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1. 发明申请

US20200246395A1 COMPOSITIONS OF MICROBIOTA AND METHODS RELATED THERETO 审中-公开
公开(公告)号：US20200246395A1
公开(公告)日：2020-08-06
申请号：US16830801
申请日：2020-03-26
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A Massachusetts General Hospital , President and Fellows of Harvard College
发明人： Lee M. Kaplan , Alice P. Liou , Peter J. Turnbaugh , Jason L. Harris
IPC分类号： A61K35/74 , A61K9/00 , C12Q1/689 , A61K45/06 , A61K35/741
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.

2. 发明申请

US20170232254A1 Methods and Devices for Activating Brown Adipose Tissue Using Electrical Energy 审中-公开
公开(公告)号：US20170232254A1
公开(公告)日：2017-08-17
申请号：US15585706
申请日：2017-05-03
申请人： Ethicon-Endo Surgery, Inc. , The General Hospital Corporation D/B/A/ Massachusetts General Hospital
发明人： Jason L. Harris , Nicholas Stylopoulos , Lee M. Kaplan , Tamara C. Baynham , Taylor W. Aronhalt
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05 , A61N1/378
CPC分类号： A61N1/0456 , A61N1/0492 , A61N1/0504 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/3606 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36196 , A61N1/3787
摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.

3. 发明申请

US20140087999A1 CLINICAL PREDICTORS OF WEIGHT LOSS 审中-公开
标题翻译：临床预防重量损失
公开(公告)号：US20140087999A1
公开(公告)日：2014-03-27
申请号：US13828809
申请日：2013-03-14
申请人： THE GENERAL HOSPITAL CORPORATION d/b/a MASSACHUSETTS GENERAL HOSPITAL , ETHICON ENDO-SURGERY, INC.
发明人： Lee M. Kaplan , Ida Hatoum , Jason L. Harris
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent. One aspect discloses methods and compositions for obtaining a sample including deoxyribonucleic acids (DNA) from the subject, evaluating the DNA for an absence or presence of one or more genetic indicators and performing a first metabolic procedure or an alternative second metabolic procedure based on the absence or presence of the genetic indicator(s). Other aspects are also disclosed.
摘要翻译：通常提供方法和组合物用于治疗代谢紊乱，例如肥胖症。一方面公开了从受试者获得生物样品的方法和组合物，评估样品中是否存在遗传指标，其中所述遗传指标选自单核苷酸多态性和基因表达水平，并且执行第一代谢过程，如果存在遗传指标，或者如果遗传指标不存在，则执行替代的第二代谢过程。一方面公开了用于获得包含来自受试者的脱氧核糖核酸（DNA）的样品的方法和组合物，基于不存在的情况评估DNA不存在或存在一种或多种遗传指标并进行第一代谢过程或替代性第二代谢过程或遗传指标的存在。还公开了其他方面。

4. 发明申请

US20170368108A1 COMPOSITIONS OF MICROBIOTA AND METHODS RELATED THERETO 审中-公开
公开(公告)号：US20170368108A1
公开(公告)日：2017-12-28
申请号：US15698965
申请日：2017-09-08
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A, Massachusetts General Hospital , President and Fellows of Harvard College
发明人： Lee M. Kaplan , Alice P. Liou , Peter J. Turnbaugh , Jason L. Harris
IPC分类号： A61K35/74 , A61K9/00 , A61K35/741 , C12Q1/68 , A61K45/06 , A61K35/00
CPC分类号： A61K35/74 , A61K9/0053 , A61K35/741 , A61K45/06 , A61K2035/11 , C12Q1/689 , Y02A50/451 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.

5. 发明申请

US20170156907A1 Methods and Devices for Activating Brown Adipose Tissue with Targeted Substance Delivery 审中-公开
公开(公告)号：US20170156907A1
公开(公告)日：2017-06-08
申请号：US15438202
申请日：2017-02-21
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A, Massachusetts General Hospital
发明人： Jason L. Harris , Taylor W. Aronhalt , Dwight Henninger , James W. Voegele , Lee M. Kaplan , Nicholas Stylopoulos
IPC分类号： A61F5/00 , A61K9/70 , A61M37/00 , A61K9/00 , A61M5/142 , A61M35/00
CPC分类号： A61F5/0003 , A61K9/0014 , A61K9/0019 , A61K9/7023 , A61M5/14 , A61M5/14276 , A61M35/00 , A61M37/00 , A61M2005/1726 , A61M2205/50 , A61M2230/06 , A61M2230/201
摘要： Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.

6. 发明申请

US20160113971A1 Compositions of Microbiota and Methods Related Thereto 审中-公开
标题翻译：微生物群的组成及其相关方法
公开(公告)号：US20160113971A1
公开(公告)日：2016-04-28
申请号：US14862663
申请日：2015-09-23
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A Massachusetts General Hospital , President and Fellows of Harvard College
发明人： Lee M. Kaplan , Alice P. Liou , Peter J. Turnbaugh , Jason L. Harris
IPC分类号： A61K35/74 , A61K9/00
CPC分类号： A61K35/74 , A61K9/0053 , A61K35/741 , A61K45/06 , A61K2035/11 , C12Q1/689 , Y02A50/451 , Y02A50/473 , A61K2300/00
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.
摘要翻译：提供了通过改变受试者中的微生物群来治疗体重相关病症和代谢疾病的方法和组合物。一个方面提供了通过向受试者施用包括来自门的基本上纯化的微生物群的组合物，例如细菌属，变形杆菌属，紧密菌属和Verrucomicrobia或诸如类杆菌属，Verrucomicrobial，梭菌和肠杆菌属或类属的序列，从而改变受试者中的微生物群的方法和组合物如Alistipes，Clostridium，Escherichia和Akkermansia。另一方面包括用于改变微生物群的药物组合物，其包括治疗有效量的基本上纯化的微生物群和药学上可接受的载体。另一方面包括在需要这种治疗的受试者中通过改变受试者的胃肠道中的微生物群的相对丰度而无需外科手术或除外科手术之外，来治疗疾病例如肥胖症的方法。

7. 发明申请

US20150258326A1 Methods and Devices for Activating Brown Adipose Tissue Using Electrical Energy 审中-公开
标题翻译：使用电能激活棕色脂肪组织的方法和设备
公开(公告)号：US20150258326A1
公开(公告)日：2015-09-17
申请号：US14700611
申请日：2015-04-30
申请人： Ethicon-Endo Surgery, Inc. , The General Hospital Corporation D/B/A Massachusetts General Hospital
发明人： Jason L. Harris , Nicholas Stylopoulos , Lee M. Kaplan , Tamara C. Baynham , Taylor W. Aronhalt
IPC分类号： A61N1/04 , A61N1/36 , A61N1/05
CPC分类号： A61N1/0456 , A61N1/0492 , A61N1/0504 , A61N1/36 , A61N1/36014 , A61N1/3605 , A61N1/3606 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/36192 , A61N1/36196 , A61N1/3787
摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.
摘要翻译：提供了用于激活棕色脂肪组织（BAT）的方法和装置。通常，方法和装置可以激活BAT以增加产热，例如增加患者的热量产生，其随着时间的推移可导致体重减轻。在一个实施方案中，提供了通过电刺激直接激活BAT和/或电刺激棕色脂肪细胞的神经来激活BAT的医疗装置，从而增加BAT中的产热并通过能量消耗引起体重减轻。

8. 发明申请

US20230096225A1 CLINICAL PREDICTORS OF WEIGHT LOSS 有权
公开(公告)号：US20230096225A1
公开(公告)日：2023-03-30
申请号：US17581335
申请日：2022-01-21
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation d/b/a Massachusetts General Hospital
发明人： Lee M. Kaplan , Ida Hatoum , Jason L. Harris
IPC分类号： C12Q1/6883
摘要： Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent. One aspect discloses methods and compositions for obtaining a sample including deoxyribonucleic acids (DNA) from the subject, evaluating the DNA for an absence or presence of one or more genetic indicators and performing a first metabolic procedure or an alternative second metabolic procedure based on the absence or presence of the genetic indicator(s). Other aspects are also disclosed.

9. 发明申请

US20200237835A1 COMPOSITIONS OF MICROBIOTA AND METHODS RELATED THERETO 审中-公开
公开(公告)号：US20200237835A1
公开(公告)日：2020-07-30
申请号：US16830881
申请日：2020-03-26
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A Massachusetts General Hospital , President and Fellows of Harvard College
发明人： Lee M. Kaplan , Alice P. Liou , Peter J. Turnbaugh , Jason L. Harris
IPC分类号： A61K35/74 , A61K35/741 , A61K45/06 , C12Q1/689 , A61K9/00
摘要： Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria, Firmicutes and Verrucomicrobia or orders such as Bacteroidales, Verrucomicrobiales, Clostridiales and Enterobacteriales or genera such as Alistipes, Clostridium, Escherichia, and Akkermansia. Another aspect includes a pharmaceutical composition for altering microbiota that includes a therapeutically effective amount of substantially purified microbiota and a pharmaceutically acceptable carrier. Yet another aspect includes methods for treating a disorder, such as obesity, in a subject in need of such treatment by changing relative abundance of microbiota in a gastrointestinal tract of the subject without or in addition to a surgical procedure.

10. 发明申请

US20170000827A1 BROWN ADIPOCYTE MODIFICATION 审中-公开
标题翻译：棕色ADIPOCYTE修改
公开(公告)号：US20170000827A1
公开(公告)日：2017-01-05
申请号：US15175777
申请日：2016-06-07
申请人： Ethicon Endo-Surgery, Inc. , The General Hospital Corporation D/B/A Massachusetts General Hospital
发明人： Lee M. Kaplan , Nicholas Stylopoulos , Jason L. Harris , Dwight Henninger , Taylor W. Aronhalt , James W. Voegele
IPC分类号： A61K35/35 , A61K38/17 , C12N7/00 , C12N5/077 , C12N15/86 , C07K14/705 , A61K48/00
CPC分类号： A61K35/35 , A61K38/177 , A61K48/005 , C07K14/47 , C07K14/705 , C12N5/0653 , C12N7/00 , C12N15/85 , C12N15/86 , C12N2506/1392 , C12N2750/14143 , C12N2799/025 , C12N2830/002
摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
摘要翻译：提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色脂肪细胞这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。

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