专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06905818B1 Method for the identification and characterization of interacting molecules by automated interaction mating 失效
标题翻译：通过自动相互作用交配识别和表征相互作用的分子的方法
公开(公告)号：US06905818B1
公开(公告)日：2005-06-14
申请号：US09583066
申请日：2000-05-30
申请人： Erich Wanker , David Bancroft , Hans Lehrach , Niels Wedemeyer , Elmar Maier , Sebastian Meier-Ewert
发明人： Erich Wanker , David Bancroft , Hans Lehrach , Niels Wedemeyer , Elmar Maier , Sebastian Meier-Ewert
IPC分类号： C12N15/00 , C12N15/10 , C12P21/06 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/1055 , G01N33/5008
摘要： The present invention relates to an improved method for the identification and optionally the characterisation of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by conventional two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention provides for high-throughput interaction screens for the reliable identification of interacting molecules, which in turn can lead to the identification of substances inhibiting said interactions. Such inhibitors can find their use in the formulation of a pharmaceutical composition. The present invention further relates to kits useful for carrying out the method of the invention.
摘要翻译：本发明涉及用于鉴定和任选地鉴定和任选地鉴定相关分子的改进方法，所述相互作用分子设计用于从常规双杂交系统分离的相当大量的假阳性克隆中检测阳性克隆。本发明的方法依赖于用于检测从假阳性克隆表达相互作用分子的克隆的选择步骤的新组合。本发明提供了用于可靠地识别相互作用的分子的高通量相互作用屏幕，这又可以导致抑制所述相互作用的物质的鉴定。这样的抑制剂可以用于药物组合物的制剂中。本发明还涉及可用于实施本发明方法的试剂盒。

2. 发明授权

US06664048B1 Identification and characterization of interacting molecules 失效
标题翻译：相互作用分子的鉴定和表征
公开(公告)号：US06664048B1
公开(公告)日：2003-12-16
申请号：US09583067
申请日：2000-05-30
申请人： Erich Wanker , David Bancroft , Hans Lehrach , Niels Wedemeyer , Elmar Maier , Sebastian Meier-Ewert
发明人： Erich Wanker , David Bancroft , Hans Lehrach , Niels Wedemeyer , Elmar Maier , Sebastian Meier-Ewert
IPC分类号： C12Q168
CPC分类号： C40B30/04 , C12N15/1055 , C12Q1/6897 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/68 , G01N33/6845 , G01N2800/52
摘要： The present invention relates to an improved method for the identification and optionally the characterization of interacting molecules designed to detect positive clones from the rather large numbers of false positive clones isolated by two-hybrid systems. The method of the invention relies on a novel combination of selection steps used to detect clones that express interacting molecules from false positive clones. The present invention further relates to a kit useful for carrying out the method of the invention. The present invention provides for parallel, high-throughput or automated interaction screens for the reliable identification of interacting molecules.
摘要翻译：本发明涉及用于鉴定和任选地鉴定和任选地鉴定相互作用的分子的改进方法，该相互作用分子设计用于通过由双杂交系统分离的相当大量的假阳性克隆来检测阳性克隆。本发明的方法依赖于用于检测从假阳性克隆表达相互作用分子的克隆的选择步骤的新组合。本发明还涉及可用于实施本发明方法的试剂盒。本发明提供用于可靠识别相互作用分子的平行，高通量或自动化相互作用屏幕。

3. 发明授权

US3933290A Explosion-driven bolt setting gun with drum magazine 失效
标题翻译：爆破驱动螺栓设置枪与鼓杂志
公开(公告)号：US3933290A
公开(公告)日：1976-01-20
申请号：US501833
申请日：1974-08-29
申请人： Elmar Maier
发明人： Elmar Maier
IPC分类号： B25C1/10 , B25C1/12
CPC分类号： B25C1/123
摘要： In a setting gun utilizing an explosive charge for driving fastening elements into a target material, a drum magazine holding both fastening elements and cartridges in receiving bores is rotatably mounted in a housing between a barrel and a breech plug. Separate spring biasing mechanisms hold the barrel and the drum magazine in a non-firing position. In moving the barrel and the drum magazine into the firing position it is necessary to overcome the spring biasing action and to displace both members opposite to the spring biasing direction.
摘要翻译：在利用用于将紧固元件驱动到目标材料中的爆炸装置的设置枪中，将容纳孔中的两个紧固元件和药筒的鼓盒可旋转地安装在枪管和后枪插头之间的壳体中。独立的弹簧偏置机构将镜筒和鼓盒保持在非点火位置。在将镜筒和鼓盒移动到发射位置时，必须克服弹簧偏压作用并使与弹簧偏置方向相反的两个构件移位。

4. 发明授权

US4213301A Compressed air apparatus for driving fastening elements 失效
标题翻译：用于驱动紧固元件的压缩空气装置
公开(公告)号：US4213301A
公开(公告)日：1980-07-22
申请号：US15612
申请日：1979-02-27
申请人： Elmar Maier , Othmar Heeb
发明人： Elmar Maier , Othmar Heeb
IPC分类号： B25C1/04 , F15B11/06
CPC分类号： B25C1/044 , Y10S60/916
摘要： In an apparatus for driving fastening elements, such as bolts and nails, into receiving material, a first or driving piston is mounted in a first chamber through which it is axially displaceable. A pressure converter arrangement is connected to an inlet to the first chamber for supplying the compressed air required for displacing the first piston for driving in a fastening element. The pressure converter includes a storage chamber, a second chamber in communication with the storage chamber and a third chamber. A double headed piston has one head in the second chamber and the other head in the third chamber. The third chamber has a much greater transverse cross-sectional area than the second chamber. Compressed air supplied to the third chamber compresses air in the second chamber which is directed into the storage chamber. From the storage chamber, the compressed air is charged into the first chamber for driving the first piston forwardly for inserting the fastening element.
摘要翻译：在用于将紧固元件（例如螺栓和钉子）驱动到接收材料中的装置中，第一或驱动活塞安装在第一室中，第一室可轴向移动。压力转换器装置连接到第一室的入口，用于供应用于移动第一活塞以在紧固元件中驱动所需的压缩空气。压力转换器包括存储室，与存储室连通的第二室和第三室。双头活塞在第二腔室中具有一个头部，在第三腔室中具有另一个头部。第三室具有比第二室大得多的横截面面积。供应到第三室的压缩空气压缩被引导到储存室中的第二室中的空气。从储存室将压缩空气装入第一室，用于向前驱动第一活塞以插入紧固元件。

5. 发明授权

US4201324A Arrangement for transporting a magazine through a setting device 失效
标题翻译：通过设置装置运送杂志的布置
公开(公告)号：US4201324A
公开(公告)日：1980-05-06
申请号：US936593
申请日：1978-08-24
申请人： Elmar Maier , Othmar Heeb
发明人： Elmar Maier , Othmar Heeb
IPC分类号： B25C1/00 , B25C1/18 , F41A9/25 , B25C1/14
CPC分类号： F41A9/25 , B25C1/003 , B25C1/184
摘要： In a setting device, a magazine is advanced through a guide channel to present fastening elements in the path of a driving member. The magazine is moved in a step-wise manner by a transport pawl, and the pawl, in turn, is reciprocated relative to the drive channel by an operating member. A linkage interconnecting the operating member and the transport pawl, includes a pin secured to the operating member extending into a triangularly shaped recess in the transport pawl. The pin pivots the transport pawl out of engagement with the magazine in the guide channel and moves the pawl rearwardly so that it can again engage the magazine and move it so that another fastening element is aligned with the driving member.
摘要翻译：在设定装置中，盒子通过引导通道前进，以在驱动构件的路径中呈现紧固元件。通过传送棘爪以分步的方式移动盒，并且棘爪又通过操作构件相对于驱动通道往复运动。将操作构件和输送爪互连的连杆包括固定到操作构件的销，该销延伸到输送爪中的三角形凹槽中。该销枢转传送棘爪与引导通道中的刀库脱离接合，并向后移动棘爪，使得其可以再次接合刀库并移动，使得另一紧固元件与驱动构件对准。

6. 发明授权

US5299366A Fluidized bed transport apparatus for coating small hardware items 失效
标题翻译：流化床运输装置，用于涂装小型五金件
公开(公告)号：US5299366A
公开(公告)日：1994-04-05
申请号：US882602
申请日：1992-05-13
申请人： Elmar Maier , Eckart Drossler
发明人： Elmar Maier , Eckart Drossler
IPC分类号： B01J8/38 , B01J8/44 , B65G53/02 , B65G53/50 , F26B3/08 , F26B3/22 , F26B17/00
CPC分类号： B01J8/44 , F26B3/082 , F26B3/225 , Y10S118/05
摘要： Transport apparatus for small sized hardware items includes a fluidized bed with a sloping gas permeable base (6) at the inlet end of the bed. Gas feed chambers (6a, 6b, 6c, 6d) are located on the lowerside of the base (6) and are sealed from one another in a gas tight manner. Powder columns (2a, 2b, 2c, 2d) of different heights extend upwardly above the base (6). Gas at different pressures is supplied through the gas feed chambers (6a, 6b, 6c, 6d) into the powder columns forming a uniform fluidized bed (2). The base slopes downwardly and has step-like transitions adjacent intersections of the chambers.
摘要翻译：用于小型五金件的运输设备包括在床的入口端具有倾斜气体可渗透基底（6）的流化床。气体供给室（6a，6b，6c，6d）位于基座（6）的下侧，并且以气密方式彼此密封。不同高度的粉末柱（2a，2b，2c，2d）向上延伸到基部（6）的上方。通过气体供给室（6a，6b，6c，6d）将不同压力的气体供给到形成均匀流化床（2）的粉末塔中。基部向下倾斜，并且在腔室的相交处具有阶梯状的过渡。

7. 发明授权

US3981424A Explosive charge driven setting gun 失效
标题翻译：爆炸充电驱动设置枪
公开(公告)号：US3981424A
公开(公告)日：1976-09-21
申请号：US599066
申请日：1975-07-25
申请人： Elmar Maier
发明人： Elmar Maier
IPC分类号： B25C1/10 , B25C1/08 , B25C1/14
CPC分类号： B25C1/087 , B25C1/085
摘要： In an explosive charge driven setting gun a breech block is located in the rear of the gun housing and the gun barrel is axially displaceable within the gun housing. A firing projection is formed on the rear end of the barrel so that a propellant charge supported on the breech block can be fired by displacing the barrel rearwardly against the breech block. The displacement force can be provided by a spring which biases the barrel rearwardly. A latch can be mounted in the housing for securing the barrel in a forward position and when the latch is released, the barrel can be displaced rearwardly against the breech block.
摘要翻译：在爆炸电荷驱动设置枪中，后枪块位于枪壳的后部，枪筒在枪壳内可轴向移动。在枪管的后端形成一个击球突起，这样一来，支撑在后膛块上的推进剂装料可以通过将镜筒向后移动抵挡后枪块来发射。位移力可以由向后偏压筒的弹簧提供。闩锁可以安装在壳体中，用于将枪管固定在向前的位置，并且当闩锁被释放时，枪管可以向后移动抵靠后膛块。

8. 发明授权

US3955674A Magazine for a fastening element setting gun 失效
标题翻译：用于紧固元件设置枪的杂志
公开(公告)号：US3955674A
公开(公告)日：1976-05-11
申请号：US531439
申请日：1974-12-10
申请人： Elmar Maier , Robert Tilg
发明人： Elmar Maier , Robert Tilg
IPC分类号： F16B19/14 , B25C1/10 , B25C1/16 , B25C3/00 , F16B15/08 , B65D85/24 , F16B15/00
CPC分类号： B25C3/00 , F16B15/08
摘要： A magazine supporting nail-like fastening elements for use in an explosive charge driven setting gun is formed of an elongated strip having spaced first openings which hold the fastening elements. Concentric with and spaced radially outwardly from each first opening is a ring-like arrangement of arcuate slots or second openings spaced apart by radially extending webs. The webs have reduced thickness portions as compared to the thickness of the strip, so that a weakened region is formed for separation of that portion of the strip radially inwardly of the second openings when a fastening element is driven through the magazine into a receiving material.
摘要翻译：用于爆炸电荷驱动设置枪的用于钉状紧固元件的杂志由具有间隔开的第一开口的细长条形成，该第一开口保持紧固元件。与每个第一开口径向向外间隔开的同心圆弧形槽或通过径向延伸腹板间隔开的第二开口。腹板与带材的厚度相比具有减小的厚度部分，从而形成弱化区域，以便当将紧固元件通过料盒驱动到接收材料中时，将条带的该部分的径向向内分开。

9. 发明授权

US3944068A Fastening element holder strip with break-off locations 失效
标题翻译：带有断路位置的紧固件支架带
公开(公告)号：US3944068A
公开(公告)日：1976-03-16
申请号：US511261
申请日：1974-10-02
申请人： Elmar Maier , Robert Tilg
发明人： Elmar Maier , Robert Tilg
IPC分类号： B25C1/10 , B25C1/08 , B25C1/18 , F16B15/08 , F16B19/14 , F16B27/00 , B65D85/24
CPC分类号： B25C1/184 , F16B15/08 , F16B27/00
摘要： In a strip for holding fastening elements, such as nails and the like, as they are fed into a setting device for insertion into a target material, break-off locations are provided in the strip to separate used portions of the strip from portions still containing fastening elements. The holder strip is an elongated flat tape or belt-like member. The fastening elements are secured within holes spaced apart in the elongated direction of the strip. The fastening elements have transversely extending heads which punch out parts of the strip as the elements are driven into the target material. Preferably, the break-off locations are in the form of notches extending inwardly from the longitudinal sides of the strip into the region punched out by the inserted elements. As a result, when a fastening element punches through the strip where break-off locations are present, at least a portion of the strip from which the fastening elements have been driven is separated from the remainder of the strip.
摘要翻译：在用于保持固定元件（例如钉子等）的条带中，当它们被馈送到用于插入目标材料的定位装置中时，在条带中设置有断开位置以将条带的使用部分与仍含有紧固件。保持器条是细长的扁平带或带状构件。紧固元件固定在沿条带的细长方向间隔开的孔内。当元件被驱动到目标材料中时，紧固元件具有横向延伸的头部，该头部穿过条带的部分。优选地，断裂位置是从带的纵向侧向内延伸到由插入元件冲压出的区域的凹口的形式。结果，当紧固元件穿过存在断裂位置的条带时，紧固元件已被驱动的条带的至少一部分与条的其余部分分离。

10. 发明授权

US6150094A Use of an osmolyte for reducing or abolishing no-covalent interactions of biological molecules to inert surfaces 失效
标题翻译：使用渗透剂减少或消除生物分子与惰性表面的非共价相互作用
公开(公告)号：US6150094A
公开(公告)日：2000-11-21
申请号：US862984
申请日：1997-05-23
申请人： Elmar Maier , Igor Ivanov
发明人： Elmar Maier , Igor Ivanov
IPC分类号： G01N33/543 , C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/567
CPC分类号： G01N33/54393
摘要： The present invention relates to the use of an osmolyte for reducing or abolishing non-covalent interactions of biological molecules to inert surfaces. Furthermore, the present invention relates to kits that may be employed for uses in accordance with the present invention.
摘要翻译：本发明涉及渗透剂用于减少或消除生物分子与惰性表面的非共价相互作用的用途。此外，本发明涉及可用于根据本发明的用途的试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式