的苄基型接头。每个接头在裂解条件下显示不同的化学稳定性，使得产物可以选择性地并且顺序地从反应容器中切割和分离。接头是独立不同的苄基型部分，并且在接头上合成的每种产物可具有不同的化学结构。载体树脂还可以包含直接连接到树脂主链上的另外的连接体。该接头可以是苄基型接头或其它传统的可切割接头。本发明还涉及一种利用上述载体树脂同时制备多组合文库的方法。在只有一个连接位点被切割使得产物从反应容器中分离出的条件下，选择性地裂解产物。

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