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1. 发明授权

US06805455B2 Wireless remote controlled mirror with integral lighting 失效
标题翻译：带整体照明的无线遥控镜
公开(公告)号：US06805455B2
公开(公告)日：2004-10-19
申请号：US10306966
申请日：2002-11-27
申请人： Erik R. Nielsen , John H. Moselage , Gordon Keller
发明人： Erik R. Nielsen , John H. Moselage , Gordon Keller
IPC分类号： G02B7182
CPC分类号： B60R1/078 , B60N2/879 , B60R1/008
摘要： A wireless remote controlled mirror having lights to illuminate a subject being viewed in the mirror, while enabling a user to selectively adjust a view of the subject from a remote location. When attached to a rear seat of a vehicle, the mirror can be remotely adjusted to view a child in a rear-facing safety seat. The mirror includes a base adapted to mount to an object, a reflective lens that moves relative to the base, one or more electric motors to drive the reflective lens, and a receiver that detects a command signal from a wireless remote controller and energizes a motor to reorient the reflective lens to view the child. A plurality of light sources are selectively energized to emit light toward the subject, so that the mirror is usable after dark. The mirror can alternatively be mounted on other portions of a vehicle.
摘要翻译：一种无线遥控镜，其具有用于照亮在镜子中观看的被摄体的灯，同时使得用户能够从远程位置选择性地调节被摄体的视图。当连接到车辆的后座时，可以远程调节镜子以便在后面安全座椅中观察孩子。反射镜包括适于安装到物体的基座，相对于基座移动的反射透镜，用于驱动反射透镜的一个或多个电动马达以及从无线遥控器检测命令信号并使电机通电的接收器重新调整反光镜的方向以观察孩子。选择性地激励多个光源以朝向被摄体发光，使得在黑暗之后可以使用反射镜。镜子可以替代地安装在车辆的其他部分上。

2. 发明授权

US06585384B2 Wireless remote controlled mirror 失效
标题翻译：无线遥控镜
公开(公告)号：US06585384B2
公开(公告)日：2003-07-01
申请号：US09895148
申请日：2001-06-29
申请人： Erik R. Nielsen , Paul R. Illian, Sr. , John H. Moselage , Adam L. Smith , Gordon Keller
发明人： Erik R. Nielsen , Paul R. Illian, Sr. , John H. Moselage , Adam L. Smith , Gordon Keller
IPC分类号： G02B7182
CPC分类号： B60R1/078 , B60R1/008
摘要： A wireless remote controlled mirror enabling a user to selectively adjust a view from a remote location. A preferred embodiment enables a driver to remotely control a mirror attached to a rear seat of a vehicle to remotely adjust the view of a child in a rear-facing safety seat. A preferred embodiment includes a base that mounts to an object (such as the safety seat or the rear seat), a reflective lens that moves relative to the base, one or more electric motors to drive the reflective lens, and a receiver that detects a command signal from a wireless remote controller and energizes the one or more motors to reorient the reflective lens to view the child. The mirror can alternatively be mounted on other portions of a vehicle, e.g., as a remote controlled side mirror.
摘要翻译：无线远程控制镜，使用户能够从远程位置选择性地调整视图。优选实施例使得驾驶员能够远程地控制附接到车辆的后座的镜子，以便在后面安全座椅中远程调节儿童的视野。优选实施例包括安装到物体（例如安全座椅或后座椅）的基座，相对于基座移动的反射透镜，一个或多个电动机以驱动反射镜头，以及接收器，其检测来自无线遥控器的命令信号并激励一个或多个电动机重新定向反射镜以观察儿童。可以替代地，镜子可以安装在车辆的其它部分上，例如安装在远程控制的侧视镜上。

3. 发明授权

US09994821B2 Methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on SIRPA expression 有权
公开(公告)号：US09994821B2
公开(公告)日：2018-06-12
申请号：US13819318
申请日：2011-08-26
申请人： Gordon Keller , April M. Craft , Nicole C. Dubois
发明人： Gordon Keller , April M. Craft , Nicole C. Dubois
IPC分类号： C12N5/00 , C12N5/071 , G01N33/53 , C12N5/077 , C12Q1/68 , G01N33/569 , G01N33/50
CPC分类号： C12N5/0657 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/415 , C12N2506/00 , C12N2506/02 , C12N2506/45 , C12Q1/6881 , C12Q2600/158 , G01N33/5073 , G01N33/53 , G01N33/56966
摘要： The present invention relates to in vitro methods of enriching populations of human pluripotent stem cells that are induced to differentiate to cardiomyocyte progenitor cells and cardiomyocyte cells. The cell populations can be enriched by isolating cells that express SIRPA. The invention also related to in vitro-enriched populations of cardiomyocyte cells and cardiomyocyte progenitor cells obtained from populations of pluripotent stem.

4. 发明申请

US20060276420A1 Mesoderm and definitive endoderm cell populations 有权
标题翻译：中胚层和确定的内胚层细胞群
公开(公告)号：US20060276420A1
公开(公告)日：2006-12-07
申请号：US10514759
申请日：2003-05-19
申请人： Gordon Keller , Valerie Kouskoff , Atsushi Kubo , Hans Fehling
发明人： Gordon Keller , Valerie Kouskoff , Atsushi Kubo , Hans Fehling
IPC分类号： A61K48/00 , C12Q1/68 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/16 , C12N2501/415 , C12N2506/02 , G01N33/5073
摘要： The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
摘要翻译：本发明提供富集中内胚层和中胚层的细胞群以及富含内胚层的细胞群。本发明的细胞群可用于产生用于细胞替代疗法的细胞。

5. 发明申请

US20090269314A1 HUMAN CARDIOVASCULAR PROGENITOR CELLS 审中-公开
标题翻译：人类心脏血管生成细胞
公开(公告)号：US20090269314A1
公开(公告)日：2009-10-29
申请号：US12410782
申请日：2009-03-25
申请人： Gordon Keller , Lei Yang , Steven Kattman
发明人： Gordon Keller , Lei Yang , Steven Kattman
IPC分类号： A61K35/12 , C12N5/08 , A61P9/00
CPC分类号： C12N5/0657 , A61K35/12 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/415 , C12N2506/02
摘要： The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.
摘要翻译：本发明提供人类心血管祖细胞群体，制备此类细胞的方法，以及使用该细胞产生心血管菌落群体和心肌细胞群体的方法。还提供了心肌细胞替代疗法。

6. 发明申请

US20100011455A1 STEM CELL GENE TARGETING 有权
标题翻译：干细胞基因靶向
公开(公告)号：US20100011455A1
公开(公告)日：2010-01-14
申请号：US12523632
申请日：2008-01-18
申请人： Gordon Keller , Stefan Irion , Herve Luche , Paul Gadue , Hans Joerg Fehling
发明人： Gordon Keller , Stefan Irion , Herve Luche , Paul Gadue , Hans Joerg Fehling
IPC分类号： A01K67/027 , C12N15/87 , C12N15/00 , C12N5/06 , C12N15/11
CPC分类号： C12N15/85 , A01K2207/15 , A01K2217/00 , C07K14/4702 , C12N5/0606 , C12N15/907 , C12N2510/00 , C12N2800/30 , C12N2830/85 , C12N2840/44
摘要： The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.
摘要翻译：本发明提供了一种产生具有经修饰的人类Rosa26基因座的转基因真核细胞群体的方法，该方法包括将功能性DNA序列引入起始真核细胞的人类Rosa26基因座。还提供了可用于该方法的靶向载体，以及包含修饰的人类Rosa26基因座的细胞群体和转基因非人动物。最后，本发明提供了对应于人类Rosa26基因座的分离的DNA序列。

7. 发明授权

US10077428B2 Human cardiovascular progenitor cells 有权
公开(公告)号：US10077428B2
公开(公告)日：2018-09-18
申请号：US12410782
申请日：2009-03-25
申请人： Gordon Keller , Lei Yang , Steven Kattman
发明人： Gordon Keller , Lei Yang , Steven Kattman
IPC分类号： C12N5/077 , A61K35/12
摘要： The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.

8. 发明申请

US20130230921A1 METHODS FOR ENRICHING PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTE PROGENITOR CELLS AND CARDIOMYOCYTE CELLS BASED ON SIRPA EXPRESSION 有权
标题翻译：基于SIRPA表达增强细胞干细胞衍生的心脏细胞祖细胞和心脏细胞的方法
公开(公告)号：US20130230921A1
公开(公告)日：2013-09-05
申请号：US13819318
申请日：2011-08-26
申请人： Gordon Keller , April M. Craft , Nicole C. Dubois
发明人： Gordon Keller , April M. Craft , Nicole C. Dubois
IPC分类号： C12N5/071
CPC分类号： C12N5/0657 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2501/165 , C12N2501/415 , C12N2506/00 , C12N2506/02 , C12N2506/45 , C12Q1/6881 , C12Q2600/158 , G01N33/5073 , G01N33/53 , G01N33/56966
摘要： The present invention relates to methods for enriching pluripotent stem cell-derived cardiomyocyte progenitor cells and cardiomyocyte cells based on SIRPA expression.
摘要翻译：本发明涉及基于SIRPA表达富集多能干细胞衍生的心肌细胞祖细胞和心肌细胞的方法。

9. 发明申请

US20090300782A1 Targeted gene addition in stem cells 审中-公开
标题翻译：干细胞中靶向基因的添加
公开(公告)号：US20090300782A1
公开(公告)日：2009-12-03
申请号：US11918698
申请日：2006-04-18
申请人： R. Michael Linden , Nathalie Dutheil , Els Henckaerts , Gordon Keller
发明人： R. Michael Linden , Nathalie Dutheil , Els Henckaerts , Gordon Keller
IPC分类号： A01K67/027 , C12N15/64 , C12N5/06
CPC分类号： C12N15/86 , A61K48/00 , C12N15/907 , C12N2750/14143
摘要： The present invention provides methods for adenoassociated virus-mediated site-specific integration of a transgene into a stem cell. Stem cells having a transgene integrated therein, and differentiated cells generated from the stem cells are also provided.
摘要翻译：本发明提供了腺病毒介导的将转基因部位特异性整合到干细胞中的方法。还提供了其中整合有转基因的干细胞，以及从干细胞产生的分化细胞。

10. 发明授权

US5389541A Erythropoietin-dependent erythroblastoid mouse cell line 失效
标题翻译：促红细胞生成素依赖性红细胞生成素小鼠细胞系
公开(公告)号：US5389541A
公开(公告)日：1995-02-14
申请号：US952880
申请日：1993-02-18
申请人： Gordon Keller , Harmut Beug , Erwin Wagner
发明人： Gordon Keller , Harmut Beug , Erwin Wagner
IPC分类号： G01N33/74 , C12N5/06 , C12N15/00
CPC分类号： G01N33/746
摘要： The invention includes a mouse erythroblastoid cell line whose growth is responsive to levels of erythropoietin present in the cell line's growth medium. Also disclosed are methods of using the mouse erythroblastoid cell line to assay the amount of erythropoietin that is present in a sample.
摘要翻译： PCT No.PCT / EP91 / 00981 Sec。 371日期：1993年2月18日 102（e）1993年2月18日PCT PCT 1991年5月28日提交PCT公布。 WO91 / 18973 PCT出版物日期1991年12月12日。本发明包括其生长对存在于细胞系生长培养基中的促红细胞生成素水平有反应的小鼠成红细胞细胞系。还公开了使用小鼠类红细胞细胞系测定样品中存在的促红细胞生成素的量的方法。

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