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    • 7. 发明授权
    • Process for producing xylitol of high purity
    • 生产高纯度木糖醇的方法
    • US06538133B1
    • 2003-03-25
    • US09631351
    • 2000-08-02
    • Yuuichi AokiEriko OnoKazutaka Nagashima
    • Yuuichi AokiEriko OnoKazutaka Nagashima
    • C07H106
    • C13B20/148C07C29/76C12P7/18C07C31/18
    • Herein are disclosed a process for producing xylitol of high purity (one-step desalting process) which comprises the steps of (1) removing the solid matter from a culture froth obtained by culturing a xylitol-producing microorganism in an aqueous culture medium, (2) desalting the resulting solid matter-removed culture broth by removing the ionic substances therefrom by means of a cation-exchange resin and an anion-exchange resin, (3) subjecting the resulting desalted solution to the chromatography using a strongly acidic cation-exchange resin to separate the xylitol from the other sugar alcohol(s) and sugar(s), and (4) obtaining the xylitol by separating it at a high purity from the resulting xylitol solution (fraction), and to a similar process (two-step desalting process) but wherein the desalting carried out twice by adding the ion-exclusion step between Steps (1) and (2) of the above-mentioned process, whereby most of the ionic substances are removed, by which processes highly pure xylitol can be obtained from a xylitol solution in a commercially effective way, in the method for producing xylitol by using a xylitol-producing microorganism.
    • 本文公开了一种生产高纯度(一步脱盐方法)的木糖醇的方法,其包括以下步骤:(1)从通过在水性培养基中培养产生木糖醇的微生物获得的培养泡中除去固体物质,(2 )通过用阳离子交换树脂和阴离子交换树脂除去其中的离子物质对所得的固体物质去除的培养液进行脱盐,(3)使用强酸性阳离子交换树脂对得到的脱盐溶液进行色谱分离 将木糖醇与其它糖醇和糖分离,和(4)通过从所得木糖醇溶液(级分)中以高纯度分离得到木糖醇,并进行类似的方法(两步法) 脱盐工艺),但是其中通过在上述方法的步骤(1)和(2)之间加入离子排除步骤进行两次脱盐,由此除去大部分离子物质,通过该过程高纯度 木糖醇可以以商业上有效的方式从木糖醇溶液中获得,在通过使用产生木糖醇的微生物生产木糖醇的方法中。
    • 8. 发明授权
    • Monatin hydrate crystals
    • 莫纳金水合物晶体
    • US07973070B2
    • 2011-07-05
    • US12401997
    • 2009-03-11
    • Kenichi MoriEriko Ono
    • Kenichi MoriEriko Ono
    • A61K31/405C07D209/04
    • C07D209/20
    • New (2R,4R) monatin monosodium salt hydrate crystals characterized by having specific characteristic X-ray diffraction peaks provide general-purpose, stable, and safe monatin sodium salt crystals incorporating no organic solvent. These crystal may be prepared by a method that requires no organic solvent in the crystallization, separation, and drying steps. These crystal are useful as sweeteners and for the preparation of orally consumed products, such as foods, beverages, pharmaceutical products, topical pharmaceutical products, and feeds containing general-purpose, stable, and safe monatin sodium salt crystals.
    • 特征在于具有特异性X射线衍射峰的新的(2R,4R)莫纳甜单钠盐水合物晶体提供不含有机溶剂的通用,稳定和安全的莫纳甜钠盐晶体。 这些晶体可以通过在结晶,分离和干燥步骤中不需要有机溶剂的方法来制备。 这些晶体可用作甜味剂和用于制备口服食品,如食品,饮料,药品,局部药物产品和含有通用,稳定和安全的莫纳甜钠盐晶体的饲料。