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1. 发明申请

US20100216779A1 Imidazopyridine Kinase Inhibitors 审中-公开
标题翻译：咪唑并吡啶激酶抑制剂
公开(公告)号：US20100216779A1
公开(公告)日：2010-08-26
申请号：US12602289
申请日：2008-05-28
申请人： Eric W. Baum , Kyle Allen Emmitte , Kevin Wayne Kuntz , Robert Anthony Mook, JR. , Kristen Elizabeth Nailor , James Michael Salovich , John Brad Shotwell , Stephon Cornell Smith , Kirk Lawrence Stevens , David Edward Uehling , Alex Gregory Waterson , Mui Cheung , Ganesh S. Moorthy , Brian John Wilson
发明人： Eric W. Baum , Kyle Allen Emmitte , Kevin Wayne Kuntz , Robert Anthony Mook, JR. , Kristen Elizabeth Nailor , James Michael Salovich , John Brad Shotwell , Stephon Cornell Smith , Kirk Lawrence Stevens , David Edward Uehling , Alex Gregory Waterson , Mui Cheung , Ganesh S. Moorthy , Brian John Wilson
IPC分类号： A61K31/506 , C07D471/04 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

2. 发明授权

US08093239B2 Imidazopyridine kinase inhibitors 有权
标题翻译：咪唑并吡啶激酶抑制剂
公开(公告)号：US08093239B2
公开(公告)日：2012-01-10
申请号：US12128099
申请日：2008-05-28
申请人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号： A61K31/55 , A61K31/505 , A61K31/497 , A61K31/535 , C07D243/08 , C07D413/14 , C07D403/14 , C07D239/02
CPC分类号： C07D471/04
摘要： The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

3. 发明申请

US20080300242A1 Imidazopyridine Kinase Inhibitors 有权
标题翻译：咪唑并吡啶激酶抑制剂
公开(公告)号：US20080300242A1
公开(公告)日：2008-12-04
申请号：US12128099
申请日：2008-05-28
申请人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
发明人： Kevin Kuntz , David Edward Uehling , Alex Gregory Waterson , Kyle Allen Emmitte , Kirk Stevens , John Brad Shotwell , Stephon Cornell Smith , Kristen E. Nailor , James M. Salovich , Brian John Wilson , Mui Cheung , Robert Anthony Mook , Erich W. Baum , Ganesh Moorthy
IPC分类号： A61K31/496 , C07D401/04 , C07D279/12 , A61P35/00 , A61K31/541 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供咪唑并吡啶化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

4. 发明授权

US07812022B2 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors 失效
公开(公告)号：US07812022B2
公开(公告)日：2010-10-12
申请号：US11721504
申请日：2005-12-06
申请人： David Edward Uehling , Kirk Lawrence Stevens , Scott Howard Dickerson , Alex Gregory Waterson , Philip Anthony Harris , Douglas McCord Sammond , Robert Dale Hubbard , Holly Kathleen Emerson , Joseph W. Wilson
发明人： David Edward Uehling , Kirk Lawrence Stevens , Scott Howard Dickerson , Alex Gregory Waterson , Philip Anthony Harris , Douglas McCord Sammond , Robert Dale Hubbard , Holly Kathleen Emerson , Joseph W. Wilson
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

5. 发明申请

US20090149456A1 2-Pyrimidinyl Pyrazolopyridine ErbB Kinase Inhibitors 失效
标题翻译： 2-嘧啶基吡唑并吡啶ErbB激酶抑制剂
公开(公告)号：US20090149456A1
公开(公告)日：2009-06-11
申请号：US12095762
申请日：2006-12-04
申请人： David Edward Uehling , Robert Dale Hubbard , Alex Gregory Waterson , Kimberly Petrov , Neil Bifulco, JR. , Joseph Wendell Wilson , Jennifer Gabriel Badiang , Mui Cheung , Mariko Yamabe
发明人： David Edward Uehling , Robert Dale Hubbard , Alex Gregory Waterson , Kimberly Petrov , Neil Bifulco, JR. , Joseph Wendell Wilson , Jennifer Gabriel Badiang , Mui Cheung , Mariko Yamabe
IPC分类号： A61K31/5377 , C07D239/24 , A61K31/506 , A61P35/00 , C07D413/14
CPC分类号： C07D471/04
摘要： The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要翻译：本发明提供2-嘧啶基吡唑并吡啶化合物，含有它们的组合物，以及制备方法及其作为药剂的用途。

6. 发明授权

US07807673B2 2-pyrimidinyl pyrazolopyridine ErbB kinase inhibitors 失效
标题翻译： 2-嘧啶基吡唑并吡啶ErbB激酶抑制剂
公开(公告)号：US07807673B2
公开(公告)日：2010-10-05
申请号：US12095762
申请日：2006-12-04
申请人： David Edward Uehling , Robert Dale Hubbard , Alex Gregory Waterson , Kimberly Petrov , Neil Bifulco, Jr. , Joseph Wendell Wilson , Jennifer Gabriel Badiang , Mul Cheung , Mariko Yamabe
发明人： David Edward Uehling , Robert Dale Hubbard , Alex Gregory Waterson , Kimberly Petrov , Neil Bifulco, Jr. , Joseph Wendell Wilson , Jennifer Gabriel Badiang , Mul Cheung , Mariko Yamabe
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要翻译：本发明提供2-嘧啶基吡唑并吡啶化合物，含有它们的组合物，以及制备方法及其作为药剂的用途。

7. 发明申请

US20110190280A1 Thiazole And Oxazole Kinase Inhibitors 审中-公开
标题翻译：噻唑和恶唑激酶抑制剂
公开(公告)号：US20110190280A1
公开(公告)日：2011-08-04
申请号：US12674016
申请日：2008-08-27
申请人： George Adjabeng , Neil Bifulco , Ronda G. Davis-Ward , Scott Howard Dickerson , Kelly Horne Donaldson , Philip Anthony Harris , Keith Hornberger , Kimberly Petrov , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , David Edward Uehling , Alex Gregory Waterson
发明人： George Adjabeng , Neil Bifulco , Ronda G. Davis-Ward , Scott Howard Dickerson , Kelly Horne Donaldson , Philip Anthony Harris , Keith Hornberger , Kimberly Petrov , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , David Edward Uehling , Alex Gregory Waterson
IPC分类号： A61K31/541 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D417/14 , C07D498/04 , A61K31/5365 , A61P35/00
CPC分类号： C07D417/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供噻唑和恶唑化合物，含有它们的组合物，以及制备方法及其用作药剂的方法。

8. 发明申请

US20090298815A1 Benzene Sulfonamide Thiazole and Oxazole Compounds 有权
标题翻译：苯磺酰胺噻唑和恶唑化合物
公开(公告)号：US20090298815A1
公开(公告)日：2009-12-03
申请号：US12434963
申请日：2009-05-04
申请人： Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
发明人： Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
IPC分类号： A61K31/506 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供噻唑磺酰胺和恶唑磺酰胺化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。

9. 发明授权

US06251925B1 Therapeutic biaryl derivatives 有权
标题翻译：治疗性联芳衍生物
公开(公告)号：US06251925B1
公开(公告)日：2001-06-26
申请号：US09719595
申请日：2000-12-13
申请人： Kelly Horne Donaldson , Barry George Shearer , David Edward Uehling
发明人： Kelly Horne Donaldson , Barry George Shearer , David Edward Uehling
IPC分类号： C07C22952
CPC分类号： C07D213/79 , C07C217/14 , C07C229/52 , C07C255/58 , C07D213/80 , C07D257/04 , C07D307/79
摘要： The present invention relates to therapeutic biaryl derivatives of formula (I), and pharmaceutically acceptable derivatives thereof wherein R1 is a phenyl, naphthyl, pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group, optionally substituted by one or more substituents selected from the group consisting of halogen, hydroxy, C1-6alkoxy, C1-6alkyl, nitro, cyano, hydroxymethyl, trifluoromethyl, —NR6R6, and —NHSO2R6, where each R6 is independently hydrogen or C1-4alkyl; R2 is hydrogen or C1-6alkyl; X is oxygen, sulfur, —NH, or —NC1-4alkyl; R3 is cyano, tetrazol-5-yl, or —CO2R7 where R7 is hydrogen or C1-6alkyl; R4 and R5 are independently hydrogen, C1-6alkyl, —CO2H, —CO2C1-6alkyl, cyano, tetrazol-5-yl, halogen, trifluoromethyl, or C1-6alkoxy, or, when R4 and R5 are bonded to adjacent carbon atoms, R4 and R5 may, together with the carbon atoms to which they are bonded, form a fused 5 or 6 membered ring optionally containing one or two nitrogen, oxygen, or sulfur atoms; and Y is N or CH, to processes for their preparation and their use in the treatment of diseases susceptible to ameleoration by treatment with a beta-3 adrenoceptor agonist.
摘要翻译：本发明涉及式（I）的治疗性联芳基衍生物及其药学上可接受的衍生物，其中R1是苯基，萘基，吡啶基，噻唑基，苯氧基甲基或嘧啶基，任选地被一个或多个选自卤素，羟基，C 1-6烷氧基，C 1-6烷基，硝基，氰基，羟甲基，三氟甲基，-NR 6 R 6和-NHSO 2 R 6，其中每个R 6独立地为氢或C 1-4烷基; R2是氢或C1-6烷基; X是氧，硫，-NH或-NC 1-4烷基; R 3是氰基，四唑-5-基或-CO 2 R 7，其中R 7是氢或C 1-6烷基; R 4和R 5独立地是氢，C 1-6烷基，-CO 2 H，-CO 2 C 1-6烷基，氰基，四唑-5-基，卤素，三氟甲基或C 1-6烷氧基，或者当R 4和R 5与相邻碳原子键合时，R 4 并且R 5可以与它们所键合的碳原子一起形成任选地含有一个或两个氮，氧或硫原子的稠合的5或6元环; 并且Y是N或CH，用于其制备及其用于治疗通过用β-3肾上腺素受体激动剂治疗而易于变形的疾病的用途。

10. 发明授权

US07034053B2 Phenethanolamine derivatives, compositions, and their use as agonists at atypical beta-adrenoreceptors 有权
标题翻译：苯乙醇胺衍生物，组合物及其作为非典型β-肾上腺素受体激动剂的用途
公开(公告)号：US07034053B2
公开(公告)日：2006-04-25
申请号：US10470860
申请日：2001-12-17
申请人： David N. Deaton , Barry George Shearer , David Edward Uehling
发明人： David N. Deaton , Barry George Shearer , David Edward Uehling
IPC分类号： A61K31/381 , A61K31/34 , C07D333/38 , C07D333/22 , C07D307/02
CPC分类号： C07D333/38 , C07D307/68
摘要： The present invention disclosed compounds of Formula I. The present invention also discloses beta-3 agonists of formula I and methods for treating beta-3 mediated diseases and condition using the compounds of formula I, in particular methods for treating diabetes or obesity.
摘要翻译：本发明公开了式I的化合物。本发明还公开了式I的β-3激动剂和使用式I化合物治疗β-3介导的疾病和病症的方法，特别是治疗糖尿病或肥胖症的方法。

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