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1. 发明申请

US20090312663A1 System and Method for Neurometric Analysis 审中-公开
标题翻译：系统与方法进行神经测量分析
公开(公告)号：US20090312663A1
公开(公告)日：2009-12-17
申请号：US12139228
申请日：2008-06-13
申请人： Erwin R. John , Leslie S. Prichep , Robert Isenhart , David Cantor
发明人： Erwin R. John , Leslie S. Prichep , Robert Isenhart , David Cantor
IPC分类号： A61B5/0476 , G06Q50/00
CPC分类号： A61B5/0476 , A61B5/0484 , A61B5/16 , G06Q50/24
摘要： A system, comprises a plurality of neurometric analyzing software modules operating on electroencephalogram (EEG) data, each module performing a defined task with respect to neurometric analysis of the EEG data and a database including normative neurometric data in combination with a server including an authorization module, the authorization module comparing data received from a remote user to determine whether the user is authorized to utilize any of the plurality of analyzing software modules and an analysis module configured to receive input data from a patient and select one of the neurometric analyzing modules based on the input data, wherein the selected one of the neurometric analyzing modules compares the input data to the normative neurometric data to generate an output, the analysis module selecting the one of neurometric analyzing modules from a set of subscribed neurometric analyzing modules.
摘要翻译：一种系统，包括对脑电图（EEG）数据进行操作的多个神经测量分析软件模块，每个模块执行关于EEG数据的神经测量分析的定义任务，以及包括规范性神经测量数据的数据库，包括与包括授权模块所述授权模块将从远程用户接收的数据进行比较，以确定所述用户是否被授权使用所述多个分析软件模块中的任何一个;以及分析模块，其被配置为从患者接收输入数据，并且基于所述神经测量分析模块所述输入数据，其中所述神经测量分析模块中的所选择的一个将所述输入数据与所述规范性神经测量数据进行比较以生成输出，所述分析模块从一组订阅的神经测量分析模块中选择所述神经测量分析模块中的一个。

2. 发明申请

US20110172553A1 QEEG Statistical Low Resolution Tomographic Analysis 审中-公开
标题翻译： QEEG统计低分辨率层析分析
公开(公告)号：US20110172553A1
公开(公告)日：2011-07-14
申请号：US12746103
申请日：2008-12-12
申请人： Erwin R. John , Leslie S. Prichep , Robert Isenhart , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep , Robert Isenhart , Leslie S. Prichep
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/4833
摘要： A system and method for analyzing electrophysical signals produced by a brain involves comparing a first selected one of the numerical values to control data including one of a self-norm and a population-norm associated with electrophysical activity in a brain region corresponding to a brain region of origin of the electrophysical activity on which the numerical value is based; calculating a standard score for the brain region of origin based on the comparing; and repeating the comparing and calculating operations for a second selected one of the numerical values, the regions of the brain including subcortical regions extending to a brain stem of the brain.
摘要翻译：用于分析由大脑产生的电物理信号的系统和方法包括将第一选定的数值与将控制数据进行比较，所述控制数据包括与对应于脑区域的脑区域中的电生理活动相关的自我规范和群体范数之一数值所依据的电物活动的起源; 根据比较计算脑区原始标准评分; 以及重复所述数值中的第二所选择的一个数值的比较和计算操作，所述脑的区域包括延伸到脑的脑干的皮质下区域。

3. 发明申请

US20110160607A1 QEED-Guided Selection and Titration of Psychotropic Medications 审中-公开
标题翻译： QEED指导精神药物的选择和滴定
公开(公告)号：US20110160607A1
公开(公告)日：2011-06-30
申请号：US12744619
申请日：2008-12-12
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61B5/0476
CPC分类号： A61B5/0476 , A61B5/4839
摘要： Data corresponding to brain electrical activity of a patient from a QEEG is processed to determine which brain activity data deviates from that of a normative profile. The deviant brain activity data is used to determine a brain state vector (BSV) in a multidimensional brain electrical signal space, wherein the orientation of the BSV indicates the nature of the deviation from a normal state and may be used to prescribe a medicine to the patient and wherein the length of the BSV quantifies the degree of abnormality exhibited by the patient and may indicate the dosage of the medicine to be prescribed to the patient.
摘要翻译：对与来自QEEG的患者的脑电活动相对应的数据进行处理，以确定哪个脑活动数据偏离规范性剖析。偏差脑活动数据用于确定多维脑电信号空间中的脑状态矢量（BSV），其中BSV的取向指示偏离正常状态的性质，并且可用于向患者，并且其中BSV的长度量化患者所呈现的异常程度，并且可以指示要向患者规定的药物的剂量。

4. 发明申请

US20100224188A1 System and Method for Guidance of Anesthesia, Analgesia and Amnesia 有权
标题翻译：麻醉，镇静和健忘指导系统和方法
公开(公告)号：US20100224188A1
公开(公告)日：2010-09-09
申请号：US12772659
申请日：2010-05-03
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61M16/01 , A61B5/048
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.
摘要翻译：一种系统和方法包括向患者施用介入药物，直到患者达到预定的麻醉平面; 在进行步骤之前和之后放大和数字化患者的脑波以产生第一组数字数据; 在医疗过程中放大和数字化患者的脑波，以产生第二组数字数据; 使用第一组和第二组的比较（包括深度指数（DI） - 麻醉深度，记忆指数（MI））的能力的比较来计算在医疗过程期间患者的麻醉状态的至少两个不同指数的至少两个不同指标的单独轨迹形成和存储记忆，疼痛指数（PI）敏感性疼痛）; 并且确定要作为轨迹的函数传递给患者的至少一种介入剂的量，所述介入剂包括对应于DI，MI和/或PI轨迹的麻醉剂，止痛剂和/或遗忘剂。

5. 发明授权

US07711417B2 System and method for guidance of anesthesia, analgesia and amnesia 有权
标题翻译：麻醉，止痛和健忘症指导系统和方法
公开(公告)号：US07711417B2
公开(公告)日：2010-05-04
申请号：US11471122
申请日：2006-06-20
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： Described is a system and method which includes the following steps. A plurality of interventional agents are administered to a patient until the patient attains a predetermined plane of anesthesia. Brain waves of the patient are amplified and digitized before and after the administering step to generate a first set of digital data. The brain waves of the patient are amplified and digitized during a medical procedure to generate a second set of digital data. Separate trajectories for at least two different indices of an anesthetic state of the patient are computed during the medical procedure as a function of a comparison of the first and second sets of digital data. The indices include a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI). The DI corresponds to a depth of anesthesia of the patient, the PI corresponds to a sensitivity of the patient to pain and the MI corresponds to an ability of the patient to form and store memories.
摘要翻译：描述了包括以下步骤的系统和方法。向患者施用多种介入剂，直到患者达到预定的麻醉平面。患者的脑波在给药步骤之前和之后被放大和数字化，以产生第一组数字数据。患者的脑波在医疗过程中被放大和数字化，以产生第二组数字数据。作为第一和第二组数字数据的比较的函数，在医疗过程期间计算患者麻醉状态的至少两个不同索引的分离轨迹。指标包括深度指数（DI），记忆指数（MI）和疼痛指数（PI）。 DI对应于患者的麻醉深度，PI对应于患者对疼痛的敏感性，MI对应于患者形成和存储记忆的能力。

6. 发明授权

US07089927B2 System and method for guidance of anesthesia, analgesia and amnesia 有权
公开(公告)号：US07089927B2
公开(公告)日：2006-08-15
申请号：US10279131
申请日：2002-10-23
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61M15/00
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： A method for monitoring anesthetization of a patient, includes the steps of removably connecting a plurality of electrodes to the scalp of the patient and administering sufficient anesthesia to the patient so that the patient attains a plane of anesthesia selected by an operator. The brain waves of the patient are then amplified and digitized after the patient has been anesthetized, before beginning the medical procedure, to obtain a first set of digital data. The brain waves of the patient are then amplified and digitized during the medical procedure to provide a second set of digital data and the first and second sets of digital data are analyzed in at least one of a time domain and a frequency domain. Separate trajectories are then computed from the data analysis trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI). A system for providing anesthesia to a patient, includes a plurality of electrodes, a first arrangement allowing an operator to administer anesthesia to the patient until the patient has attained a selected plane of anesthesia and a second arrangement coupled to the electrodes for amplifying and digitizing brain waves of the patient after the patient has been anesthetized, before the medical procedure has been begun to obtain a first set of digital data, the second arrangement amplifying and digitizing ongoing brain waves of the patient during the medical procedure to provide a second set of digital data in combination with a third arrangement analyzing the first and second sets of digital data in at least one of a time domain and a frequency domain, a fourth arrangement computing from the data analysis separate trajectories for at least two different indices of a state of the patient during the medical procedure, the indices being selected from a group including a Depth Index (DI), a Memory Index (MI) and a Pain Index (PI), a fifth arrangement providing control signals when any of the trajectories indicates that the patient is deviating from the selected plane of anesthesia and a sixth arrangement automatically adjusting two different anesthetic agents administered to the patient based on the control signal to restore the patient to the selected plane of anesthesia.

7. 发明申请

US20110162645A1 System and Method for Guidance of Anesthesia, Analgesia and Amnesia 有权
标题翻译：麻醉，镇静和健忘指导系统和方法
公开(公告)号：US20110162645A1
公开(公告)日：2011-07-07
申请号：US13036730
申请日：2011-02-28
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61M16/01
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories. The system also includes a display outputting the trajectories for the at least two different indices of anesthetic state of the patient to a user for consideration in formulating subsequent dosages of the interventional agents to be administered to the patient.
摘要翻译：描述了一种方法和系统，其包括通过在向患者施用初始剂量的介入药剂之前和之后放大和数字化患者的脑波而产生的第一组数字数据和通过放大和数字化脑产生的第二组数字数据在医疗过程中患者的波浪。此外，该系统包括微处理器，用于根据第一和第二组数字数据的比较来计算在医疗过程期间患者的麻醉状态的至少两个不同指数的分离轨迹，所述指数包括深度指数（DI），记忆指数（MI）和疼痛指数（PI），DI对应于患者的麻醉深度，PI对应于患者对疼痛的敏感性和对应于患者能力的MI 形成和存储回忆。该系统还包括向用户输出用于患者的至少两个不同麻醉状态指标的轨迹的显示器，以便在制定待给予患者的介入剂的后续剂量时考虑。

8. 发明授权

US07899525B2 System and method for guidance of anesthesia, analgesia and amnesia 有权
标题翻译：麻醉，止痛和健忘症指导系统和方法
公开(公告)号：US07899525B2
公开(公告)日：2011-03-01
申请号：US12772659
申请日：2010-05-03
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories.
摘要翻译：一种系统和方法包括向患者施用介入药物，直到患者达到预定的麻醉平面; 在进行步骤之前和之后放大和数字化患者的脑波以产生第一组数字数据; 在医疗过程中放大和数字化患者的脑波，以产生第二组数字数据; 使用第一组和第二组的比较（包括深度指数（DI） - 麻醉深度，记忆指数（MI））的能力的比较来计算在医疗过程期间患者的麻醉状态的至少两个不同指数的至少两个不同指标的单独轨迹形成和存储记忆，疼痛指数（PI）敏感性疼痛）; 并且确定要作为轨迹的函数传递给患者的至少一种介入剂的量，所述介入剂包括对应于DI，MI和/或PI轨迹的麻醉剂，止痛剂和/或遗忘剂。

9. 发明授权

US08352023B2 System and method for guidance of anesthesia, analgesia and amnesia 有权
标题翻译：麻醉，止痛和健忘症指导系统和方法
公开(公告)号：US08352023B2
公开(公告)日：2013-01-08
申请号：US13036730
申请日：2011-02-28
申请人： Erwin R. John , Leslie S. Prichep
发明人： Erwin R. John , Leslie S. Prichep
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/01 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/04012 , A61B5/048 , A61B5/04845 , A61B5/08 , A61B5/4839 , A61B5/7225 , A61B5/7257 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B5/746 , A61M5/00 , A61M5/1407 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/06 , A61M16/0683 , A61M16/12 , A61M16/18 , A61M16/201 , A61M2016/0661 , A61M2202/048 , A61M2210/0618 , A61M2230/10
摘要： Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories. The system also includes a display outputting the trajectories for the at least two different indices of anesthetic state of the patient to a user for consideration in formulating subsequent dosages of the interventional agents to be administered to the patient.
摘要翻译：描述了一种方法和系统，其包括通过在向患者施用初始剂量的介入药剂之前和之后放大和数字化患者的脑波而产生的第一组数字数据和通过放大和数字化脑产生的第二组数字数据在医疗过程中患者的波浪。此外，该系统包括微处理器，用于根据第一和第二组数字数据的比较来计算在医疗过程期间患者的麻醉状态的至少两个不同指数的分离轨迹，所述指数包括深度指数（DI），记忆指数（MI）和疼痛指数（PI），DI对应于患者的麻醉深度，PI对应于患者对疼痛的敏感性和对应于患者能力的MI 形成和存储回忆。该系统还包括向用户输出用于患者的至少两个不同麻醉状态指标的轨迹的显示器，以便在制定待给予患者的介入剂的后续剂量时考虑。

10. 发明授权

US07016722B2 System and method for fetal brain monitoring 失效
标题翻译：胎儿脑部监测系统与方法
公开(公告)号：US07016722B2
公开(公告)日：2006-03-21
申请号：US10377967
申请日：2003-02-28
申请人： Leslie S. Prichep
发明人： Leslie S. Prichep
IPC分类号： A61B5/04
CPC分类号： A61B5/0476 , A61B5/048 , A61B5/04845 , A61B5/7203 , A61B5/7207 , A61B5/7257 , A61B5/726 , A61B2503/02 , A61N1/36014 , Y10S607/902
摘要： A system for monitoring a brain wave response of a fetus in utero, comprises removably connecting an auditory transducer, including at least one biosensor electrode, producing pulsed auditory sounds to a mother's abdomen to detect brain wave activity in a fetus. The transducer is pulsed with one of rectangular waves and tone pips of a selected frequency to emit pulsed audible sounds at predetermined times. The at least one biosensor electrode, including connected amplifier, detects brain stem auditory responses (BAER) of the fetus. For each pulsed audible sound a series of voltage oscillations corresponding to BAER of the fetus are time-locked to the corresponding audible sound. BAER analog output is converted to BAER digital data. A computer-based QEEG (Quantitative EEG) system improves a signal to noise ratio of the BAER digital data using an adaptive optimum filtering algorithm and analyzes the BAER digital data relative to a reference database.
摘要翻译：一种用于监测子宫内胎儿的脑波响应的系统，包括可移除地连接包括至少一个生物传感器电极的听觉换能器，产生脉冲听觉声音到母亲的腹部以检测胎儿中的脑波活动。传感器用选定频率的矩形波和音调点之一脉冲，以在预定时间发射脉冲的可听见的声音。包括连接的放大器的至少一个生物传感器电极检测胎儿的脑干听觉反应（BAER）。对于每个脉冲可听声音，对应于胎儿的BAER的一系列电压振荡被时间锁定到相应的可听见的声音。 BAER模拟输出转换为BAER数字数据。基于计算机的QEEG（定量脑电图）系统使用自适应最优滤波算法提高了BAER数字数据的信噪比，并分析了相对于参考数据库的BAER数字数据。

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